2.7.1.60: N-acylmannosamine kinase

This is an abbreviated version!
For detailed information about N-acylmannosamine kinase, go to the full flat file.

Word Map on EC 2.7.1.60

2.7.1.60

sialic

myopathy

n-acetylneuraminic

2.7.1.59

sialylation

glycoconjugates

rimmed

n-acetylmannosamine-6-phosphate

n-acetyl-d-glucosamine

glucokinase

nanks

aminosugars

neu5ac

medicine

molecular biology

Reaction

Synonyms

acetylamidodeoxymannokinase, acetylmannosamine kinase, acylaminodeoxymannokinase, acylmannosamine kinase, acylmannosamine kinase (phosphorylating), ATP:N-acetylmannosamine 6-phosphotransferase, EC 2.7.1.59/EC 2.7.1.60, EC 5.1.3.14/EC 2.7.1.60, GNE, GNE2, GNE3, ManAc kinase, MNK, N-acetylmannosamine kinase, N-acetylmannosamine-6-phosphate 2-epimerase, N-acyl-D-mannosamine kinase, nanK, UDP-GlcNAc 2-epimerase/ManAc kinase, UDP-GlcNAc 2-epimerase/ManNAc 6-kinase, UDP-GlcNAc 2-epimerase/ManNAc kinase, UDP-GlcNAc-2 epimerase/ManNAc kinase, UDP-GlcNAc-epimerase/ManNAc kinase, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase, UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.60 N-acylmannosamine kinase

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Results	in table
4	Activating Compound
1936	AA Sequence
3	Application
1	CAS Registry Number
26	Cloned(Commentary)
2	Cofactor
5	Crystallization (Commentary)
28	Disease/ Diagnostics
1	Expression
26	General Information
4	General Stability
24	IC50 Value
39	Inhibitors
7	kcat/KM [mM/s]
1	Ki Value [mM]
21	KM Value [mM]
21	Localization
18	Metals/Ions
23	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
1074	Organism
6	Pathway
17	PDB ID
4	pH Optimum
2	pH Stability
68	Protein Variants
18	Purification (Commentary)
1	Reaction
1	Reaction Type
63	Reference
74	Source Tissue
10	Specific Activity [micromol/min/mg]
6	Storage Stability
99	Substrates and Products (Substrate)
34	Subunits
92	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
8	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.7.1.60 - N-acylmannosamine kinase

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0.011

(2Z)-1-(4-chlorophenyl)-3-(2-hydroxy-5-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

Homo sapiens

at pH 8.0 and 37°C

759052

2.5

1,3-dimethyl-4-(trifluoromethyl)-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one

Homo sapiens

IC50 above 2.5 mM, at pH 8.0 and 37°C

758987

0.4

1,6-dimethyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

Homo sapiens

at pH 8.0 and 37°C

758987

0.0072

2,3-bis[(2-hydroxyethyl)sulfanyl]naphthalene-1,4-dione

Homo sapiens

at pH 8.0 and 37°C

759052

2.5

2-ethyl-4-(trifluoromethyl)-2,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one

Homo sapiens

IC50 above 2.5 mM, at pH 8.0 and 37°C

758987

2.5

2-hydroxy-6-propyl-4-(trifluoromethyl)pyridine-3-carbonitrile

Homo sapiens

IC50 above 2.5 mM, at pH 8.0 and 37°C

758987

0.9

2-methoxy-4-(trifluoromethyl)pyridine-3-carboxylic acid

Homo sapiens

at pH 8.0 and 37°C

758987

0.7

3-acetyl-5-chloropyridine-2-carboxylic acid

Homo sapiens

at pH 8.0 and 37°C

758987

0.9

4-(trifluoromethyl)picolinic acid

Homo sapiens

at pH 8.0 and 37°C

758987

0.9

4-(trifluoromethyl)pyridine-2-carboxylic acid

Homo sapiens

at pH 8.0 and 37°C

758987

0.078

4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid

Homo sapiens

at pH 8.0 and 37°C

758987

0.0006

5-(anthracen-9-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Homo sapiens

at pH 8.0 and 37°C

759052

2.5

5-(cyanomethyl)pyridine-2-carboxylic acid

Homo sapiens

IC50 above 2.5 mM, at pH 8.0 and 37°C

758987

0.8

5-carbamoyl-3-chloropyridine-2-carboxylic acid

Homo sapiens

at pH 8.0 and 37°C

758987

3.7

6-(cyclopentylcarbamoyl)pyridine-2-carboxylic acid

Homo sapiens

at pH 8.0 and 37°C

758987

0.08

6-(pyrrolidin-1-ylcarbonyl)pyridine-2-carboxylic acid

Homo sapiens

at pH 8.0 and 37°C

758987

0.8

6-6'-diselenobis-(2-acetamido-2-deoxy-D-mannopyranose)

Homo sapiens

at pH 8.0 and 37°C

759052

0.7

6-acetylpicolinic acid

Homo sapiens

at pH 8.0 and 37°C

758987

0.7

6-acetylpyridine-2-carboxylic acid

Homo sapiens

at pH 8.0 and 37°C

758987

0.076

6-carbamoylpyridine-2-carboxylic acid

Homo sapiens

at pH 8.0 and 37°C

758987

2.5

6-cyclopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

Homo sapiens

IC50 above 2.5 mM, at pH 8.0 and 37°C

758987

1.6

6-methyl-4-(trifluoromethyl)pyridin-2(1H)-one

Homo sapiens

at pH 8.0 and 37°C

758987

0.8

methyl 5,6-diaminopyridine-2-carboxylate

Homo sapiens

at pH 8.0 and 37°C

758987

0.0004

N-[4-[(E)-(3,5-dioxo-1-phenylpyrazolidin-4-ylidene)methyl]phenyl]acetamide

Homo sapiens

at pH 8.0 and 37°C

759052