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Literature summary for 2.7.1.60 extracted from

  • Grover, S.; Arya, R.
    Role of UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase (GNE) in beta1-integrin-mediated cell adhesion (2014), Mol. Neurobiol., 50, 257-273.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
D176V the mutation leads to impaired N-acetylmannosamine kinase activity (40.58% of wild type activity) Homo sapiens
V572L the mutation leads to impaired N-acetylmannosamine kinase activity (15.9% of wild type activity) Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
Golgi membrane
-
Homo sapiens 139
-
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + N-acyl-D-mannosamine Homo sapiens
-
ADP + N-acyl-D-mannosamine 6-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y223
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + N-acyl-D-mannosamine
-
Homo sapiens ADP + N-acyl-D-mannosamine 6-phosphate
-
?

Synonyms

Synonyms Comment Organism
GNE
-
Homo sapiens
UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme mutation affects beta1-integrin-mediated cell adhesion process Homo sapiens