2.5.1.6: methionine adenosyltransferase

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For detailed information about methionine adenosyltransferase, go to the full flat file.

Reaction

Synonyms

(Met) adenosyltransferase 4, adenosylmethionine synthase, adenosylmethionine synthetase, AdoMet synthase, AdoMet synthease, AdoMet synthetase, AdoMetS, ATP-methionine adenosyltransferase, ATP: L-methionine S-adenosyltransferase, EC 2.4.2.13, MAT, MAT I, MAT II, MAT IIalpha, MAT III, MAT1A, MAT2, MAT2A, MAT2beta, MAT3, MAT4, MATalpha1, MATalpha2, methionine adenosyl transferase 2A, methionine adenosyltransferase, methionine adenosyltransferase 2A, methionine adenosyltransferase 2beta, methionine adenosyltransferase 4, methionine adenosyltransferase alpha1, methionine adenosyltransferase II, methionine adenosyltransferase II-alpha, methionine adenosyltransferase IIalpha, methionine S-adenosyltransferase, methionine-activating enzyme, MetK, Mj-MAT, MJ1208, pDS16, PF1866, PfMAT, S-adenosyl-L-methionine synthetase, S-adenosyl-Lmethionine synthetase, S-adenosyl-Met synthetase 3, S-adenosylmethionine synthase, S-adenosylmethionine synthetase, S-adenosylmethionine synthetase 1, S-adenosylmethionine synthetase 2, S-adenosylmethionine synthetase 3, S-adenosylmethionine synthetase A, S-adenosylmethionine synthetase B, S-adenosylmethionine-L-synthetase, SAM synthase, SAM synthetase, SAM-s, Sam1, SAM2, SAMS, SAMS1, SAMS2, SMAT, SSO0199

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.6 methionine adenosyltransferase

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Results	in table
47	Activating Compound
52082	AA Sequence
12	Application
1	CAS Registry Number
61	Cloned(Commentary)
35	Cofactor
15	Crystallization (Commentary)
1189	Disease/ Diagnostics
10	Expression
37	General Information
9	General Stability
4	IC50 Value
226	Inhibitors
24	kcat/KM [mM/s]
32	Ki Value [mM]
220	KM Value [mM]
9	Localization
96	Metals/Ions
88	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
202	Organism
11	Pathway
219	PDB ID
32	pH Optimum
12	pH Range
5	pH Stability
7	pI Value
3	Posttranslational Modification
88	Protein Variants
52	Purification (Commentary)
7	Reaction
1	Reaction Type
183	Reference
6	Renatured (Commentary)
123	Source Tissue
76	Specific Activity [micromol/min/mg]
12	Storage Stability
290	Substrates and Products (Substrate)
78	Subunits
204	Synonyms
1	Systematic Name
32	Temperature Optimum [°C]
10	Temperature Range [°C]
17	Temperature Stability [°C]
72	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 2.5.1.6 - methionine adenosyltransferase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

acylation

Escherichia coli

P0A817

12 lysine residues of the protein are acetylated. Acetylation lead to a decrease in its enzymatic activity, which could be reversed by CobB deacetylation. Lysine acetylation regulates the activity of the enzyme

758589

glutathionylation

Plasmodium falciparum

Q7K6A4

the enzyme is inhibited upon glutathionylation

759436

nitrosylation

Plasmodium falciparum

Q7K6A4

the enzyme is inhibited upon S-nitrosylation. S-Nitrosylation of PfalMAT is mediated via several cysteine residues, including Cys52, Cys113 and Cys187. Nitrosylation is a reversible posttranslational modification upon nitrosative stress

759436