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2.5.1.6: methionine adenosyltransferase

This is an abbreviated version!
For detailed information about methionine adenosyltransferase, go to the full flat file.

Word Map on EC 2.5.1.6

Reaction

ATP
+
L-methionine
 +
H2O
=
phosphate
 +
diphosphate
 +
S-adenosyl-L-methionine

Synonyms

(Met) adenosyltransferase 4, adenosylmethionine synthase, adenosylmethionine synthetase, AdoMet synthase, AdoMet synthease, AdoMet synthetase, AdoMetS, ATP-methionine adenosyltransferase, ATP: L-methionine S-adenosyltransferase, EC 2.4.2.13, MAT, MAT I, MAT II, MAT IIalpha, MAT III, MAT1A, MAT2, MAT2A, MAT2beta, MAT3, MAT4, MATalpha1, MATalpha2, methionine adenosyl transferase 2A, methionine adenosyltransferase, methionine adenosyltransferase 2A, methionine adenosyltransferase 2beta, methionine adenosyltransferase 4, methionine adenosyltransferase alpha1, methionine adenosyltransferase II, methionine adenosyltransferase II-alpha, methionine adenosyltransferase IIalpha, methionine S-adenosyltransferase, methionine-activating enzyme, MetK, Mj-MAT, MJ1208, pDS16, PF1866, PfMAT, S-adenosyl-L-methionine synthetase, S-adenosyl-Lmethionine synthetase, S-adenosyl-Met synthetase 3, S-adenosylmethionine synthase, S-adenosylmethionine synthetase, S-adenosylmethionine synthetase 1, S-adenosylmethionine synthetase 2, S-adenosylmethionine synthetase 3, S-adenosylmethionine synthetase A, S-adenosylmethionine synthetase B, S-adenosylmethionine-L-synthetase, SAM synthase, SAM synthetase, SAM-s, Sam1, SAM2, SAMS, SAMS1, SAMS2, SMAT, SSO0199

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.6 methionine adenosyltransferase

Source Tissue

Source Tissue on EC 2.5.1.6 - methionine adenosyltransferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
mainly MAT2beta variant 1
Manually annotated by BRENDA team
-
L1210 cell line, two isoenzymes
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
hepatocellular carcinoma, MAT1A is replaced by MAT2A
Manually annotated by BRENDA team
regulatory subunit MAT2beta is expressed at a higher level in liver and duodenum, followed by the stomach, fat and longissinus dorsi muscle
Manually annotated by BRENDA team
-
preimplantation embryo
Manually annotated by BRENDA team
lung epithelial isoform of MAT 2A
Manually annotated by BRENDA team
maximum mRNA accumulation is attained in the evening
Manually annotated by BRENDA team
-
mainly MAT2beta variant 2
Manually annotated by BRENDA team
-
leukemia promyelotic cells
Manually annotated by BRENDA team
regulatory subunit MAT2beta is expressed at a higher level in liver and duodenum, followed by the stomach, fat and longissinus dorsi muscle. MAT2beta mRNA abundance is lower in both subcutaneous adipose tissue and skeletal muscle in obese pigs compared with lean pigs. MAT II beta protein content is lower in skeletal muscle in obese than in lean pigs
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
a single form of enzyme
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
at night, 2.5fold increase of activity of isoform MAT II
Manually annotated by BRENDA team
highly expressed in pollen
Manually annotated by BRENDA team
-
mainly MAT2beta variant 1
Manually annotated by BRENDA team
-
green of 14-days old of seedlings
Manually annotated by BRENDA team
-
isoforms MAT2AandMAT2beta are induced in culture-activated primary hepatic stellate cells and hepatic stellate cells from 10-day bile duct ligated rat livers. Hepatic stellate cell activation leads to a decline in intracellular S-adenosylmethionine and methyhthioadenosine levels, a drop in the S-adenosylmethionine/S-adenosylhomocysteine ratio, and global DNA hypomethylation. The decrease in S-adenosylmethionen levels is associated with lower MATII activity during activation
Manually annotated by BRENDA team
T helper CD4+ lymphocyte
Manually annotated by BRENDA team
-
mainly MAT2beta variant 2
Manually annotated by BRENDA team
-
MAT2beta variant 1 and 2
Manually annotated by BRENDA team
-
mainly MAT2beta variant 1
Manually annotated by BRENDA team
additional information