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2.5.1.6: methionine adenosyltransferase

This is an abbreviated version!
For detailed information about methionine adenosyltransferase, go to the full flat file.

Word Map on EC 2.5.1.6

Reaction

ATP
+
L-methionine
+
H2O
=
phosphate
+
diphosphate
+
S-adenosyl-L-methionine

Synonyms

(Met) adenosyltransferase 4, adenosylmethionine synthase, adenosylmethionine synthetase, AdoMet synthase, AdoMet synthease, AdoMet synthetase, AdoMetS, ATP-methionine adenosyltransferase, ATP: L-methionine S-adenosyltransferase, EC 2.4.2.13, MAT, MAT I, MAT II, MAT IIalpha, MAT III, MAT1A, MAT2, MAT2A, MAT2beta, MAT3, MAT4, MATalpha1, MATalpha2, methionine adenosyl transferase 2A, methionine adenosyltransferase, methionine adenosyltransferase 2A, methionine adenosyltransferase 2beta, methionine adenosyltransferase 4, methionine adenosyltransferase alpha1, methionine adenosyltransferase II, methionine adenosyltransferase II-alpha, methionine adenosyltransferase IIalpha, methionine S-adenosyltransferase, methionine-activating enzyme, MetK, Mj-MAT, MJ1208, pDS16, PF1866, PfMAT, S-adenosyl-L-methionine synthetase, S-adenosyl-Lmethionine synthetase, S-adenosyl-Met synthetase 3, S-adenosylmethionine synthase, S-adenosylmethionine synthetase, S-adenosylmethionine synthetase 1, S-adenosylmethionine synthetase 2, S-adenosylmethionine synthetase 3, S-adenosylmethionine synthetase A, S-adenosylmethionine synthetase B, S-adenosylmethionine-L-synthetase, SAM synthase, SAM synthetase, SAM-s, Sam1, SAM2, SAMS, SAMS1, SAMS2, SMAT, SSO0199

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.6 methionine adenosyltransferase

Specific Activity

Specific Activity on EC 2.5.1.6 - methionine adenosyltransferase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0002
-
activity Peak II, adult erythrocytes
0.001
-
brain
0.0011
-
muscle
0.0041
-
pancreas
0.0042
-
intestine
0.0061
-
kidney
0.039
-
MAT I
0.0431
-
liver
0.058
tripolyphosphase activity
0.065
-
S-adenosylmethionine synthetase B
0.068
-
crude enzyme, at pH 8.5 and 45°C
0.096
-
glutathione/glutathione disulfide-refolded MAT III
0.098
-
MAT III
0.1
-
glutathione/glutathione disulfide-refolded MAT I
0.109
purified recombinant His-tagged isozyme SAMS1
0.11
-
dithiothreitol-refolded MAT III
0.138
-
S-adenosylmethionine synthetase A
0.2
S-adenosylmethionine synthesis activity
0.28
-
low-MW isozyme
0.94
-
pH 8.0, 37°C
1.82
pH 8, 37°C, wild-type enzyme
1.828
-
after 26.9fold purification, at pH 8.5 and 45°C
11
-
isoenzyme II
110000
wild-type, presence of dithiothreitol
12.2
-
-
12.4
-
-
138
mutant D249N, pH 8.0
18.7
-
isoenzyme I
210
mutant H17A, presence of 0.05 mM S-adenosyl methionine, pH 8.0
216
-
pH 7.0, 37°C
222
wild-type, pH 8.0
23.83
after 3.71fold purification, at 35°C
240
mutant D282N, presence of 0.05 mM S-adenosyl methionine, pH 8.0
3
-
beta isoenzyme from liver
3.78
pH 8, 37°C, mutant enzyme I303V/I65V/L186V
3000
wild-type, presence of 0.05 mM S-adenosyl methionine, pH 8.0
31500
mutant C61S, presence of glutathione
318
mutant K280A, pH 8.0
32.75
-
beta form from liver
32700
mutant C35S, presence of glutathione
330
mutant D249N, presence of 0.05 mM S-adenosyl methionine, pH 8.0
39
-
gamma isoenzyme from liver
4.3
pH 8.0, 80°C
4.61
-
high-MW isozyme
4400
-
pH 8.2, 37°C
6.02
pH 8, 37°C, mutant enzyme I303V/I65V/L186V/N104K
6.42
crude extract, at 35°C
66
mutant D121N, presence of 0.05 mM S-adenosyl methionine, pH 8.0
69070
mutant C61S, presence of dithiothreitol
7.5
-
alpha isoenzyme from liver
720
mutant K280A, presence of 0.05 mM S-adenosyl methionine, pH 8.0
78.24
-
alpha form from liver
792
mutant D166N, presence of 0.05 mM S-adenosyl methionine, pH 8.0
94470
mutant C35S, presence of dithiothreitol
95800
wild-type, presence of glutathione
960
mutant H17N, presence of 0.05 mM S-adenosyl methionine, pH 8.0
additional information