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2.5.1.46: deoxyhypusine synthase

This is an abbreviated version!
For detailed information about deoxyhypusine synthase, go to the full flat file.

Word Map on EC 2.5.1.46

Reaction

dehydrospermidine
+
[enzyme]-lysine
=
N-(4-aminobutylidene)-[enzyme]-lysine
 +
propane-1,3-diamine

Synonyms

CpDHS, deoxyhypusine synthase, deoxyhypusine synthase (Caulobacter crescentus gene CC0359), deoxyhypusine synthase (Halobacterium strain NRC-1 gene dhs), deoxyhypusine synthase (human clone 30649 gene DHPS subunit reduced), deoxyhypusine synthase (Nicotiana tabacum gene DHS1), deoxyhypusine synthase (Senecio vernalis gene DHS1), deoxyhypusinesynthase, DHPS, DHS, DHS1, DHS2, DHS20, DHS34, DHSc, DHSp, DHYS, Dys1, Dys1p, EC 1.1.1.249, HVO 2297, PF3D7_1412600, speY, synthase, deoxyhypusine, TbDHSc, TbDHSp

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.46 deoxyhypusine synthase

Inhibitors

Inhibitors on EC 2.5.1.46 - deoxyhypusine synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(4-[[2-(1H-benzimidazol-2-yl)hydrazinylidene]methyl]phenyl)(hydroxy)oxoammonium
55% inhibition
(R)-3-methylspermidine
competitive inhibition versus spermidine
(S)-3-methylspermidine
competitive inhibition versus spermidine
1,3-diaminopropane
1,7-Diaminoheptane
1,8-diaminooctane
1,9-diaminononane
-
-
1-(3-aminopropyl)-4-aminomethylpiperidine
-
1 mM, less than 50% inhibition
1-amino-7-guanidinoheptane
-
competitive, inhibits binding of spermidine to the enzyme
1-aminooctane
-
1 mM, less than 50% inhibition
1-methylspermidine
-
0.184 mM, 50% inhibition
2-methylspermidine
-
-
3-methylspermidine
-
-
4-methylspermidine
-
-
6,6'-difluorospermidine
6-bromo-N-(1H-indol-4-yl)-1-benzothiophene-2-carboxamide
the 6'-bromo substituent is necessary for binding to DHPS
6-fluorospermidine
-
0.048 mM, 50% inhibition
7,7-Difluorospermidine
-
1 mM, less than 50% inhibition
8-fluoro-N-[3-(morpholin-4-yl)propyl]-5H-pyrimido[5,4-b]indol-4-amine
23.6% inhibition
aminopropylcadaverine
-
inhibition of deoxyhypusine synthesis
caldine
CNI-1493
deoxyspergualin
diaminononane
weaker inhibition
GC7
-
a specific DHS-inhibitor, inhibits DHS by competitive replacement of its native spermidine substrate. Inhibition of DHS by GC7 induces antiproliferative effects in vitro. The compound shows a strong antiproliferative effect in glioblastoma cell lines in vitro, while normal human astrocytes are not affected, and it causes p53 dependent premature senescence, a permanent cell cycle arrestin U-MG 87 cells
guazatine
-
-
hirudonine
-
-
Homospermidine
-
inhibition of deoxyhypusine synthesis
N''-guanyl-1,7-diaminoheptane
N,N'-bis-benzyldiaminooctane
-
1 mM, less than 50% inhibition
N,N'-bis[3,5-bis[1(aminoiminomethyl)-hydrazoethyl]phenyl]decanediamide-tetrahydrochloride
N,N'-bis[3,5-bis[1(aminoiminomethyl)-hydrazoethyl]phenyl]dodecanediamide-tetrahydrochloride
N-(2-cyanoethyl)-1,3-diaminopropane
-
1 mM, less than 50% inhibition
N-(3-aminopropyl)-1,3-diaminopropane
-
1 mM, less than 50% inhibition
N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene
-
-
N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene
-
-
N-(3-aminopropyl)-cadaverine
-
-
N-(3-aminopropyl)-cis-1,4-diaminocyclohexane
-
1 mM, less than 50% inhibition
N-(3-aminopropyl)-N'-methylbutane-1,4-diamine
-
-
N-(3-aminopropyl)-trans-1,4-diaminocyclohexane
-
1 mM, less than 50% inhibition
N-(3-cyanopropyl)-1,3-diaminopropane
-
1 mM, less than 50% inhibition
N-(7-chloroquinolin-4-yl)-N'-methylpropane-1,3-diamine
12.45% inhibition
N-butyl-1,3-diaminopropane
-
1 mM, less than 50% inhibition
N-guanyl-1,7-diaminoheptane
shows only little inhibitory effect on the leishmanial recombinant DHS34
N1,N3-bis-guanyl-1,3-diaminopropane
-
1 mM, less than 50% inhibition
N1,N3-bis-tert-butyloxycarbonylspermidine
-
1 mM, less than 50% inhibition
N1,N6-bis-guanyl-1,6-diaminohexane
-
-
N1,N7-bis-allylcaldine
-
1 mM, less than 50% inhibition
N1,N7-bis-benzylcaldine
-
1 mM, less than 50% inhibition
N1,N7-bis-dimethylcaldine
-
1 mM, less than 50% inhibition
N1,N7-bis-guanyl-1,7-diaminoheptane
-
-
N1,N7-bis-guanylcaldine
-
-
N1,N8-bis-guanyl-1,8-diaminooctane
-
-
N1-acetylspermidine
-
1 mM, less than 50% inhibition
N1-ethylspermidine
N1-guanyl-1,3-diaminopropane
-
1 mM, less than 50% inhibition
N1-guanyl-1,7-diaminoheptane
N1-guanyl-1,8-diaminooctane
-
-
N1-guanylcaldine
-
-
N1-guanylspermine
-
-
N1-methylspermidine
-
inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine
N3-ethylspermidine
-
1 mM, less than 50% inhibition
N4-(3-aminopropyl)-4-methylpentane-1,4-diamine
-
1 mM, less than 50% inhibition
N4-acetylspermidine
-
1 mM, less than 50% inhibition
N4-benzoylspermidine
-
1 mM, less than 50% inhibition
N4-benzylspermidine
-
1 mM, less than 50% inhibition
N4-bromoacetylspermidine
-
1 mM, less than 50% inhibition
N4-methylcaldine
-
1 mM, less than 50% inhibition
paromomycin
inhibits oocysts formation
putrescine
-
1 mM, less than 50% inhibition
spermidine
additional information
-