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2.5.1.46: deoxyhypusine synthase

This is an abbreviated version!
For detailed information about deoxyhypusine synthase, go to the full flat file.

Word Map on EC 2.5.1.46

Reaction

dehydrospermidine
+
[enzyme]-lysine
=
N-(4-aminobutylidene)-[enzyme]-lysine
 +
propane-1,3-diamine

Synonyms

CpDHS, deoxyhypusine synthase, deoxyhypusine synthase (Caulobacter crescentus gene CC0359), deoxyhypusine synthase (Halobacterium strain NRC-1 gene dhs), deoxyhypusine synthase (human clone 30649 gene DHPS subunit reduced), deoxyhypusine synthase (Nicotiana tabacum gene DHS1), deoxyhypusine synthase (Senecio vernalis gene DHS1), deoxyhypusinesynthase, DHPS, DHS, DHS1, DHS2, DHS20, DHS34, DHSc, DHSp, DHYS, Dys1, Dys1p, EC 1.1.1.249, HVO 2297, PF3D7_1412600, speY, synthase, deoxyhypusine, TbDHSc, TbDHSp

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.46 deoxyhypusine synthase

Specific Activity

Specific Activity on EC 2.5.1.46 - deoxyhypusine synthase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000096
low specific activity of DHS34 could be due to the fact that one of the NAD+ binding regions in the DHS34 is present in the big long insertion when compared with human deoxyhypusine synthase
0.000137
-
-
0.00325
-
-
0.0034
with donor homospermidine
0.0091
with donor homospermidine
0.0101
with acceptor eIF5A-prcursor
0.0211
with donor spermidine
0.0442
with acceptor putrescine
additional information