2.5.1.46: deoxyhypusine synthase

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For detailed information about deoxyhypusine synthase, go to the full flat file.

Reaction

Synonyms

CpDHS, deoxyhypusine synthase, deoxyhypusine synthase (Caulobacter crescentus gene CC0359), deoxyhypusine synthase (Halobacterium strain NRC-1 gene dhs), deoxyhypusine synthase (human clone 30649 gene DHPS subunit reduced), deoxyhypusine synthase (Nicotiana tabacum gene DHS1), deoxyhypusine synthase (Senecio vernalis gene DHS1), deoxyhypusinesynthase, DHPS, DHS, DHS1, DHS2, DHS20, DHS34, DHSc, DHSp, DHYS, Dys1, Dys1p, EC 1.1.1.249, HVO 2297, PF3D7_1412600, speY, synthase, deoxyhypusine, TbDHSc, TbDHSp

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.46 deoxyhypusine synthase

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Results	in table
3209	AA Sequence
7	Application
6	CAS Registry Number
35	Cloned(Commentary)
42	Cofactor
5	Crystallization (Commentary)
80	Disease/ Diagnostics
71	General Information
1	General Stability
2	IC50 Value
108	Inhibitors
22	Ki Value [mM]
40	KM Value [mM]
11	Localization
37	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
231	Organism
45	PDB ID
15	pH Optimum
3	pH Range
1	pI Value
3	Posttranslational Modification
57	Protein Variants
16	Purification (Commentary)
6	Reaction
1	Reaction Type
108	Reference
71	Source Tissue
14	Specific Activity [micromol/min/mg]
162	Substrates and Products (Substrate)
34	Subunits
84	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
9	Turnover Number [1/s]

Crystallization

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Crystallization on EC 2.5.1.46 - deoxyhypusine synthase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

at 2.2 A a new form II crystal of the deoxyhypusine synthase:NAD holoenzyme is grown at low ionic strength and pH 8.0, near the optimal pH for enzymatic activity

Homo sapiens

P49366

659357

in complex with inhibitors 6-bromo-N-(1H-indol-4-yl)-1-benzothiophene-2-carboxamide and N''-guanyl-1,7-diaminoheptane. Presence of 6-bromo-N-(1H-indol-4-yl)-1-benzothiophene-2-carboxamide induces a dramatic conformational change in DHPS

Homo sapiens

P49366

759614

structures of the apoprotein, as well as ligand-bound states at 1.41 to 1.69 A resolution. Polyamines namely spermine and putrescine bind DHS in a similar manner as spermidine. Spermine may to some extent serve as an alternative DHS substrate. No conformational changes occur in the DHS structure upon spermidine binding. A conserved ball-and-chain motif is indispensable to assembling a functional DHS tetramer

Homo sapiens

P49366

758884

vapor diffusion in hanging drops, crystal structure of the enzyme-NAD complex at 2.2 A resolution

Homo sapiens

-

638071

heterotetramer, to 3.5 A resolution. The activity is dependent on heterotetramer formation between paralogs DHSc and DHSp. The X-ray structure of DHS shows a single functional shared active site formed at the DHSc/DHSp heterodimer interface. Deficiencies in one subunit are complemented by the other

Trypanosoma brucei brucei

Q38BX0; Q4GZD1

760209