2.5.1.46: deoxyhypusine synthase

This is an abbreviated version!
For detailed information about deoxyhypusine synthase, go to the full flat file.

Word Map on EC 2.5.1.46

2.5.1.46

polyamine

gc7

homospermidine

pyrrolizidine

n1-guanyl-1,7-diaminoheptane

nepsilon-4-amino-2-hydroxybutyllysine

aminobutylation

hypusine-containing

1,7-diaminoheptane

deoxyhypusine-containing

butylamine

polyamine-derived

eif-4d

medicine

1,3-diaminopropane

triamine

wolff

drug development

analysis

Reaction

Synonyms

CpDHS, deoxyhypusine synthase, deoxyhypusine synthase (Caulobacter crescentus gene CC0359), deoxyhypusine synthase (Halobacterium strain NRC-1 gene dhs), deoxyhypusine synthase (human clone 30649 gene DHPS subunit reduced), deoxyhypusine synthase (Nicotiana tabacum gene DHS1), deoxyhypusine synthase (Senecio vernalis gene DHS1), deoxyhypusinesynthase, DHPS, DHS, DHS1, DHS2, DHS20, DHS34, DHSc, DHSp, DHYS, Dys1, Dys1p, EC 1.1.1.249, HVO 2297, PF3D7_1412600, speY, synthase, deoxyhypusine, TbDHSc, TbDHSp

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.46 deoxyhypusine synthase

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Results	in table
3209	AA Sequence
7	Application
6	CAS Registry Number
35	Cloned(Commentary)
42	Cofactor
5	Crystallization (Commentary)
80	Disease/ Diagnostics
71	General Information
1	General Stability
2	IC50 Value
108	Inhibitors
22	Ki Value [mM]
40	KM Value [mM]
11	Localization
37	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
231	Organism
45	PDB ID
15	pH Optimum
3	pH Range
1	pI Value
3	Posttranslational Modification
57	Protein Variants
16	Purification (Commentary)
6	Reaction
1	Reaction Type
108	Reference
71	Source Tissue
14	Specific Activity [micromol/min/mg]
162	Substrates and Products (Substrate)
34	Subunits
84	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
9	Turnover Number [1/s]

KI Value

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KI Value on EC 2.5.1.46 - deoxyhypusine synthase

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0.141

(R)-3-methylspermidine

Homo sapiens

P49366

pH and temperature not specified in the publication

737314

0.019

(S)-3-methylspermidine

Homo sapiens

P49366

pH and temperature not specified in the publication

737314

0.0129

1,3-diaminopropane

Saccharomyces cerevisiae

638077

0.0009

1,7-Diaminoheptane

Saccharomyces cerevisiae

638077

0.00191

1,8-diaminooctane

Saccharomyces cerevisiae

638077

0.00752

1,9-diaminononane

Saccharomyces cerevisiae

638077

2.27

FAD

Saccharomyces cerevisiae

638077

1.28

FMN

Saccharomyces cerevisiae

638077

0.012

guazatine

Rattus norvegicus

638076

0.00489

hirudonine

Rattus norvegicus

638076

0.035

N1,N6-bis-guanyl-1,6-diaminohexane

Rattus norvegicus

638076

0.0017

N1,N7-bis-guanyl-1,7-diaminoheptane

Rattus norvegicus

638076

0.1545

N1,N7-bis-guanylcaldine

Rattus norvegicus

638076

0.00565

N1,N8-bis-guanyl-1,8-diaminooctane

Rattus norvegicus

638076

0.0000097 - 0.01

N1-guanyl-1,7-diaminoheptane

2 entries

0.00024

N1-guanyl-1,8-diaminooctane

Rattus norvegicus

638076

0.00074

N1-guanylcaldine

Rattus norvegicus

638076

0.00033

N1-guanylspermine

Rattus norvegicus

638076

0.85

NADH

Saccharomyces cerevisiae

638077

0.00649

spermidine

Saccharomyces cerevisiae

638077

additional information

2 entries