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Literature summary for 2.5.1.46 extracted from

  • Liao, D.I.; Wolff, E.C.; Park, M.H.; Davies, D.R.
    Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site (1998), Structure, 6(1), 23-32.
No PubMed abstract available

Crystallization (Commentary)

Crystallization (Comment) Organism
vapor diffusion in hanging drops, crystal structure of the enzyme-NAD complex at 2.2 A resolution Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[eIF5A-precursor]-lysine + spermidine
-
Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine ?

Subunits

Subunits Comment Organism
tetramer four identical subunits arranged in 222 symmetry Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens