2.5.1.46: deoxyhypusine synthase
This is an abbreviated version!
For detailed information about deoxyhypusine synthase, go to the full flat file.
Word Map on EC 2.5.1.46
-
2.5.1.46
-
polyamine
-
gc7
-
homospermidine
-
pyrrolizidine
-
n1-guanyl-1,7-diaminoheptane
-
nepsilon-4-amino-2-hydroxybutyllysine
-
aminobutylation
-
hypusine-containing
-
1,7-diaminoheptane
-
deoxyhypusine-containing
-
butylamine
-
polyamine-derived
-
eif-4d
-
medicine
-
1,3-diaminopropane
-
triamine
-
wolff
-
drug development
-
analysis
- 2.5.1.46
- polyamine
- gc7
- homospermidine
-
pyrrolizidine
- n1-guanyl-1,7-diaminoheptane
-
nepsilon-4-amino-2-hydroxybutyllysine
-
aminobutylation
-
hypusine-containing
- 1,7-diaminoheptane
-
deoxyhypusine-containing
- butylamine
-
polyamine-derived
-
eif-4d
- medicine
- 1,3-diaminopropane
- triamine
-
wolff
- drug development
- analysis
Reaction
Synonyms
CpDHS, deoxyhypusine synthase, deoxyhypusine synthase (Caulobacter crescentus gene CC0359), deoxyhypusine synthase (Halobacterium strain NRC-1 gene dhs), deoxyhypusine synthase (human clone 30649 gene DHPS subunit reduced), deoxyhypusine synthase (Nicotiana tabacum gene DHS1), deoxyhypusine synthase (Senecio vernalis gene DHS1), deoxyhypusinesynthase, DHPS, DHS, DHS1, DHS2, DHS20, DHS34, DHSc, DHSp, DHYS, Dys1, Dys1p, EC 1.1.1.249, HVO 2297, PF3D7_1412600, speY, synthase, deoxyhypusine, TbDHSc, TbDHSp
ECTree
Advanced search results
Disease
Disease on EC 2.5.1.46 - deoxyhypusine synthase
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Adenocarcinoma
A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer.
Carcinogenesis
Hypusine biosynthesis in ? cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
Carcinoma
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma.
Diabetes Mellitus, Type 1
Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes.
Diabetes Mellitus, Type 1
Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy.
Diabetes Mellitus, Type 2
Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes.
Glioblastoma
Expression of Eukaryotic Initiation Factor 5A and Hypusine Forming Enzymes in Glioblastoma Patient Samples: Implications for New Targeted Therapies.
Hyperglycemia
Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy.
Leishmaniasis
Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.
Leukemia
Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias.
Leukemia, Erythroblastic, Acute
Effects of inhibitors of deoxyhypusine synthase on the differentiation of mouse neuroblastoma and erythroleukemia cells.
Malaria
A suggested vital function for eIF-5A and dhs genes during murine malaria blood-stage infection.
Malaria
Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax.
Melanoma
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
Neoplasm Metastasis
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma.
Neoplasms
Aminohexanoic hydroxamate is a potent inducer of the differentiation of mouse neuroblastoma cells.
Neoplasms
Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients.
Neoplasms
Effects of inhibitors of deoxyhypusine synthase on the differentiation of mouse neuroblastoma and erythroleukemia cells.
Neoplasms
Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias.
Neoplasms
N1-guanyl-1,7-diaminoheptane enhances the chemosensitivity of acute lymphoblastic leukemia cells to vincristine through inhibition of eif5a-2 activation.
Neoplasms
The polyamine-derived amino acid hypusine: its post-translational formation in eIF-5A and its role in cell proliferation.
Neuroblastoma
Aminohexanoic hydroxamate is a potent inducer of the differentiation of mouse neuroblastoma cells.
Neuroblastoma
Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients.
Neuroblastoma
Effects of inhibitors of deoxyhypusine synthase on the differentiation of mouse neuroblastoma and erythroleukemia cells.
Pancreatitis
[Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism]
Squamous Cell Carcinoma of Head and Neck
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma.
html completed