Protein Variants | Comment | Organism |
---|---|---|
additional information | DHS knock-down by stable lentiviral expression of shRNAs in G55T2 and U87-MG cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GC7 | a specific DHS-inhibitor, inhibits DHS by competitive replacement of its native spermidine substrate. Inhibition of DHS by GC7 induces antiproliferative effects in vitro. The compound shows a strong antiproliferative effect in glioblastoma cell lines in vitro, while normal human astrocytes are not affected, and it causes p53 dependent premature senescence, a permanent cell cycle arrestin U-MG 87 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioblastoma cell | - |
Homo sapiens | - |
NCE-G55T2 cell | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
DHS | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of DHS by GC7 induces antiproliferative effects in vitro. GC7 treatment induces premature senescence in U87-MG cells, co-treatment of glioblastoma cells with TMZ/BCNU and GC7 has an additive antiproliferative effect | Homo sapiens |