2.4.2.8: hypoxanthine phosphoribosyltransferase

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For detailed information about hypoxanthine phosphoribosyltransferase, go to the full flat file.

Reaction

Synonyms

6-hydroxypurine phosphoribosyltransferase, 6-mercaptopurine phosphoribosyltransferase, 6-oxo PRTase, 6-oxopurine phosphoribosyltransferase, 6-oxopurine PRTase, Cthe_2254, EcHPRT, GMP pyrophosphorylase, GPRT, gpT-2, guanine phosphoribosyltransferase, guanine PRTase, guanine-hypoxanthine phosphoribosyltransferase, guanosine 5'-phosphate pyrophosphorylase, guanosine phosphoribosyltransferase, guanylate pyrophosphorylase, guanylic pyrophosphorylase, HGPRT, HGPRT-1, HGPRTase, HGXPRT, HGXPRTase, HG[X]PRT, HPRT, HPRT1, HPRTJerusalem, HPT, HXGPRT, hypoxanthine guanine phosphoribosyltransferase, hypoxanthine guanine xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyl transferase, hypoxanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase 1, hypoxanthine PRTase, hypoxanthine-guanine phosphoribosyl transferase, hypoxanthine-guanine phosphoribosyltransferase, hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase, hypoxanthine-guanine-(xanthine) phosphoribosyltransferase, hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine-guanine-[xanthine]-phosphoribosyltransferase, hypoxanthine-xanthine-guanine phosphoribosyltransferase, IMP pyrophosphorylase, IMP-GMP pyrophosphorylase, inosinate pyrophosphorylase, inosine 5'-phosphate pyrophosphorylase, inosine monophosphate:pyrophosphate phosphoribosyltransferase, inosinic acid pyrophosphorylase, inosinic pyrophosphorylase, More, MSMEG_6110, MtHGPRT, Pf HGXPRT, PF3D7_1012400, PfHGXPRT, PhHGXPRT, phosphoribosyltransferase, 6-mercaptopurine, phosphoribosyltransferase, hypoxanthine, PhPRT, plasma hypoxanthine-guanine phosphoribosyl transferase, PRT, purine-6-thiol phosphoribosyltransferase, PvHGPRT, SmHGPRT1, SSO2424, Tb927.10.1400, TcHPRT, transphosphoribosidase, TthHPRT, TT_C1766, ZgHGPRT/AMPK

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.8 hypoxanthine phosphoribosyltransferase

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Results	in table
11	Activating Compound
30876	AA Sequence
39	Application
1	CAS Registry Number
54	Cloned(Commentary)
24	Crystallization (Commentary)
4142	Disease/ Diagnostics
1	Expression
61	General Information
7	General Stability
299	Inhibitors
54	kcat/KM [mM/s]
152	Ki Value [mM]
274	KM Value [mM]
22	Localization
68	Metals/Ions
53	Molecular Weight [Da]
161	Natural Substrates/ Products (Substrates)
531	Organism
10	Pathway
262	PDB ID
71	pH Optimum
9	pH Range
4	pH Stability
2	Posttranslational Modification
111	Protein Variants
63	Purification (Commentary)
35	Reaction
2	Reaction Type
147	Reference
1	Renatured (Commentary)
60	Source Tissue
77	Specific Activity [micromol/min/mg]
14	Storage Stability
394	Substrates and Products (Substrate)
81	Subunits
246	Synonyms
1	Systematic Name
42	Temperature Optimum [°C]
1	Temperature Range [°C]
16	Temperature Stability [°C]
182	Turnover Number [1/s]

Expression

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Expression on EC 2.4.2.8 - hypoxanthine phosphoribosyltransferase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

mutational HPRT deficiency influences early developmental processes controlling the dopaminergic phenotype, and causes Lesch-Nyhan disease pathogenesis, microarray analysis of HPRT-deficient MN9D cells, phenotype, e.g. with increases in the mRNAs for engrailed 1 and 2, En1 and En2, transcription factors, overview. Restoration of HPRT reverses engrailed overexpression in MN9D cells

Homo sapiens

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703955