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2.4.2.8: hypoxanthine phosphoribosyltransferase

This is an abbreviated version!
For detailed information about hypoxanthine phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.8

Reaction

IMP
+
diphosphate
=
hypoxanthine
 +
5-phospho-alpha-D-ribose 1-diphosphate

Synonyms

6-hydroxypurine phosphoribosyltransferase, 6-mercaptopurine phosphoribosyltransferase, 6-oxo PRTase, 6-oxopurine phosphoribosyltransferase, 6-oxopurine PRTase, Cthe_2254, EcHPRT, GMP pyrophosphorylase, GPRT, gpT-2, guanine phosphoribosyltransferase, guanine PRTase, guanine-hypoxanthine phosphoribosyltransferase, guanosine 5'-phosphate pyrophosphorylase, guanosine phosphoribosyltransferase, guanylate pyrophosphorylase, guanylic pyrophosphorylase, HGPRT, HGPRT-1, HGPRTase, HGXPRT, HGXPRTase, HG[X]PRT, HPRT, HPRT1, HPRTJerusalem, HPT, HXGPRT, hypoxanthine guanine phosphoribosyltransferase, hypoxanthine guanine xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyl transferase, hypoxanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase 1, hypoxanthine PRTase, hypoxanthine-guanine phosphoribosyl transferase, hypoxanthine-guanine phosphoribosyltransferase, hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase, hypoxanthine-guanine-(xanthine) phosphoribosyltransferase, hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine-guanine-[xanthine]-phosphoribosyltransferase, hypoxanthine-xanthine-guanine phosphoribosyltransferase, IMP pyrophosphorylase, IMP-GMP pyrophosphorylase, inosinate pyrophosphorylase, inosine 5'-phosphate pyrophosphorylase, inosine monophosphate:pyrophosphate phosphoribosyltransferase, inosinic acid pyrophosphorylase, inosinic pyrophosphorylase, More, MSMEG_6110, MtHGPRT, Pf HGXPRT, PF3D7_1012400, PfHGXPRT, PhHGXPRT, phosphoribosyltransferase, 6-mercaptopurine, phosphoribosyltransferase, hypoxanthine, PhPRT, plasma hypoxanthine-guanine phosphoribosyl transferase, PRT, purine-6-thiol phosphoribosyltransferase, PvHGPRT, SmHGPRT1, SSO2424, Tb927.10.1400, TcHPRT, transphosphoribosidase, TthHPRT, TT_C1766, ZgHGPRT/AMPK

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.8 hypoxanthine phosphoribosyltransferase

Cloned

Cloned on EC 2.4.2.8 - hypoxanthine phosphoribosyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21(DE3) as soluble protein
DNA and amino acid sequence determination and analysis, functional expression in Escherichia coli BL21(DE3)
DNA sequence determination, expression in Escherichia coli
-
expressed in Escherichia coli
expressed in Escherichia coli strain BL21(DE3)
-
expressed in Escherichia coli strain Sphi609 cells
expressed in MN-9D cells
-
expression as His-tagged enzyme in Escherichia coli strain BL21(DE3)
-
expression in Escherichia coli
expression of active wild-type and of mutant enzymes in Escherichia coli strain DH5alpha
-
expression of wild-type and chimeric enzymes in enzyme-deficient Escherichia coli strain, complementation study
-
expression of wild-type and chimeric enzymes in enzyme-deficient Escherichia coli strain, complementation study, overexpression of chimeric mutant DS1
-
expression of wild-type and mutant enzyme in Escherichia coli, complementation of an enzyme-deficient Escherichia coli strain by the wild-type and mutant L44F at growth temperatures 20°C and 37°C, and at 42°C only by the wild-type enzyme
-
expression of wild-type and mutant enzyme in Escherichia coli, functional complementation study
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expression of wild-type and mutant enzymes in Escherichia coli
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expression of wild-type and mutant enzymes in Escherichia coli, functional complementation study
expression of wild-type and mutant L160I enzymes in Escherichia coli strain BL21(DE3)
-
from genomic DNA in pGEM-T-Eeasy, in pET15b for expression with hexa-His tag in Escherichia coli B21 Star (DE3)
-
functional expression in Escherichia coli
-
functional expression of the HPRT enzyme from a minigene encoding human HPRT driven by the chicken beta-actin promoter in enzyme-deficient MN9D cell lines, which restores HPRT activity and reverses the engrailed transcription factor, En1 and En2, overexpression of the mutant
-
functional expression of wild-type and loop II-deletion mutant in Escherichia coli
-
functional expression of wild-type and mutant T47K in an enzyme-deficient Escherichia coli strain
-
functional expression of wild-type enzyme and mutants in an enzyme-deficient Escherichia coli strain
functional overexpression of wild-type enzyme and expression of mutants in Escherichia coli
-
gene HGPRT, expression in Escherichia coli strain BL21(DE3)
-
gene HGPRT, recombinant expression of N-terminally His6-tagged enzyme in Escherichia coli strain BL21(DE3). The His6 tag does not appear to affect the activity of the enzyme
gene HGPRT, sequence comparisons of HGPRT isozymes of Schistosoma mansoni, recombinant expression of His-tagged enzyme SmHGPRT1 in Escherichia coli strain Lemo21(DE3)
gene HGPRTase, recombinant expression of His6-tagged enzyme and of nontagged enzyme in Escherichia coli strain BL21(DE3)
gene HPRT, determination of the mutagenic potential of succinyl-acetone by determining the frequencies of somatic mutations in the HPRT reporter gene, overview
-
gene HPRT, DNA and amino acid sequence determination
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gene HPRT, DNA sequence determination, expression analysis under different radiation conditions, overview
-
gene hprt, sequencing of wild-type and mutant enzymes
gene HPRT1
-
gene HPRT1, construction of expression vectors for recombinant expression of HPRT1, recombinant expression of GFP-tagged enzyme in HEK-293 cells on the outside of the plasma membrane, connected via the glycosyl-phosphatidylinositol, GPI, anchor on the cell surface, fluorescence analysis, method, overview
gene HXGPRT, two isozymes, genetic organization, expression analysis of two alternative-splicing-derived isozymes, which differ in the presence or absence of a 49-amino acid insertion, specified by a single differentially spliced exon, but exhibit similar temporal expression patterns, isozyme expression in parasites lacking the endogenous hxgprt gene, expression of isozyme I in the cytosol and of isozyme II inthe inner membrane complex in enzyme-deficient parasites, co-expression of both isoforms results in the formation of heterooligomers, which distribute between the cytosol and IMC
-
gene PF3D7_1012400, recombinant expression of His6-tagged enzyme in Escherichia coli strain BL21(DE3)
gene PF3D7_1012400, recombinant expression of N-terminally His6-tagged enzyme in Escherichia coli strain BL21-AI
HGPRT, DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21 (DE3)
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HPRT mutations, TCR gene rearrangements, and HTLV-1 integration sites define in vivo T-cell clonal lineages, overview, establishing of HPRT mutant mass cultures
-
mouse neuroblastoma hypoxanthine-guanine phosphoribosyltransferase cDNA clone
-
overexpression in an enzyme-deficient Escherichia coli strain
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overexpression in Escherichia coli
-
overexpression of the chimeric mutant enzyme in Escherichia coli strain Su609
recombinant expression of HPRT in Escherichia coli strain C3030/pER
recombinant expression of wild-type and mutant enzymes in Escherichia coli strain Sphi609
sequence comparisons, recombinant expression of N-terminally His6-tagged enzyme with a thrombin cleavage site in Escherichia coli strain BL21(DE3)
wild-type and mutant enzymes from lymphocytes treated or not treated with myosmine
-