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2.4.2.8: hypoxanthine phosphoribosyltransferase

This is an abbreviated version!
For detailed information about hypoxanthine phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.8

Reaction

IMP
+
diphosphate
=
hypoxanthine
+
5-phospho-alpha-D-ribose 1-diphosphate

Synonyms

6-hydroxypurine phosphoribosyltransferase, 6-mercaptopurine phosphoribosyltransferase, 6-oxo PRTase, 6-oxopurine phosphoribosyltransferase, 6-oxopurine PRTase, Cthe_2254, EcHPRT, GMP pyrophosphorylase, GPRT, gpT-2, guanine phosphoribosyltransferase, guanine PRTase, guanine-hypoxanthine phosphoribosyltransferase, guanosine 5'-phosphate pyrophosphorylase, guanosine phosphoribosyltransferase, guanylate pyrophosphorylase, guanylic pyrophosphorylase, HGPRT, HGPRT-1, HGPRTase, HGXPRT, HGXPRTase, HG[X]PRT, HPRT, HPRT1, HPRTJerusalem, HPT, HXGPRT, hypoxanthine guanine phosphoribosyltransferase, hypoxanthine guanine xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyl transferase, hypoxanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase 1, hypoxanthine PRTase, hypoxanthine-guanine phosphoribosyl transferase, hypoxanthine-guanine phosphoribosyltransferase, hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase, hypoxanthine-guanine-(xanthine) phosphoribosyltransferase, hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine-guanine-[xanthine]-phosphoribosyltransferase, hypoxanthine-xanthine-guanine phosphoribosyltransferase, IMP pyrophosphorylase, IMP-GMP pyrophosphorylase, inosinate pyrophosphorylase, inosine 5'-phosphate pyrophosphorylase, inosine monophosphate:pyrophosphate phosphoribosyltransferase, inosinic acid pyrophosphorylase, inosinic pyrophosphorylase, More, MSMEG_6110, MtHGPRT, Pf HGXPRT, PF3D7_1012400, PfHGXPRT, PhHGXPRT, phosphoribosyltransferase, 6-mercaptopurine, phosphoribosyltransferase, hypoxanthine, PhPRT, plasma hypoxanthine-guanine phosphoribosyl transferase, PRT, purine-6-thiol phosphoribosyltransferase, PvHGPRT, SmHGPRT1, SSO2424, Tb927.10.1400, TcHPRT, transphosphoribosidase, TthHPRT, TT_C1766, ZgHGPRT/AMPK

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.8 hypoxanthine phosphoribosyltransferase

Specific Activity

Specific Activity on EC 2.4.2.8 - hypoxanthine phosphoribosyltransferase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000021 - 0.0000072
-
purified native enzyme
0.00016
F199C mutant erythrocytes
0.0002 - 0.00029
wild-type erythrocytes
0.0007
-
enzyme activity in erythrocytes, pH 8.8, 25°C
0.0008
-
wild-type MN9D cells
0.00085
-
pH 9.0, 37°C, hypoxanthine phosphoribosyltransferase activity
0.0021
enzyme activity in erythrocytes, pH 8.8, 25°C
0.0027
-
pH 9.0, 37°C, guanine phosphoribosyltransferase activity
0.032
0.108
-
substrate xanthine
0.147
0.226
0.27
-
purified recombinant enzyme, substrate allopurinol, pH 8.0
0.28
-
substrate hypoxanthine
0.346
-
substrate guanine
0.39
-
purified enzyme, reverse reaction
0.4
-
purified recombinant enzyme, substrate guanine
0.47
substrate guanosine, pH 8.0, 50°C, with 2.4 mM Mg2+
0.53
substrate hypoxanthine, pH 7.0, 50°C, with 2.4 mM Mg2+
0.57 - 0.76
-
recombinant enzyme, reverse reaction
0.65
-
purified enzyme
1.4
-
purified recombinant enzyme, substrate hypoxanthine, pH 8.0
1.44
-
purified recombinant enzyme, substrate hypoxanthine
1.45
-
purified recombinant enzyme, substrate hypoxanthine, in presence of 0.008 mM IMP, after 6 h
11.9
-
purified recombinant enzyme, substrate hypoxanthine
13.25
-
substrate guanine
17.5
-
purified enzyme, erythrocytes
21 - 23
-
recombinant enzyme, forward reaction
2130
-
substrate IMP, crude cell extract, pH 7.5, temperature not specified in the publication
2340
-
substrate IMP, crude cell extract, pH 7.5, temperature not specified in the publication
2450
-
substrate GMP, crude cell extract, pH 7.5, temperature not specified in the publication
25.8
-
purified recombinant enzyme, substrate guanine
2524
purified enzyme in phosphate buffer, pH 7.4, 25°C
27
-
purified recombinant enzyme, substrate hypoxanthine, pH 8.0
46
-
purified recombinant enzyme, substrate guanine, pH 8.0
5.22
-
purified recombinant enzyme, substrate hypoxanthine, in presence of 0.038 mM IMP, after 48 h
5.9
-
recombinant enzyme, substrate hypoxanthine
66.5
-
purified enzyme
698.1
-
purified enzyme, method 1
7.6
-
purified enzyme, substrate guanine
705
-
purified enzyme, immunopurification
8.1
-
recombinant enzyme, substrate guanine
870
-
substrate GMP, crude cell extract, pH 7.5, temperature not specified in the publication
9
-
purified enzyme, brain
9.25
-
substrate hypoxanthine
additional information