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2.4.2.22: xanthine phosphoribosyltransferase

This is an abbreviated version!
For detailed information about xanthine phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.22

Reaction

XMP
+
diphosphate
=
5-phospho-alpha-D-ribose 1-diphosphate
 +
xanthine

Synonyms

5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase, EcXGPRT, HGXPRT, hypoxanthine-guanine-(xanthine) phosphoribosyltransferase, hypoxanthine-guanine-xanthine phosphoribosyltransferase, More, Pf HGXPRT, phosphoribosyltransferase, xanthine, ttha0535, TtXPRT, Xan phosphoribosyltransferase, xanthine phosphoribosyltransferase, xanthine PRT, xanthine-guanine PRT, xanthosine 5'-phosphate pyrophosphorylase, xanthylate pyrophosphorylase, xanthylic pyrophosphorylase, XGPRT , XMP pyrophosphorylase, XPRT, XPRTase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.22 xanthine phosphoribosyltransferase

Inhibitors

Inhibitors on EC 2.4.2.22 - xanthine phosphoribosyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2-[(2,3-dihydroxypropyl)[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl]amino]ethyl)phosphonic acid
-
(2-[3-(8-bromoguanin-9-yl)-2-(2-(bishydroxyphosphoryl)-ethoxy)propoxy]ethyl)phosphonic acid
-
(2-[[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][2-(2-phosphonoethoxy)ethyl]amino]ethyl)phosphonic acid
-
([2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-3-(2-phosphonoethoxy)propoxy]methyl)phosphonic acid
-
([2-[(6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-3-(2-phosphonoethoxy)propoxy]methyl)phosphonic acid
-
([3-(7-deazaguanine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methyl)phosphonic acid
sodium salt
([3-(7-deazahypoxanthine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methyl)phosphonic acid
sodium salt
([3-(8-bromoguanine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methyl)phosphonic acid
sodium salt
([3-(8-bromohypoxanthine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methyl)phosphonic acid
sodium salt
([3-(guanine-9-yl)-2-((2-phosphonoethoxy)-methyl)propoxy]methyl)phosphonic acid
sodium salt
([3-(hypoxanthine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methyl)phosphonic acid
sodium salt
1-Methylxanthine
-
-
2,4-dihydroxy-5,6-tetramethylenepyrimidine
-
-
2,4-Dihydroxypteridine
-
-
2,4-dihydroxypyrido[2,3-d]pyrimidine
-
-
2,4-dihydroxypyrido[3,2-d]pyrimidine
-
-
2,4-dihydroxypyrido[3,4-d]pyrimidine
-
-
2,4-dihydroxypyrrolo[2,3-d]pyrimidine
-
-
2,6-diaminopurine
-
-
2,6-dichloropurine
-
-
2,6-dioxo-1,3,7-trimethylpurine
-
-
2,6-dioxo-1,3,9-trimethylpurine
-
-
2,6-dioxo-3-isobutyl-1-methylpurine
-
-
2,6-dioxo-7-(beta-hydroxypropyl)-1,3-dimethylpurine
-
-
2,6-dithiopurine
-
-
2,6-dithioxanthine
-
-
2-amino-1-methylhypoxanthine
-
-
2-amino-1-methylpurine
-
-
2-amino-6-chloropurine
-
-
2-amino-7-deazahypoxanthine
-
-
2-amino-7-methylhypoxanthine
-
-
2-amino-9-deazahypoxanthine
-
-
2-amino-9-methylhypoxanthine
-
-
2-aminohypoxanthine
-
-
2-Aminopurine
-
-
2-aminopurine-6-thione
-
-
2-aza-3-deazahypoxanthine
-
-
2-aza-6-amino-3-deazapurine
-
-
2-aza-6-thio-3-deazapurine
-
-
2-hydroxy-6-methylthiopurine
-
-
2-Hydroxypurine
-
-
2-mercaptopurine
-
-
2-methylhypoxanthine
-
-
2-methylthio-6-hydroxypurine
-
-
2-oxo 7-methylhypoxanthine
-
-
2-oxo-1-methylhypoxanthine
-
-
2-oxo-3-methylhypoxanthine
-
-
2-oxo-6-thiopurine
-
-
2-oxohypoxanthine
-
-
2-oxohypoxanthine-N3-oxide
-
-
2-oxopurine
-
-
2-thiohypoxanthine
-
-
2-Thioxanthine
-
-
3-Methylxanthine
-
-
4,6-dihydroxypyrazolo[3,4-d]-pyrimidine
-
-
4-aminoimidazole-5-carboxamide
-
-
4-hydroxypyrazolo[3,4-d]pyrimidine
-
-
4-mercapto-6-hydroxypyrazolo[3,4-d]pyrimidine
-
-
4-mercaptopyrazolo[3,4-d]pyrimidine
-
-
4-oxopyrimidine
-
-
5(4)-amino-4-imidazolecarboxamide
-
-
5,7-dihydroxy(1,2,5)thiadiazolo[3,4-d]pyrimidine
-
-
5,7-dihydroxy-v-triazolo[4,5-d]pyrimidine
-
-
5,7-dihydroxypyrazolo[4,3-d]pyrimidine
-
-
5-acetamidouracil
-
-
5-Aminouracil
-
-
5-anilinouracil
-
-
5-fluorocytosine
-
-
5-formamidouracil
-
-
5-phospho-alpha-D-ribose 1-diphosphate
-
-
6-amino-1-methylpurine
-
-
6-amino-2,8-diaza-3-deazapurine
-
-
6-amino-2-chloropurine
-
-
6-amino-2-methylpurine
-
-
6-amino-2-oxopurine
-
-
6-amino-7-deazapurine
-
-
6-amino-8-bromopurine
-
-
6-benzylaminopurine
-
-
6-Chloropurine
-
-
6-Hydroxymethylpterin
-
-
6-Mercaptopurine
-
-
6-methoxypurine
-
-
6-Methylaminopurine
-
-
6-Thiopurine
-
-
6-Thioxanthine
-
-
7-methylxanthine
-
-
8-aza-1,3-dideazapurine
-
-
8-aza-1-nitro-1,3-dideazapurine
-
-
8-aza-2,6-diaminopurine
-
-
8-aza-2-aminohypoxanthine
-
-
8-aza-6-aminopurine
-
-
8-aza-7-deaza-6-aminopurine
-
-
8-aza-7-deaza-6-thiopurine
-
-
8-aza-7-deazahypoxanthine
-
-
8-Azahypoxanthine
-
-
8-bromo-2-aminohypoxanthine
-
-
8-mercaptoxanthine
-
-
8-methylxanthine
-
-
8-oxohypoxanthine
-
-
8-thiohypoxanthine
-
-
9-methylxanthine
-
-
9-[(N-phosphonoethyl-N-phosphonobutyl)-2-aminoethyl]hypoxanthine
-
9-[(N-phosphonoethyl-N-phosphonoethoxyethyl)-2-aminoethyl]-hypoxanthine
-
9-[(N-phosphonoethyl-N-phosphonomethoxyethyl)-2-aminoethyl]hypoxanthine
-
9-[(N-phosphonoethyl-N-phosphonomethyl)-2-aminoethyl]-hypoxanthine
-
adenine
ATP
-
1 mM, 11% inhibition
Benzonitrile
-
-
CDP
-
1 mM, 10% inhibition
CTP
-
1 mM, 27% inhibition
cytosine
-
-
diethyl (2S,15S)-2,15-dibenzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-8-[(4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl]-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
diethyl (2S,15S)-2,15-dibenzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-8-[(6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
diethyl (2S,15S)-2,15-dibenzyl-8-[(8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
diethyl (2S,15S)-4,13-bis[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-4,13-dioxo-8-[(6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-2,15-bis(2-phenylethyl)-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
-
diethyl (2S,15S)-8-[(2-amino-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl]-2,15-dibenzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
diethyl (2S,15S)-8-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-2,15-dibenzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
diethyl (2S,15S)-8-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-2,15-dibenzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-7,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
diethyl (2S,15S)-8-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-4,13-bis[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-4,13-dioxo-2,15-bis(2-phenylethyl)-6,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
-
diethyl (2S,15S)-8-[(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-2,15-dibenzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4,13-dioxo-7,10-dioxa-3,14-diaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate
prodrug
GDP
-
1 mM, 93 inhibition
GTP
-
1 mM, 91% inhibition
guanine
hypoxanthine
isocytosine
-
-
isoguanine
-
-
pGpp
competitive inhibitor
ppGpp
competitive inhibitor
pppGpp
competitive inhibitor
Pyrophosphate
noncompetitive
TDP
-
1 mM, 18% inhibition
TTP
-
1 mM, 13% inhibition
UDP
-
1 mM, 15% inhibition
Uracil
UTP
-
1 mM, 17% inhibition
xanthine
XDP
-
1 mM, 89% inhibition
XTP
-
1 mM, 92% inhibition
[3-(guanine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methylphosphonic acid
-
[[2-[(6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]propane-1,3-diyl]bis(oxymethylene)]bis(phosphonic acid)
[[[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]azanediyl]di(propane-3,1-diyl)]bis(phosphonic acid)
-
additional information
-