2.4.2.22: xanthine phosphoribosyltransferase
This is an abbreviated version!
For detailed information about xanthine phosphoribosyltransferase, go to the full flat file.
Word Map on EC 2.4.2.22
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2.4.2.22
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purine
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salvage
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falciparum
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plasmodium
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6-oxopurine
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phosphoribosylation
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phosphoribosyltransferases
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tritrichomonas
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prtases
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2.4.2.8
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cho-k1-bh4
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hgprts
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2.7.1.20
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psv2-gpt
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medicine
- 2.4.2.22
- purine
-
salvage
- falciparum
- plasmodium
-
6-oxopurine
-
phosphoribosylation
-
phosphoribosyltransferases
-
tritrichomonas
-
prtases
-
2.4.2.8
-
cho-k1-bh4
- hgprts
-
2.7.1.20
-
psv2-gpt
- medicine
Reaction
Synonyms
5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase, EcXGPRT, HGXPRT, hypoxanthine-guanine-(xanthine) phosphoribosyltransferase, hypoxanthine-guanine-xanthine phosphoribosyltransferase, More, Pf HGXPRT, phosphoribosyltransferase, xanthine, ttha0535, TtXPRT, Xan phosphoribosyltransferase, xanthine phosphoribosyltransferase, xanthine PRT, xanthine-guanine PRT, xanthosine 5'-phosphate pyrophosphorylase, xanthylate pyrophosphorylase, xanthylic pyrophosphorylase, XGPRT
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Natural Substrates Products
Natural Substrates Products on EC 2.4.2.22 - xanthine phosphoribosyltransferase
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REACTION DIAGRAM
5-phospho-alpha-D-ribose 1-diphosphate + guanine
GMP + diphosphate
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-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
IMP + diphosphate
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-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
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the enzyme is involved in purine nucleotide synthesis via phosphorylation of purines acquisited from the host, since Leishmania donovani is not able to perform de novo biosynthesis of purine nucleotides
-
-
?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
-
-
-
r
guanosine + 5-phospho-alpha-D-ribose 1-diphosphate
GMP + diphosphate
-
-
-
?
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
IMP + diphosphate
reaction of EC 2.4.2.8
-
-
?
XMP + diphosphate
-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
XMP + diphosphate
-
-
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
XMP + diphosphate
-
-
-
-
?
XMP + diphosphate
-
-
-
r
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
-
-
-
?
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
-
-
-
r
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
-
-
-
r
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate
-
-
-
r
?
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-
either hypoxanthine-guanine phosphoribosyltransferase or xanthine phosphoribosyltransferase is absolutely essential for purine acquisition, parasite viability, and parasite infectivity of mouse macrophages
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-
?
additional information
?
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-
xanthine phosphoribosyltransferase is involved in acquirement of purine nutrients of Leimania from the host, the enzyme is not essential for purine salvage or viability
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-
?