2.4.2.22: xanthine phosphoribosyltransferase
This is an abbreviated version!
For detailed information about xanthine phosphoribosyltransferase, go to the full flat file.
Word Map on EC 2.4.2.22
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2.4.2.22
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purine
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salvage
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falciparum
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plasmodium
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6-oxopurine
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phosphoribosylation
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phosphoribosyltransferases
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tritrichomonas
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prtases
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2.4.2.8
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cho-k1-bh4
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hgprts
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2.7.1.20
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psv2-gpt
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medicine
- 2.4.2.22
- purine
-
salvage
- falciparum
- plasmodium
-
6-oxopurine
-
phosphoribosylation
-
phosphoribosyltransferases
-
tritrichomonas
-
prtases
-
2.4.2.8
-
cho-k1-bh4
- hgprts
-
2.7.1.20
-
psv2-gpt
- medicine
Reaction
Synonyms
5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase, EcXGPRT, HGXPRT, hypoxanthine-guanine-(xanthine) phosphoribosyltransferase, hypoxanthine-guanine-xanthine phosphoribosyltransferase, More, Pf HGXPRT, phosphoribosyltransferase, xanthine, ttha0535, TtXPRT, Xan phosphoribosyltransferase, xanthine phosphoribosyltransferase, xanthine PRT, xanthine-guanine PRT, xanthosine 5'-phosphate pyrophosphorylase, xanthylate pyrophosphorylase, xanthylic pyrophosphorylase, XGPRT
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Metals Ions
Metals Ions on EC 2.4.2.22 - xanthine phosphoribosyltransferase
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Co2+
Mg2+
Mn2+
Zn2+
Mg2+
magnesium and sulfate can bind together in the active site, in the absence of other products or substrates. The magnesium interacts with a highly conserved aspartate residue
Mn2+
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maximal catalytic activity with 0.06 mM. Substitution of Mn2+ for Mg2+ results in ca. 2fold increase in the XPRT turnover rate without altering the xanthine Km value. Replacement of Mg2+ with Mn2+ increases the 5-phospho-alpha-D-ribose 1-diphosphate Km value ca. 2fold. XPRT-catalyzed hypoxanthine phosphoribosylation reveals that substitution of Mg2+ with Mn2+ results in a ca. 4fold increase in the hypoxanthine kcat value and ca. 3fold decrease in the hypoxanthine Km value