2.4.1.11: glycogen(starch) synthase

This is an abbreviated version!
For detailed information about glycogen(starch) synthase, go to the full flat file.

Word Map on EC 2.4.1.11

2.4.1.11

kinase-3

phosphorylase

insulin-stimulated

hepatocytes

alzheimer

3-kinase

clamp

mellitus

tau

hexokinase

neuroprotective

hyperglycemia

6-phosphate

lithium

phosphatidylinositol

glucose-6-phosphatase

glycogenolysis

amylose

disposal

hyperphosphorylation

insulin-resistant

insulin-mediated

hyperinsulinemic

irs-1

waxy

glycogenesis

amylopectin

licl

adp-glucose

niddm

glucokinase

soleus

glucose-6-p

non-insulin-dependent

insulin-induced

amp-dependent

vastus

euglycemic

phosphatase-1

gsk-3beta

agpase

debranching

p-gsk-3

medicine

substrate-1

2,6-bisphosphate

euglycemic-hyperinsulinemic

nonoxidative

phosvitin

kinase-3beta

nutrition

lafora

Reaction

UDP-alpha-D-glucose

+

[(1->4)-alpha-D-glucosyl]n

=

UDP

+

[(1->4)-alpha-D-glucosyl]n+1

Synonyms

Cg-GYS, GBSS, GBSSI, glucosyltransferase, uridine diphosphoglucose-glycogen, glycogen synthase, glycogen synthase 2, glycogen synthase-2, glycogen synthetase (starch), granule bound starch synthase, granule-bound starch synthase, GS-I, GSN, GSY2p, Gys-2, GYS1, GYS2, Gys2p, starch synthase I, starch/glycogen synthase, TVAG_258220, UDP-glucose-glycogen glucosyltransferase, UDP-glycogen synthase, UDPG-glycogen synthetase, UDPG-glycogen transglucosylase, uridine diphosphoglucose-glycogen glucosyltransferase

ECTree

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.11 glycogen(starch) synthase

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Results	in table
67	Activating Compound
6161	AA Sequence
7	Application
1	CAS Registry Number
19	Cloned(Commentary)
5	Crystallization (Commentary)
2414	Disease/ Diagnostics
7	Expression
11	General Information
13	General Stability
112	Inhibitors
14	Ki Value [mM]
61	KM Value [mM]
13	Localization
36	Metals/Ions
32	Molecular Weight [Da]
69	Natural Substrates/ Products (Substrates)
116	Organism
6	Pathway
90	PDB ID
34	pH Optimum
1	pH Range
5	pH Stability
4	pI Value
49	Posttranslational Modification
55	Protein Variants
6	Purification (Commentary)
7	Reaction
1	Reaction Type
115	Reference
1	Renatured (Commentary)
141	Source Tissue
32	Specific Activity [micromol/min/mg]
20	Storage Stability
123	Substrates and Products (Substrate)
31	Subunits
42	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
2	Temperature Range [°C]
8	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 2.4.1.11 - glycogen(starch) synthase

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(NH4)2SO4

-

20% inactivation at 20 mM

1,5-gluconolactone

Rattus norvegicus

-

-

2,3-diphosphoglyceric acid

Hymenolepis diminuta

-

high concentrations

2-mercaptoethanol

-

high concentrations

acarbose

Cyanophora paradoxa

-

adenine

Pyrococcus furiosus

-

-

adenine nucleotides

Oryctolagus cuniculus

-

-

ADP

show

ADP-glucose

Pyrococcus furiosus

-

competitive with UDPglucose

AMP

Pyrococcus furiosus

-

-

ATP

show

beta-Glycerophosphate

Oryctolagus cuniculus

-

-

CaCl2

show

Caffeine

-

10-50 mM

calyculin A

-

-

Cl-

-

-

Co2+

Neurospora crassa

-

-

Cu2+

Neurospora crassa

-

1 mM

CuCl2

Phymatotrichopsis omnivora

-

-

D-glucose

Pyrococcus furiosus

-

-

D-glucose-1-phosphate

Pyrococcus furiosus

-

-

dithiobis-(2-nitrobenzoic acid)

Saccharomyces cerevisiae

-

77% inactivation at 1 mM

dithiothreitol

-

high concentrations

epinephrine

-

leads to phosphorylation of enzyme

ethanol

-

traces inactivate the enzyme

fructose 1,6-diphosphate

Hymenolepis diminuta

-

high concentrations

GDP

Biomphalaria glabrata

-

-

glucagon

-

leads to phosphorylation of enzyme

glucosamine

Rattus norvegicus

-

high concentrations during cultivation

glucose

show

Hg2+

Neurospora crassa

-

1 mM

HgCl2

Phymatotrichopsis omnivora

-

-

Insulin

-

pre-treatment of cells inhibits, 0.001 mM isoproterenol reverses inhibition

-

iodoacetate

show

iodobenzoate

Saccharomyces cerevisiae

-

22% inactivation at 1 mM

KCN

Rattus norvegicus

-

58% inhibition at 0.1 M

LiBr

Oryctolagus cuniculus

-

-

Mg2+

show

microcystin

-

-

-

MnCl2

Phymatotrichopsis omnivora

-

-

N-ethylmaleimide

Saccharomyces cerevisiae

-

83% inactivation at 3 mM

Na2SO4

-

high concentrations

NaCl

show

nucleoside phosphates

Dictyostelium discoideum

-

overview

okadaic acid

-

-

Oxytocin

Rattus norvegicus

-

leads to phosphorylation of enzyme

p-chloromercuribenzoate

Saccharomyces cerevisiae

-

90% inactivation at 0.01 mM, dithiothreitol reverses

phenylmercuric acetate

Neurospora crassa

-

-

phloridzin

Rattus norvegicus

-

50% inhibition at 3.3 mM

Phorbol esters

-

-

phosphate

show

potassium borate

Rattus norvegicus

-

80% inhibition at 0.2 M

SDS

Neurospora crassa

-

-

SO42-

show

theophylline

-

10-50 mM

trehalose phosphate

Rattus norvegicus

-

59% inhibition at 10 mM

UDP

show

UDP-galactose

Pyrococcus furiosus

-

-

UDP-glucose

show

UDP-pyridoxal

show

UMP

show

uridine

Pyrococcus furiosus

-

-

uridine 5'-phosphate

Rattus norvegicus

-

50% inhibition

UTP

show

Vasopressin

-

leads to phosphorylation of enzyme

Zn2+

Neurospora crassa

-

1 mM

additional information

show

-

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Release 2023.1 (January 2023)