Activating Compound | Comment | Organism | Structure |
---|---|---|---|
galactose 6-phosphate | 57% of the glucose-6-phosphate activation | Homo sapiens | |
glucosamine 6-phosphate | 50% of the glucose-6-phosphate activation | Homo sapiens | |
glucose 6-phosphate | synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(NH4)2SO4 | 20% inactivation at 20 mM | Homo sapiens | |
phosphate | Mg2+, Ca2+ or Mn2+ relieves inhibition | Homo sapiens | |
SO42- | Mg2+, Ca2+ or Mn2+ relieves inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | dependence on glucose 6-phosphate concentration | Homo sapiens | |
0.57 | 1.25 | UDP-glucose | value dependent on the presence of glucose 6-phosphate | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activation in presence of glucose 6-phosphate | Homo sapiens | |
CaSO4 | to a lesser extent, absence of glucose-6-phosphate | Homo sapiens | |
CoSO4 | absence of glucose-6-phosphate | Homo sapiens | |
FeSO4 | to a lesser extent, absence of glucose-6-phosphate | Homo sapiens | |
KCl | activation in presence of glucose 6-phosphate | Homo sapiens | |
Mg2+ | activation in presence of glucose 6-phosphate | Homo sapiens | |
MgSO4 | to a lesser extent, absence of glucose-6-phosphate | Homo sapiens | |
Mn2+ | activation in presence of glucose 6-phosphate | Homo sapiens | |
MnSO4 | absence of glucose-6-phosphate | Homo sapiens | |
NaCl | activation in presence of glucose 6-phosphate | Homo sapiens | |
NH4Cl | activation in presence of glucose 6-phosphate | Homo sapiens | |
NiSO4 | absence of glucose-6-phosphate | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + glycogen | Homo sapiens | - |
glycogen + UDP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | interconversion of D form to I form is Mn2+ dependent | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
14.13 | - |
- |
Homo sapiens |
Storage Stability | Organism |
---|---|
-20°C, 45 mM Tris/HCl buffer, pH 7.5, 1 mM DTT, 10% glycerol, several months | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + glycogen | - |
Homo sapiens | glycogen + UDP | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | 9.2 | synthase D, presence of glucose 6-phosphate | Homo sapiens |
7 | 8.5 | synthase D, absence of glucose 6-phosphate | Homo sapiens |