Activating Compound | Comment | Organism | Structure |
---|---|---|---|
aspartate | increased uptake leads to activation | Mammalia | |
D-glucose | - |
Mammalia | |
D-glucose | - |
Rattus norvegicus | |
dihydroxyacetone | increase of activity | Mammalia | |
fructose | increase of activity | Mammalia | |
galactose | increase of activity | Mammalia | |
glutamate | increased uptake leads to activation | Mammalia | |
Insulin | - |
Rattus norvegicus | |
Insulin | inhibits phosphorylation by kinases and synthase phospatase | Mammalia | |
mannose | increase of activity | Mammalia | |
proline | increased uptake leads to activation | Mammalia | |
propionate | significant activation | Ovis aries | |
staurosporine | - |
Mammalia | |
xylitol | increase of activity | Mammalia |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CaCl2 | - |
Mammalia | |
calyculin A | - |
Mammalia | |
Cl- | - |
Mammalia | |
epinephrine | leads to phosphorylation of enzyme | Mammalia | |
glucagon | leads to phosphorylation of enzyme | Mammalia | |
microcystin | - |
Mammalia | |
okadaic acid | - |
Mammalia | |
Oxytocin | leads to phosphorylation of enzyme | Rattus norvegicus | |
Phorbol esters | - |
Mammalia | |
Vasopressin | leads to phosphorylation of enzyme | Mammalia |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Li+ | - |
Mammalia | |
additional information | - |
Oryctolagus cuniculus | |
additional information | regulation of enzyme activity | Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + glycogen | Mammalia | - |
glycogen + UDP | - |
? | |
UDP-glucose + glycogen | Rattus norvegicus | - |
glycogen + UDP | - |
? | |
UDP-glucose + glycogen | Oryctolagus cuniculus | - |
glycogen + UDP | - |
? | |
UDP-glucose + glycogen | Ovis aries | - |
glycogen + UDP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Ovis aries | - |
sheep | - |
Rattus norvegicus | - |
diabetic rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Rattus norvegicus |
phosphoprotein | phosphorylation of glucose-6-phosphate independent enzyme, i.e. I enzyme, results in glucose-6-phosphate dependent enzyme, i.e. D enzyme | Mammalia |
phosphoprotein | phosphorylation of glucose-6-phosphate independent enzyme, i.e. I enzyme, results in glucose-6-phosphate dependent enzyme, i.e. D enzyme | Oryctolagus cuniculus |
phosphoprotein | multiple phosphorylations on serine residues leads to inactivation | Mammalia |
phosphoprotein | phosphorylation at more than 10 sites | Oryctolagus cuniculus |
phosphoprotein | phosphorylation leads to loss of activity | Mammalia |
phosphoprotein | phosphorylation leads to loss of activity | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Rattus norvegicus | - |
hepatocyte | - |
Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + glycogen | - |
Mammalia | glycogen + UDP | - |
? | |
UDP-glucose + glycogen | - |
Rattus norvegicus | glycogen + UDP | - |
? | |
UDP-glucose + glycogen | - |
Oryctolagus cuniculus | glycogen + UDP | - |
? | |
UDP-glucose + glycogen | - |
Ovis aries | glycogen + UDP | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | - |
Rattus norvegicus |
? | - |
Oryctolagus cuniculus |
? | x * 80000-93000 | Mammalia |