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Literature summary for 2.4.1.11 extracted from
- Kinetic properties of glycogen synthase from skeletal muscle after phosphorylation by glycogen synthase kinase 4 (1986), Biochem. Biophys. Res. Commun., 134, 1129-1135.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glucose 6-phosphate | synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa | Rattus norvegicus |  |
| glucose 6-phosphate | synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa | Oryctolagus cuniculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| UDP | 50% inhibition at 0.05 mM | Oryctolagus cuniculus | |
| UDP | 50% inhibition at 0.03 mM | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | regulation by phosphorylation | Rattus norvegicus | |
| additional information | - |
additional information | regulation by phosphorylation | Oryctolagus cuniculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucose + glycogen | Rattus norvegicus | - |
glycogen + UDP | - |
? | |
| UDP-glucose + glycogen | Oryctolagus cuniculus | - |
glycogen + UDP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | 0.8 phosphates per subunit | Rattus norvegicus |
| phosphoprotein | 0.8 phosphates per subunit | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| muscle | - |
Rattus norvegicus | - |
| muscle | - |
Oryctolagus cuniculus | - |
| skeletal muscle | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
| additional information | - |
- |
Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucose + glycogen | - |
Rattus norvegicus | glycogen + UDP | - |
? | |
| UDP-glucose + glycogen | - |
Oryctolagus cuniculus | glycogen + UDP | - |
? | |
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