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Literature summary for 2.4.1.11 extracted from
- Interconversion and characterization of D and I forms of glycogen synthase from frog muscle (1978), Biochim. Biophys. Acta, 524, 305-315.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2-deoxyglucose 6-phosphate | stimulates interconversion of D to I form | Pelophylax ridibundus |  |
| galactose 6-phosphate | stimulates interconversion of D to I form | Pelophylax ridibundus | |
| glucosamine 6-phosphate | stimulates interconversion of D to I form | Pelophylax ridibundus | |
| glucose 6-phosphate | synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa | Pelophylax ridibundus | |
| glucose 6-phosphate | stimulates at UDP-glucose concentration of 0.4 mM | Pelophylax ridibundus | |
| phosphate | below 2 mM | Pelophylax ridibundus | |
| ribose 5-phosphate | stimulates interconversion of D to I form | Pelophylax ridibundus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Pelophylax ridibundus | |
| Mg2+ | above 2 mM | Pelophylax ridibundus | |
| phosphate | high concentrations | Pelophylax ridibundus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | stimulates interconversion of D to I from | Pelophylax ridibundus | |
| Mg2+ | stimulates D form but not I form | Pelophylax ridibundus | |
| Mn2+ | stimulates interconversion of D to I form | Pelophylax ridibundus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucose + glycogen | Pelophylax ridibundus | - |
glycogen + UDP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pelophylax ridibundus | - |
frog | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Pelophylax ridibundus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leg muscle | - |
Pelophylax ridibundus | - |
| muscle | - |
Pelophylax ridibundus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucose + glycogen | - |
Pelophylax ridibundus | glycogen + UDP | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
- |
Pelophylax ridibundus |
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