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2.3.1.87: aralkylamine N-acetyltransferase

This is an abbreviated version!
For detailed information about aralkylamine N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.87

Reaction

acetyl-CoA
+
a 2-arylethylamine
=
CoA
 +
an N-acetyl-2-arylethylamine

Synonyms

AA-NAT, AANAT, AANAT1, AANAT2, AANAT3, AANATL7, AATNATL2, acetyl-CoA:aralkylamine N-acetyltransferase, acetyltransferase, arylalkylamine N-, arylalkylamine N-acetyltransferase, arylalkylamine N-acetyltransferase 1, arylalkylamine N-acetyltransferase 1a, arylalkylamine N-acetyltransferase 1b, arylalkylamine N-acetyltransferase 2, arylalkylamine N-acetyltransferase like 7, arylalkylamine N-acetyltransferase-2, Bm-iAANAT, Eis, hAANAT, More, MSMEG_3513, N-acetyltransferase, NAT, oAANAT, PA4534, PaaNAT, Rv2416c, serotonin acetylase, serotonin acetyltransferase, serotonin N-acetyltransferase, serotonin-N-acetyltransferase, SNA, SNAT, SNAT1, SNAT2

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.87 aralkylamine N-acetyltransferase

Activating Compound

Activating Compound on EC 2.3.1.87 - aralkylamine N-acetyltransferase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
14-3-3 protein
-
14-3-3zeta, interaction with the phosphorylated enzyme activates activity, binding analysis, overview
-
4beta-phorbol 12-myristate 13-acetate
-
stimulates activity on a posttranscriptional level in a cAMP-independent manner
5-hydroxytryptophan
-
activates, best at 0.1 mM
forskolin
-
decreases KM-value for tryptamine by 32%
leptin
-
increases enzyme activity only in fed fish not in fasted fish, independently of the seasons
-
Melatonin
-
activates, best at 0.1 mM
N-acetylserotonin
-
activates, best at 0.1 mM
phorbol 12,13-dibutyrate
-
stimulates activity on a posttranscriptional level
phorbol 12-myristate 13-acetate
-
decreases KM-value for tryptamine by 44%
phosphate
serotonin
-
activates, best at 0.1 mM
UV light
-
NAT activity and melatonin content are suppressed by blue light of 450 nm wavelength, no effects of red light at 650 nm.UV radiation has intensity-dependent dual effects on the NAT activity and melatonin content: it is supressing at low intensity and activating at high intensity irradiation, overview
-
additional information
-
the enzyme is activated by Ser and Thr phosphorylations, e.g. AANAT Thr31 phosphorylation on its own can enhance catalytic efficiency up to 7fold
-