2.3.1.87: aralkylamine N-acetyltransferase
This is an abbreviated version!
For detailed information about aralkylamine N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.87
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2.3.1.87
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melatonin
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pineal
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rhythm
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circadian
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clock
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retina
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night
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nocturnal
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norepinephrine
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hiomt
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pinealocytes
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arylalkylamine-n-acetyltransferase
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hydroxyindole-o-methyltransferase
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photoreceptors
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oscillator
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n-acetylserotonin
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diurnal
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suprachiasmatic
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photoperiodic
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snats
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light-dark
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sodium-coupled
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adrenergic
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tryptamine
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entrain
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photoreceptive
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synthesis
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n-acetyl-5-methoxytryptamine
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gcn5-related
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photic
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zeitgeber
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clockwork
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day-night
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octopamine
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night-time
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clock-controlled
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medicine
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analysis
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ne-stimulated
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hydroxyindole
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meaib
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melatoninergic
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rhythm-generating
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extrapineal
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slc38a2
- 2.3.1.87
- melatonin
-
pineal
- rhythm
-
circadian
- clock
- retina
-
night
-
nocturnal
- norepinephrine
- hiomt
- pinealocytes
-
arylalkylamine-n-acetyltransferase
- hydroxyindole-o-methyltransferase
- photoreceptors
-
oscillator
- n-acetylserotonin
-
diurnal
-
suprachiasmatic
-
photoperiodic
-
snats
-
light-dark
-
sodium-coupled
-
adrenergic
- tryptamine
-
entrain
-
photoreceptive
- synthesis
- n-acetyl-5-methoxytryptamine
-
gcn5-related
-
photic
-
zeitgeber
-
clockwork
-
day-night
- octopamine
-
night-time
-
clock-controlled
- medicine
- analysis
-
ne-stimulated
-
hydroxyindole
-
meaib
-
melatoninergic
-
rhythm-generating
-
extrapineal
-
slc38a2
Reaction
Synonyms
AA-NAT, AANAT, AANAT1, AANAT2, AANAT3, AANATL7, AATNATL2, acetyl-CoA:aralkylamine N-acetyltransferase, acetyltransferase, arylalkylamine N-, arylalkylamine N-acetyltransferase, arylalkylamine N-acetyltransferase 1, arylalkylamine N-acetyltransferase 1a, arylalkylamine N-acetyltransferase 1b, arylalkylamine N-acetyltransferase 2, arylalkylamine N-acetyltransferase like 7, arylalkylamine N-acetyltransferase-2, Bm-iAANAT, Eis, hAANAT, More, MSMEG_3513, N-acetyltransferase, NAT, oAANAT, PA4534, PaaNAT, Rv2416c, serotonin acetylase, serotonin acetyltransferase, serotonin N-acetyltransferase, serotonin-N-acetyltransferase, SNA, SNAT, SNAT1, SNAT2
ECTree
2.3.1.87 aralkylamine N-acetyltransferaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 2.3.1.87 - aralkylamine N-acetyltransferase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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female. The left gland contains higher activity than the right gland
strongly expressed in the head, fat body, midgut, and integument tubules of 5th instar larvae
esophagus, stomach, pyloric ceca, foregut, midgut, hindgut. AANAT2 is expressed only in the muscular layer of all segments. No significant differences are obtained among the different segments evaluated
in foregut AANAT activity shows a daily rhythm while in hindgut significant but not rhythmic levels of AANAT activity are found. The active isoform in gut is AANAT1
isoforms Aanat1a and Aanat1b display a wide and distinct distribution in the nervous system and peripheral tissues
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photoreceptor cells, ependymal cells of the 3rd ventricle and discrete cells of the suprachiasmatic area. Expression of AANAT2 and absence of AANAT2
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mainly pars tuberalis, much less than in pineal gland, probably different regulation
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AANAT-specific immunoreactivity is observed in the nuclei of spinal neurons, and is significantly increased in aged dog spinal neurons compared to young adult spinal neurons. Melatonin receptor type 1B-specific immunoreactivity is found in the cytoplasm of spinal neurons, and is predominantly increased in the margin of the neuron cytoplasm in aged spinal cord compared to that in the young adult dogs
additional information
the enzymatic activity is higher in adult than in pupal brain. No difference is observed between day and night in the pupal brain and adult brain
strongly expressed in the head, fat body, midgut, and integument tubules of 5th instar larvae
strongly expressed in the head, fat body, midgut, and integument tubules of 5th instar larvae
in liver significant but not rhythmic levels of AANAT activity are found
strongly expressed in the head, fat body, midgut, and integument tubules of 5th instar larvae
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from fish in different phases of the annual breeding cycle, and pineal organ culture
transcripts are detected almost exclusively in the pineal gland
exposure of dark-adapted animals to near ultraviolet light significantly decreases melatonin content and the activity of serotonin N-acetyltransferase
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the enzyme catalyzes the first step in melatonin biosynthesis, melatonin biosynthesis follows a day and night rhythm, which is different in fasted, fed, and refed fish, overview
rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands
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pineal gland-specific isozyme AANAT2 is specifically expressed in pineal opsin-immunoreactive photoreceptor cells, developmental expression pattern, s significant 60fold reduction in Aanat2 expression occurs just before metamorphosis, overview
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photoreceptor cells, enzyme activity is regulated by circadian system, the photoperiodic control is direct in fish and frogs and indirect in mammals. Structural and functional evolution of the melatonin-producing units in vertebrates, overview
treatment of pinealocytes with norepinephrine causes an increase in the mRNA and protein levels of MKP-1 and AA-NAT, as well as in the AA-NAT activity
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AANAT activity is low during the daytime, increases rapidly early in the night and beginsto decline in anticipation of dawn
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photic regulation of arylalkylamine N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells
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photoreceptor cells, ependymal cells of the 3rd ventricle and discrete cells of the suprachiasmatic area. Expression of AANAT2 and absence of AANAT2
photoreceptor layer, inner nuclear layer. Low activity during the night and high activity during the day. Activity starts to increase during the second part of the night and reaches its maximal levels at dawn
additional information
tissue expression pattern of wild-type and mutant enzymes, overview. No expression in ovary, testis, midgut, fatbody, hemozyte, trachea, and Malpighian gland
additional information
tissue expression pattern of wild-type and mutant enzymes, overview. No expression in ovary, testis, midgut, fatbody, hemozyte, trachea, and Malpighian gland
additional information
tissue expression pattern of wild-type and mutant enzymes, overview. No expression in ovary, testis, midgut, fatbody, hemozyte, trachea, and Malpighian gland
additional information
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tissue expression pattern of wild-type and mutant enzymes, overview. No expression in ovary, testis, midgut, fatbody, hemozyte, trachea, and Malpighian gland
additional information
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offspring populations are maintained on Phaseolus vulgaris leaves
