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2.3.1.87: aralkylamine N-acetyltransferase

This is an abbreviated version!
For detailed information about aralkylamine N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.87

Reaction

acetyl-CoA
+
a 2-arylethylamine
=
CoA
 +
an N-acetyl-2-arylethylamine

Synonyms

AA-NAT, AANAT, AANAT1, AANAT2, AANAT3, AANATL7, AATNATL2, acetyl-CoA:aralkylamine N-acetyltransferase, acetyltransferase, arylalkylamine N-, arylalkylamine N-acetyltransferase, arylalkylamine N-acetyltransferase 1, arylalkylamine N-acetyltransferase 1a, arylalkylamine N-acetyltransferase 1b, arylalkylamine N-acetyltransferase 2, arylalkylamine N-acetyltransferase like 7, arylalkylamine N-acetyltransferase-2, Bm-iAANAT, Eis, hAANAT, More, MSMEG_3513, N-acetyltransferase, NAT, oAANAT, PA4534, PaaNAT, Rv2416c, serotonin acetylase, serotonin acetyltransferase, serotonin N-acetyltransferase, serotonin-N-acetyltransferase, SNA, SNAT, SNAT1, SNAT2

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.87 aralkylamine N-acetyltransferase

Application

Application on EC 2.3.1.87 - aralkylamine N-acetyltransferase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
-
colorimetric method for rapid detection of biogenic amines based on arylalkylamine N-acetyltransferase with distinct advantages including simple handling, high speed, low cost, good sensitivity and selectivity. The enzyme can specially recognize biogenic amines and catalyse their acetylation in the presence of AcCoA, and even in the presence of amino acids and aminoglycoside antibiotics having similar structures
medicine
-
AANAT-specific immunoreactivity is observed in the nuclei of spinal neurons, and is significantly increased in aged dog spinal neurons compared to young adult spinal neurons. Melatonin receptor type 1B-specific immunoreactivity is found in the cytoplasm of spinal neurons, and is predominantly increased in the margin of the neuron cytoplasm in aged spinal cord compared to that in the young adult dogs
synthesis
recombinant Escherichia coli that expresses sheep SNAT with rice caffeic acid O-methyltransferase produces up to 1.46 mg/l meatonin in culture medium in response to 1 mM serotonin