2.3.1.87: aralkylamine N-acetyltransferase
This is an abbreviated version!
For detailed information about aralkylamine N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.87
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2.3.1.87
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melatonin
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pineal
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rhythm
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circadian
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clock
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retina
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night
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nocturnal
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norepinephrine
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hiomt
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pinealocytes
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arylalkylamine-n-acetyltransferase
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hydroxyindole-o-methyltransferase
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photoreceptors
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oscillator
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n-acetylserotonin
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diurnal
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suprachiasmatic
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photoperiodic
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snats
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light-dark
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sodium-coupled
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adrenergic
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tryptamine
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entrain
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photoreceptive
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synthesis
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n-acetyl-5-methoxytryptamine
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gcn5-related
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photic
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zeitgeber
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clockwork
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day-night
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octopamine
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night-time
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clock-controlled
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medicine
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analysis
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ne-stimulated
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hydroxyindole
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meaib
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melatoninergic
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rhythm-generating
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extrapineal
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slc38a2
- 2.3.1.87
- melatonin
-
pineal
- rhythm
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circadian
- clock
- retina
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night
-
nocturnal
- norepinephrine
- hiomt
- pinealocytes
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arylalkylamine-n-acetyltransferase
- hydroxyindole-o-methyltransferase
- photoreceptors
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oscillator
- n-acetylserotonin
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diurnal
-
suprachiasmatic
-
photoperiodic
-
snats
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light-dark
-
sodium-coupled
-
adrenergic
- tryptamine
-
entrain
-
photoreceptive
- synthesis
- n-acetyl-5-methoxytryptamine
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gcn5-related
-
photic
-
zeitgeber
-
clockwork
-
day-night
- octopamine
-
night-time
-
clock-controlled
- medicine
- analysis
-
ne-stimulated
-
hydroxyindole
-
meaib
-
melatoninergic
-
rhythm-generating
-
extrapineal
-
slc38a2
Reaction
Synonyms
AA-NAT, AANAT, AANAT1, AANAT2, AANAT3, AANATL7, AATNATL2, acetyl-CoA:aralkylamine N-acetyltransferase, acetyltransferase, arylalkylamine N-, arylalkylamine N-acetyltransferase, arylalkylamine N-acetyltransferase 1, arylalkylamine N-acetyltransferase 1a, arylalkylamine N-acetyltransferase 1b, arylalkylamine N-acetyltransferase 2, arylalkylamine N-acetyltransferase like 7, arylalkylamine N-acetyltransferase-2, Bm-iAANAT, Eis, hAANAT, More, MSMEG_3513, N-acetyltransferase, NAT, oAANAT, PA4534, PaaNAT, Rv2416c, serotonin acetylase, serotonin acetyltransferase, serotonin N-acetyltransferase, serotonin-N-acetyltransferase, SNA, SNAT, SNAT1, SNAT2
ECTree
2.3.1.87 aralkylamine N-acetyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.1.87 - aralkylamine N-acetyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
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-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
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-
-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
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-
-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
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-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
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rate-limiting in melatonin, i.e. N-acetyl-5-methoxytryptamine synthesis
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-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
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key enzyme of circadian rhythm of melatonin synthesis
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-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
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rate-limiting in melatonin synthesis
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-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
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the enzyme catalyzes the first step in melatonin biosynthesis
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-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
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initial reaction in melatonin synthesis from serotonin
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-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
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penultimate enzyme in melatonin pathway
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-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
penultimate step in melatonin biosynthesis
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-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
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initial reaction in melatonin synthesis from serotonin
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
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first step in melatonin biosynthesis
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-
?
additional information
?
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aaNAT2, a protein from the typical insect aaNAT cluster, uses histamine as a substrate as well as arylalkylamines
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-
?
additional information
?
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aaNAT2, a protein from the typical insect aaNAT cluster, uses histamine as a substrate as well as arylalkylamines
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-
?
additional information
?
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enzyme activity in cultured cells is suppressed by light, as it is in vivo. The ability to express circadian regulation of the enzyme activity is an intrinsic property of retinal cells that can develop in vitro
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-
?
additional information
?
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the enzyme catalyzes the rate-limiting step in melatonin synthesis
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-
?
additional information
?
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enzyme light and diurnal regulation involves phosphorylation on key AANAT Ser and Thr residues, which results in 14-3-3 protein recruitment and changes in catalytic activity and protein stability
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-
?
additional information
?
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the enzyme catalyzes the limiting step for melatonin synthesis
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-
?
additional information
?
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the enzyme catalyzes the limiting step for melatonin synthesis
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-
?
additional information
?
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NAT could be a clock-controlled gene functioning as an output regulator of the circadian clock
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-
?
additional information
?
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overexpression of inducible cAMP early repressor can suppress the norepinephrine induction of aa-nat
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-
?
additional information
?
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AANAT1 may carry out an as yet unknown function that involves acetylation of arylalkylamines other than serotonin
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-
?
additional information
?
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AANAT1 may carry out an as yet unknown function that involves acetylation of arylalkylamines other than serotonin
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-
?
additional information
?
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AANAT1 may carry out an as yet unknown function that involves acetylation of arylalkylamines other than serotonin
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-
?
additional information
?
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AANAT2 is responsible for the production of large amounts of melatonin that is released into the circulation and exerts an endocrine role
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?
additional information
?
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AANAT2 is responsible for the production of large amounts of melatonin that is released into the circulation and exerts an endocrine role
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-
?
additional information
?
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AANAT2 is responsible for the production of large amounts of melatonin that is released into the circulation and exerts an endocrine role
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-
?
additional information
?
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AANAT is a key regulatory enzyme in the melatonin biosynthetic pathway
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-
?
