2.3.1.87: aralkylamine N-acetyltransferase
This is an abbreviated version!
For detailed information about aralkylamine N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.87
-
2.3.1.87
-
melatonin
-
pineal
-
rhythm
-
circadian
-
clock
-
retina
-
night
-
nocturnal
-
norepinephrine
-
hiomt
-
pinealocytes
-
arylalkylamine-n-acetyltransferase
-
hydroxyindole-o-methyltransferase
-
photoreceptors
-
oscillator
-
n-acetylserotonin
-
diurnal
-
suprachiasmatic
-
photoperiodic
-
snats
-
light-dark
-
sodium-coupled
-
adrenergic
-
tryptamine
-
entrain
-
photoreceptive
-
synthesis
-
n-acetyl-5-methoxytryptamine
-
gcn5-related
-
photic
-
zeitgeber
-
clockwork
-
day-night
-
octopamine
-
night-time
-
clock-controlled
-
medicine
-
analysis
-
ne-stimulated
-
hydroxyindole
-
meaib
-
melatoninergic
-
rhythm-generating
-
extrapineal
-
slc38a2
- 2.3.1.87
- melatonin
-
pineal
- rhythm
-
circadian
- clock
- retina
-
night
-
nocturnal
- norepinephrine
- hiomt
- pinealocytes
-
arylalkylamine-n-acetyltransferase
- hydroxyindole-o-methyltransferase
- photoreceptors
-
oscillator
- n-acetylserotonin
-
diurnal
-
suprachiasmatic
-
photoperiodic
-
snats
-
light-dark
-
sodium-coupled
-
adrenergic
- tryptamine
-
entrain
-
photoreceptive
- synthesis
- n-acetyl-5-methoxytryptamine
-
gcn5-related
-
photic
-
zeitgeber
-
clockwork
-
day-night
- octopamine
-
night-time
-
clock-controlled
- medicine
- analysis
-
ne-stimulated
-
hydroxyindole
-
meaib
-
melatoninergic
-
rhythm-generating
-
extrapineal
-
slc38a2
Reaction
Synonyms
AA-NAT, AANAT, AANAT1, AANAT2, AANAT3, AANATL7, AATNATL2, acetyl-CoA:aralkylamine N-acetyltransferase, acetyltransferase, arylalkylamine N-, arylalkylamine N-acetyltransferase, arylalkylamine N-acetyltransferase 1, arylalkylamine N-acetyltransferase 1a, arylalkylamine N-acetyltransferase 1b, arylalkylamine N-acetyltransferase 2, arylalkylamine N-acetyltransferase like 7, arylalkylamine N-acetyltransferase-2, Bm-iAANAT, Eis, hAANAT, More, MSMEG_3513, N-acetyltransferase, NAT, oAANAT, PA4534, PaaNAT, Rv2416c, serotonin acetylase, serotonin acetyltransferase, serotonin N-acetyltransferase, serotonin-N-acetyltransferase, SNA, SNAT, SNAT1, SNAT2
ECTree
2.3.1.87 aralkylamine N-acetyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.1.87 - aralkylamine N-acetyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + 2,5-dimethoxyphenylethylamine
CoA + ?
24% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2,5-dimethoxyphenylethylamine
CoA + N-acetyl-2,5-dimethoxyphenylethylamine
-
68% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(2,3-dichlorophenyl)-ethylamine
CoA + N-acetyl-2-(2,3-dichlorophenyl)-ethylamine
acetyl-CoA + 2-(3,4-dihydroxyphenyl)-ethylamine
CoA + N-acetyl-2-(3,4-dihydroxyphenyl)-ethylamine
acetyl-CoA + 2-(3,4-dimethoxyphenyl)-ethylamine
CoA + N-acetyl-2-(3,4-dimethoxyphenyl)-ethylamine
acetyl-CoA + 2-fluorophenylethylamine
CoA + ?
69% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-fluorophenylethylamine
CoA + N-acetyl-2-fluorophenylethylamine
-
52% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-(trifluoromethyl)phenethylamine
CoA + N-acetyl-3-(trifluoromethyl)phenethylamine
-
-
-
-
?
acetyl-CoA + 3-hydroxy-4-methoxyphenethylamine
CoA + ?
1% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-hydroxy-4-methoxyphenethylamine
CoA + N-acetyl-3-hydroxy-4-methoxyphenethylamine
-
7.2% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-hydroxyphenethylamine
CoA + ?
24% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-hydroxyphenethylamine
CoA + N-acetyl-3-hydroxyphenethylamine
-
36% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-indolebutylamine
CoA + N-acetyl-(3-indol-3-yl-butyl)-amine
-
60-fold less efficiently than serotonin
-
-
?
acetyl-CoA + 3-indolepropylamine
CoA + N-acetyl-(3-indol-3-yl-propyl)-amine
-
20-fold less efficiently than serotonin
-
-
?
acetyl-CoA + 3-methoxy-2-phenylethylamine
CoA + ?
23% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-methoxy-2-phenylethylamine
CoA + N-acetyl-3-methoxy-2-phenylethylamine
-
55% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-methoxyphenethylamine
CoA + N-acetyl-3-methoxyphenethylamine
-
-
-
-
?
acetyl-CoA + 3-methoxytyramine
CoA + ?
17% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 3-methoxytyramine
CoA + N-acetyl-3-methoxytyramine
-
73% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 4-(2-aminoethyl)-benzenesulfonamide
CoA + ?
-
1% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 5-benzyloxytryptamine
CoA + N-acetyl-5-benzyloxytryptamine
-
-
-
-
?
acetyl-CoA + 5-hydroxydopamine
CoA + N-acetyl-5-hydroxydopamine
-
4.4% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 6-hydroxydopamine
CoA + ?
51% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 6-hydroxydopamine
CoA + N-acetyl-6-hydroxydopamine
-
1.5% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + alpha-methyltryptamine
CoA + N-acetyl-alpha-methyltryptamine
-
racemic, 9:1 stereoselectivity for R-enantiomer, less efficiently than serotonin
-
-
?
acetyl-CoA + beta-methylphenethylamine
CoA + N-acetyl-beta-methylphenethylamine
-
-
-
-
?
acetyl-CoA + Nomega-methyltryptamine
CoA + ?
-
less efficiently than serotonin
-
-
?
acetyl-CoA + tryptophol
CoA + N-acetyltryptophol
-
structural analogue to tryptamine
-
-
?
acetyl-CoA + tyramine
CoA + ?
8% of the activity with 2-phenylethylamine
-
-
?
arachidonoyl-CoA + octopamine
CoA + N-arachidonoyloctopamine
-
-
-
?
palmitoyl-CoA + octopamine
CoA + N-palmitoyloctopamine
-
-
-
?
acetyl-CoA + 2-(2,3-dichlorophenyl)-ethylamine
CoA + N-acetyl-2-(2,3-dichlorophenyl)-ethylamine
78% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(2,3-dichlorophenyl)-ethylamine
CoA + N-acetyl-2-(2,3-dichlorophenyl)-ethylamine
-
84% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(2-chlorophenyl)-ethylamine
CoA + N-acetyl-2-(2-chlorophenyl)-ethylamine
130% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(2-chlorophenyl)-ethylamine
CoA + N-acetyl-2-(2-chlorophenyl)-ethylamine
-
102% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3,4-dihydroxyphenyl)-ethylamine
CoA + N-acetyl-2-(3,4-dihydroxyphenyl)-ethylamine
7% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3,4-dihydroxyphenyl)-ethylamine
CoA + N-acetyl-2-(3,4-dihydroxyphenyl)-ethylamine
-
64% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3,4-dimethoxyphenyl)-ethylamine
CoA + N-acetyl-2-(3,4-dimethoxyphenyl)-ethylamine
4.4% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3,4-dimethoxyphenyl)-ethylamine
CoA + N-acetyl-2-(3,4-dimethoxyphenyl)-ethylamine
-
15% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3-chlorophenyl)-ethylamine
CoA + N-acetyl-2-(3-chlorophenyl)-ethylamine
67% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3-chlorophenyl)-ethylamine
CoA + N-acetyl-2-(3-chlorophenyl)-ethylamine
-
110% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3-fluorophenyl)-ethylamine
CoA + N-acetyl-2-(3-fluorophenyl)-ethylamine
65% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(3-fluorophenyl)-ethylamine
CoA + N-acetyl-2-(3-fluorophenyl)-ethylamine
-
93% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(4-bromophenyl)-ethylamine
CoA + N-acetyl-2-(4-bromophenyl)-ethylamine
48% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(4-bromophenyl)-ethylamine
CoA + N-acetyl-2-(4-bromophenyl)-ethylamine
-
87% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(4-chlorophenyl)ethylamine
CoA + N-acetyl-2-(4-chlorophenyl)ethylamine
68% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(4-chlorophenyl)ethylamine
CoA + N-acetyl-2-(4-chlorophenyl)ethylamine
-
91% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(4-fluorophenyl)-ethylamine
CoA + N-acetyl-2-(4-fluorophenyl)-ethylamine
116% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(4-fluorophenyl)-ethylamine
CoA + N-acetyl-2-(4-fluorophenyl)-ethylamine
-
60% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(p-fluorophenyl)-ethylamine
CoA + N-acetyl-2-(p-fluorophenyl)-ethylamine
56% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(p-fluorophenyl)-ethylamine
CoA + N-acetyl-2-(p-fluorophenyl)-ethylamine
-
as active as with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(p-nitrophenyl)-ethylamine
CoA + N-acetyl-2-(p-nitrophenyl)-ethylamine
9% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(p-nitrophenyl)-ethylamine
CoA + N-acetyl-2-(p-nitrophenyl)-ethylamine
-
53% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(p-tolyl)-ethylamine
CoA + N-acetyl-2-(p-tolyl)-ethylamine
60% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-(p-tolyl)-ethylamine
CoA + N-acetyl-2-(p-tolyl)-ethylamine
-
87% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-methoxyphenylethylamine
CoA + N-acetyl-2-methoxyphenylethylamine
52% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-methoxyphenylethylamine
CoA + N-acetyl-2-methoxyphenylethylamine
-
97% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 2-phenylethylamine
CoA + N-acetyl-2-phenylethylamine
-
-
-
?
acetyl-CoA + 2-phenylethylamine
CoA + N-acetyl-2-phenylethylamine
-
-
-
?
acetyl-CoA + 4-(2-aminoethyl)-benzenesulfonyl fluoride
CoA + ?
8% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 4-(2-aminoethyl)-benzenesulfonyl fluoride
CoA + ?
-
7.4% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 4-methoxyphenylethylamine
CoA + N-acetyl-4-methoxyphenylethylamine
11% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 4-methoxyphenylethylamine
CoA + N-acetyl-4-methoxyphenylethylamine
-
10% of the activity with 2-phenylethylamine
-
-
?
acetyl-CoA + 5-hydroxytryptamine
CoA + N-acetyl-5-hydroxytryptamine
-
-
-
-
?
acetyl-CoA + 5-hydroxytryptamine
CoA + N-acetyl-5-hydroxytryptamine
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
-
-
-
?
acetyl-CoA + 6-fluorotryptamine
CoA + N-acetyl-6-fluorotryptamine
-
-
-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
-
-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
-
-
-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
-
-
-
-
?
acetyl-CoA + a 2-arylethylamine
CoA + an N-acetyl-2-arylethylamine
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
also substrate: phenylethylamine derivatives without a beta-hydroxy group
-
-
?
acetyl-CoA + dopamine
CoA + N-acetyldopamine
-
-
-
?
acetyl-CoA + histamine
CoA + N-acetylhistamine
-
-
-
?
acetyl-CoA + norepinephrine
CoA + N-acetylnorepinephrine
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
?
acetyl-CoA + octopamine
CoA + N-acetyloctopamine
-
-
-
?
acetyl-CoA + phenylethylamine
CoA + N-acetyl-phenylethylamine
-
-
-
?
acetyl-CoA + phenylethylamine
CoA + N-acetylphenylethylamine
-
-
-
?
acetyl-CoA + phenylethylamine
CoA + N-acetylphenylethylamine
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
rate-limiting in melatonin, i.e. N-acetyl-5-methoxytryptamine synthesis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
best substrate
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
key enzyme of circadian rhythm of melatonin synthesis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
rate-limiting in melatonin synthesis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
the enzyme catalyzes the first step in melatonin biosynthesis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
initial reaction in melatonin synthesis from serotonin
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
penultimate enzyme in melatonin pathway
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
penultimate step in melatonin biosynthesis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
reaction mechanism involving Pro64 that plays a critical role in structure and catalysis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
i.e. 5-hydroxytryptamine
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
initial reaction in melatonin synthesis from serotonin
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
first step in melatonin biosynthesis
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
AANAT2 acetylates serotonin about 10times faster than AANAT1
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
-
-
?
acetyl-CoA + tyramine
CoA + N-acetyltyramine
-
10% of the activity with 2-phenylethylamine
-
-
?
propionyl-CoA + histamine
CoA + N-propionylhistamine
-
-
-
?
propionyl-CoA + histamine
CoA + N-propionylhistamine
-
-
-
?
propionyl-CoA + histamine
CoA + N-propionylhistamine
-
-
-
?
propionyl-CoA + histamine
CoA + N-propionylhistamine
-
-
-
?
propionyl-CoA + tyramine
CoA + N-propionyltyramine
-
-
-
?
propionyl-CoA + tyramine
CoA + N-propionyltyramine
-
-
-
?
additional information
?
-
aaNAT2, a protein from the typical insect aaNAT cluster, uses histamine as a substrate as well as arylalkylamines
-
-
?
additional information
?
-
-
aaNAT2, a protein from the typical insect aaNAT cluster, uses histamine as a substrate as well as arylalkylamines
-
-
?
additional information
?
-
-
substrate specificity, aaNAT1 and aaNAT2 show a broad substrate specificity and their affinity and catalytic efficiency to each of the seven arylalkylamines tested. The affinity between aaNAT1 and aaNAT2 to most of the arylalkylamines is similar except that aaNAT2 has less affinity than aaNAT1 to norepinephrine. Also aaNAT1 is more efficient in catalyzing all the tested substrates than that of aaNAT2
-
-
?
additional information
?
-
-
ordered sequential mechanism, with acetyl-CoA binding first followed by histamine to generate an AANATL7-acetyl-CoA-histamine ternary complex prior to catalysis. An ionizable group with a pKa of 7.1 is assigned to Glu-26 as a general base and a second with a pKa of 9.5 is assigned to the protonation of the thiolate of the coenzyme A product
-
-
?
additional information
?
-
-
enzyme activity in cultured cells is suppressed by light, as it is in vivo. The ability to express circadian regulation of the enzyme activity is an intrinsic property of retinal cells that can develop in vitro
-
-
?
additional information
?
-
-
further substrates: selected synthetic amines
-
-
?
additional information
?
-
-
the enzyme catalyzes the rate-limiting step in melatonin synthesis
-
-
?
additional information
?
-
no activity with 2-(4-aminophenyl)-ethylamine, 3,4-(dibenzyloxy)phenethylamine, 5-hydroxydopamine, 4-(2-aminoethyl)-benzenesulfonamide or 2-(p-chlorophenoxy)-2-methylpropionic acid
-
-
?
additional information
?
-
-
no activity with 2-(4-aminophenyl)-ethylamine, 3,4-(dibenzyloxy)phenethylamine, 5-hydroxydopamine, 4-(2-aminoethyl)-benzenesulfonamide or 2-(p-chlorophenoxy)-2-methylpropionic acid
-
-
?
additional information
?
-
-
enzyme light and diurnal regulation involves phosphorylation on key AANAT Ser and Thr residues, which results in 14-3-3 protein recruitment and changes in catalytic activity and protein stability
-
-
?
additional information
?
-
the enzyme catalyzes the limiting step for melatonin synthesis
-
-
?
additional information
?
-
-
the enzyme catalyzes the limiting step for melatonin synthesis
-
-
?
additional information
?
-
-
arylamines, such as aniline or p-phenetidine are very poor substrates
-
-
?
additional information
?
-
-
arylamines, such as aniline or p-phenetidine are very poor substrates
-
-
?
additional information
?
-
-
no activity with 2-(4-aminophenyl)-ethylamine, 3,4-(dibenzyloxy)phenethylamine or 2-(p-chlorophenoxy)-2-methylpropionic acid
-
-
?
additional information
?
-
-
NAT could be a clock-controlled gene functioning as an output regulator of the circadian clock
-
-
?
additional information
?
-
-
no substrates are phenylethanolamine derivatives with a beta-hydroxy group
-
-
?
additional information
?
-
-
arylamines, such as aniline or p-phenetidine are very poor substrates
-
-
?
additional information
?
-
-
arylamines, such as aniline or p-phenetidine are very poor substrates
-
-
?
additional information
?
-
overexpression of inducible cAMP early repressor can suppress the norepinephrine induction of aa-nat
-
-
?
additional information
?
-
AANAT1 may carry out an as yet unknown function that involves acetylation of arylalkylamines other than serotonin
-
-
?
additional information
?
-
AANAT1 may carry out an as yet unknown function that involves acetylation of arylalkylamines other than serotonin
-
-
?
additional information
?
-
-
AANAT1 may carry out an as yet unknown function that involves acetylation of arylalkylamines other than serotonin
-
-
?
additional information
?
-
AANAT2 is responsible for the production of large amounts of melatonin that is released into the circulation and exerts an endocrine role
-
-
?
additional information
?
-
AANAT2 is responsible for the production of large amounts of melatonin that is released into the circulation and exerts an endocrine role
-
-
?
additional information
?
-
-
AANAT2 is responsible for the production of large amounts of melatonin that is released into the circulation and exerts an endocrine role
-
-
?
additional information
?
-
insignificant activity in presence of phenylethylamine or tyramine
-
-
?
additional information
?
-
insignificant activity in presence of phenylethylamine or tyramine
-
-
?
additional information
?
-
-
insignificant activity in presence of phenylethylamine or tyramine
-
-
?
additional information
?
-
-
AANAT is a key regulatory enzyme in the melatonin biosynthetic pathway
-
-
?
