2.3.1.87: aralkylamine N-acetyltransferase

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For detailed information about aralkylamine N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.87

2.3.1.87

melatonin

pineal

rhythm

circadian

clock

retina

night

nocturnal

norepinephrine

hiomt

pinealocytes

arylalkylamine-n-acetyltransferase

hydroxyindole-o-methyltransferase

photoreceptors

oscillator

n-acetylserotonin

diurnal

suprachiasmatic

photoperiodic

snats

light-dark

sodium-coupled

adrenergic

tryptamine

entrain

photoreceptive

synthesis

n-acetyl-5-methoxytryptamine

gcn5-related

photic

zeitgeber

clockwork

day-night

octopamine

night-time

clock-controlled

medicine

analysis

ne-stimulated

hydroxyindole

meaib

melatoninergic

rhythm-generating

extrapineal

slc38a2

Reaction

Synonyms

AA-NAT, AANAT, AANAT1, AANAT2, AANAT3, AANATL7, AATNATL2, acetyl-CoA:aralkylamine N-acetyltransferase, acetyltransferase, arylalkylamine N-, arylalkylamine N-acetyltransferase, arylalkylamine N-acetyltransferase 1, arylalkylamine N-acetyltransferase 1a, arylalkylamine N-acetyltransferase 1b, arylalkylamine N-acetyltransferase 2, arylalkylamine N-acetyltransferase like 7, arylalkylamine N-acetyltransferase-2, Bm-iAANAT, Eis, hAANAT, More, MSMEG_3513, N-acetyltransferase, NAT, oAANAT, PA4534, PaaNAT, Rv2416c, serotonin acetylase, serotonin acetyltransferase, serotonin N-acetyltransferase, serotonin-N-acetyltransferase, SNA, SNAT, SNAT1, SNAT2

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.87 aralkylamine N-acetyltransferase

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Results	in table
14	Activating Compound
95	AA Sequence
3	Application
1	CAS Registry Number
36	Cloned(Commentary)
14	Cofactor
4	Crystallization (Commentary)
225	Disease/ Diagnostics
5	Expression
49	General Information
11	General Stability
42	IC50 Value
88	Inhibitors
54	kcat/KM [mM/s]
2	Ki Value [mM]
182	KM Value [mM]
8	Localization
3	Metals/Ions
21	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
126	Organism
6	Pathway
41	PDB ID
18	pH Optimum
2	pH Range
1	pI Value
7	Posttranslational Modification
37	Protein Variants
13	Purification (Commentary)
12	Reaction
1	Reaction Type
124	Reference
119	Source Tissue
11	Specific Activity [micromol/min/mg]
4	Storage Stability
289	Substrates and Products (Substrate)
22	Subunits
120	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
10	Temperature Range [°C]
10	Temperature Stability [°C]
68	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.87 - aralkylamine N-acetyltransferase

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acetyl-CoA:2-arylethylamine N-acetyltransferase

Narrow specificity towards 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4, acetylserotonin O-methyltransferase). Differs from EC 2.3.1.5 arylamine N-acetyltransferase.