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2.3.1.50: serine C-palmitoyltransferase

This is an abbreviated version!
For detailed information about serine C-palmitoyltransferase, go to the full flat file.

Word Map on EC 2.3.1.50

Reaction

palmitoyl-CoA
+
L-serine
=
CoA
 +
3-dehydro-D-sphinganine
 +
CO2

Synonyms

3-oxosphinganine synthetase, acyl-CoA:serine C-2 acyltransferase decarboxylating, LCB1, LCB2, LCB2a, LCB2b, More, palmitoyltransferase, serine, serine palmitoyl transferase, serine palmitoyltransferase, serine palmitoyltransferase 1, serine palmitoyltransferase a, serine-palmitoyl transferase, serine-palmitoyltransferase, SPT, SPT1, SPT2, SPT3, SPTase, SPTLC1, SPTLC2, ssSPT, ssSPTa, Tsc3

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.50 serine C-palmitoyltransferase

Expression

Expression on EC 2.3.1.50 - serine C-palmitoyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
imatinib does not affect SPTLC1 expression
LCB2 is upregulated during hypersensitive cell death nduced by the Phytophthora boehmeriae elicitor PB90
lithospermic acid and two derivative esters, 9''-methyl lithospermate and 9'-methyl lithospermate,isolated from roots of Lithospermum erythrorhizon, significantly increase SPT expression in the relative quantity of SPT1 mRNA as well as SPT2 mRNA, by 21-59%, overview
-
Pseudomonas cichorii infection induces expression of subunit LCB2
short-term Mg deficiency results in an upregulation of major subunit 1 and 2 in cardiovascular tissues
-
the enzyme is highly expressed at early stages of infection of the host Emiliania huxleyi
the levels of subunits SPTLC1 and 2 progressively increase at both the protein and mRNA levels in oligodendrocytes as the cells differentiate from immature oligodendrocyte progenitors (day 2) into mature myelinating oligodendrocytes (day 16)