2.3.1.50: serine C-palmitoyltransferase
This is an abbreviated version!
For detailed information about serine C-palmitoyltransferase, go to the full flat file.
Word Map on EC 2.3.1.50
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2.3.1.50
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sphingolipids
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ceramide
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myriocin
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sphingomyelin
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sphingosine
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sphingomyelinase
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neuropathy
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sphingoid
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cholesterol
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fumonisin
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glucosylceramide
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sphingosine-1-phosphate
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3-ketodihydrosphingosine
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corneum
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glycosphingolipids
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dihydroceramide
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dihydrosphingosine
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plp-dependent
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l-cycloserine
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ormdl3
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molecular biology
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sphingomonas
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paucimobilis
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transepidermal
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charcot-marie-tooth
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analysis
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ceramide-induced
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phytosphingosine
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medicine
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asmase
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aldimine
- 2.3.1.50
- sphingolipids
- ceramide
- myriocin
- sphingomyelin
- sphingosine
- sphingomyelinase
- neuropathy
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sphingoid
- cholesterol
- fumonisin
- glucosylceramide
- sphingosine-1-phosphate
- 3-ketodihydrosphingosine
- corneum
- glycosphingolipids
- dihydroceramide
- dihydrosphingosine
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plp-dependent
- l-cycloserine
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ormdl3
- molecular biology
- sphingomonas
- paucimobilis
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transepidermal
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charcot-marie-tooth
- analysis
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ceramide-induced
- phytosphingosine
- medicine
- asmase
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aldimine
Reaction
Synonyms
3-oxosphinganine synthetase, acyl-CoA:serine C-2 acyltransferase decarboxylating, LCB1, LCB2, LCB2a, LCB2b, More, palmitoyltransferase, serine, serine palmitoyl transferase, serine palmitoyltransferase, serine palmitoyltransferase 1, serine palmitoyltransferase a, serine-palmitoyl transferase, serine-palmitoyltransferase, SPT, SPT1, SPT2, SPT3, SPTase, SPTLC1, SPTLC2, ssSPT, ssSPTa, Tsc3
ECTree
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Activating Compound
Activating Compound on EC 2.3.1.50 - serine C-palmitoyltransferase
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pioglitazone
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increases the enzyme activity in vitro and in vivo independent of standard or high-fat diet
retinoic acid
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up-regulates enzyme activity in embryonic carcinoma cell ine PCC7-Mz1
S-(2-oxoheptadecyl)-CoA
binds to the smSPT-external aldimine complex and enhances the exchange rate of the alpha-proton of L-serine by smSPT
small activating subunit of serine palmitoyltransferase
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ssSPT, the small subunits of human serine palmitoyltransferase (hssSPTs) are glycoproteins and activate the catalytic hLCB1/hLCB2 heterodimer. Two isoforms exist, ssSPTa and ssSPTb, a single amino acid, residue 25, difference between ssSPTa and ssSPTb is responsible for the acyl-CoA preference of heterotrimers containing each isoform. the role of the small activating subunits of serine palmitoyltransferase, ssSPTs, is to increase SPT activity without compromising substrate specificity. Activity and acyl-CoA selectivity of the ssSPTs reside in the conserved core. Deletion of the N-terminal 10 amino acids of small activating subunit of serine palmitoyltransferase isoforms ssSPTa or ssSPTb has no effect on the ability of the proteins to activate hLCB1/hLCB2a heterodimers sufficiently to complement growth of yeast lacking endogenous serine palmitoyltransferase. The region responsible for the acyl-CoA selectivity of ssSPTa lays between residues Ser11 and Glu27, the acyl-CoA selectivity does not lie in the C-terminal region of ssSPTb, overview
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etoposide
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enhanced activity due to chemotherapy with epotoside as therapeutic agent in Molt-4 leukemic cells
etoposide
activates enzyme activity, but decreases mRNA level, time-dependent
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isoforms ssSPTa and ssSPTb, UniProt A8MSB8 and F4IPU5, strongly stimulate SPT activity. Small subunit ssSPTa transcripts are more enriched in all organs and over 400fold more abundant in pollen than small subunit ssSPTb transcripts. Homozygous ssSPTa T-DNA mutants are not recoverable, and 50% nonviable pollen is detected in heterozygous ssspta mutants. The small subunits are essential for male gametophytes, are important for mycotoxin fumonisin B1 sensitivity, and limit sphingolipid synthesis in planta
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small subunits of serine palmitoyltransferase
small subunits of SPT, ssSPTa and ssSPTb, increase human SPT activity by 50-100fold when coexpressed with enzyme subunits hLCB1 and hLCBa
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enzyme activity is enhanced under stress and in apoptosis, e.g. in pancreatic cells in a model for diabetes, in case of angiotensin II type receptor occupancy
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additional information
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enzyme activity is enhanced under stress and in apoptosis, e.g. in pancreatic cells in a model for diabetes, in case of angiotensin II type receptor occupancy
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additional information
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increased SPT enzyme activity in reactive astrocytes of the hippocampus at 2 weeks post-kainate injection
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additional information
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the enzyme activity and expression in the heart is not affected by high-fat feeding
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