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2.3.1.50: serine C-palmitoyltransferase

This is an abbreviated version!
For detailed information about serine C-palmitoyltransferase, go to the full flat file.

Word Map on EC 2.3.1.50

Reaction

palmitoyl-CoA
+
L-serine
=
CoA
 +
3-dehydro-D-sphinganine
 +
CO2

Synonyms

3-oxosphinganine synthetase, acyl-CoA:serine C-2 acyltransferase decarboxylating, LCB1, LCB2, LCB2a, LCB2b, More, palmitoyltransferase, serine, serine palmitoyl transferase, serine palmitoyltransferase, serine palmitoyltransferase 1, serine palmitoyltransferase a, serine-palmitoyl transferase, serine-palmitoyltransferase, SPT, SPT1, SPT2, SPT3, SPTase, SPTLC1, SPTLC2, ssSPT, ssSPTa, Tsc3

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.50 serine C-palmitoyltransferase

Specific Activity

Specific Activity on EC 2.3.1.50 - serine C-palmitoyltransferase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000018
-
HEK cell extract
0.000044
0.0000465
-
activity in microsomes
0.000063
-
-
0.00011
-
substrate alanine, C133W mutant protein, pH not specified in the publication, temperature not specified in the publication
0.00027
-
-
0.000275
-
substrate serine, C133W mutant protein, pH not specified in the publication, temperature not specified in the publication
0.00135
-
substrate serine, wild type protein, pH not specified in the publication, temperature not specified in the publication
0.0104
with [2,3,3-D] L-serine as cosubstrate, at pH 8.1 and 37°C
0.0113
with[2-13C] L-serine as cosubstrate, at pH 8.1 and 37°C
0.0116
with L-serine as cosubstrate, at pH 8.1 and 37°C
0.0122
with [3,3-D] L-serine as cosubstrate, at pH 8.1 and 37°C
0.0129
with [1,2,3-13C,2-15N] L-serine as cosubstrate, at pH 8.1 and 37°C
0.057 - 0.084
-
-
0.177
-
with [2,3,3-D] L-serine as cosubstrate, at pH 8.1 and 37°C
0.386
-
with L-serine as cosubstrate, at pH 8.1 and 37°C
0.397
-
with [3,3-D] L-serine as cosubstrate, at pH 8.1 and 37°C
0.411
-
with [2-13C] L-serine as cosubstrate, at pH 8.1 and 37°C
0.441
-
with [1,2,3-13C,2-15N] L-serine as cosubstrate, at pH 8.1 and 37°C
0.7
-
purified enzyme
additional information