2.3.1.50: serine C-palmitoyltransferase

This is an abbreviated version!
For detailed information about serine C-palmitoyltransferase, go to the full flat file.

Word Map on EC 2.3.1.50

2.3.1.50

sphingolipids

ceramide

myriocin

sphingomyelin

sphingosine

sphingomyelinase

neuropathy

sphingoid

cholesterol

fumonisin

glucosylceramide

sphingosine-1-phosphate

3-ketodihydrosphingosine

corneum

glycosphingolipids

dihydroceramide

dihydrosphingosine

plp-dependent

l-cycloserine

ormdl3

molecular biology

sphingomonas

paucimobilis

transepidermal

charcot-marie-tooth

analysis

ceramide-induced

phytosphingosine

medicine

asmase

aldimine

Reaction

Synonyms

3-oxosphinganine synthetase, acyl-CoA:serine C-2 acyltransferase decarboxylating, LCB1, LCB2, LCB2a, LCB2b, More, palmitoyltransferase, serine, serine palmitoyl transferase, serine palmitoyltransferase, serine palmitoyltransferase 1, serine palmitoyltransferase a, serine-palmitoyl transferase, serine-palmitoyltransferase, SPT, SPT1, SPT2, SPT3, SPTase, SPTLC1, SPTLC2, ssSPT, ssSPTa, Tsc3

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.50 serine C-palmitoyltransferase

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Results	in table
17	Activating Compound
1022	AA Sequence
8	Application
1	CAS Registry Number
52	Cloned(Commentary)
54	Cofactor
6	Crystallization (Commentary)
331	Disease/ Diagnostics
9	Expression
50	General Information
14	IC50 Value
84	Inhibitors
26	kcat/KM [mM/s]
2	Ki Value [mM]
68	KM Value [mM]
73	Localization
5	Metals/Ions
20	Molecular Weight [Da]
93	Natural Substrates/ Products (Substrates)
124	Organism
7	Pathway
49	PDB ID
30	pH Optimum
4	pH Range
3	pH Stability
6	Posttranslational Modification
75	Protein Variants
18	Purification (Commentary)
18	Reaction
17	Reaction Type
109	Reference
1	Renatured (Commentary)
104	Source Tissue
29	Specific Activity [micromol/min/mg]
1	Storage Stability
206	Substrates and Products (Substrate)
39	Subunits
168	Synonyms
1	Systematic Name
32	Temperature Optimum [°C]
2	Temperature Stability [°C]
34	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.3.1.50 - serine C-palmitoyltransferase

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0.0000054

(2S,3R)-2-amino-12-hydroxy-2-hydroxymethyl-3-sulfooxy-octadecanoic acid

Cricetulus griseus

IC50: 5.4 nM

658109

0.00003

(2S,3R)-2-amino-12-[(Z)-hydroxyimino]-2-hydroxymethyl-3-sulfooxy-octadecanoic acid

Cricetulus griseus

IC50: 30 nM

658109

0.0000032

(2S,3R)-2-amino-3,12-dihydroxy-2-hydroxymethyl-octadecanoic acid

Cricetulus griseus

IC50: 3.2 nM

658109

0.0000035

(2S,3R)-2-amino-3-hydroxy-2-hydroxymethyl-12-oxo-octadecanoic acid

Cricetulus griseus

IC50: 3.5 nM

658109

0.000017

(2S,3R)-2-amino-3-hydroxy-2-hydroxymethyl-12-oxo-octadecanoic acid methyl ester

Cricetulus griseus

IC50: 17 nM

658109

0.0000008 - 0.0000041

2-chloro-N-[(7S)-4-(3,4-dimethoxybenzoyl)-1-(propan-2-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridin-7-yl]benzamide

2 entries

0.00000013 - 0.00000041

myriocin

2 entries

0.00000076 - 0.0000016

N-[(7S)-4-(5,6-dimethoxypyridine-3-carbonyl)-1-(propan-2-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridin-7-yl]-2-(trifluoromethoxy)benzamide

2 entries

0.000003

sulfamisterin

Cricetulus griseus

antibiotic derived from Pycnidiella sp., IC50: 3 nM

658109

0.00000024 - 0.0000008

[N-[(7S)-4-(3,4-dimethoxybenzoyl)-1-[5-(3-[2-[(3,5-dimethyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN]propanamido)pentyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridin-7-yl]-2-(trifluoromethoxy)benzamidato](difluorido)boron

2 entries