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Literature summary for 2.3.1.50 extracted from

  • He, X.; Guan, X.L.; Ong, W.Y.; Farooqui, A.A.; Wenk, M.R.
    Expression, activity, and role of serine palmitoyltransferase in the rat hippocampus after kainate injury (2007), J. Neurosci. Res., 85, 423-432.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information increased SPT enzyme activity in reactive astrocytes of the hippocampus at 2 weeks post-kainate injection Rattus norvegicus

Application

Application Comment Organism
medicine results suggest that SPT activity might contribute to neuronal injury after kainate excitotoxicity in the rat hippocampus Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
L-Cycloserine
-
Rattus norvegicus
myriocin
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
microtubule
-
Rattus norvegicus 5874
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
x * 65000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Rattus norvegicus the enzyme catalyses the first step in the ceramide biosynthesis pathway CoA + 3-dehydro-D-sphinganine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte increased SPT enzyme activity in reactive astrocytes of the hippocampus at 2 weeks post-kainate injection Rattus norvegicus
-
brain
-
Rattus norvegicus
-
hippocampus increased SPT enzyme activity in reactive astrocytes of the hippocampus at 2 weeks post-kainate injection Rattus norvegicus
-
hippocampus increased expression of SPT in reactive astrocytes of the hippocampus after kainate injections is shown Rattus norvegicus
-
neuron
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
quantitation of ceramide or sphingomyelin Rattus norvegicus
additional information
-
increased enzymatic activity of SPT in reactive astrocytes of the hippocampus after kainate injections is shown Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-serine
-
Rattus norvegicus CoA + 3-dehydro-D-sphinganine + CO2
-
?
palmitoyl-CoA + L-serine the enzyme catalyses the first step in the ceramide biosynthesis pathway Rattus norvegicus CoA + 3-dehydro-D-sphinganine + CO2
-
?

Subunits

Subunits Comment Organism
? x * 65000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
serine palmitoyltransferase
-
Rattus norvegicus
SPT
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus