Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | increased SPT enzyme activity in reactive astrocytes of the hippocampus at 2 weeks post-kainate injection | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | results suggest that SPT activity might contribute to neuronal injury after kainate excitotoxicity in the rat hippocampus | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-Cycloserine | - |
Rattus norvegicus | |
myriocin | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
microtubule | - |
Rattus norvegicus | 5874 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
x * 65000, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-serine | Rattus norvegicus | the enzyme catalyses the first step in the ceramide biosynthesis pathway | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | increased SPT enzyme activity in reactive astrocytes of the hippocampus at 2 weeks post-kainate injection | Rattus norvegicus | - |
brain | - |
Rattus norvegicus | - |
hippocampus | increased SPT enzyme activity in reactive astrocytes of the hippocampus at 2 weeks post-kainate injection | Rattus norvegicus | - |
hippocampus | increased expression of SPT in reactive astrocytes of the hippocampus after kainate injections is shown | Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantitation of ceramide or sphingomyelin | Rattus norvegicus |
additional information | - |
increased enzymatic activity of SPT in reactive astrocytes of the hippocampus after kainate injections is shown | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-serine | - |
Rattus norvegicus | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
palmitoyl-CoA + L-serine | the enzyme catalyses the first step in the ceramide biosynthesis pathway | Rattus norvegicus | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 65000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
serine palmitoyltransferase | - |
Rattus norvegicus |
SPT | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.3 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Rattus norvegicus |