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Literature summary for 2.3.1.50 extracted from

  • Thuong, P.T.; Kang, K.W.; Kim, J.K.; Seo, D.B.; Lee, S.J.; Kim, S.H.; Oh, W.K.
    Lithospermic acid derivatives from Lithospermum erythrorhizon increased expression of serine palmitoyltransferase in human HaCaT cells (2009), Bioorg. Med. Chem. Lett., 19, 1815-1817.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
SPT1 and SPT2 real-time PCR expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Homo sapiens
-
CoA + 3-dehydro-D-sphinganine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes SPT1 and SPT2
-

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-serine
-
Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
?

Synonyms

Synonyms Comment Organism
serine palmitoyltransferase
-
Homo sapiens
SPT
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens lithospermic acid and two derivative esters, 9''-methyl lithospermate and 9'-methyl lithospermate,isolated from roots of Lithospermum erythrorhizon, significantly increase SPT expression in the relative quantity of SPT1 mRNA as well as SPT2 mRNA, by 21-59%, overview up