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2.3.1.5: arylamine N-acetyltransferase

This is an abbreviated version!
For detailed information about arylamine N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.5

Reaction

acetyl-CoA
+
an arylamine
=
CoA
 +
an N-acetylarylamine

Synonyms

(BACAN)NAT3, (MYCAB)NAT1, 2-naphthylamine N-acetyltransferase, 4-aminobiphenyl N-acetyltransferase, ABW01_24350, acetyl CoA-arylamine N-acetyltransferase, acetyltransferase, 2-naphthylamine N-, acetyltransferase, 4-aminobiphenyl, acetyltransferase, arylamine, acetyltransferase, p-aminosalicylate N-, acetyltransferase, procainamide N-, acetyltransferase, serotonin N-, arylamine acetylase, arylamine acetyltransferase, arylamine N-acetyl transferase, arylamine N-acetyltransferase, arylamine N-acetyltransferase 1, arylamine N-acetyltransferase 2, arylamine N-acetyltransferase C, arylamine N-acetyltransferase I, arylamine N-acetyltransferase type 1, arylamine N-acetyltransferase type 2, arylamine N-acetyltransferase type I, arylamine-N-acetyltransferase 1, BanatA, BanatB, BanatC, beta-naphthylamine N-acetyltransferase, indoleamine N-acetyltransferase, MlNAT1, MMNAT, More, MSNAT, N-acetyltransferase, N-acetyltransferase a, N-acetyltransferase b, N-acetyltransferase type 2, N-hydroxyarylamine O-acetyltransferase, NAT, NAT 1, NAT-a, NAT-b, NAT1, NAT2, NAT2*1, NAT2*2, NAT3, NAT31, NfNAT, p-aminosalicylate N-acetyltransferase, PANAT, rhesus NAT2, serotonin acetyltransferase, serotonin N-acetyltransferase, STNAT, TBNAT, Tpau_4046, UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid 3-N-acetyltransferase, UDP-D-Glc(2NAc3N)A 3-N-acetyltransferase, WbpD

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.5 arylamine N-acetyltransferase

IC50 Value

IC50 Value on EC 2.3.1.5 - arylamine N-acetyltransferase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0011
(5Z)-3-amino-5-(3-hydroxy-2,4-diiodobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH 8.0, 25°C
0.0011
(5Z)-5-(2-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH 8.0, 25°C
0.0039
(5Z)-5-(2-methylbenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH 8.0, 25°C
0.0034
(5Z)-5-(3,4-dichlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH 8.0, 25°C
0.0018
(5Z)-5-(3-hydroxy-2,4-diiodobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH 8.0, 25°C
0.0006
(5Z)-5-(3-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH 8.0, 25°C
0.0047
(5Z)-5-(4-chlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH 8.0, 25°C
0.055
17-hydroxy-beta-estradiol
Mus musculus
-
-
0.5
17-hydroxy-progesterone
Mus musculus
-
value above 0.5 mM
0.00004
2-nitrosofluorene
0.091
2-nitrosotoluene
0.237
4-nitrosobenzene
Homo sapiens
-
-
0.00006
4-nitrosobiphenyl
0.065
4-OH tamoxifen
Mus musculus
-
-
0.07
alpha-zearalenol
Mus musculus
-
-
0.5
androstenedione
Mus musculus
-
value above 0.5 mM
1.7 - 3.9
ATP
0.007
Benzyl isothiocyanate
Homo sapiens
-
at pH 7.5 and 37°C
0.45
beta-zearalenol
Mus musculus
-
-
0.29
bisphenol A
Mus musculus
-
-
0.1
cisplatin
0.05
diethylstilbestrol
Mus musculus
-
-
0.37
estrone
Mus musculus
-
-
0.045
genistein
Mus musculus
-
-
0.03
N-(3-((2''-methoxyethyl)amino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.008
N-(3-(2''-chlorophenyl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0121
N-(3-(3'',5''-dimethylphenoxy)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0041
N-(3-(3'',5''-dimethylphenylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0066
N-(3-(3'',5''-dimethylphenylamino)-5-nitro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.03
N-(3-(3'',5''-dimethylphenylamino)-6-nitro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide, N-(3-(3'',5''-dimethylphenylamino)-8-nitro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0145
N-(3-(3''-chlorophenyl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.01 - 0.019
N-(3-(3''-formylphenyl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzamide
-
0.0084
N-(3-(3''-formylphenyl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0221
N-(3-(3''-formylphenyl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)phenylacetamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0019
N-(3-(4''-bromophenoxy)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0009
N-(3-(4''-bromophenylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0121
N-(3-(4''-chlorophenyl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0103
N-(3-(4''-formylphenyl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.03
N-(3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide, N-(3-(cyclopentylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0096
N-(3-(furan-2''-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.01
N-(3-(furan-3''-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0193
N-(3-(furan-3''-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)phenylacetamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0028
N-(3-phenoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0017
N-(3-phenylamino-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0042
N-(5-amino-3-(3'',5''-dimethylphenylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0026
N-(7-amino-3-(3'',5''-dimethylphenylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.00012
N-(8-amino-1,4-dioxo-3-(phenylamino)-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.00054
N-(8-amino-3-(3'',5''-dimethylphenylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.03
N-(8-nitro-1,4-dioxo-3-(phenylamino)-1,4-dihydronaphthalen-2-yl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0058
N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-N-methylbenzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0019 - 0.0053
N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide
0.237
nitrosobenzene
Homo sapiens
-
HeLa cell NAT1
0.015
phenethyl isothiocyanate
Homo sapiens
-
at pH 7.5 and 37°C
0.1
pregnenolone
Mus musculus
-
value above 0.1 mM
0.057
tamoxifen
Mus musculus
-
-
0.5
testosterone
Mus musculus
-
value above 0.5 mM
0.22
zearalenone
Mus musculus
-
-