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3'-dephospho-acetyl-CoA + 4-aminobenzoate
3'-dephospho-CoA + N-acetyl-4-aminobenzoate
-
-
-
-
?
4-nitrophenyl acetate + 2-aminofluorene
4-nitrophenol + N-acetyl-2-aminofluorene
4-nitrophenyl acetate + 3,4-dichloroaniline
4-nitrophenol + N-acetyl-3,4-dichloroaniline
-
-
-
?
4-nitrophenyl acetate + 4-amino-3-methylbenzoic acid
4-nitrophenol + N-acetyl-4-amino-3-methylbenzoic acid
4-nitrophenyl acetate + 4-aminobenzoate
4-nitrophenol + N-acetyl-4-aminobenzoate
-
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoate
-
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
4-nitrophenyl acetate + 4-aminobiphenyl
4-nitrophenol + N-acetyl-4-aminobiphenyl
4-nitrophenyl acetate + 4-aminosalicylate
4-nitrophenol + N-acetyl-4-aminosalicylate
-
-
-
?
4-nitrophenyl acetate + 4-anisidine
4-nitrophenol + N-acetyl-4-anisidine
-
-
-
-
?
4-nitrophenyl acetate + 4-nitroaniline
4-nitrophenol + N-acetyl-4-nitroaniline
-
-
-
?
4-nitrophenyl acetate + 5-aminosalicylic acid
4-nitrophenol + 5-acetylaminosalicylic acid
-
-
-
?
4-nitrophenyl acetate + 5-aminosalicylic acid
4-nitrophenol + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
4-nitrophenyl acetate + aniline
4-nitrophenol + N-acetyl-aniline
-
-
-
-
?
4-nitrophenyl acetate + anisidine
4-nitrophenol + N-acetyl-anisidine
4-nitrophenyl acetate + hydralazine
4-nitrophenol + N-acetyl-hydralazine
4-nitrophenyl acetate + isoniazid
4-nitrophenol + N-acetyl-isoniazid
-
-
-
-
?
4-nitrophenyl acetate + isoniazid
4-nitrophenol + N-acetylisoniazid
-
-
-
?
4-nitrophenyl acetate + N-(4-aminobenzoyl)-L-glutamate
4-nitrophenol + N-(4-acetylaminobenzoyl)-L-glutamate
a protein + 1-[4-[(6-azidohexyl)oxy]phenyl]-1-hydroxypropan-2-one
?
-
-
-
?
a protein + 5-azido-N-[[4-(1-hydroxy-2-oxopropyl)phenyl]methyl]pentanamide
?
-
-
-
?
a protein + N-(5-azidopentyl)-4-(1-hydroxy-2-oxopropyl)benzamide
?
-
-
-
?
acetyl-CoA + (1-methyl-5-piperazin-1-yl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-(5-methyl-pyridin-2-yl)-amine
CoA + ?
acetyl-CoA + 2,3-dimethylaniline
CoA + N-acetyl-2,3-dimethylaniline
-
-
-
-
?
acetyl-CoA + 2,4-dimethylaniline
CoA + N-acetyl-2,4-dimethylaniline
-
-
-
-
?
acetyl-CoA + 2,5-dimethylaniline
CoA + N-acetyl-2,5-dimethylaniline
-
-
-
-
?
acetyl-CoA + 2-(4-aminobenzamido)pyridine
CoA + 2-(4-acetylamidobenzamido)pyridine
acetyl-CoA + 2-amino-4-chlorophenol
CoA + 2-acetylamino-4-chlorophenol
-
-
-
?
acetyl-CoA + 2-amino-4-chlorophenol
CoA + N-(5-chloro-2-hydroxyphenyl)acetamide
-
-
-
-
?
acetyl-CoA + 2-amino-4-chlorophenol
CoA + N-acetyl-2-amino-4-chlorophenol
-
-
-
-
?
acetyl-CoA + 2-amino-4-methylphenol
CoA + 2-acetylamino-4-methylphenol
best substrate
-
-
?
acetyl-CoA + 2-amino-4-methylphenol
CoA + N-(2-hydroxy-5-methylphenyl)acetamide
-
-
-
-
?
acetyl-CoA + 2-amino-4-methylphenol
CoA + N-acetyl-2-amino-4-methylphenol
-
-
-
-
?
acetyl-CoA + 2-aminobenzoic acid
CoA + N-acetyl-2-aminobenzoic acid
acetyl-CoA + 2-aminobenzoic acid
CoA + N-acetylanthranilate
-
i.e. anthranilate, ir
-
ir
acetyl-CoA + 2-aminobiphenyl
?
-
-
-
?
acetyl-CoA + 2-aminofluorene
?
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
acetyl-CoA + 2-aminophenol
CoA + 2-acetylaminophenol
acetyl-CoA + 2-aminophenol
CoA + N-(2-hydroxyphenyl)acetamide
-
-
-
-
?
acetyl-CoA + 2-aminophenol
CoA + N-acetyl-2-aminophenol
acetyl-CoA + 2-chloroaniline
CoA + N-acetyl-2-chloroaniline
acetyl-CoA + 2-ethylaniline
CoA + N-acetyl-2-ethylaniline
-
-
-
-
?
acetyl-CoA + 2-methylaniline
CoA + N-acetyl-2-methylaniline
-
-
-
-
?
acetyl-CoA + 2-nitroaniline
CoA + N-acetyl-2-nitroaniline
acetyl-CoA + 2-phenylendiamine
CoA + ?
acetyl-CoA + 2-toluidine
CoA + N-acetyl-2-toluidine
acetyl-CoA + 3,4-dichloraniline
CoA + N-acetyl-3,4-dichloraniline
-
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
?
-
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)acetamide
acetyl-CoA + 3,4-dichloroaniline
CoA + N-acetyl-3,4-dichloroaniline
acetyl-CoA + 3,4-dimethylaniline
CoA + N-acetyl-3,4-dimethylaniline
-
-
-
-
?
acetyl-CoA + 3,5-dimethyl-4-nitroaniline
CoA + ?
-
-
-
-
?
acetyl-CoA + 3,5-dimethylaniline
CoA + N-acetyl-3,5-dimethylaniline
acetyl-CoA + 3-amino-4-hydroxybenzaldehyde
CoA + 3-acetylamino-4-hydroxybenzaldehyde
acetyl-CoA + 3-amino-4-hydroxybenzenesulfonic acid
CoA + 3-acetylamino-4-hydroxybenzenesulfonic acid
-
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzoic acid
CoA + 3-(acetylamino)-4-hydroxybenzoic acid
-
-
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzoic acid
CoA + 3-acetylamino-4-hydroxybenzoic acid
acetyl-CoA + 3-amino-4-hydroxybenzoic acid
CoA + N-acetyl-3-amino-4-hydroxybenzoic acid
-
-
-
-
?
acetyl-CoA + 3-aminobenzoic acid
CoA + N-acetyl-3-aminobenzoic acid
acetyl-CoA + 3-aminophenol
CoA + N-acetyl-3-aminophenol
acetyl-CoA + 3-chloraniline
CoA + N-acetyl-3-chloroaniline
-
relative activity: 48%
-
-
?
acetyl-CoA + 3-ethylaniline
CoA + N-acetyl-3-ethylaniline
acetyl-CoA + 3-nitroaniline
CoA + N-acetyl-3-nitroaniline
acetyl-CoA + 3-phenylendiamine
CoA + ?
-
relative activity: 0%
-
-
?
acetyl-CoA + 3-toluidine
CoA + N-acetyl-3-toluidine
acetyl-CoA + 3-tyramine
CoA + N-acetyl-3-tyramine
-
-
-
-
?
acetyl-CoA + 4,4'-methylenebis(2-chloroaniline)
CoA + N-acetyl-4,4'-methylenebis(2-chloroaniline)
acetyl-CoA + 4,4'-methylenedianiline
CoA + N-acetyl-4,4'-methylenedianiline
-
-
-
?
acetyl-CoA + 4-amino-3-hydroxybenzoic acid
CoA + 4-(acetylamino)-3-hydroxybenzoic acid
-
-
-
-
?
acetyl-CoA + 4-amino-3-hydroxybenzoic acid
CoA + 4-acetylamino-3-hydroxybenzoic acid
low activity
-
-
?
acetyl-CoA + 4-amino-3-hydroxybenzoic acid
CoA + N-acetyl-4-amino-3-hydroxybenzoic acid
-
-
-
-
?
acetyl-CoA + 4-amino-4'-nitroazobenzene
CoA + ?
-
-
-
-
?
acetyl-CoA + 4-aminoacetanilide
CoA + N-acetyl-4-aminoacetanilide
-
relative activity: 0%
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + 4-acetylaminobenzoate
acetyl-CoA + 4-aminobenzoate
CoA + N-acetyl-4-aminobenzoate
acetyl-CoA + 4-aminobenzoic acid
?
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-(acetylamino)benzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoate
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
acetyl-CoA + 4-aminobenzoyl-L-glutamate
CoA + 4-acetylaminobenzoyl-L-glutamate
-
-
-
-
?
acetyl-CoA + 4-aminobenzoyl-L-glutamate
CoA + N-acetyl-4-aminobenzoyl-L-glutamate
-
-
-
-
?
acetyl-CoA + 4-aminobenzoyl-L-glutamic acid
CoA + 4-acetylaminobenzoyl-L-glutamic acid
-
-
-
?
acetyl-CoA + 4-aminobiphenyl
CoA + 4-acetylaminobiphenyl
-
-
-
?
acetyl-CoA + 4-aminobiphenyl
CoA + N-acetyl-4-aminobiphenyl
acetyl-CoA + 4-aminobiphenyl
N-acetyl-4-aminobiphenyl + CoA
acetyl-CoA + 4-aminofluorene
?
-
-
-
?
acetyl-CoA + 4-aminophenol
?
acetyl-CoA + 4-aminophenol
CoA + N-acetyl-4-aminophenol
acetyl-CoA + 4-aminopyridine
?
acetyl-CoA + 4-aminopyridine
CoA + N-acetyl-4-aminopyridine
-
-
-
-
?
acetyl-CoA + 4-aminosalicylate
?
-
-
-
?
acetyl-CoA + 4-aminosalicylate
CoA + N-acetyl-4-aminosalicylate
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
acetyl-CoA + 4-aminoveratrole
?
acetyl-CoA + 4-aminoveratrole
CoA + 1,2-dimethoxy-4-acetylaminobenzene
acetyl-CoA + 4-aminoveratrole
CoA + N-acetyl-4-aminoveratrole
acetyl-CoA + 4-anisidine
?
-
-
-
?
acetyl-CoA + 4-anisidine
CoA + 4-methoxyacetanilide
acetyl-CoA + 4-anisidine
CoA + N-acetyl-4-anisidine
acetyl-CoA + 4-bromaniline
CoA + N-acetyl-4-bromaniline
-
-
-
-
?
acetyl-CoA + 4-bromoaniline
CoA + 4-bromoacetanilide
acetyl-CoA + 4-bromoaniline
CoA + N-(4-bromophenyl)acetamide
-
-
-
-
?
acetyl-CoA + 4-bromoaniline
CoA + N-acetyl-4-bromoaniline
acetyl-CoA + 4-butoxyaniline
?
-
-
-
-
?
acetyl-CoA + 4-butoxyaniline
CoA + 4-butoxyacetanilide
acetyl-CoA + 4-butoxyaniline
CoA + N-acetyl-4-butoxyaniline
acetyl-CoA + 4-chloroaniline
CoA + 4-chloroacetanilide
acetyl-CoA + 4-chloroaniline
CoA + N-(4-chlorophenyl)acetamide
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
acetyl-CoA + 4-chlorobenzoic hydrazide
?
acetyl-CoA + 4-chlorobenzoic hydrazide
CoA + ?
-
-
-
-
?
acetyl-CoA + 4-chlorobenzoic hydrazide
CoA + N'-acetyl-(4-chlorobenzo)-hydrazide
-
-
-
?
acetyl-CoA + 4-chlorobenzoic hydrazide
CoA + N-acetyl-4-chlorobenzoic hydrazide
acetyl-CoA + 4-dimethylaminobenzaldehyde
CoA + 5-acetyl-4-dimethylaminobenzaldehyde
-
-
-
?
acetyl-CoA + 4-ethoxyaniline
?
-
-
-
-
?
acetyl-CoA + 4-ethoxyaniline
CoA + 4-ethoxyacetanilide
acetyl-CoA + 4-ethoxyaniline
CoA + N-acetyl-4-ethoxyaniline
acetyl-CoA + 4-ethylaniline
CoA + 4-ethylacetanilide
acetyl-CoA + 4-ethylaniline
CoA + N-acetyl-4-ethylaniline
-
-
-
-
?
acetyl-CoA + 4-fluoroaniline
CoA + N-(4-fluorophenyl)acetamide
-
-
-
-
?
acetyl-CoA + 4-fluoroaniline
CoA + N-acetyl-4-fluoroaniline
-
-
-
-
?
acetyl-CoA + 4-hexyloxyaniline
?
-
-
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + 4-hexyloxyacetanilide
acetyl-CoA + 4-hexyloxyaniline
CoA + N-acetyl-4-hexyloxyaniline
acetyl-CoA + 4-hydroxybenzhydrazide
CoA + N'-acetyl-4-hydroxybenzohydrazide
-
-
-
-
?
acetyl-CoA + 4-hydroxybenzhydrazide
CoA + N-acetyl-4-hydroxybenzhydrazide
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + 4-iodoacetanilide
acetyl-CoA + 4-iodoaniline
CoA + N-(4-iodophenyl)acetamide
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
acetyl-CoA + 4-methoxyaniline
CoA + N-acetyl-4-methoxyaniline
acetyl-CoA + 4-methoxyphenylhydrazine
?
-
-
-
?
acetyl-CoA + 4-methoxyphenylhydrazine
CoA + ?
-
-
-
-
?
acetyl-CoA + 4-methoxyphenylhydrazine
CoA + N'-(4-methoxyphenyl)acetohydrazide
-
-
-
-
?
acetyl-CoA + 4-methoxyphenylhydrazine
CoA + N-acetyl-4-methoxyphenylhydrazine
-
-
-
-
?
acetyl-CoA + 4-methylaniline
CoA + N-(4-methylphenyl)acetamide
-
-
-
-
?
acetyl-CoA + 4-methylaniline
CoA + N-acetyl-4-methylaniline
acetyl-CoA + 4-nitroaniline
CoA + 4-nitroacetanilide
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
acetyl-CoA + 4-nitrobenzalhydrazone
CoA + ?
-
-
-
-
?
acetyl-CoA + 4-phenoxyaniline
?
-
-
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + 4-phenoxyacetanilide
acetyl-CoA + 4-phenoxyaniline
CoA + N-acetyl-4-phenoxyaniline
acetyl-CoA + 4-phenylenediamine
CoA + 4-aminoacetanilide
-
-
-
-
?
acetyl-CoA + 4-toluidine
CoA + N-acetyl-4-toluidine
acetyl-CoA + 4-trifluoromethylaniline
?
acetyl-CoA + 4-trifluoromethylaniline
CoA + N-acetyl-4-trifluoromethylaniline
-
-
-
-
?
acetyl-CoA + 5-aminosalicylate
?
acetyl-CoA + 5-aminosalicylate
CoA + 5-acetylamino-2-hydroxybenzoate
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylamino-2-hydroxybenzoate
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylaminosalicylic acid
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
acetyl-CoA + 8-aminoisoindolo (1,2-b)quinazolin-12(10H)-one
?
-
batricylin, an antitumor agent, is shown to be a substrate for NAT2
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
acetyl-CoA + aniline
?
-
-
-
-
?
acetyl-CoA + aniline
CoA + acetanilide
acetyl-CoA + aniline
CoA + N-acetyl-aniline
acetyl-CoA + aniline
CoA + N-acetylaniline
-
-
-
-
?
acetyl-CoA + aniline
CoA + N-phenylacetamide
-
-
-
-
?
acetyl-CoA + anisidine
CoA + N-(4-methoxyphenyl)acetamide
-
-
-
-
?
acetyl-CoA + anisidine
CoA + N-acetyl-anisidine
acetyl-CoA + benzidine
?
-
-
-
?
acetyl-CoA + benzidine
CoA + ?
-
-
-
-
?
acetyl-CoA + benzidine
CoA + N-acetyl-benzidine
-
-
-
?
acetyl-CoA + benzoic acid hydrazide
CoA + N'-acetylbenzohydrazide
-
-
-
-
?
acetyl-CoA + benzoic acid hydrazide
CoA + N-acetyl-benzoic acid hydrazide
-
-
-
-
?
acetyl-CoA + beta-naphthylamine
?
-
-
-
?
acetyl-CoA + beta-naphthylamine
CoA + N-acetyl-beta-naphthylamine
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
acetyl-CoA + butoxyaniline
CoA + 4-butoxyacetanilide
-
-
-
-
?
acetyl-CoA + D-glucosamine
CoA + N-acetyl-D-glucosamine
-
-
-
-
?
acetyl-CoA + decylamine
CoA + N-acetyldecylamine
acetyl-CoA + diaminodiphenylsulfone
CoA + ?
-
-
-
-
?
acetyl-CoA + diaminodiphenylsulfone
monoacetyldiaminodiphenylsulfone + CoA
-
i.e. dapsone, predominantly acetylated by NAT2
-
-
?
acetyl-CoA + dodecylamine
CoA + N-acetyldodecylamine
-
-
-
-
?
acetyl-CoA + hexylamine
CoA + N-acetylhexylamine
-
-
-
-
?
acetyl-CoA + histamine
CoA + N-acetylhistamine
acetyl-CoA + hydralazine
?
acetyl-CoA + hydralazine
CoA + ?
acetyl-CoA + hydralazine
CoA + N'-phthalazin-1-ylacetohydrazide
-
-
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetyl-hydralazine
acetyl-CoA + hydralazine
CoA + N-acetylhydralazine
acetyl-CoA + hydroxytyramine
CoA + ?
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + acetylniazide
acetyl-CoA + isoniazid
CoA + an N-acetylisoniazid
-
-
-
?
acetyl-CoA + isoniazid
CoA + N'-acetylpyridine-4-carbohydrazide
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
acetyl-CoA + isoniazid
CoA + N-acetylisoniazid
acetyl-CoA + isoniazide
CoA + acetylniazide
acetyl-CoA + isoniazide
CoA + N-acetylisoniazid
-
-
-
-
?
acetyl-CoA + long-chain primary amines
CoA + ?
-
C6-C16
-
-
?
acetyl-CoA + methyl bis-2-chloroaniline
CoA + ?
-
-
-
-
?
acetyl-CoA + N,N-1,4-phenylenediamine
CoA + ?
-
relative activity: 100%
-
-
?
acetyl-CoA + N-(4-acetylaminobenzoyl)-L-glutamate
CoA + 4-acetylaminobenzoyl-L-glutamate
-
-
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
acetyl-CoA + N-hydroxy-4-aminobiphenyl
N-acetyl-N-hydroxy-4-aminobiphenyl + CoA
substrate of isozyme NAT2 in liver cytosol
-
-
?
acetyl-CoA + N-hydroxy-4-aminobiphenyl
N-hydroxy-O-acetyl-4-aminobiphenyl + CoA
acetyl-CoA + naphthylamine
CoA + N-acetylnaphthylamine
-
-
-
-
?
acetyl-CoA + nicotinic acid hydrazide
CoA + N'-acetylpyridine-3-carbohydrazide
-
-
-
-
?
acetyl-CoA + nicotinic acid hydrazide
CoA + N-acetyl-nicotinic acid hydrazide
-
-
-
-
?
acetyl-CoA + noradrenaline
CoA + ?
-
-
-
-
?
acetyl-CoA + normetanephrine
CoA + N-acetylnormetanephrine
-
-
-
-
?
acetyl-CoA + octylamine
CoA + N-acetyloctylamine
acetyl-CoA + p-aminobenzoic acid
?
acetyl-CoA + p-aminobenzoic acid
CoA + 4-(acetylamino)benzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
acetyl-CoA + p-aminobenzoylglutamate
CoA + N-[(4-acetylamino)]benzoyl-L-glutamate
acetyl-CoA + p-aminosalicylate
CoA + N-acetyl-p-aminosalicylate
-
-
-
-
?
acetyl-CoA + p-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
acetyl-CoA + p-anisidine
?
acetyl-CoA + p-anisidine
CoA + N-acetyl-anisidine
-
-
-
-
?
acetyl-CoA + p-anisidine
CoA + N-acetylanisidine
-
-
-
?
acetyl-CoA + p-anisidine
CoA + p-methoxyacetanilide
-
-
-
?
acetyl-CoA + p-octopamine
CoA + N-acetyloctopamine
acetyl-CoA + p-phenetidine
CoA + N-(4-ethoxyphenyl)-acetamide
acetyl-CoA + p-tyramine
CoA + N-acetyl-p-tyramine
acetyl-CoA + peptide
CoA + Nalpha-acetylpeptide
acetyl-CoA + phenelzine
CoA + ?
-
-
-
-
?
acetyl-CoA + phenylhydrazine
CoA + N-acetyl-phenylhydrazine
-
low specific activity
-
-
?
acetyl-CoA + procainamide
?
acetyl-CoA + procainamide
CoA + N-acetyl- procainamide
-
low specific activity
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
acetyl-CoA + procainamide
CoA + N-acetyl-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetylprocainamide
acetyl-CoA + serotonin
CoA + N-acetylserotonin
acetyl-CoA + sulfadiazine
CoA + ?
acetyl-CoA + sulfadiazine
CoA + N-acetylsulfadiazine
acetyl-CoA + sulfamerazine
CoA + ?
acetyl-CoA + sulfamethazine
?
acetyl-CoA + sulfamethazine
CoA + N-4-acetylsulfamethazine
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
acetyl-CoA + sulfamethazine
CoA + N-acetylsulfamethazine
acetyl-CoA + sulfamethoxazole
?
acetyl-CoA + sulfamethoxazole
CoA + ?
-
-
-
-
?
acetyl-CoA + sulfamethoxazole
CoA + N-acetyl-sulfamethoxazole
acetyl-CoA + sulfamethoxazole
CoA + N-[4-[(5-methylisoxazol-3-yl)sulfamoyl]phenyl]acetamide
-
-
-
-
?
acetyl-CoA + sulfanilamide
CoA + ?
-
-
-
-
?
acetyl-CoA + sulfapyridine
CoA + ?
-
-
-
-
?
acetyl-CoA + sulphamethazine
CoA + N-acetylsulphamethazine
-
-
-
?
acetyl-CoA + sulphamethoxazole
CoA + N-acetylsulphamethoxazole
-
-
-
-
?
acetyl-CoA + sulphisoxazole
CoA + 4-acetylamino-N-(3,4-dimethylisoxazol-5-yl)-benzenesulfonamide
-
-
-
-
?
acetyl-CoA + sulphisoxazole
CoA + N-acetylsulphisoxazole
-
-
-
-
?
acetyl-CoA + tetradecylamine
CoA + N-acetyltetradecylamine
-
-
-
-
?
acetyl-CoA + thiazolsulfone
CoA + ?
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid
CoA + UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronic acid
malonyl-CoA + 2-aminophenol
CoA + N-malonyl-2-aminophenol
malonyl-CoA + 3,4-dichloroaniline
CoA + 3-(3,4-dichloroanilino)-3-oxopropanoic acid
malonyl-CoA + 4-aminobenzoate
CoA + N-malonyl-4-aminobenzoate
malonyl-CoA + 5-aminosalicylate
CoA + N-malonyl-5-aminosalicylate
malonyl-CoA again is the preferred donor substrate
-
-
?
N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene
CoA + ?
-
much better acetyl donor for NAT1 than for NAT2
-
-
?
p-nitroacetanilide + aniline
p-nitroaniline + acetanilide
-
-
-
?
p-nitrophenyl acetate + 2-aminofluorene
p-nitrophenol + N-acetyl-2-aminofluorene
-
-
-
-
?
p-nitrophenyl acetate + 5-aminosalicylic acid
p-nitrophenol + 5-acetylaminosalicylic acid
-
-
-
-
?
p-nitrophenyl acetate + aniline
p-nitrophenol + N-acetyl-aniline
-
-
-
-
?
p-nitrophenyl acetate + hydralazine
p-nitrophenol + N-acetyl-hydralazine
-
-
-
-
?
p-nitrophenyl acetate + isoniazid
p-nitrophenol + N-acetyl-isoniazid
-
-
-
-
?
p-nitrophenyl acetate + p-aminobenzoic acid
p-nitrophenol + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
p-nitrophenyl acetate + p-anisidine
p-nitrophenol + N-acetyl-4-anisidine
-
-
-
-
?
p-nitrophenylacetate + 2-aminofluorene
?
-
-
-
-
?
p-nitrophenylacetate + 5-aminosalicylic acid
4-nitrophenol + N-acetyl-5-aminosalicylate
-
-
-
-
?
p-nitrophenylacetate + aniline
?
-
-
-
-
?
p-nitrophenylacetate + hydralazine
?
-
-
-
-
?
p-nitrophenylacetate + isoniazid
?
-
-
-
-
?
p-nitrophenylacetate + p-aminobenzoic acid
?
-
-
-
-
?
p-nitrophenylacetate + p-aminosalicylic acid
?
-
-
-
-
?
p-nitrophenylacetate + p-anisidine
?
-
-
-
-
?
propionyl-CoA + 5-aminosalicylate
CoA + N-propionyl-5-aminosalicylate
-
-
-
?
succinyl-CoA + 5-aminosalicylate
CoA + N-succinyl-5-aminosalicylate
-
-
-
?
sulphamethazine + acetyl-CoA
N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]acetamide
-
-
-
?
additional information
?
-
4-nitrophenyl acetate + 2-aminofluorene
4-nitrophenol + N-acetyl-2-aminofluorene
-
-
-
?
4-nitrophenyl acetate + 2-aminofluorene
4-nitrophenol + N-acetyl-2-aminofluorene
-
-
-
-
?
4-nitrophenyl acetate + 2-aminofluorene
4-nitrophenol + N-acetyl-2-aminofluorene
-
-
-
-
?
4-nitrophenyl acetate + 4-amino-3-methylbenzoic acid
4-nitrophenol + N-acetyl-4-amino-3-methylbenzoic acid
-
-
-
?
4-nitrophenyl acetate + 4-amino-3-methylbenzoic acid
4-nitrophenol + N-acetyl-4-amino-3-methylbenzoic acid
substrate of isozyme NAT1
-
-
?
4-nitrophenyl acetate + 4-amino-3-methylbenzoic acid
4-nitrophenol + N-acetyl-4-amino-3-methylbenzoic acid
very low activity with isozyme NAT2
-
-
?
4-nitrophenyl acetate + 4-amino-3-methylbenzoic acid
4-nitrophenol + N-acetyl-4-amino-3-methylbenzoic acid
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
a sunscreen additive
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
substrate of isozyme NAT1
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
very low activity with isozyme NAT2
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
4-nitrophenyl acetate + 4-aminobiphenyl
4-nitrophenol + N-acetyl-4-aminobiphenyl
a tobacco smoke carcinogen
-
-
?
4-nitrophenyl acetate + 4-aminobiphenyl
4-nitrophenol + N-acetyl-4-aminobiphenyl
substrate of isozyme NAT1
-
-
?
4-nitrophenyl acetate + 4-aminobiphenyl
4-nitrophenol + N-acetyl-4-aminobiphenyl
very low activity with isozyme NAT2
-
-
?
4-nitrophenyl acetate + 4-aminobiphenyl
4-nitrophenol + N-acetyl-4-aminobiphenyl
-
-
-
?
4-nitrophenyl acetate + anisidine
4-nitrophenol + N-acetyl-anisidine
-
-
-
-
?
4-nitrophenyl acetate + anisidine
4-nitrophenol + N-acetyl-anisidine
-
-
-
?
4-nitrophenyl acetate + hydralazine
4-nitrophenol + N-acetyl-hydralazine
-
-
-
?
4-nitrophenyl acetate + hydralazine
4-nitrophenol + N-acetyl-hydralazine
-
-
-
-
?
4-nitrophenyl acetate + N-(4-aminobenzoyl)-L-glutamate
4-nitrophenol + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
-
?
4-nitrophenyl acetate + N-(4-aminobenzoyl)-L-glutamate
4-nitrophenol + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
?
acetyl-CoA + (1-methyl-5-piperazin-1-yl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-(5-methyl-pyridin-2-yl)-amine
CoA + ?
-
i.e. UK-469,413. Acetylation by isozyme NAT2 in liver cytosol to N-acetylpiperazine metabolite
-
-
?
acetyl-CoA + (1-methyl-5-piperazin-1-yl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-(5-methyl-pyridin-2-yl)-amine
CoA + ?
-
i.e. UK-469,413. Rapid acetylation in liver cytosol to N-acetylpiperazine metabolite
-
-
?
acetyl-CoA + 2-(4-aminobenzamido)pyridine
CoA + 2-(4-acetylamidobenzamido)pyridine
-
-
-
-
?
acetyl-CoA + 2-(4-aminobenzamido)pyridine
CoA + 2-(4-acetylamidobenzamido)pyridine
-
-
-
-
?
acetyl-CoA + 2-(4-aminobenzamido)pyridine
CoA + 2-(4-acetylamidobenzamido)pyridine
-
-
-
-
?
acetyl-CoA + 2-(4-aminobenzamido)pyridine
CoA + 2-(4-acetylamidobenzamido)pyridine
-
-
-
-
?
acetyl-CoA + 2-aminobenzoic acid
CoA + N-acetyl-2-aminobenzoic acid
-
relative activity: 0%
-
-
?
acetyl-CoA + 2-aminobenzoic acid
CoA + N-acetyl-2-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
N-acetyltransferase 2
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
interactions and substrate binding structure, overview
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
NAT1, poor substrate
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
high specific activity
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
mutant Y71F, 128% of wild-type activity, mutant M209T, 62% of wild-type activity
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
Vibrio cholerae serotype O1 54.315
-
-
-
-
?
acetyl-CoA + 2-aminophenol
CoA + 2-acetylaminophenol
-
-
-
?
acetyl-CoA + 2-aminophenol
CoA + 2-acetylaminophenol
-
-
-
?
acetyl-CoA + 2-aminophenol
CoA + N-acetyl-2-aminophenol
-
relative activity: 36%
-
-
?
acetyl-CoA + 2-aminophenol
CoA + N-acetyl-2-aminophenol
-
relative activity: 72%
-
-
?
acetyl-CoA + 2-aminophenol
CoA + N-acetyl-2-aminophenol
-
-
-
-
?
acetyl-CoA + 2-chloroaniline
CoA + N-acetyl-2-chloroaniline
-
relative activity: 12%
-
-
?
acetyl-CoA + 2-chloroaniline
CoA + N-acetyl-2-chloroaniline
-
relative activity: 18%
-
-
?
acetyl-CoA + 2-nitroaniline
CoA + N-acetyl-2-nitroaniline
-
relative activity: 0%
-
-
?
acetyl-CoA + 2-nitroaniline
CoA + N-acetyl-2-nitroaniline
-
relative activity: 3%
-
-
?
acetyl-CoA + 2-phenylendiamine
CoA + ?
-
relative activity: 80%
-
-
?
acetyl-CoA + 2-phenylendiamine
CoA + ?
-
relative activity: 90%
-
-
?
acetyl-CoA + 2-toluidine
CoA + N-acetyl-2-toluidine
-
relative activity: 0%
-
-
?
acetyl-CoA + 2-toluidine
CoA + N-acetyl-2-toluidine
-
-
-
?
acetyl-CoA + 2-toluidine
CoA + N-acetyl-2-toluidine
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)acetamide
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)acetamide
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-acetyl-3,4-dichloroaniline
-
mutant Y71F, 194% of wild-type activity, mutant M209T, 88% of wild-type activity
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-acetyl-3,4-dichloroaniline
-
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-acetyl-3,4-dichloroaniline
-
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-acetyl-3,4-dichloroaniline
-
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-acetyl-3,4-dichloroaniline
-
-
-
-
?
acetyl-CoA + 3,5-dimethylaniline
CoA + N-acetyl-3,5-dimethylaniline
-
-
-
-
?
acetyl-CoA + 3,5-dimethylaniline
CoA + N-acetyl-3,5-dimethylaniline
-
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzaldehyde
CoA + 3-acetylamino-4-hydroxybenzaldehyde
-
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzaldehyde
CoA + 3-acetylamino-4-hydroxybenzaldehyde
an intermediate of grixazone synthesis
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzaldehyde
CoA + 3-acetylamino-4-hydroxybenzaldehyde
-
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzaldehyde
CoA + 3-acetylamino-4-hydroxybenzaldehyde
an intermediate of grixazone synthesis
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzoic acid
CoA + 3-acetylamino-4-hydroxybenzoic acid
best substrate
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzoic acid
CoA + 3-acetylamino-4-hydroxybenzoic acid
an intermediate of grixazone synthesis
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzoic acid
CoA + 3-acetylamino-4-hydroxybenzoic acid
best substrate
-
-
?
acetyl-CoA + 3-aminobenzoic acid
CoA + N-acetyl-3-aminobenzoic acid
-
relative activity: 105%
-
-
?
acetyl-CoA + 3-aminobenzoic acid
CoA + N-acetyl-3-aminobenzoic acid
-
relative activity: 122%
-
-
?
acetyl-CoA + 3-aminobenzoic acid
CoA + N-acetyl-3-aminobenzoic acid
-
relative activity: 105%
-
-
?
acetyl-CoA + 3-aminobenzoic acid
CoA + N-acetyl-3-aminobenzoic acid
-
relative activity: 122%
-
-
?
acetyl-CoA + 3-aminobenzoic acid
CoA + N-acetyl-3-aminobenzoic acid
-
-
-
?
acetyl-CoA + 3-aminophenol
CoA + N-acetyl-3-aminophenol
-
relative activity: 33%
-
-
?
acetyl-CoA + 3-aminophenol
CoA + N-acetyl-3-aminophenol
-
relative activity: 56%
-
-
?
acetyl-CoA + 3-ethylaniline
CoA + N-acetyl-3-ethylaniline
-
-
-
-
?
acetyl-CoA + 3-ethylaniline
CoA + N-acetyl-3-ethylaniline
-
-
-
?
acetyl-CoA + 3-nitroaniline
CoA + N-acetyl-3-nitroaniline
-
relative activity: 2%
-
-
?
acetyl-CoA + 3-nitroaniline
CoA + N-acetyl-3-nitroaniline
-
relative activity: 6%
-
-
?
acetyl-CoA + 3-toluidine
CoA + N-acetyl-3-toluidine
-
relative activity: 21%
-
-
?
acetyl-CoA + 3-toluidine
CoA + N-acetyl-3-toluidine
-
relative activity: 28%
-
-
?
acetyl-CoA + 4,4'-methylenebis(2-chloroaniline)
CoA + N-acetyl-4,4'-methylenebis(2-chloroaniline)
-
-
-
?
acetyl-CoA + 4,4'-methylenebis(2-chloroaniline)
CoA + N-acetyl-4,4'-methylenebis(2-chloroaniline)
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + 4-acetylaminobenzoate
-
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + 4-acetylaminobenzoate
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + 4-acetylaminobenzoate
-
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + N-acetyl-4-aminobenzoate
-
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + N-acetyl-4-aminobenzoate
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + N-acetyl-4-aminobenzoate
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + N-acetyl-4-aminobenzoate
6% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + N-acetyl-4-aminobenzoate
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
N-acetyltransferase 1
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
poor
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
poor
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
the catalytic mechanism depends on the formation of a thiolate-imidazolium ion pair (Cys-S-)-(His-ImH+)
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoate
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoate
-
best substrate
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
relative activity: 19%
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
relative activity: 26%
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
isozyme NAT1
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
preferred substrate
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
high specific activity
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobiphenyl
CoA + N-acetyl-4-aminobiphenyl
-
-
-
-
?
acetyl-CoA + 4-aminobiphenyl
CoA + N-acetyl-4-aminobiphenyl
-
-
-
?
acetyl-CoA + 4-aminobiphenyl
N-acetyl-4-aminobiphenyl + CoA
substrate of isozyme NAT2 in liver cytosol
-
-
?
acetyl-CoA + 4-aminobiphenyl
N-acetyl-4-aminobiphenyl + CoA
substrate of isozyme NAT2
-
-
?
acetyl-CoA + 4-aminophenol
?
-
-
-
?
acetyl-CoA + 4-aminophenol
?
-
-
-
-
?
acetyl-CoA + 4-aminophenol
CoA + N-acetyl-4-aminophenol
-
relative activity: 48%
-
-
?
acetyl-CoA + 4-aminophenol
CoA + N-acetyl-4-aminophenol
-
relative activity: 94%
-
-
?
acetyl-CoA + 4-aminopyridine
?
very low activity
-
-
?
acetyl-CoA + 4-aminopyridine
?
-
very low activity
-
-
?
acetyl-CoA + 4-aminosalicylate
CoA + N-acetyl-4-aminosalicylate
-
-
-
?
acetyl-CoA + 4-aminosalicylate
CoA + N-acetyl-4-aminosalicylate
-
substrate for isoform NAT1
-
-
?
acetyl-CoA + 4-aminosalicylate
CoA + N-acetyl-4-aminosalicylate
-
-
-
?
acetyl-CoA + 4-aminosalicylate
CoA + N-acetyl-4-aminosalicylate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylate
CoA + N-acetyl-4-aminosalicylate
-
-
-
?
acetyl-CoA + 4-aminosalicylate
CoA + N-acetyl-4-aminosalicylate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
N-acetyltransferase 1
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
relative activity: 100%
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
relative activity: 90%
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
high specific activity
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
mutant Y71F, 17% of wild-type activity, mutant M209T, 128% of wild-type activity
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
Vibrio cholerae serotype O1 54.315
-
-
-
-
?
acetyl-CoA + 4-aminoveratrole
?
-
-
-
-
?
acetyl-CoA + 4-aminoveratrole
?
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + 1,2-dimethoxy-4-acetylaminobenzene
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + 1,2-dimethoxy-4-acetylaminobenzene
-
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + 1,2-dimethoxy-4-acetylaminobenzene
-
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + N-acetyl-4-aminoveratrole
57% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + N-acetyl-4-aminoveratrole
-
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + N-acetyl-4-aminoveratrole
-
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + N-acetyl-4-aminoveratrole
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + N-acetyl-4-aminoveratrole
-
-
-
-
?
acetyl-CoA + 4-anisidine
CoA + 4-methoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-anisidine
CoA + 4-methoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-anisidine
CoA + 4-methoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-anisidine
CoA + N-acetyl-4-anisidine
-
-
-
-
?
acetyl-CoA + 4-anisidine
CoA + N-acetyl-4-anisidine
-
mutant Y71F, 860% of wild-type activity, mutant M209T, 673% of wild-type activity
-
-
?
acetyl-CoA + 4-anisidine
CoA + N-acetyl-4-anisidine
-
-
-
-
?
acetyl-CoA + 4-anisidine
CoA + N-acetyl-4-anisidine
-
-
-
-
?
acetyl-CoA + 4-bromoaniline
CoA + 4-bromoacetanilide
-
-
-
-
?
acetyl-CoA + 4-bromoaniline
CoA + 4-bromoacetanilide
-
-
-
?
acetyl-CoA + 4-bromoaniline
CoA + 4-bromoacetanilide
-
-
-
-
?
acetyl-CoA + 4-bromoaniline
CoA + 4-bromoacetanilide
-
-
-
-
?
acetyl-CoA + 4-bromoaniline
CoA + N-acetyl-4-bromoaniline
72% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-bromoaniline
CoA + N-acetyl-4-bromoaniline
-
-
-
-
?
acetyl-CoA + 4-bromoaniline
CoA + N-acetyl-4-bromoaniline
-
-
-
-
?
acetyl-CoA + 4-butoxyaniline
CoA + 4-butoxyacetanilide
-
-
-
?
acetyl-CoA + 4-butoxyaniline
CoA + 4-butoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-butoxyaniline
CoA + 4-butoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-butoxyaniline
CoA + N-acetyl-4-butoxyaniline
-
-
-
-
?
acetyl-CoA + 4-butoxyaniline
CoA + N-acetyl-4-butoxyaniline
-
-
-
-
?
acetyl-CoA + 4-butoxyaniline
CoA + N-acetyl-4-butoxyaniline
-
-
-
-
?
acetyl-CoA + 4-butoxyaniline
CoA + N-acetyl-4-butoxyaniline
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + 4-chloroacetanilide
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + 4-chloroacetanilide
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + 4-chloroacetanilide
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + 4-chloroacetanilide
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-(4-chlorophenyl)acetamide
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-(4-chlorophenyl)acetamide
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
-
relative activity: 18%
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
-
relative activity: 21%
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
71% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
-
mutant Y71F, 174% of wild-type activity, mutant M209T, 122% of wild-type activity
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
-
-
-
-
?
acetyl-CoA + 4-chlorobenzoic hydrazide
?
-
-
-
-
?
acetyl-CoA + 4-chlorobenzoic hydrazide
?
-
-
-
-
?
acetyl-CoA + 4-chlorobenzoic hydrazide
CoA + N-acetyl-4-chlorobenzoic hydrazide
-
-
-
-
?
acetyl-CoA + 4-chlorobenzoic hydrazide
CoA + N-acetyl-4-chlorobenzoic hydrazide
-
-
-
-
?
acetyl-CoA + 4-ethoxyaniline
CoA + 4-ethoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-ethoxyaniline
CoA + 4-ethoxyacetanilide
-
-
-
?
acetyl-CoA + 4-ethoxyaniline
CoA + 4-ethoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-ethoxyaniline
CoA + 4-ethoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-ethoxyaniline
CoA + N-acetyl-4-ethoxyaniline
-
-
-
-
?
acetyl-CoA + 4-ethoxyaniline
CoA + N-acetyl-4-ethoxyaniline
-
-
-
-
?
acetyl-CoA + 4-ethoxyaniline
CoA + N-acetyl-4-ethoxyaniline
-
-
-
-
?
acetyl-CoA + 4-ethylaniline
CoA + 4-ethylacetanilide
-
-
-
-
?
acetyl-CoA + 4-ethylaniline
CoA + 4-ethylacetanilide
-
-
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + 4-hexyloxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + 4-hexyloxyacetanilide
best substrate
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + 4-hexyloxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + 4-hexyloxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + N-acetyl-4-hexyloxyaniline
51% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + N-acetyl-4-hexyloxyaniline
-
-
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + N-acetyl-4-hexyloxyaniline
-
-
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + N-acetyl-4-hexyloxyaniline
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + 4-iodoacetanilide
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + 4-iodoacetanilide
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + 4-iodoacetanilide
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + 4-iodoacetanilide
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
65% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
-
mutant Y71F, 196% of wild-type activity, mutant M209T, 83% of wild-type activity
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
-
-
-
-
?
acetyl-CoA + 4-methoxyaniline
CoA + N-acetyl-4-methoxyaniline
9% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-methoxyaniline
CoA + N-acetyl-4-methoxyaniline
-
-
-
-
?
acetyl-CoA + 4-methylaniline
CoA + N-acetyl-4-methylaniline
-
-
-
-
?
acetyl-CoA + 4-methylaniline
CoA + N-acetyl-4-methylaniline
-
-
-
-
?
acetyl-CoA + 4-methylaniline
CoA + N-acetyl-4-methylaniline
-
-
-
-
?
acetyl-CoA + 4-methylaniline
CoA + N-acetyl-4-methylaniline
-
-
-
-
?
acetyl-CoA + 4-methylaniline
CoA + N-acetyl-4-methylaniline
-
-
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + 4-nitroacetanilide
-
-
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + 4-nitroacetanilide
-
-
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
-
-
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
-
relative activity: 0%
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
-
relative activity: 0%
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
-
-
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
-
-
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
-
-
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
-
-
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
-
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + 4-phenoxyacetanilide
-
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + 4-phenoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + 4-phenoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + N-acetyl-4-phenoxyaniline
62% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + N-acetyl-4-phenoxyaniline
-
-
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + N-acetyl-4-phenoxyaniline
-
-
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + N-acetyl-4-phenoxyaniline
-
-
-
-
?
acetyl-CoA + 4-toluidine
CoA + N-acetyl-4-toluidine
-
relative activity: 40%
-
-
?
acetyl-CoA + 4-toluidine
CoA + N-acetyl-4-toluidine
-
relative activity: 80%
-
-
?
acetyl-CoA + 4-trifluoromethylaniline
?
-
-
-
?
acetyl-CoA + 4-trifluoromethylaniline
?
-
-
-
-
?
acetyl-CoA + 5-aminosalicylate
?
-
-
-
?
acetyl-CoA + 5-aminosalicylate
?
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + 5-acetylamino-2-hydroxybenzoate
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + 5-acetylamino-2-hydroxybenzoate
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + 5-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
64% activity compared to hydralazine
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylaminosalicylic acid
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylaminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylaminosalicylic acid
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylaminosalicylic acid
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
relative activity: 510%
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
relative activity: 550%
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
high specific activity
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
mutant Y71F, 147% of wild-type activity, mutant M209T, 21% of wild-type activity
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
Vibrio cholerae serotype O1 54.315
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
poor substrate
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
constitutive enzyme
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
constitutive enzyme
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
constitutive enzyme
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
involved in metabolism of drugs and endogenous substances containing an amine or hydrazine group
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
expression of NAT1 in muscle cells may be an important factor in the detoxification/activation process because of the potential involvement of the muscle in the pharmacokinetics of many xenobiotics
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
important role in detoxification and metabolic activation of a variety of aromatic xenobiotics, including numerous carcinogens. Cellular generation of peroxinitrite may contribute to carcinogenesis and tumor progression by weakening key cellular defense enzymes such as NAT1
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
constitutive enzyme
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
constitutive enzyme
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
pineal gland: inducible
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
constitutive enzyme
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
pineal gland: inducible
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
Q81R98
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
NAT2 is responsible for the biotransformation of numerous arylamine drugs and carcinogens
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
NATs are important enzymes involved in the metabolic activation of aromatic and heterocyclic amines
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
NATs are xenobiotic metabolizing enzymes responsible for the acetylation of many arylamine and heterocyclic amines, they therefore play an important role in the detoxification and activation of numerous drugs and carcinogens, regulation, overview
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
the enzyme is important for the activation and deactivation of exocyclic amine-containing pro-carcinogens, and for the metabolism of some pharmaceutical drugs
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
the enzyme catalyzes the N-acetylation of arylamines and hydrazines and O-acetylation of N-hydroxy-arylamines and heterocyclic amines
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
endogenous role of the enzyme in the protection of bacteria from aromatic and lipophilic toxins
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
catalytic pathway, overview
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
-
-
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
-
-
-
?
acetyl-CoA + aniline
CoA + acetanilide
-
-
-
?
acetyl-CoA + aniline
CoA + acetanilide
-
-
-
?
acetyl-CoA + aniline
CoA + acetanilide
-
-
-
-
?
acetyl-CoA + aniline
CoA + acetanilide
-
-
-
?
acetyl-CoA + aniline
CoA + acetanilide
-
-
-
?
acetyl-CoA + aniline
CoA + acetanilide
-
-
-
-
?
acetyl-CoA + aniline
CoA + acetanilide
-
-
-
-
?
acetyl-CoA + aniline
CoA + N-acetyl-aniline
-
relative activity: 12%
-
-
?
acetyl-CoA + aniline
CoA + N-acetyl-aniline
-
relative activity: 24%
-
-
?
acetyl-CoA + aniline
CoA + N-acetyl-aniline
-
-
-
-
?
acetyl-CoA + aniline
CoA + N-acetyl-aniline
-
-
-
-
?
acetyl-CoA + aniline
CoA + N-acetyl-aniline
-
-
-
-
?
acetyl-CoA + aniline
CoA + N-acetyl-aniline
-
-
-
-
?
acetyl-CoA + anisidine
CoA + N-acetyl-anisidine
-
-
-
?
acetyl-CoA + anisidine
CoA + N-acetyl-anisidine
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
poor substrate
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
not chicken pineal gland and brain
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + decylamine
CoA + N-acetyldecylamine
-
-
-
-
?
acetyl-CoA + decylamine
CoA + N-acetyldecylamine
-
-
-
-
?
acetyl-CoA + histamine
CoA + N-acetylhistamine
-
-
-
-
?
acetyl-CoA + histamine
CoA + N-acetylhistamine
-
-
-
-
?
acetyl-CoA + histamine
CoA + N-acetylhistamine
-
-
-
-
?
acetyl-CoA + hydralazine
?
-
-
-
?
acetyl-CoA + hydralazine
?
-
-
-
-
?
acetyl-CoA + hydralazine
?
-
-
-
?
acetyl-CoA + hydralazine
?
-
-
-
?
acetyl-CoA + hydralazine
?
-
-
-
-
?
acetyl-CoA + hydralazine
?
-
-
-
-
?
acetyl-CoA + hydralazine
CoA + ?
-
-
-
-
?
acetyl-CoA + hydralazine
CoA + ?
-
-
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetyl-hydralazine
-
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetyl-hydralazine
-
low specific activity
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetyl-hydralazine
-
-
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetyl-hydralazine
-
-
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetyl-hydralazine
-
-
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetyl-hydralazine
-
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetyl-hydralazine
-
-
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetylhydralazine
100% activity
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetylhydralazine
-
substrate for isoform NAT2
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetylhydralazine
-
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetylhydralazine
-
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetylhydralazine
-
-
-
-
?
acetyl-CoA + isoniazid
?
-
-
-
-
?
acetyl-CoA + isoniazid
?
inactivation of the anti-tubercular drug isoniazid by acetyltransfer
-
-
?
acetyl-CoA + isoniazid
?
-
-
-
-
?
acetyl-CoA + isoniazid
?
-
-
-
-
?
acetyl-CoA + isoniazid
?
-
-
-
?
acetyl-CoA + isoniazid
?
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + acetylniazide
-
-
-
?
acetyl-CoA + isoniazid
CoA + acetylniazide
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
low specific activity
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetylisoniazid
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetylisoniazid
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetylisoniazid
62% activity compared to hydralazine
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetylisoniazid
-
mutant Y71F, 102% of wild-type activity, mutant M209T, 229% of wild-type activity
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetylisoniazid
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetylisoniazid
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetylisoniazid
-
-
-
-
?
acetyl-CoA + isoniazide
CoA + acetylniazide
-
-
-
-
?
acetyl-CoA + isoniazide
CoA + acetylniazide
-
-
-
-
?
acetyl-CoA + isoniazide
CoA + acetylniazide
-
-
-
-
?
acetyl-CoA + isoniazide
CoA + acetylniazide
-
-
-
-
?
acetyl-CoA + isoniazide
CoA + acetylniazide
-
i.e. isonicotinyl hydrazide
-
?
acetyl-CoA + isoniazide
CoA + acetylniazide
-
-
-
-
?
acetyl-CoA + isoniazide
CoA + acetylniazide
-
isoniazide binds the enzyme prior to acetyl-CoA
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
3% activity compared to hydralazine
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
substrate for isoform NAT1
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
-
?
acetyl-CoA + N-hydroxy-4-aminobiphenyl
N-hydroxy-O-acetyl-4-aminobiphenyl + CoA
substrate of isozyme NAT2, O-acetylation activity of NAT2
-
-
?
acetyl-CoA + N-hydroxy-4-aminobiphenyl
N-hydroxy-O-acetyl-4-aminobiphenyl + CoA
O-acetylation activity
-
-
?
acetyl-CoA + octylamine
CoA + N-acetyloctylamine
-
-
-
-
?
acetyl-CoA + octylamine
CoA + N-acetyloctylamine
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
?
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
?
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
activity assay
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
in vitro N-acetylation assay
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
poor activity
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
Vibrio cholerae serotype O1 54.315
-
-
-
-
?
acetyl-CoA + p-aminobenzoylglutamate
CoA + N-[(4-acetylamino)]benzoyl-L-glutamate
-
-
-
-
?
acetyl-CoA + p-aminobenzoylglutamate
CoA + N-[(4-acetylamino)]benzoyl-L-glutamate
-
-
-
-
?
acetyl-CoA + p-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + p-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + p-anisidine
?
-
-
-
?
acetyl-CoA + p-anisidine
?
-
-
-
-
?
acetyl-CoA + p-octopamine
CoA + N-acetyloctopamine
-
-
-
-
?
acetyl-CoA + p-octopamine
CoA + N-acetyloctopamine
-
-
-
-
?
acetyl-CoA + p-phenetidine
CoA + N-(4-ethoxyphenyl)-acetamide
-
-
-
-
?
acetyl-CoA + p-phenetidine
CoA + N-(4-ethoxyphenyl)-acetamide
-
i.e. 4-ethoxybenzenamine, best substrate
-
-
?
acetyl-CoA + p-phenetidine
CoA + N-(4-ethoxyphenyl)-acetamide
-
-
-
-
?
acetyl-CoA + p-tyramine
CoA + N-acetyl-p-tyramine
-
-
-
-
?
acetyl-CoA + p-tyramine
CoA + N-acetyl-p-tyramine
-
-
-
-
?
acetyl-CoA + p-tyramine
CoA + N-acetyl-p-tyramine
-
-
-
?
acetyl-CoA + p-tyramine
CoA + N-acetyl-p-tyramine
-
ie. 4-(2-aminoethyl)phenol
-
-
?
acetyl-CoA + p-tyramine
CoA + N-acetyl-p-tyramine
-
-
-
?
acetyl-CoA + p-tyramine
CoA + N-acetyl-p-tyramine
-
-
-
-
?
acetyl-CoA + peptide
CoA + Nalpha-acetylpeptide
-
-
-
-
?
acetyl-CoA + peptide
CoA + Nalpha-acetylpeptide
-
-
-
-
?
acetyl-CoA + procainamide
?
-
-
-
?
acetyl-CoA + procainamide
?
-
-
-
-
?
acetyl-CoA + procainamide
?
-
-
-
?
acetyl-CoA + procainamide
?
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
lower activity
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
Vibrio cholerae serotype O1 54.315
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetylprocainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetylprocainamide
-
N-acetyltransferase 2
-
-
?
acetyl-CoA + procainamide
CoA + N-acetylprocainamide
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetylprocainamide
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + sulfadiazine
CoA + ?
-
-
-
-
?
acetyl-CoA + sulfadiazine
CoA + ?
-
-
-
-
?
acetyl-CoA + sulfadiazine
CoA + N-acetylsulfadiazine
-
-
-
-
?
acetyl-CoA + sulfadiazine
CoA + N-acetylsulfadiazine
-
-
-
-
?
acetyl-CoA + sulfamerazine
CoA + ?
-
-
-
-
?
acetyl-CoA + sulfamerazine
CoA + ?
-
-
-
-
?
acetyl-CoA + sulfamethazine
?
-
-
-
?
acetyl-CoA + sulfamethazine
?
-
-
-
?
acetyl-CoA + sulfamethazine
?
very low activity
-
-
?
acetyl-CoA + sulfamethazine
?
-
-
-
?
acetyl-CoA + sulfamethazine
?
-
very low activity
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-4-acetylsulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-4-acetylsulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-4-acetylsulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-4-acetylsulfamethazine
-
N-acetyltransferase 2
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-4-acetylsulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-4-acetylsulfamethazine
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-4-acetylsulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-4-acetylsulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
relative activity: 0%
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
relative activity: 46%
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
isozyme NAT2
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
low specific activity
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetylsulfamethazine
46% activity compared to hydralazine
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetylsulfamethazine
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetylsulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethoxazole
?
-
-
-
-
?
acetyl-CoA + sulfamethoxazole
?
-
-
-
?
acetyl-CoA + sulfamethoxazole
?
-
-
-
?
acetyl-CoA + sulfamethoxazole
CoA + N-acetyl-sulfamethoxazole
-
-
-
?
acetyl-CoA + sulfamethoxazole
CoA + N-acetyl-sulfamethoxazole
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
not chicken pineal gland and brain
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
-
-
-
?
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid
CoA + UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronic acid
-
WbpD is a putative 3-N-acetyltransferase that has been implicated in the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid, a precursor for the D-Man(2NAc3NAc)A residues in the B-band O antigen of Pseudomonas aeruginosa, the enzyme is involved in the catalysis of the fourth step by acting as an UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid 3-N-acetyltransferase
-
-
?
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid
CoA + UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronic acid
-
WbpD utilizes a direct-transfer reaction mechanism
-
-
?
malonyl-CoA + 2-aminophenol
CoA + N-malonyl-2-aminophenol
-
-
-
?
malonyl-CoA + 2-aminophenol
CoA + N-malonyl-2-aminophenol
-
-
-
?
malonyl-CoA + 3,4-dichloroaniline
CoA + 3-(3,4-dichloroanilino)-3-oxopropanoic acid
-
-
-
?
malonyl-CoA + 3,4-dichloroaniline
CoA + 3-(3,4-dichloroanilino)-3-oxopropanoic acid
-
-
-
?
malonyl-CoA + 4-aminobenzoate
CoA + N-malonyl-4-aminobenzoate
-
-
-
?
malonyl-CoA + 4-aminobenzoate
CoA + N-malonyl-4-aminobenzoate
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
no substrate: o-nitroaniline
-
-
?
additional information
?
-
-
no substrate: 2-methyl-4-nitroaniline, 2,4-dinitroaniline, 4-nitrophenylhydrazine, carbopyridine
-
-
?
additional information
?
-
-
the reaction proceeds via a covalent acetyl-enzyme intermediate
-
-
?
additional information
?
-
-
no substrate: o-nitroaniline
-
-
?
additional information
?
-
-
4-nitroacetanilide, 4-nitrophenylacetate can replace acetyl-CoA
-
-
?
additional information
?
-
-
no substrate: 2-amino-6-nitropyridine
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
the reaction proceeds via a covalent acetyl-enzyme intermediate
-
-
?
additional information
?
-
-
xenobiotic metabolizing enzyme. Catalyzes the biotransformation of primary aromatic amine or hydrazine drugs and carcinogens. In addition to genetically controlled interindividual variations in NAT1 activity, oxidative stress and cellular redox status may also regulate NAT1 activity
-
-
?
additional information
?
-
isozyme NAT1 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT1 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
-
isozyme NAT1 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT1 is not increased in breast tumors compared to healthy tissue, the grade of malignancy is positively related with NAT1
-
-
?
additional information
?
-
isozyme NAT1 is not increased in breast tumors compared to healthy tissue, the grade of malignancy is positively related with NAT1
-
-
?
additional information
?
-
isozyme NAT2 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT2 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
-
isozyme NAT2 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT2 is increased in breast tumors compared to healthy tissue, the grade of malignancy is negatively associated with NAT2
-
-
?
additional information
?
-
isozyme NAT2 is increased in breast tumors compared to healthy tissue, the grade of malignancy is negatively associated with NAT2
-
-
?
additional information
?
-
NAT plays a key role in the metabolic activation of aromatic amine and nitroaromatic mutagens to electrophilic reactive intermediates
-
-
?
additional information
?
-
-
NAT plays a key role in the metabolic activation of aromatic amine and nitroaromatic mutagens to electrophilic reactive intermediates
-
-
?
additional information
?
-
the enzyme catalyzes the acetylation of arylamines, a key step in the detoxification of many carcinogens
-
-
?
additional information
?
-
the enzyme catalyzes the acetylation of arylamines, a key step in the detoxification of many carcinogens
-
-
?
additional information
?
-
-
the enzyme catalyzes the acetylation of arylamines, a key step in the detoxification of many carcinogens
-
-
?
additional information
?
-
-
the human enzyme NAT1 bioactivates arylamine and heterocyclic amine carcinogens present in red meat and tobacco products, overview
-
-
?
additional information
?
-
the human enzyme NAT1 bioactivates arylamine and heterocyclic amine carcinogens present in red meat and tobacco products, overview
-
-
?
additional information
?
-
-
variable expression of isozyme NAT1 due to genetic polymorphism, gene regulation or environmental influences is associated with individual susceptibility to various cancers, overview
-
-
?
additional information
?
-
poor activity wit 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
poor activity wit 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
-
poor activity wit 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
poor activity with 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
poor activity with 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
-
poor activity with 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
-
isoform NAT1 catalyzes acetyl-CoA hydrolysis in a folate-dependent manner, while isoform NAT2 does not
-
-
?
additional information
?
-
enzyme additionally O-acetylates N-hydroxy-4,4'-methylenebis(2-chloroaniline)
-
-
-
additional information
?
-
-
enzyme additionally O-acetylates N-hydroxy-4,4'-methylenebis(2-chloroaniline)
-
-
-
additional information
?
-
-
not butyryl-CoA
-
-
?
additional information
?
-
-
no substrate: glucosamine 6-phosphate
-
-
?
additional information
?
-
-
propionyl-CoA can replace acetyl-CoA
-
-
?
additional information
?
-
-
not butyryl-CoA
-
-
?
additional information
?
-
-
no substrate: glucosamine 6-phosphate
-
-
?
additional information
?
-
-
propionyl-CoA can replace acetyl-CoA
-
-
?
additional information
?
-
-
no expression of NAT2
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
the reaction proceeds via a covalent acetyl-enzyme intermediate
-
-
?
additional information
?
-
-
no acetylation of sulfamethazine and procainamide
-
-
?
additional information
?
-
isozyme NAT1 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT1 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT2 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT2 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
the enzyme catalyzes an acetyl group transfer from AcCoA to primary arylamines, hydrazines, and hydrazides and play a very important role in the metabolism and bioactivation of drugs, carcinogens, and other xenobiotics
-
-
?
additional information
?
-
the enzyme catalyzes the acetylation of arylamines, a key step in the detoxification of many carcinogens
-
-
?
additional information
?
-
4-aminobenzoic acid is the preferred substrate
-
-
?
additional information
?
-
poor activity wit 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
-
the reaction proceeds via a covalent acetyl-enzyme intermediate
-
-
?
additional information
?
-
the isozymes catalyze the N-acetylation of aromatic amine and hydrazine drugs and carcinogens, after N-hydroxylation, they also catalyze the metabolic activation of N-hydroxy-arylamines via O-acetylation
-
-
?
additional information
?
-
the isozymes catalyze the N-acetylation of aromatic amine and hydrazine drugs and carcinogens, after N-hydroxylation, they also catalyze the metabolic activation of N-hydroxy-arylamines via O-acetylation
-
-
?
additional information
?
-
-
mouse Nat2 is very similar to human NAT1 in substrate specificity
-
-
?
additional information
?
-
-
the reaction proceeds via a covalent acetyl-enzyme intermediate
-
-
?
additional information
?
-
-
results confirm that substituted anilines are excellent substrates and that TBNAT is ineffective in hydrazide N-acetylation
-
-
?
additional information
?
-
-
the enzyme is required for synthesis of mycolic acids and complex lipids
-
-
?
additional information
?
-
-
no activity with 4-aminobenzoic acid, ambroxol, trimethoprim, sulfamethazine, sulfamethoxazole, sulfadiazine, and sulfapyridine
-
-
?
additional information
?
-
-
no activity with 4-aminobenzoic acid, ambroxol, trimethoprim, sulfamethazine, sulfamethoxazole, sulfadiazine, and sulfapyridine
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
the enzyme exhibits arylhydroxamic acid N,O-acetyltransferase activity
-
-
?
additional information
?
-
-
the reaction proceeds via a covalent acetyl-enzyme intermediate
-
-
?
additional information
?
-
-
N-diacetyl cysteamine can replace acetyl-CoA with less than 10% efficiency
-
-
?
additional information
?
-
-
N-diacetyl cysteamine can replace acetyl-CoA with less than 10% efficiency
-
-
?
additional information
?
-
-
no substrate: phenylalanine, cyclohexylamine
-
-
?
additional information
?
-
-
acetylthiocholine can replace acetyl-CoA
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
the enzyme is an important drug- and carcinogen metabolising enzyme that catalyses the transfer of an acetyl group from a donor, such as acetyl coenzyme A, to an aromatic or heterocyclic amine, hydrazine, hydrazide or N-hydroxylamine acceptor substrate
-
-
?
additional information
?
-
-
NAT acceptor substrate specificity, overview
-
-
?
additional information
?
-
-
enzyme follows a Ping Pong Bi Bi kinetic mechanism
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
substrate specificities of isozymes Nat1-Nat3, overview
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
substrate specificity, product identification by LC-MS, 4-aminobenzoic acid, 3-aminobenzoic acid, and aniline are poor substrates, overview
-
-
?
additional information
?
-
-
substrate specificity, product identification by LC-MS, 4-aminobenzoic acid, 3-aminobenzoic acid, and aniline are poor substrates, overview
-
-
?
additional information
?
-
substrate specificity, product identification by LC-MS, 4-aminobenzoic acid, 3-aminobenzoic acid, and aniline are poor substrates, overview
-
-
?
additional information
?
-
-
no substrate: polyamines, amino acids, sphingosine bases, ethanolamine, C1-C4 primary amines, some secondary and tertiary amines
-
-
?
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0.000000007
-
2-aminofluorene, pH 7.4, 37°C
0.000000008
-
4-aminosalicylic acid, pH 7.4, 37°C
0.000000014
-
strain YG1024, p-aminobenzoic acid, pH 7.4, 37°C
0.00000004
-
strain TA1538, 2-aminofluorene, pH 7.4, 37°C
0.000000075
isoform NAT 2, 4-aminosalicylic acid, pH 7.4, 37°C
0.00000015
-
2-aminofluorene, pH 7.4, 37°C
0.00000032
-
2-aminofluorene, pH 7.4, 37°C
0.00000033
-
5-aminosalicylic acid, pH 7.4, 37°C
0.00000059
-
5-aminosalicylic acid, pH 7.4, 37°C
0.00000061
-
5-aminosalicylic acid, pH 7.4, 37°C
0.00000099
isoform NAT 2, 2-aminofluorene, pH 7.4, 37°C
0.00000106
-
2-aminofluorene, pH 7.4, 37°C
0.00000189
isoform NAT 2, 5-aminosalicylic acid, pH 7.4, 37°C
0.0000022
-
5-aminosalicylic acid, pH 7.4, 37°C
0.00000241
isoform NAT 2, sulfamethazine, pH 7.4, 37°C
0.00000568
isoform NAT 1, procainamide, pH 7.4, 37°C
0.0000083
isoform NAT 1, sulfamethazine, pH 7.4, 37°C
0.0000208
-
strain YG1024, 5-aminosalicylic acid, pH 7.4, 37°C
0.0000275
-
strain YG1024, 2-aminofluorene, pH 7.4, 37°C
0.00052
isoform NAT 1, 2-aminofluorene, pH 7.4, 37°C
0.00058
isoform NAT 1, p-aminobenzoic acid, pH 7.4, 37°C
0.001
-
breast cancer cell line MCF-7, estrogen receptor (ER)-positive
0.00109
isoform NAT 1, 4-aminosalicylic acid, pH 7.4, 37°C
0.00117
isoform NAT 1, 5-aminosalicylic acid, pH 7.4, 37°C
0.00161
-
HeLa cell + N-acetyl-L-cysteine + 4-nitrosobiphenyl
0.00172
-
HeLa cell + 4-nitrosobiphenyl
0.00408
-
in HeLa cells, substrate: p-aminosalicylic acid
0.0044
-
in HeLa cells, substrate: p-aminobenzoic acid
0.00454
-
HeLa cell + N-acetyl-L-cysteine
0.005
-
breast cancer cell line T47D, estrogen receptor (ER)-positive
0.008
-
enzymatic activity found in peripheral blood mononuclear cell of investigated donors: 8-23.5 nmol/mg/min
0.0104
effect of androgen receptor expression in PC-3 cells, control, plus R1881
0.0105
-
enzymatic activity found in HepG2 cells
0.0109
effect of androgen receptor expression in PC-3 cells, plus pCMV-AR3.1, plus R1881
0.0113
effect of androgen receptor expression in PC-3 cells, control
0.0115
effect of androgen receptor expression in PC-3 cells, plus pCMV-AR3.1
0.013
substrate: 2-aminofluorene
0.0234
-
enzymatic activity found in monocyte-derived dendritic cells of investigated donors: 23.4-26.6 nmol/mg/min
0.024
substrate: 4-aminobiphenyl
0.02463
substrate: 5-aminosalicylate
0.038
22Rv1 cell, plus R1881, plus flutamide
0.042
22Rv1 cell, plus DMSO
0.046
22Rv1 cells and LNCAP cells (both androgene-positive lines) show a high basal level of NAT1 activity between 46-51 nmol/min/mg protein
0.052
substrate: benzidine
0.054
-
cytokine mixture, 2.5 microM p-aminobenzoic acid
0.079
substrate: 4-aminoveratrole
0.08
22Rv1 cell, plus R1881, 24h
0.087
substrate: hydralazine
0.097
-
cytokine mixture, 7.5 microM p-aminobenzoic acid
0.108
-
control, 2.5 microM p-aminobenzoic acid
0.124
-
cytokine mixture, 40 microM p-aminobenzoic acid
0.13
22Rv1 cell, treated with R1881
0.14
22Rv1 prostate cells upon treatment with 100 nmol of synthetic androgen R1881 for 24h
0.146
-
control, 7.5 microM p-aminobenzoic acid
0.19
-
after streptomycin sulfate treatment
0.2
-
control, 40 microM p-aminobenzoic acid
0.202
-
breast cancer cell line ZR-75-1, estrogen receptor (ER)-positive
0.237
-
recombinant NAT1, substrate: p-aminobenzoic acid
0.29
purified recombinant enzyme, with substrate 3-amino-4-hydroxybenzenesulfonic acid
0.33
purified recombinant enzyme, with substrate 3-amino-4-hydroxybenzaldehyde
0.337
-
recombinant NAT1, substrate: p-aminosalicylic acid
0.38
-
purification step ammonium sulfate precipitation
0.47
purified recombinant enzyme, with substrate 2-aminophenol
0.532
-
4-aminobenzoic acid L-glutamate, pH 8, 37°C
0.641
-
4-methoxyphenylhydrazine, pH 8, 37°C
0.75
-
4-aminobenzoic acid
1
-
sulphisoxazole, pH 8, 37°C
1.1
purified recombinant enzyme, with substrate 3-amino-4-hydroxybenzoic acid or 2-amino-4-methylphenol
1.31
-
sulphametoxazole, pH 8, 37°C
1.908
donor acetyl-CoA, pH 7.5, temperature not specified in the publication
12.05
-
4-hexyloxyaniline, pH 8, 37°C
13.47
-
4-anisidine, pH 8, 37°C
13.8
-
4-iodoaniline, pH 8, 37°C
14
-
4-chorobenzoic hydrazide, pH 8, 37°C
18.66
-
4-aminosalicylate, pH 8, 37°C
19.24
-
4-ethoxyaniline, pH 8, 37°C
2.012
donor propionyl-CoA, pH 7.5, temperature not specified in the publication
2.54
-
4-aminobenzoic acid
2.76
-
4-trifluoromethylaniline, pH 8, 37°C
21.97
-
4-phenoxyaniline, pH 8, 37°C
25.66
-
4-butoxyaniline, pH 8, 37°C
26
-
purification step DEAE Toyopearl column
27
-
purification step DEAE Toyopearl column
28
-
thrombin cleaved fusion protein
3.53
donor malonyl-CoA, pH 7.5, temperature not specified in the publication
4.14
-
4-chloroaniline, pH 8, 37°C
44.51
-
4-aminoveratrole, pH 8, 37°C
5.71
-
4-bromoaniline, pH 8, 37°C
6.76
-
3,4-dichloroaniline, pH 8, 37°C
7
-
purification step POROS 20PE column
7.3
-
purification step DE52-cellulose column
0.000000001
-
strain K-12, sulfamethazine, pH 7.4, 37°C
0.000000001
-
sulfamethazine, pH 7.4, 37°C
0.000000001
-
2-aminofluorene, pH 7.4, 37°C
0.000000002
-
p-aminobenzoic acid, pH 7.4, 37°C
0.000000002
-
sulfamethazine, pH 7.4, 37°C
0.000000002
isoform NAT 2, p-aminobenzoic acid, pH 7.4, 37°C
0.000000002
-
2-aminofluorene, pH 7.4, 37°C
0.000000002
-
sulfamethazine, pH 7.4, 37°C
0.000000003
-
sulfamethazine, pH 7.4, 37°C
0.000000003
-
sulfamethazine, pH 7.4, 37°C
0.000000004
-
procainamide, pH 7.4, 37°C
0.000000004
-
strain 54.8, 4-aminosalicylic acid, pH 7.4, 37°C
0.000000004
-
2-aminofluorene, pH 7.4, 37°C
0.000000005
-
p-aminobenzoic acid, pH 7.4, 37°C
0.000000005
-
4-aminosalicylic acid, pH 7.4, 37°C
0.000000005
-
strain 60.62, p-aminobenzoic acid, pH 7.4, 37°C
0.000000005
-
4-aminosalicylic acid, pH 7.4, 37°C
0.000000006
-
4-aminosalicylic acid, pH 7.4, 37°C
0.000000006
-
sulfamethazine, pH 7.4, 37°C
0.000000006
-
sulfamethazine, pH 7.4, 37°C
0.000000006
-
procainamide, pH 7.4, 37°C
0.000000006
-
5-aminosalicylic acid, pH 7.4, 37°C
0.00000001
-
strain K-12, 4-aminosalicylic acid, pH 7.4, 37°C
0.00000001
-
2-aminofluorene, pH 7.4, 37°C
0.00000002
-
5-aminosalicylic acid, pH 7.4, 37°C
0.00000002
-
strain K-12, 2-aminofluorene, pH 7.4, 37°C
0.00000002
-
4-aminosalicylic acid, pH 7.4, 37°C
0.00000005
-
p-aminobenzoic acid, pH 7.4, 37°C
0.00000005
-
strain 54.8, 2-aminofluorene, pH 7.4, 37°C
0.00000006
isoform NAT 2, procainamide, pH 7.4, 37°C
0.00000006
-
strain 60.62, 2-aminofluorene, pH 7.4, 37°C
0.00000006
-
strain TA98, 2-aminofluorene, pH 7.4, 37°C
0.00000009
-
2-aminofluorene, pH 7.4, 37°C
0.00000009
-
strain 54.8, 5-aminosalicylic acid, pH 7.4, 37°C
0.0000001
-
5-aminosalicylic acid, pH 7.4, 37°C
0.0000001
-
2-aminofluorene, pH 7.4, 37°C
0.00000014
-
2-aminofluorene, pH 7.4, 37°C
0.00000014
-
p-aminobenzoic acid, pH 7.4, 37°C
0.00000016
-
5-aminosalicylic acid, pH 7.4, 37°C
0.00000016
-
2-aminofluorene, pH 7.4, 37°C
0.00000027
-
4-aminosalicylic acid, pH 7.4, 37°C
0.00000027
-
strain 60.62, 5-aminosalicylic acid, pH 7.4, 37°C
0.0001
-
breast cancer cell line Cal51c, estrogen receptor (ER)-negative
0.0002
-
breast cancer cell line MDA-MB-231, estrogen receptor (ER)-negative
0.0005
mutant GGSG
0.0006
mutant GGSG
0.0007
-
breast cancer cell line MDA-MB-436, estrogen receptor (ER)-negative
0.0021
-
breast cancer cell line MDA-MB-453, estrogen receptor (ER)-negative
0.01
HEK-293 cell, treated with R1881
0.011
HEK-293 cell
0.011
PC-3 cell, treated with R1881
0.015
HeLa cell, treated with R1881
0.015
substrate: sulfamethazine
0.023
-
mutant G129V
0.023
substrate: beta-naphthylamine
0.029
substrate: sulfamethoxazole
0.04
22Rv1 cell, 24h
0.04
22Rv1 cell, plus bicalutamide, 24h
0.04
22Rv1 cell, plus bicalutamide, 48h
0.04
22Rv1 cell, plus R1881, plus bicalutamide
0.04
22Rv1 cell, plus R1881, plus bicalutamide, 24h
0.07
22Rv1 cell, plus R1881
0.07
LNCaP cell, treated with R1881
0.111
4-aminobenzoic acid
0.111
substrate: 4-aminobenzoic acid
0.168
-
0.168
enzymatic activity detected in the absence of an arylamine substrate: BanatB, but not BanatC, displays AcCoA and /or p-nitrophenyl acetate hydrolysis activity in the absence of an arylamine substrate
0.372
4-aminosalicylate
0.372
substrate: 4-aminosalicylate
0.416
substrate: sulfamethoxazole, isoenzyme BanatC
0.46
-
4-aminobenzoic acid
0.46
purified recombinant enzyme, with substrate 2-amino-4-chlorophenol
0.567
-
substrate aniline, p-nitrophenylacetate as an acetyl donor
0.567
-
substrates: aniline and p-nitrophenyl acetate
0.602
-
substrate isoniazid, p-nitrophenylacetate as an acetyl donor
0.602
-
substrates: isoniazid and p-nitrophenyl acetate
0.603
2-aminofluorene
0.603
substrate: 2-aminofluorenea
0.629
-
aniline, pH 8, 37°C
0.629
-
substrate aniline, AcCoA as an acetyl donor
0.629
-
substrates: aniline and acetyl-CoA
0.841
-
substrate p-aminobenzoic acid, p-nitrophenylacetate as an acetyl donor
0.841
-
substrates: p-aminobenzoic acid and p-nitrophenyl acetate
0.969
hydralazine
0.969
substrate: hydralazine
1.04
-
substrate 5-aminosalicylic acid, p-nitrophenylacetate as an acetyl donor
1.04
-
substrates: 5-aminosalicylic acid and p-nitrophenyl acetate
1.36
5-aminosalicylate
1.36
substrate: 5-aminosalicylate
1.47
-
substrate 2-aminofluorene, p-nitrophenylacetate as an acetyl donor
1.47
-
substrates: 2-aminofluorene and p-nitrophenyl acetate
1.47
donor succinyl-CoA, pH 7.5, temperature not specified in the publication
1.744
hydralazine
1.744
substrate: hydralazine, isoenzyme BanatC
13.5
-
substrate p-anisidine, AcCoA as an acetyl donor
13.5
-
substrates: p-anisidine and acetyl-CoA
2.22
-
substrate p-anisidine, p-nitrophenylacetate as an acetyl donor
2.22
-
substrates: p-anisidine and p-nitrophenyl acetate
2.324
-
isoniazid, pH 8, 37°C
2.324
-
substrate isoniazid, AcCoA as an acetyl donor
2.324
-
substrates: isoniazid and acetyl-CoA
2.878
isoniazid
2.878
substrate: isoniazid
2.99
-
substrate hydralazine, p-nitrophenylacetate as an acetyl donor
2.99
-
substrates: hydralazine and p-nitrophenyl acetate
29.55
-
hydralazine, pH 8, 37°C
29.55
-
substrate hydralazine, AcCoA as an acetyl donor
29.55
-
substrates: hydralazine and acetyl-CoA
3.109
4-aminosalicylate
3.109
substrate: 4-aminosalicylate, isoenzyme BanatC
3.679
5-aminosalicylate
3.679
substrate: 5-aminosalicylate, isoenzyme BanatC
44.71
-
2-aminofluorene, pH 8, 37°C
44.71
-
substrate 2-aminofluorene, AcCoA as an acetyl donor
44.71
-
substrates: 2-aminofluorene and acetyl-CoA
5.078
-
wild-type enzyme
5.852
2-aminofluorene
5.852
substrate: 2-aminofluorene, isoenzyme BanatC
73.3
-
5-aminosalicylate, pH 8, 37°C
73.3
-
substrate 5-aminosalicylic acid, AcCoA as an acetyl donor
73.3
-
substrates: 5-aminosalicylic acid and acetyl-CoA
8.2
-
4-aminobenzoic acid, pH 8, 37°C
8.2
-
substrate p-aminobenzoic acid, AcCoA as an acetyl donor
8.2
-
substrates: p-aminobenzoic acid and acetyl-CoA
9
-
purification step DE52-cellulose column
9
-
purification step POROS 20PE column
additional information
-
activity below 0.000000001 2-aminofluorene, 4-aminosalicylic acid, 5-aminosalicylic acid, procainamide, p-aminobenzoic acid, sulfamethazine, pH 7.4, 37°C
additional information
-
activity below 0.000000001 2-aminofluorene, 4-aminosalicylic acid, 5-aminosalicylic acid, procainamide, sulfamethazine, pH 7.4, 37°C
additional information
BanatA is devoid of NAT or AcCoA/p-nitrophenyl acetate hydrolysis activities, suggesting that it may be a new bacterial NAT-like protein with unknown function
additional information
Q81PT0
BanatA is devoid of NAT or AcCoA/p-nitrophenyl acetate hydrolysis activities, suggesting that it may be a new bacterial NAT-like protein with unknown function
additional information
Q81R98
BanatA is devoid of NAT or AcCoA/p-nitrophenyl acetate hydrolysis activities, suggesting that it may be a new bacterial NAT-like protein with unknown function
additional information
-
BanatA is devoid of NAT or AcCoA/p-nitrophenyl acetate hydrolysis activities, suggesting that it may be a new bacterial NAT-like protein with unknown function
additional information
no activity with substrates: isoniazid, 4-aminobenzoic acid, isoenzyme BanatC
additional information
Q81PT0
no activity with substrates: isoniazid, 4-aminobenzoic acid, isoenzyme BanatC
additional information
Q81R98
no activity with substrates: isoniazid, 4-aminobenzoic acid, isoenzyme BanatC
additional information
-
no activity with substrates: isoniazid, 4-aminobenzoic acid, isoenzyme BanatC
additional information
substrate: sulfamethoxazolea, 4-aminobenzoic, 4-aminosalicylate, isoniazid acid no activity detected
additional information
Q81PT0
substrate: sulfamethoxazolea, 4-aminobenzoic, 4-aminosalicylate, isoniazid acid no activity detected
additional information
Q81R98
substrate: sulfamethoxazolea, 4-aminobenzoic, 4-aminosalicylate, isoniazid acid no activity detected
additional information
-
substrate: sulfamethoxazolea, 4-aminobenzoic, 4-aminosalicylate, isoniazid acid no activity detected
additional information
-
relative activity isoenzyme NAT-a (substrate): 12% (aniline), 90% (2-phenylendiamine), 0% (3-phenylendiamine), 100% (4-phenylendiamine), 72% (2-aminophenol), 33% (3-aminophenol), 94% (4-aminophenol), 0% (2-aminobenzoic acid), 122% (3-aminobenzoic acid), 19% (4-aminobenzoic acid), 0% (2-nitroaniline), 2% (3-nitroaniline), 0% (4-nitroaniline), 18% (2-chloraniline), 48% (3-chloraniline), 18% (4-chloraniline), 0% (2-toluidine), 21% (3-toluidine), 80% (4-toluidine), 46% (sulfamethazine), 90% (4-aminosalicylic acid), 550% (5-aminosalicylic acid), 0% (4-aminoacetanilide)
additional information
-
relative activity isoenzyme Nat-b (substrate): 24% (aniline), 80% (2-phenylendiamine), 0% (3-phenylendiamine), 100% (4-phenylendiamine), 36% (2-aminophenol), 56% (3-aminophenol), 48% (4-aminophenol), 0% (2-aminobenzoic acid), 105% (3-aminobenzoic acid), 26% (4-aminobenzoic acid), 3% (2-nitroaniline), 6% (3-nitroaniline), 0% (4-nitroaniline), 12% (2-chloraniline), 48% (3-chloraniline), 21% (4-chloraniline), 0% (2-toluidine), 28% (3-toluidine), 40% (4-toluidine), 0% (sulfamethazine), 100% (4-aminosalicylic acid), 510% (5-aminosalicylic acid), 0% (4-aminoacetanilide)
additional information
-
activity below 0.000000001 2-aminofluorene, 4-aminosalicylic acid, procainamide, sulfamethazine, pH 7.4, 37°C
additional information
-
activity below 0.000000001 4-aminosalicylic acid, sulfamethazine, pH 7.4, 37°C
additional information
-
activity below 0.000000001 procainamide, p-aminobenzoic acid, pH 7.4, 37°C
additional information
-
activity below 0.000000001 p-aminobenzoic acid, procainamide, activity below 0.000000002 sulfamethazine, pH 7.4, 37°C
additional information
-
activity below 0.000000001 procainamide, p-aminobenzoic acid, pH 7.4, 37°C
additional information
-
-
additional information
-
below 0.000000001 5-aminosalicylic acid, procainamide, p-aminobenzoic acid, strain K-12, pH 7.4, 37°C
additional information
-
below 0.000000003 sulfamethazine, below 0.000000001 procainamide, p-aminobenzoic acid, strain 54.8 pH 7.4, 37°C
additional information
-
Vmax 0.0034
additional information
-
-
additional information
-
activity below 0.000000002 5-aminosalicylic acid, activity below 0.000000001 4-aminosalicylic acid, procainamide, p-aminobenzoic acid, sulfamethazine, pH 7.4, 37°C
additional information
-
-
additional information
-
-
additional information
Vmax 0.00000298, isoform NAT 2, 5-aminosalicylic acid, pH 7.4, 37°C
additional information
Vmax 0.00000298, isoform NAT 2, 5-aminosalicylic acid, pH 7.4, 37°C
additional information
-
Vmax 0.00000298, isoform NAT 2, 5-aminosalicylic acid, pH 7.4, 37°C
additional information
Vmax 0.001715, isoform NAT 1, 5-aminosalicylic acid, pH 7.4, 37°C
additional information
Vmax 0.001715, isoform NAT 1, 5-aminosalicylic acid, pH 7.4, 37°C
additional information
-
Vmax 0.001715, isoform NAT 1, 5-aminosalicylic acid, pH 7.4, 37°C
additional information
activity of recombinant wild-type and mutant NAT2, overview
additional information
-
activity of recombinant wild-type and mutant NAT2, overview
additional information
isozyme activities in healthy and tumor breast tissue, overview
additional information
isozyme activities in healthy and tumor breast tissue, overview
additional information
-
it is shown that NAT1 activity is induced by synthetic androgen R1881 in androgen receptor (AR)-positive prostate lines 22Rv1 and LNCaP, but not in the AR-negative PC-3, HK-293, or HeLa cells. The effect of R1881 is dose dependent, with an EC50 for R1881 of 1.6 nmol/L
additional information
it is shown that NAT1 activity is induced by synthetic androgen R1881 in androgen receptor (AR)-positive prostate lines 22Rv1 and LNCaP, but not in the AR-negative PC-3, HK-293, or HeLa cells. The effect of R1881 is dose dependent, with an EC50 for R1881 of 1.6 nmol/L
additional information
-
NAT1 activity is highly regulated by oxidative stress. NAT1 activity is highly sensitive to reactive oxygen or nitrogen species an is reversibly inactivated by H2O2
additional information
-
wild-type enzyme 100% activity, + cisplatin 9%, + AcCoA and cisplatin 13 - 77%, depending on the AcCoA concentration, + CoA and cysplatin 7%
additional information
-
activity below 0.000000001 4-aminosalicylic acid, procainamide, p-aminobenzoic acid, pH 7.4, 37°C
additional information
-
activity below 0.000000001 5-aminosalicylic acid, 4-aminosalicylic acid, p-aminobenzoic acid, procainamide, pH 7.4, 37°C
additional information
-
not detectable 5-aminosalicylic acid, 4-aminosalicylic acid, p-aminobenzoic acid, procainamide, sulfamethazine, pH 7.4, 37°C
additional information
-
activity below 0.000000002 4-aminosalicylic acid, p-aminobenzoic acid, procainamide, sulfamethazine, not detectable 5-aminosalicylic acid, pH 7.4, 37°C
additional information
-
specific activities of various substrates (pmol/min/luminescence unit): 183 (p-anisidine), 4 (procainamide), 3 (sulphamethazine), 11 (5-aminosalicylate), 3 (p-aminobenzoic acid)
additional information
specific activities of various substrates (pmol/min/luminescence unit): 183 (p-anisidine), 4 (procainamide), 3 (sulphamethazine), 11 (5-aminosalicylate), 3 (p-aminobenzoic acid)
additional information
-
specific activities of various substrates (pmol/min/luminescence unit): 197 (p-anisidine), 18 (procainamide), 12 (sulphamethazine), 2 (5-aminosalicylate), 0 (p-aminobenzoic acid)
additional information
specific activities of various substrates (pmol/min/luminescence unit): 197 (p-anisidine), 18 (procainamide), 12 (sulphamethazine), 2 (5-aminosalicylate), 0 (p-aminobenzoic acid)
additional information
-
-
additional information
-
enzymatic activity of mutants G129I and G129P are very low and not accurately measurable
additional information
-
mutant G129I and G129P display only very low enzymatic activity which can not be measured accurately
additional information
-
activity below 0.000000001 5-aminosalicylic acid, procainamide, p-aminobenzoic acid, sulfamethazine, pH 7.4, 37°C
additional information
-
-
additional information
-
low enzymatic activity as a recombinant protein
additional information
-
MMNAT is found to acetylate a broad range of substrates, including isoniazid, 4-anisidine and 4-aminoveratrole, compounds that have been identified as substrates of the NAT enzyme of Mycobacterium tuberculosis. The specific activity profile differs somewhat from that of the other characterised mycobacterial NAT, NAT from Mycobacterium smegmatis, particularly in the rate of acetylation of hydralazine and 2-aminofluorene, which are both acetylated 100times more rapidly by MMNAT
additional information
-
-
additional information
-
activity below 0.000000001 2-aminofluorene, not detectable 4-aminosalicylic acid, 5-aminosalicylic acid, procainamide, p-aminobenzoic acid, sulfamethazine, pH 7.4, 37°C
additional information
-
activity below 0.000000002 5-aminosalicylic acid, activity below 0.000000001 2-aminofluorene, 4-aminosalicylic acid, sulfamethazine, p-aminobenzoic acid, pH 7.4, 37°C
additional information
-
activity below 0.000000001 2-aminofluorene, 4-aminosalicylic acid, 5-aminosalicylic acid, procainamide, p-aminobenzoic acid, sulfamethazine, pH 7.4, 37°C
additional information
-
activity below 0.000000001 2-aminofluorene, 4-aminosalicylic acid, 5-aminosalicylic acid, procainamide, p-aminobenzoic acid, sulfamethazine, pH 7.4, 37°C
additional information
-
-
additional information
-
activity below 0.000000001 procainamide, sulfamethazine, pH 7.4, 37°C
additional information
-
intact cell: 1.37 nmol/min/10 000 000 000 CFU
additional information
-
no detectable activity: sulphacetamide, sulphanilamide, sulphadiazine, sulphamethazine, trimethoprim, phenylhydrazine
additional information
-
Vmax 0.0293
additional information
-
Vmax 2-aminofluorene: 0.01715, in the presence of ellagic acid: 0.001732
additional information
-
-
additional information
substrate specificities of isozymes Nat1-Nat3
additional information
-
activity below 0.000000001 strain 60.62, 4-aminosalicylic acid, sulfamethazine, pH 7.4, 37°C
additional information
-
activity below 0.000000001 strain Ta1538, 4-aminosalicylic acid, p-aminobenzoic acid, sulfamethazine, procainamide, pH 7.4, 37°C, not detectable: 5-aminosalicylic acid
additional information
-
activity below 0.000000001 strain Ta1538, 4-aminosalicylic acid, sulfamethazine, procainamide, below 0.000000002 p-aminobenzoic acid, pH 7.4, 37°C, not detectable: 5-aminosalicylic acid
additional information
-
activity below 0.000000001 strain TA98 1,8/DNP, 2-aminofluorene, 5-aminosalicylic acid, 4-aminosalicylic acid, p-aminobenzoic acid, sulfamethazine, procainamide, pH 7.4, 37°C
additional information
-
activity below 0.000000001 strain YG1024, 4-aminosalicylic acid, procainamide, sulfamethazine, pH 7.4, 37°C
additional information
-
activity below 0.000000001 4-aminosalicylic acid, procainamide, p-aminobenzoic acid, pH 7.4, 37°C
additional information
-
activity below 0.000000001 2-aminofluorene, 5-aminosalicylic acid, 4-aminosalicylic acid, p-aminobenzoic acid, activity below 0.000000006 procainamide, pH 7.4, 37°C
additional information
-
-
additional information
-
activity below 0.000000001 5-aminosalicylic acid, procainamide, p-aminobenzoic acid, sulfamethazine, pH 7.4, 37°C
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E123D
-
the catalytic efficiency is 1.6-4.4 times higher than that of the wild type enzyme
A434C
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
A54V
-
activity with 2-aminofluorene is about 10% of the wild-type activity
A752T
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
A803G
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
C223G
-
NAT2, enzymatically active, markedly reduced in vitro stability
C44G
-
NAT2, enzymatically active, markedly reduced in vitro stability
C481T
-
NAT2 single nucleotide polymorphism
C559T
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
C97T
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
D122N
single nucleotide polymorphism, evaluation of functional effect based on crystal strucutre, PDB 2PFR
D251G
-
activity with 2-aminofluorene is about 15% of the wild-type activity
E167K
single nucleotide polymorphism, evaluation of functional effect based on crystal strucutre, PDB 2PFR. Reduction in maximum activity
E203D
-
609T, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect missense
E8G
site-directed mutagenesis, the NAT2 mutant shows reduced activity compared to the wild-type enzyme
F192Y
site-directed mutagenesis, the NAT2 mutant shows highly reduced activity compared to the wild-type enzyme
F202L
-
activity with 2-aminofluorene is about 20% of the wild-type activity
G364A
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
G499A
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
G560A
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
H43R
site-directed mutagenesis, the NAT2 mutant shows reduced activity compared to the wild-type enzyme
I238T
-
activity with 2-aminofluorene is about 30% of the wild-type activity, the KM-value for 2-aminofluorene is 1.3fold higher than the wild-type value
I32V
site-directed mutagenesis, the NAT2 mutant shows reduced activity compared to the wild-type enzyme
K100E
-
the mutation significantly increases the Ka value for acetyl-CoA without changing the Kb value for the acetyl acceptor 4-aminobenzoate
K100L
-
the mutation significantly increases the Ka value for acetyl-CoA without changing the Kb value for the acetyl acceptor 4-aminobenzoate
K100Q
mutation decreases the potency of ATP as an inhibitor of NAT1. The Hill coefficient increases twofold
K13R
site-directed mutagenesis, the NAT2 mutant shows reduced activity compared to the wild-type enzyme
K141E
site-directed mutagenesis, the NAT2 mutant shows reduced activity compared to the wild-type enzyme
K185N
-
activity with 2-aminofluorene is about 35% of the wild-type activity, the KM-value for 2-aminofluorene is 1.5fold higher than the wild-type value
K282T
single nucleotide polymorphism, evaluation of functional effect based on crystal strucutre, PDB 2PFR
L135V
-
403G, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect missense
L137F
single nucleotide polymorphism, evaluation of functional effect based on crystal strucutre, PDB 2PFR
L181A
-
activity with 2-aminofluorene is about 80% of the wild-type activity
L194R
-
activity with 2-aminofluorene is about 30% of the wild-type activity
L239F
site-directed mutagenesis, the NAT2 mutant shows reduced activity compared to the wild-type enzyme
L24I
-
70A, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect missense
L40H
-
activity with 2-aminofluorene is about 5% of the wild-type activity
L69P
site-directed mutagenesis, the NAT2 mutant shows highly reduced activity compared to the wild-type enzyme
L74P
site-directed mutagenesis, the NAT2 mutant shows reduced activity compared to the wild-type enzyme
M205V
-
activity with 2-aminofluorene is about 40% of the wild-type activity
N172I
-
activity with 2-aminofluorene is about 20% of the wild-type activity, the KM-value for 2-aminofluorene is 3.6fold higher than the wild-type value
NAT2*12A.U4
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
NAT2*13.U1
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
NAT2*4.U1
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
NAT2*4.U2
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
NAT2*4.U3
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
NAT2*4.U5
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
NAT2*4.U6
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
NAT2*4.U7
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
NAT2*5B.U1
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
NAT2*5B.U4
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
NAT2*6A.U1
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
NAT2*7B.U2
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
NAT2*7B.U3
-
polymorphism, proposed new nomenclature composed of haplotype in the promoter region and conventional NAT2 haplotype in the coding region
P228L
-
683T, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect missense
P96L
-
activity with 2-aminofluorene is slightly higher than wild-type activity
Q133R
site-directed mutagenesis, the NAT2 mutant shows reduced activity compared to the wild-type enzyme
Q145P
single nucleotide polymorphism, evaluation of functional effect based on crystal strucutre, PDB 2PFR. Reduction in both N- and O-acetyltransferase catalytic activitiy
Q226R
-
activity with 2-aminofluorene is about 15% of the wild-type activity
R127S
-
mutant shows a 42fold decreased affinity for the NAT1-selective substrate p-aminobenzoic acid
R242M
single nucleotide variant, identified within a South African mixed ancestry population, displays a similar profile to the published variant, I263V (proposed fast acetylator), and the wild-type protein structure
S102C
site-directed mutagenesis, the NAT2 mutant shows reduced activity compared to the wild-type enzyme
S125F/S127R/S129Y
-
mutation of all three Ser residues 125, 127 and 129 to those normally present in NAT1 is required to produce the low affinity for sulfamethazine approximating that of native NAT1
T198A
-
activity with 2-aminofluorene is about 50% of the wild-type activity
T207S
-
activity with 2-aminofluorene is slightly higher than wild-type activity
T250P
site-directed mutagenesis, the NAT2 mutant shows reduced activity compared to the wild-type enzyme
V146A
-
activity with 2-aminofluorene is about 50% of the wild-type activity
V280M
-
838A, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect missense
W77R
-
activity with 2-aminofluorene is about 25% of the wild-type activity, the KM-value for 2-aminofluorene is 1.3fold higher than the wild-type value
Y190C
site-directed mutagenesis, the NAT2 mutant shows highly reduced activity compared to the wild-type enzyme
Y190F
site-directed mutagenesis, the NAT2 mutant shows reduced activity compared to the wild-type enzyme
C624T
synonymous polymorphism
D115Y
non-synonymous single nucleotide variation, about 68% decrease in stability, about 82% decrease in activity
E155Q
non-synonymous single nucleotide variation, about 62% decrease in stability, about 22% decrease in activity
F175L
non-synonymous single nucleotide variation, about 50% decrease in stability, about 82% decrease in activity
G51A
non-synonymous single nucleotide variation, about 60% decrease in stability, about 45% decrease in activity
G691A
nonsynonymous polymorphism, causing a V231I substitution
L89F
non-synonymous single nucleotide variation, about 56% decrease in stability, about 69% decrease in activity
L89F/D115Y
non-synonymous single nucleotide variation, about 95% decrease in stability, less about 95% decrease in activity
M82V
non-synonymous single nucleotide variation, about 68% decrease in stability, about 32% decrease in activity
R187Q
non-synonymous single nucleotide variation, about 27% decrease in stability, about 73% decrease in activity
recombinant (MACMU)NAT2 protein
analysed for the ability to acetylate NAT substrates and bind anti-NAT antibodies
V231I
polymorphic allele Nat2*2 found in rhesus macaque, differentiated by one nonsynonymous G691A polymorphism, resulting in a Val231Ile substitution. Mutant shows differences in activity with most substrates (pmol/min/luminescence unit): 183 (p-anisidine), 4 (procainamide), 3 (sulphamethazine), 11 (5-aminosalicylate), 3 (p-aminobenzoic acid)
H107N
site-directed mutagenesis, no expression in Escherichia coli cells possible
H107Q
site-directed mutagenesis, no expression in Escherichia coli cells possible, insoluble inactive enzyme
Y190A
-
no significant alteration in the overall fold of the protein
Y190F
-
no significant alteration in the overall fold of the protein
Y190I
-
no significant alteration in the overall fold of the protein
F42W
the mutant displays enzymatic properties similar to those of the wild type enzyme
I95T
-
in liver of homozygous animals, 90% reduction in activity with substrate isoniazid
R99I
-
Mus musculus A/J slow acetylating strain harbours a R99I mutation in the Nat2 gene, causing instability and degradation of the mutant protein
E26D/L82M
-
in Mus spretus mice, slow acetylation is associated with an unstable Nat2 protein in which there are two amino acid changes Glu26Asp and Leu82Met
M209T
-
replacement of residue M209 with the corresponding residue from Mycobacterium tuberculosis enzyme. Activities against several substrates similar to wild-type, with similar overall trends
Y71F
-
replacement of residue Y71 with the corresponding residue from Mycobacterium tuberculosis enzyme. Activities against several substrates similar to wild-type, with similar overall trends
G207R
-
mutation found in clinically isolated strains of Mycobacterium tuberculosis, resulting in a NAT enzyme with very poor activity
K136A
-
site-directed mutagenesis, the mutant can only partially complement the wbpD knockout mutant strain, and shows also reduced stabilizing effects of acetyl-CoA on the mutant enzyme, while a K136R mutation shows no discernible effect on complementation of the wbpD mutant or the stabilizing effects of acetyl-CoA on the purified mutant protein
K136R
-
site-directed mutagenesis, partial complementation of the knockout mutant strain
K58A
-
site-directed mutagenesis, complete complementation of the knockout mutant strain to wild-type levels
K58R
-
site-directed mutagenesis, complete complementation of the knockout mutant strain to wild-type levels
Q60A
-
site-directed mutagenesis, partial complementation of the knockout mutant strain
Q60N
-
site-directed mutagenesis, partial complementation of the knockout mutant strain
C69A
BanatC inactive mutant, replacement of the catalytic cysteine residue
C69A
mutant devoid of NAT activity. Expression of the C69A mutant in Escherichia coli does not afford higher-than-normal resistance to sulfonamide antibiotic sulfamethoxazole in the recombinant bacteria
Y38F
-
crystallization studies are carried out with mutant Y38F since it leads to a decreased proteolysis when recombinantly expressed in Escherichia coli and enzymatic properties are shown to be identical. Crystals belong to the tetragonal space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 53.70, c = 172.40 A, and diffract to 1.95 A resolution on a synchrotron source
Y38F
-
whereas wild-type BanatC proves difficult to crystallize, the mutant displaying the same enzymatic characterisics as the wild-type is found to crystallize and to diffract
C190T
-
NAT2 single nucleotide polymorphism
C190T
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
C68G
-
NAT2, no enzymatic activity
C68G
-
the sulfhydryl-group of a single cysteine residue participates in the mechanism of acetyl transfer from acetyl CoA to acceptor amine substrate via a two step, substituted-enzyme (ping pong, bi bi) reaction mechanism: Site-directed mutagenesis studies using recombinant human NAT2 shows that only Cys with Gly at position 68 completely abolishes catalytic function, establishing Cys68 as the key sulfhydryl-containing residue in the catalytic mechanism
E264K
single nucleotide variant, identified within a South African mixed ancestry population, substitution occupies less conformational clusters of folded states as compared to the wild-type and is destabilizing
E264K
single nucleotide variant, identified within a South African mixed ancestry population. Less thermodynamically stable protein structure is predicted
F125S
-
high resolution crystal structure of mutant F125S is generated
F125S
-
mutant produces a 220fold increased affinity for the NAT2-selective substrate sulfamethazine, Km (sulfamethazine): 0.02 mM
G191A
-
NAT2 single nucleotide polymorphism
G191A
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
G286E
-
857A, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect missense
G286E
single nucleotide polymorphism, evaluation of functional effect based on crystal strucutre, PDB 2PFR. Reduction in maximum activity
G590A
-
NAT2 single nucleotide polymorphism
G590A
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
G857A
-
NAT2 single nucleotide polymorphism
G857A
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
I114T
-
341C, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect missense
I114T
single nucleotide polymorphism, evaluation of functional effect based on crystal strucutre, PDB 2PFR. Reduction in both N- and O-acetyltransferase catalytic activitiy
K100R
-
the mutation significantly decreases the Ka value for acetyl-CoA without changing the Kb value for the acetyl acceptor 4-aminobenzoate
K100R
mutation decreases the potency of ATP as an inhibitor of NAT1. The Hill coefficient increases threefold
K268R
-
803G, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect missense
K268R
single nucleotide polymorphism, evaluation of functional effect based on crystal strucutre, PDB 2PFR
N245I
-
activity with 2-aminofluorene is about 85% of the wild-type activity, the KM-value for 2-aminofluorene is 1.3fold higher than the wild-type value
N245I
single nucleotide variant, identified within a South African mixed ancestry population. Thermodynamically stabilizing effect structure is predicted and affecting NAT1 protein function
R197Q
-
590A, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect missense
R197Q
single nucleotide polymorphism, evaluation of functional effect based on crystal strucutre, PDB 2PFR. Reduction in both N- and O-acetyltransferase catalytic activitiy. Reduction in maximum activity
R64Q
structural basis of the effects of the common genetic polymorphism on NAT2 activity, enzyme and active site structure analysis, phenotype, overview
R64Q
-
191A, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect missense
R64Q
single nucleotide polymorphism, evaluation of functional effect based on crystal strucutre, PDB 2PFR. Reduction in both N- and O-acetyltransferase catalytic activitiy
R64W
naturally occuring polymorphism in gene NAT1, the R64W mutation also causes constitutive ubiquitinylation and NAT1 to aggregate in cultured cells, does not interfere with NAT catalysis in vitro, overall protein structure and thermostability are not compromised
R64W
-
SNP resulting in an inactive protein
R64W
single nucleotide polymorphism, evaluation of functional effect based on crystal strucutre, PDB 2PFR. Reduction in both N- and O-acetyltransferase catalytic activitiy
T341C
-
NAT2 single nucleotide polymorphism
T341C
single nucleotide polymorphism (SNP) found in human, resulting in a decreased activity of enzyme
V231G
single nucleotide variant, identified within a South African mixed ancestry population, substitution occupies less conformational clusters of folded states as compared to the wild-type and is destabilizing
V231G
single nucleotide variant, identified within a South African mixed ancestry population. Less thermodynamically stable protein structure and is predicted, and affecting NAT1 protein function
R64W
naturally occuring polymorphism in gene NAT2, the R64W mutation also causes constitutive ubiquitinylation and NAT2 to aggregate in cultured cells, does not interfere with NAT catalysis in vitro, overall protein structure and thermostability are not compromised
R64W
-
change from arginine to tryptophane at residue 64 seriously affects protein stability. Mutant is shown to cluster in cytosolic aggresomes and is rapidly ubiquitinylated and degraded
G129A
-
final protein yield similar to wild-type: approximately 30 mg. Enzymatic activity: 4.758 micromol/min/mg, Km (mM): 0.184 (substrate: p-aminosalicylic acid)
G129A
-
mutation of the conserved glycine residue in the active-site P-loop
G129A
-
protein production similar to wild-type
G129I
-
mutation of the conserved glycine residue in the active-site P-loop
G129I
-
only low levels of protein production, NAT activity: 0.034 micromol/min/mg
G129I
-
only small amount of NAT protein, final protein yield: 0.75-0.5 mg of protein. Enzymatic activity: very low, not accurately measurable
G129P
-
mutation of the conserved glycine residue in the active-site P-loop
G129P
-
only low levels of protein production, NAT activity: 0.023 micromol/min/mg
G129P
-
only small amount of NAT protein, final protein yield: 0.75-0.5 mg of protein. Enzymatic activity: very low, not accurately measurable
G129S
-
final protein yield similar to wild-type: approximately 30 mg. Enzymatic activity: 4.152 micromol/min/mg, Km (mM): 0.447 (substrate: p-aminosalicylic acid)
G129S
-
mutation of the conserved glycine residue in the active-site P-loop
G129S
-
protein production similar to wild-type
G129T
-
mutation of the conserved glycine residue in the active-site P-loop
G129T
-
only low levels of protein production, NAT activity: 4.758 micromol/min/mg
G129T
-
only small amount of NAT protein, final protein yield: 0.75-0.5 mg of protein. Enzymatic activity: 0.034 micromol/min/mg
G129V
-
mutation of the conserved glycine residue in the active-site P-loop
G129V
-
only low levels of protein production, NAT activity: 4.152 micromol/min/mg
G129V
-
only small amount of NAT protein, final protein yield: 0.75-0.5 mg of protein. Enzymatic activity: 0.022 micromol/min/mg
additional information
expression of BanatC in Escherichia coli affords higher-than-normal resistance to sulfonamide antibiotic sulfamethoxazole in the recombinant bacteria
additional information
Q81PT0
expression of BanatC in Escherichia coli affords higher-than-normal resistance to sulfonamide antibiotic sulfamethoxazole in the recombinant bacteria
additional information
Q81R98
expression of BanatC in Escherichia coli affords higher-than-normal resistance to sulfonamide antibiotic sulfamethoxazole in the recombinant bacteria
additional information
-
expression of BanatC in Escherichia coli affords higher-than-normal resistance to sulfonamide antibiotic sulfamethoxazole in the recombinant bacteria
additional information
native gene contains a c.580delG frameshift mutation leading to expression of a truncated protein. Artificial reintroduction of residue G580 in the NAT3 gene leads to a functional enzyme able to acetylate several arylamine drugs
additional information
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native gene contains a c.580delG frameshift mutation leading to expression of a truncated protein. Artificial reintroduction of residue G580 in the NAT3 gene leads to a functional enzyme able to acetylate several arylamine drugs
additional information
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study of NAT1/NAT2 chimerea
additional information
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construction of several insertion and deletion mutants of NAT2, overview
additional information
construction of several insertion and deletion mutants of NAT2, overview
additional information
construction of several insertion and deletion mutants of NAT2, overview
additional information
humans harboring certain genetic variations within the NAT genes exhibit increased likelihood of developing various cancer types, especially urinary bladder cancer, polymorphisms, the mutants exhibit reduced cellular activity, which is proposed to be due to their constitutive ubiquitylation and enhanced proteasomal degradation, overview
additional information
humans harboring certain genetic variations within the NAT genes exhibit increased likelihood of developing various cancer types, especially urinary bladder cancer, polymorphisms, the mutants exhibit reduced cellular activity, which is proposed to be due to their constitutive ubiquitylation and enhanced proteasomal degradation, overview
additional information
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humans harboring certain genetic variations within the NAT genes exhibit increased likelihood of developing various cancer types, especially urinary bladder cancer, polymorphisms, the mutants exhibit reduced cellular activity, which is proposed to be due to their constitutive ubiquitylation and enhanced proteasomal degradation, overview
additional information
-
mutations responsible for reduced NAT1 stability and down-regulation occur in nature, the NAT1 slow acetylator phenotype is associated with a protection against spina bifida, a condition that is linked to the level of maternal folic acid intake
additional information
mutations responsible for reduced NAT1 stability and down-regulation occur in nature, the NAT1 slow acetylator phenotype is associated with a protection against spina bifida, a condition that is linked to the level of maternal folic acid intake
additional information
NAT2 random mutagenesis, developement of a system in which the activation of mutagens by recombinant human NAT 2, expressed in Escherichia coli, can be detected by the appearance of LacZ revertants, screening for variants of the human NAT2 sequence with altered activity, detailed overview
additional information
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NAT2 random mutagenesis, developement of a system in which the activation of mutagens by recombinant human NAT 2, expressed in Escherichia coli, can be detected by the appearance of LacZ revertants, screening for variants of the human NAT2 sequence with altered activity, detailed overview
additional information
-
variable expression of isozyme NAT1 due to genetic polymorphism, gene regulation or environmental influences is associated with individual susceptibility to various cancers, overview
additional information
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282T, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect silent, amino acid change none
additional information
-
345T, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect silent, amino acid change none
additional information
-
481T, single nucleotide polymorphism, point mutation in the arylamine N-acetyltransferase 2 gene, effect silent, amino acid change none
additional information
-
alleles NAT2*7 in patients indicate slow acetylators the ratio acetyl-INH/INH is 0.93-1.19 opposite 7.4 in patients with NAT2*4/NAT2*4 genotype, but in vitro similar kinetc parameters in NAT2*4 and NAT2*7 for INH are shown (Km (INH): 0.374 nM for NAT2*4 and 0.366 for NAT2*7)
additional information
-
ANDH, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
ANDH, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
ANDH, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
-
chimera production and site-directed mutagenesis identified amino acids 123, 125 and 127 that contribute significantly toward NAT1 and NAT2 substrate and kintic selectivity. Human NAT2 possesses a Ser residue at each of these three positions whereas NAT1 has Phe125, Arg127 and Tyr129
additional information
-
chimera production and site-directed mutagenesis identified amino acids 125, 127 and 129 that contribute significantly toward NAT1 and NAT2 substrate and kintic selectivity. Human NAT2 possesses a Ser residue at each of these three positions whereas NAT1 has Phe125, Arg127 and Tyr129
additional information
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distribution of NAT1 genotypes is determined in 107 colon cancer cases, 77 rectal cancer cases, and 185 controls. In addition, possible occupational and nonoccupational risk factors are determined by a personal interview. Cancer cases and controls are derived from an area of former coal, iron, and steel industries, which is known for elevated colon cancer mortality. The result does not support a relevant impact of the NAT1 genotype on colorectal cancer risk development in the study area
additional information
-
genotoxic activation of PBTA derivatives using Salmonella typhimurium NM6001 (human NAT1-expressing strain), Salmonella typhimurium NM6002 (human NAT2-expressing strain), and Salmonella typhimurium NM6000 (O-acetyltransferase-deficient parent strain) in the presence of S9 mix is determined. PBTA-4 shows almost similar sensitivity in the NAT1-expressing strain and the NAT2-expressing strain, although NAT2-expressing strain exhibits relatively higher sensitivity to PBTA-6, PBTA-7, and PBTA-8 than NAT1-expressing strain. The NM6000 strain is not found to be sensitive to all of these chemicals The results support the view that O-acetylation by human NAT1 and NAT2 enzymes is involved in the genotoxic activation of PBTA compounds
additional information
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genotypes of drug-metabolizing enzymes (NAT2, CYP2E15*B, CYP2E1*6, Glutathione-S-transferase (GST) M1 and GST T1) involved in isoniazid metabolism and the serum concentrations of isoniazid and its metabolites in 129 tuberculosis patients are investigated. Acetylating pathway of isoniazid to acetyl isoniazid tends to shift to the hydrolytic pathway generating hydrazine with the increase of mutant alleles in NAT2 gene
additional information
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GG, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
GG, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
GG, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
-
GGSG, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
GGSG, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
GGSG, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
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GRSG, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
GRSG, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
GRSG, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
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HHEH, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
HHEH, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
HHEH, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
-
human NAT1 and NAT2 are each 290 amino acids in length. They share 81% amino acid sequence identity, and only 28 of the 55 amino acid differences between the two proteins are non-conservative
additional information
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NAT1*10, phenotype has higher than normal activity in some tissues, associated with increased risk of cancer
additional information
NAT1*10, phenotype has higher than normal activity in some tissues, associated with increased risk of cancer
additional information
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NAT1*14, slow acetylator phenotype, loss of function alleles
additional information
NAT1*14, slow acetylator phenotype, loss of function alleles
additional information
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NAT1*15, slow acetylator phenotype, loss of function alleles
additional information
NAT1*15, slow acetylator phenotype, loss of function alleles
additional information
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NAT1*17, slow acetylator phenotype, loss of function alleles
additional information
NAT1*17, slow acetylator phenotype, loss of function alleles
additional information
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NAT1*19, slow acetylator phenotype, loss of function alleles
additional information
NAT1*19, slow acetylator phenotype, loss of function alleles
additional information
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NAT1*22, slow acetylator phenotype, loss of function alleles
additional information
NAT1*22, slow acetylator phenotype, loss of function alleles
additional information
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overexpression of human NAT1 in mice results in serious developmental problems: deevelopmentally deleterious effects are observed in which embryos either do not survive or show malformations with a phenotype in which the tail is kinked, reminiscent of a spina-bifida phenotype
additional information
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PHAG, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
PHAG, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
PHAG, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
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QEGST, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
QEGST, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
QEGST, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
-
SDGSD, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
SDGSD, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
SDGSD, human NAT2 mutant, a 17-residue segment is deleted and replaced
additional information
identification of seven non-synonymous single nucleotide variations in NAT1 gene, showing compromised enzyme function, mainly through destabilization of NAT1 protein and consequent activity loss
additional information
-
identification of seven non-synonymous single nucleotide variations in NAT1 gene, showing compromised enzyme function, mainly through destabilization of NAT1 protein and consequent activity loss
additional information
-
it is shown that a small amino acid (such as Gly or Ala) at position 429 (start of the active-site P-loop) is important not only for maintaining the functions of the active-site P-loop but also for maintaining the overall structural integrity of NAT enzymes. Results suggest that in addition to its role in substrate binding and selectivity, the active-site P-loop plays a wider structural role in NAT enzymes
additional information
-
results show that amino acid 129, which is the start of the active-site P-loop, is important to be a small amino acid (such as Gly or Ala) not only for maintaining the functions of the active-site P-loop but also for maintaining the overall structural integrity of NAT enzymes. Results suggest that in addition to its role in substrate binding and selectivity, the active-site P-loop plays a wider structural role in NAT enzymes
additional information
construction of NAT2 knockout mice, phenotype, overview
additional information
construction of NAT2 knockout mice, phenotype, overview
additional information
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Nat1 knockout mice do not show an obvious phenotype, apart from the expected reduction in arylamine metabolism
additional information
-
Nat2 knockout mice do not show an obvious phenotype, apart from the expected reduction in arylamine metabolism. From analyses following breeding studies it appears that lack of NAT2 affects the sex ratios in offspring such that there is an excess of females among heterozygotes
additional information
-
Nat3 knockout mice: lack of Nat3 has no effect in the metabolism of arylamines by mice
additional information
-
the developmental role of Nat2 is investigated using transgenic Nat2 knockout/lacZ knockin mice: The transgene is bred onto an A/J background and offspring are scored for developmental defects at weaning. After backcross generation eight, an ocular defect, ranging from cataract to microphthalmia and anophthalmia, is recorded among offspring of backcross and intercross pairs. While Nat2-/- mice are described as overtly aphenotypic, the presence of a Nat2 null allele in one or both parents can result in ocular defects. These ocular phenotypes and their association with Nat2 genotype indicate that the Nat2 locus may be responsible for the described microphthalmic phenotype
additional information
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replacement of the third domain of Mycobacterium marinum enzyme with that from Mycobacterium tuberculosis and vice versa
additional information
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replacement of the third domain of Mycobacterium marinum enzyme with that from Mycobacterium tuberculosis and vice versa
additional information
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deletion of the nat gene causes an extended lag phase in strain BCG and a cell morphology associated with an altered pattern of cell wall mycolates, overview
additional information
-
deletion of the NAT gene results in an increased sensitivity to isoniazid by up to 3fold. Furthermore, growth of NAT deleted strains is delayed, organisms become more susceptible to antibiotics such as gentamycin and the characteristic mycobacterial cell wall lipid components are not present. NAT gene is essential for survival of Mycobacterium bovis within macrophage
additional information
-
effect of deleting NAT gene: slows growth, increases sensitivity to isoniazid, changes colony morphology, reduces the thickness of the cell wall of individual cells, decreases mycolic acid and complex lipids but not phosholipids, leads to intracellular killing of Mycobacterium bovis in macrophages
additional information
deletion of the NAT gene results in an increased sensitivity to isoniazid by up to 3fold. Furthermore, growth of NAT deleted strains is delayed, organisms become more susceptible to antibiotics such as gentamycin and the characteristic mycobacterial cell wall lipid components are not present
additional information
-
deletion of the NAT gene results in an increased sensitivity to isoniazid by up to 3fold. Furthermore, growth of NAT deleted strains is delayed, organisms become more susceptible to antibiotics such as gentamycin and the characteristic mycobacterial cell wall lipid components are not present
additional information
overexpression in Mycobacterium bovis results in a decreased susceptibility to isoniazid in the slow growing mycobacterium
additional information
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overexpression in Mycobacterium bovis results in a decreased susceptibility to isoniazid in the slow growing mycobacterium
additional information
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construction of a chromosomal knockout mutant of wbpD is incapable of producing either long-chain B-band O antigen, with 2 or more repeating units, or semi-rough LPS, i.e. lipid A-core + one repeat, adding wbpD in trans restores LPS production to the wild-type level, overview
additional information
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truncation mutants with either C-terminal undecapeptide or C-terminal 85 amino acids missing, in contrast to complete protein, mutants hydrolyse acetyl-CoA even in the absence of arylamine substrate
additional information
construction of a natA disruption mutant that is catalytically inactive
additional information
-
construction of a natA disruption mutant that is catalytically inactive
additional information
-
construction of a natA disruption mutant that is catalytically inactive
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