2.3.1.5: arylamine N-acetyltransferase
This is an abbreviated version!
For detailed information about arylamine N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.5
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2.3.1.5
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pineal
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melatonin
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rhythm
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circadian
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n-acetylation
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retina
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2-aminofluorene
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night
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p-aminobenzoic
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nocturnal
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arylalkylamine
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n-acetylserotonin
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hydrazine
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medicine
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diurnal
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isoniazid
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light-dark
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aa-nat
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paba
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pinealocytes
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nighttime
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hydroxyindole-o-methyltransferase
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sulfamethazine
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hiomt
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accoa
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xenobiotic-metabolizing
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monomorphic
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daytime
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quinpirole
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tryptamine
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anti-tubercular
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pharmacology
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sulpiride
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light-exposed
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analysis
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molecular biology
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n-hydroxylated
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drug development
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midnight
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p-aminosalicylic
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o-acetyltransferase
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n-hydroxyarylamine
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spiroperidol
- 2.3.1.5
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pineal
- melatonin
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rhythm
-
circadian
-
n-acetylation
- retina
- 2-aminofluorene
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night
-
p-aminobenzoic
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nocturnal
- arylalkylamine
- n-acetylserotonin
- hydrazine
- medicine
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diurnal
- isoniazid
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light-dark
- aa-nat
- paba
- pinealocytes
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nighttime
- hydroxyindole-o-methyltransferase
- sulfamethazine
- hiomt
- accoa
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xenobiotic-metabolizing
-
monomorphic
-
daytime
- quinpirole
- tryptamine
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anti-tubercular
- pharmacology
- sulpiride
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light-exposed
- analysis
- molecular biology
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n-hydroxylated
- drug development
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midnight
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p-aminosalicylic
- o-acetyltransferase
- n-hydroxyarylamine
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spiroperidol
Reaction
Synonyms
(BACAN)NAT3, (MYCAB)NAT1, 2-naphthylamine N-acetyltransferase, 4-aminobiphenyl N-acetyltransferase, ABW01_24350, acetyl CoA-arylamine N-acetyltransferase, acetyltransferase, 2-naphthylamine N-, acetyltransferase, 4-aminobiphenyl, acetyltransferase, arylamine, acetyltransferase, p-aminosalicylate N-, acetyltransferase, procainamide N-, acetyltransferase, serotonin N-, arylamine acetylase, arylamine acetyltransferase, arylamine N-acetyl transferase, arylamine N-acetyltransferase, arylamine N-acetyltransferase 1, arylamine N-acetyltransferase 2, arylamine N-acetyltransferase C, arylamine N-acetyltransferase I, arylamine N-acetyltransferase type 1, arylamine N-acetyltransferase type 2, arylamine N-acetyltransferase type I, arylamine-N-acetyltransferase 1, BanatA, BanatB, BanatC, beta-naphthylamine N-acetyltransferase, indoleamine N-acetyltransferase, MlNAT1, MMNAT, More, MSNAT, N-acetyltransferase, N-acetyltransferase a, N-acetyltransferase b, N-acetyltransferase type 2, N-hydroxyarylamine O-acetyltransferase, NAT, NAT 1, NAT-a, NAT-b, NAT1, NAT2, NAT2*1, NAT2*2, NAT3, NAT31, NfNAT, p-aminosalicylate N-acetyltransferase, PANAT, rhesus NAT2, serotonin acetyltransferase, serotonin N-acetyltransferase, STNAT, TBNAT, Tpau_4046, UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid 3-N-acetyltransferase, UDP-D-Glc(2NAc3N)A 3-N-acetyltransferase, WbpD
ECTree
2.3.1.5 arylamine N-acetyltransferaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 2.3.1.5 - arylamine N-acetyltransferase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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presence of isoform Nat1. Exposure of cells to pathophysiologically relevant amounts of oxidants such as H2O2 or peroxyntrite, impairs the cellular biotransformation of aromatic amines
NAT1-specific protein expression is higher in CD3+ cells than in CD19 or CD56 cells
NAT1-specific protein expression is higher in CD3+ cells than in CD19 or CD56 cells
NAT1-specific protein expression is higher in CD3+ cells than in CD19 or CD56 cells
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expressed in placenta during the first trimester of embryonic development
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both NAT2 mRNA and enzyme are readily detected in fetal, newborn, and adult muscles. High expression in fetal muscle. Despite the presence of its mRNA, NAT2 enzyme level is below the limit of detection
additional information
NAT1 expression is up-regulated by synthetic androgen R1881 in androgen receptor (AR)-positive prostate lines 22Rv1. Androgen up-regulation of NAT1 is prevented by the androgen antagonist flutamide
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type II alveolar cell, presence of isoform Nat1. Exposure of cells to pathophysiologically relevant amounts of oxidants such as H2O2 or peroxyntrite, impairs the cellular biotransformation of aromatic amines
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type II alveolar cell, presence of isoform Nat2. Exposure of cells to pathophysiologically relevant amounts of oxidants such as H2O2 or peroxyntrite, impairs the cellular biotransformation of aromatic amines
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methylation status and the transcriptional activity of NAT1 in breast cancer tissues: methylation of NAT1 gene is identified in 39 of the breast carcinomas (54.2%), 23 normal (76.7%) and 25 benign breast tissue samples (80.6%). Breast cancer tissues show significantly lower methylation rates of the NAT1 promoters than the normal and benign tissues. Cancer tissues show lower methylation density rates than normal and benign breast tissues. Tissues that show aberrant methylation of NAT1 show significantly less mRNA expression compared with the unmethylated cases. 20 cancers from the methylated group show positive staining for the estrogen receptor (ER) (51.3%), while 72.7% from the unmethylated group stain positive
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NAT1 is overexpressed in estrogen receptor-positive breast cancer
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presence of isoform Nat1. Exposure of cells to pathophysiologically relevant amounts of oxidants such as H2O2 or peroxyntrite, impairs the cellular biotransformation of aromatic amines
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presence of isoform Nat2. Exposure of cells to pathophysiologically relevant amounts of oxidants such as H2O2 or peroxyntrite, impairs the cellular biotransformation of aromatic amines
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breast cancer cell line, estrogen receptor (ER)-negative, expression below detection limits in Western blot analysis
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cytokine treatment and S-nitroso-glutathione treatment of cholangiocarcinoma KKU-100 cells induces a decreased NAT1 mRNA expression
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NAT activity is detected in human embryos from first prenatal trimester
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in mouse embryos of transgenic mice bearing a lacZ transgene expression of NAT2 is detected in ensory epithelia, epithelial placodes giving rise to visceral sensory neurons, the developing pituitary gland, sympathetic chain and urogenital ridge. Nat2 is active in these tissues
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in mouse embryos of transgenic mice bearing a lacZ transgene expression of NAT2 is detected in sensory epithelia, epithelial placodes giving rise to visceral sensory neurons, the developing pituitary gland, sympathetic chain and urogenital ridge. Nat2 is active in these tissues
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presence of isoform Nat1. Exposure of cells to pathophysiologically relevant amounts of oxidants such as H2O2 or peroxyntrite, impairs the cellular biotransformation of aromatic amines
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presence of isoform Nat2. Exposure of cells to pathophysiologically relevant amounts of oxidants such as H2O2 or peroxyntrite, impairs the cellular biotransformation of aromatic amines
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Nat2 expression is both temporally and spatially regulated during development. In neonatal mice, cardiac Nat2 expression is most extensive in the central fibrous body and is evident in the atrioventricular valves and the valves of the great vessels. Nat2 expression is not detected in ventricular myocardial cells. Nat2 is strongly expressed in scattered cells in the region of the sinus node, the epicardium of the right atrial appendage, and in the pulmonary artery. Expression of active NAT2 protein is maximal when the developing heart attains the adult circulation pattern and moves from metabolizing glucose to fatty acids
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the hepatoma-derived cell line expresses a high level of P3 mRNA with the same spliced structure and start site pattern as found in normal tissues
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breast cancer cell line, estrogen receptor (ER)-positive, expression below detection limits in Western blot analysis
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breast cancer cell line, estrogen receptor (ER)-negative, expression below detection limits in Western blot analysis
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breast cancer cell line, estrogen receptor (ER)-negative, expression below detection limits in Western blot analysis
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breast cancer cell line, estrogen receptor (ER)-negative, expression below detection limits in Western blot analysis
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NAT-1 mRNA expression is found in 9 of 10 donors
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NAT-2 mRNA expression weaker thn NAT-1 mRNA expression
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NAT-1 mRNA expression is found in 5 of 7 examined individuals
NAT1 is strongly localized to androgen-positive epithelium in human prostate
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breast cancer cell line, estrogen receptor (ER)-positive, expression below detection limits in Western blot analysis
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breast cancer cell line, estrogen receptor (ER)-positive, strong expression in Western blot analysis
additional information
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isozyme NAT1 tissue-specific expression, analysis, overview
additional information
no isozyme NAT2 activity in cholangiocarcinoma cells
additional information
no isozyme NAT2 activity in cholangiocarcinoma cells
additional information
broad tissue distribution of isozyme NAT1, tissue-specific expression analysis of isozyme NAT1
additional information
broad tissue distribution of isozyme NAT1, tissue-specific expression analysis of isozyme NAT1
additional information
broad tissue distribution of isozyme NAT2, tissue-specific expression analysis of isozymes NAT2
additional information
broad tissue distribution of isozyme NAT2, tissue-specific expression analysis of isozymes NAT2
