2.3.1.5: arylamine N-acetyltransferase
This is an abbreviated version!
For detailed information about arylamine N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.5
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2.3.1.5
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pineal
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melatonin
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rhythm
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circadian
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n-acetylation
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retina
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2-aminofluorene
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night
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p-aminobenzoic
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nocturnal
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arylalkylamine
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n-acetylserotonin
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hydrazine
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medicine
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diurnal
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isoniazid
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light-dark
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aa-nat
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paba
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pinealocytes
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nighttime
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hydroxyindole-o-methyltransferase
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sulfamethazine
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hiomt
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accoa
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xenobiotic-metabolizing
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monomorphic
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daytime
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quinpirole
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tryptamine
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anti-tubercular
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pharmacology
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sulpiride
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light-exposed
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analysis
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molecular biology
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n-hydroxylated
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drug development
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midnight
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p-aminosalicylic
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o-acetyltransferase
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n-hydroxyarylamine
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spiroperidol
- 2.3.1.5
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pineal
- melatonin
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rhythm
-
circadian
-
n-acetylation
- retina
- 2-aminofluorene
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night
-
p-aminobenzoic
-
nocturnal
- arylalkylamine
- n-acetylserotonin
- hydrazine
- medicine
-
diurnal
- isoniazid
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light-dark
- aa-nat
- paba
- pinealocytes
-
nighttime
- hydroxyindole-o-methyltransferase
- sulfamethazine
- hiomt
- accoa
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xenobiotic-metabolizing
-
monomorphic
-
daytime
- quinpirole
- tryptamine
-
anti-tubercular
- pharmacology
- sulpiride
-
light-exposed
- analysis
- molecular biology
-
n-hydroxylated
- drug development
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midnight
-
p-aminosalicylic
- o-acetyltransferase
- n-hydroxyarylamine
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spiroperidol
Reaction
Synonyms
(BACAN)NAT3, (MYCAB)NAT1, 2-naphthylamine N-acetyltransferase, 4-aminobiphenyl N-acetyltransferase, ABW01_24350, acetyl CoA-arylamine N-acetyltransferase, acetyltransferase, 2-naphthylamine N-, acetyltransferase, 4-aminobiphenyl, acetyltransferase, arylamine, acetyltransferase, p-aminosalicylate N-, acetyltransferase, procainamide N-, acetyltransferase, serotonin N-, arylamine acetylase, arylamine acetyltransferase, arylamine N-acetyl transferase, arylamine N-acetyltransferase, arylamine N-acetyltransferase 1, arylamine N-acetyltransferase 2, arylamine N-acetyltransferase C, arylamine N-acetyltransferase I, arylamine N-acetyltransferase type 1, arylamine N-acetyltransferase type 2, arylamine N-acetyltransferase type I, arylamine-N-acetyltransferase 1, BanatA, BanatB, BanatC, beta-naphthylamine N-acetyltransferase, indoleamine N-acetyltransferase, MlNAT1, MMNAT, More, MSNAT, N-acetyltransferase, N-acetyltransferase a, N-acetyltransferase b, N-acetyltransferase type 2, N-hydroxyarylamine O-acetyltransferase, NAT, NAT 1, NAT-a, NAT-b, NAT1, NAT2, NAT2*1, NAT2*2, NAT3, NAT31, NfNAT, p-aminosalicylate N-acetyltransferase, PANAT, rhesus NAT2, serotonin acetyltransferase, serotonin N-acetyltransferase, STNAT, TBNAT, Tpau_4046, UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid 3-N-acetyltransferase, UDP-D-Glc(2NAc3N)A 3-N-acetyltransferase, WbpD
ECTree
2.3.1.5 arylamine N-acetyltransferaseAdvanced search results
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results (Activating Compound
Activating Compound on EC 2.3.1.5 - arylamine N-acetyltransferase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
R1881
the androgen R1881 induces NAT1 activity in androgen receptor-positive prostate cancer cells
5-methoxypsoralen
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i.e. 5-MOP, activates the enzyme at 50 mM in Colo 205 cells, inhibitory at lower dosage of 0.05-0.5 mM in Colo 205 cells and at 0.5-0.25 mM in SC-M1 cells, concentrations of 5-25 mM have no effect in Colo 205 cells
5-methoxypsoralen
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i.e. 5-MOP, activates the enzyme at 50 mM and the further metabolism of the product of the enzyme catalytic reaction 2-acetylaminofluorene in the stomach and colon
additional information
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the androgen R1881 induces the enzyme about 4.5fold in androgen receptor AR-positive prostate cell lines 22Rv1 and LNCaP, but not in the AR-negative PC-3, HK-293, or HeLa cells, androgen up-regulation of NAT1 is prevented by the AR antagonist flutamide, the effect of R1881 may not be by direct transcriptional activation of NAT1, overview
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additional information
the androgen R1881 induces the enzyme about 4.5fold in androgen receptor AR-positive prostate cell lines 22Rv1 and LNCaP, but not in the AR-negative PC-3, HK-293, or HeLa cells, androgen up-regulation of NAT1 is prevented by the AR antagonist flutamide, the effect of R1881 may not be by direct transcriptional activation of NAT1, overview
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additional information
the activity of NAT1 in cell culture does not change when cells are stimulated with different concentrations of sirtuin agonist resveratrol, compared to cells in culture medium. NAT2 metabolizing capacity increases significantly when sirtuins are inhibited with nicotinamide
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additional information
the activity of NAT1 in cell culture does not change when cells are stimulated with different concentrations of sirtuin agonist resveratrol, compared to cells in culture medium. NAT2 metabolizing capacity increases significantly when sirtuins are inhibited with nicotinamide
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additional information
the activity of NAT1 in cell culture does not change when cells are stimulated with different concentrations of sirtuin agonist resveratrol, compared to cells in culture medium. No effect on NAT1 activity is observed when sirtuins are inhibited with different concentrations of nicotinamide for 24 h
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additional information
the activity of NAT1 in cell culture does not change when cells are stimulated with different concentrations of sirtuin agonist resveratrol, compared to cells in culture medium. No effect on NAT1 activity is observed when sirtuins are inhibited with different concentrations of nicotinamide for 24 h
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