2.3.1.5: arylamine N-acetyltransferase
This is an abbreviated version!
For detailed information about arylamine N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.5
-
2.3.1.5
-
pineal
-
melatonin
-
rhythm
-
circadian
-
n-acetylation
-
retina
-
2-aminofluorene
-
night
-
p-aminobenzoic
-
nocturnal
-
arylalkylamine
-
n-acetylserotonin
-
hydrazine
-
medicine
-
diurnal
-
isoniazid
-
light-dark
-
aa-nat
-
paba
-
pinealocytes
-
nighttime
-
hydroxyindole-o-methyltransferase
-
sulfamethazine
-
hiomt
-
accoa
-
xenobiotic-metabolizing
-
monomorphic
-
daytime
-
quinpirole
-
tryptamine
-
anti-tubercular
-
pharmacology
-
sulpiride
-
light-exposed
-
analysis
-
molecular biology
-
n-hydroxylated
-
drug development
-
midnight
-
p-aminosalicylic
-
o-acetyltransferase
-
n-hydroxyarylamine
-
spiroperidol
- 2.3.1.5
-
pineal
- melatonin
-
rhythm
-
circadian
-
n-acetylation
- retina
- 2-aminofluorene
-
night
-
p-aminobenzoic
-
nocturnal
- arylalkylamine
- n-acetylserotonin
- hydrazine
- medicine
-
diurnal
- isoniazid
-
light-dark
- aa-nat
- paba
- pinealocytes
-
nighttime
- hydroxyindole-o-methyltransferase
- sulfamethazine
- hiomt
- accoa
-
xenobiotic-metabolizing
-
monomorphic
-
daytime
- quinpirole
- tryptamine
-
anti-tubercular
- pharmacology
- sulpiride
-
light-exposed
- analysis
- molecular biology
-
n-hydroxylated
- drug development
-
midnight
-
p-aminosalicylic
- o-acetyltransferase
- n-hydroxyarylamine
-
spiroperidol
Reaction
Synonyms
(BACAN)NAT3, (MYCAB)NAT1, 2-naphthylamine N-acetyltransferase, 4-aminobiphenyl N-acetyltransferase, ABW01_24350, acetyl CoA-arylamine N-acetyltransferase, acetyltransferase, 2-naphthylamine N-, acetyltransferase, 4-aminobiphenyl, acetyltransferase, arylamine, acetyltransferase, p-aminosalicylate N-, acetyltransferase, procainamide N-, acetyltransferase, serotonin N-, arylamine acetylase, arylamine acetyltransferase, arylamine N-acetyl transferase, arylamine N-acetyltransferase, arylamine N-acetyltransferase 1, arylamine N-acetyltransferase 2, arylamine N-acetyltransferase C, arylamine N-acetyltransferase I, arylamine N-acetyltransferase type 1, arylamine N-acetyltransferase type 2, arylamine N-acetyltransferase type I, arylamine-N-acetyltransferase 1, BanatA, BanatB, BanatC, beta-naphthylamine N-acetyltransferase, indoleamine N-acetyltransferase, MlNAT1, MMNAT, More, MSNAT, N-acetyltransferase, N-acetyltransferase a, N-acetyltransferase b, N-acetyltransferase type 2, N-hydroxyarylamine O-acetyltransferase, NAT, NAT 1, NAT-a, NAT-b, NAT1, NAT2, NAT2*1, NAT2*2, NAT3, NAT31, NfNAT, p-aminosalicylate N-acetyltransferase, PANAT, rhesus NAT2, serotonin acetyltransferase, serotonin N-acetyltransferase, STNAT, TBNAT, Tpau_4046, UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid 3-N-acetyltransferase, UDP-D-Glc(2NAc3N)A 3-N-acetyltransferase, WbpD
ECTree
2.3.1.5 arylamine N-acetyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.1.5 - arylamine N-acetyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3'-dephospho-acetyl-CoA + 4-aminobenzoate
3'-dephospho-CoA + N-acetyl-4-aminobenzoate
-
-
-
-
?
4-nitrophenyl acetate + 3,4-dichloroaniline
4-nitrophenol + N-acetyl-3,4-dichloroaniline
-
-
-
?
4-nitrophenyl acetate + 4-amino-3-methylbenzoic acid
4-nitrophenol + N-acetyl-4-amino-3-methylbenzoic acid
4-nitrophenyl acetate + 4-aminobenzoate
4-nitrophenol + N-acetyl-4-aminobenzoate
-
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoate
-
-
-
-
?
4-nitrophenyl acetate + 4-aminosalicylate
4-nitrophenol + N-acetyl-4-aminosalicylate
-
-
-
?
4-nitrophenyl acetate + 4-anisidine
4-nitrophenol + N-acetyl-4-anisidine
-
-
-
-
?
4-nitrophenyl acetate + 4-nitroaniline
4-nitrophenol + N-acetyl-4-nitroaniline
-
-
-
?
4-nitrophenyl acetate + 5-aminosalicylic acid
4-nitrophenol + 5-acetylaminosalicylic acid
-
-
-
?
4-nitrophenyl acetate + 5-aminosalicylic acid
4-nitrophenol + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
4-nitrophenyl acetate + aniline
4-nitrophenol + N-acetyl-aniline
-
-
-
-
?
4-nitrophenyl acetate + isoniazid
4-nitrophenol + N-acetyl-isoniazid
-
-
-
-
?
4-nitrophenyl acetate + isoniazid
4-nitrophenol + N-acetylisoniazid
-
-
-
?
4-nitrophenyl acetate + N-(4-aminobenzoyl)-L-glutamate
4-nitrophenol + N-(4-acetylaminobenzoyl)-L-glutamate
a protein + 1-[4-[(6-azidohexyl)oxy]phenyl]-1-hydroxypropan-2-one
?
-
-
-
?
a protein + 5-azido-N-[[4-(1-hydroxy-2-oxopropyl)phenyl]methyl]pentanamide
?
-
-
-
?
a protein + N-(5-azidopentyl)-4-(1-hydroxy-2-oxopropyl)benzamide
?
-
-
-
?
acetyl-CoA + (1-methyl-5-piperazin-1-yl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-(5-methyl-pyridin-2-yl)-amine
CoA + ?
acetyl-CoA + 2-amino-4-chlorophenol
CoA + 2-acetylamino-4-chlorophenol
-
-
-
?
acetyl-CoA + 2-amino-4-chlorophenol
CoA + N-(5-chloro-2-hydroxyphenyl)acetamide
-
-
-
-
?
acetyl-CoA + 2-amino-4-chlorophenol
CoA + N-acetyl-2-amino-4-chlorophenol
-
-
-
-
?
acetyl-CoA + 2-amino-4-methylphenol
CoA + 2-acetylamino-4-methylphenol
best substrate
-
-
?
acetyl-CoA + 2-amino-4-methylphenol
CoA + N-(2-hydroxy-5-methylphenyl)acetamide
-
-
-
-
?
acetyl-CoA + 2-amino-4-methylphenol
CoA + N-acetyl-2-amino-4-methylphenol
-
-
-
-
?
acetyl-CoA + 2-aminobenzoic acid
CoA + N-acetylanthranilate
-
i.e. anthranilate, ir
-
ir
acetyl-CoA + 2-aminophenol
CoA + N-(2-hydroxyphenyl)acetamide
-
-
-
-
?
acetyl-CoA + 3,4-dichloraniline
CoA + N-acetyl-3,4-dichloraniline
-
-
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzenesulfonic acid
CoA + 3-acetylamino-4-hydroxybenzenesulfonic acid
-
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzoic acid
CoA + 3-(acetylamino)-4-hydroxybenzoic acid
-
-
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzoic acid
CoA + N-acetyl-3-amino-4-hydroxybenzoic acid
-
-
-
-
?
acetyl-CoA + 3-chloraniline
CoA + N-acetyl-3-chloroaniline
-
relative activity: 48%
-
-
?
acetyl-CoA + 4,4'-methylenebis(2-chloroaniline)
CoA + N-acetyl-4,4'-methylenebis(2-chloroaniline)
acetyl-CoA + 4,4'-methylenedianiline
CoA + N-acetyl-4,4'-methylenedianiline
-
-
-
?
acetyl-CoA + 4-amino-3-hydroxybenzoic acid
CoA + 4-(acetylamino)-3-hydroxybenzoic acid
-
-
-
-
?
acetyl-CoA + 4-amino-3-hydroxybenzoic acid
CoA + 4-acetylamino-3-hydroxybenzoic acid
low activity
-
-
?
acetyl-CoA + 4-amino-3-hydroxybenzoic acid
CoA + N-acetyl-4-amino-3-hydroxybenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminoacetanilide
CoA + N-acetyl-4-aminoacetanilide
-
relative activity: 0%
-
-
?
acetyl-CoA + 4-aminobenzoyl-L-glutamate
CoA + 4-acetylaminobenzoyl-L-glutamate
-
-
-
-
?
acetyl-CoA + 4-aminobenzoyl-L-glutamate
CoA + N-acetyl-4-aminobenzoyl-L-glutamate
-
-
-
-
?
acetyl-CoA + 4-aminobenzoyl-L-glutamic acid
CoA + 4-acetylaminobenzoyl-L-glutamic acid
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylate
-
-
-
-
?
acetyl-CoA + 4-chlorobenzoic hydrazide
CoA + N'-acetyl-(4-chlorobenzo)-hydrazide
-
-
-
?
acetyl-CoA + 4-dimethylaminobenzaldehyde
CoA + 5-acetyl-4-dimethylaminobenzaldehyde
-
-
-
?
acetyl-CoA + 4-fluoroaniline
CoA + N-(4-fluorophenyl)acetamide
-
-
-
-
?
acetyl-CoA + 4-fluoroaniline
CoA + N-acetyl-4-fluoroaniline
-
-
-
-
?
acetyl-CoA + 4-hydroxybenzhydrazide
CoA + N'-acetyl-4-hydroxybenzohydrazide
-
-
-
-
?
acetyl-CoA + 4-hydroxybenzhydrazide
CoA + N-acetyl-4-hydroxybenzhydrazide
-
-
-
-
?
acetyl-CoA + 4-methoxyphenylhydrazine
CoA + N'-(4-methoxyphenyl)acetohydrazide
-
-
-
-
?
acetyl-CoA + 4-methoxyphenylhydrazine
CoA + N-acetyl-4-methoxyphenylhydrazine
-
-
-
-
?
acetyl-CoA + 4-methylaniline
CoA + N-(4-methylphenyl)acetamide
-
-
-
-
?
acetyl-CoA + 4-trifluoromethylaniline
CoA + N-acetyl-4-trifluoromethylaniline
-
-
-
-
?
acetyl-CoA + 8-aminoisoindolo (1,2-b)quinazolin-12(10H)-one
?
-
batricylin, an antitumor agent, is shown to be a substrate for NAT2
-
-
?
acetyl-CoA + anisidine
CoA + N-(4-methoxyphenyl)acetamide
-
-
-
-
?
acetyl-CoA + benzoic acid hydrazide
CoA + N'-acetylbenzohydrazide
-
-
-
-
?
acetyl-CoA + benzoic acid hydrazide
CoA + N-acetyl-benzoic acid hydrazide
-
-
-
-
?
acetyl-CoA + beta-naphthylamine
CoA + N-acetyl-beta-naphthylamine
-
-
-
?
acetyl-CoA + diaminodiphenylsulfone
monoacetyldiaminodiphenylsulfone + CoA
-
i.e. dapsone, predominantly acetylated by NAT2
-
-
?
acetyl-CoA + hydralazine
CoA + N'-phthalazin-1-ylacetohydrazide
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N'-acetylpyridine-4-carbohydrazide
-
-
-
-
?
acetyl-CoA + N,N-1,4-phenylenediamine
CoA + ?
-
relative activity: 100%
-
-
?
acetyl-CoA + N-(4-acetylaminobenzoyl)-L-glutamate
CoA + 4-acetylaminobenzoyl-L-glutamate
-
-
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
?
acetyl-CoA + N-hydroxy-4-aminobiphenyl
N-acetyl-N-hydroxy-4-aminobiphenyl + CoA
substrate of isozyme NAT2 in liver cytosol
-
-
?
acetyl-CoA + nicotinic acid hydrazide
CoA + N'-acetylpyridine-3-carbohydrazide
-
-
-
-
?
acetyl-CoA + nicotinic acid hydrazide
CoA + N-acetyl-nicotinic acid hydrazide
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + 4-(acetylamino)benzoic acid
-
-
-
-
?
acetyl-CoA + phenylhydrazine
CoA + N-acetyl-phenylhydrazine
-
low specific activity
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl- procainamide
-
low specific activity
-
-
?
acetyl-CoA + sulfamethoxazole
CoA + N-[4-[(5-methylisoxazol-3-yl)sulfamoyl]phenyl]acetamide
-
-
-
-
?
acetyl-CoA + sulphamethoxazole
CoA + N-acetylsulphamethoxazole
-
-
-
-
?
acetyl-CoA + sulphisoxazole
CoA + 4-acetylamino-N-(3,4-dimethylisoxazol-5-yl)-benzenesulfonamide
-
-
-
-
?
acetyl-CoA + tetradecylamine
CoA + N-acetyltetradecylamine
-
-
-
-
?
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid
CoA + UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronic acid
malonyl-CoA + 5-aminosalicylate
CoA + N-malonyl-5-aminosalicylate
malonyl-CoA again is the preferred donor substrate
-
-
?
N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene
CoA + ?
-
much better acetyl donor for NAT1 than for NAT2
-
-
?
p-nitrophenyl acetate + 2-aminofluorene
p-nitrophenol + N-acetyl-2-aminofluorene
-
-
-
-
?
p-nitrophenyl acetate + 5-aminosalicylic acid
p-nitrophenol + 5-acetylaminosalicylic acid
-
-
-
-
?
p-nitrophenyl acetate + aniline
p-nitrophenol + N-acetyl-aniline
-
-
-
-
?
p-nitrophenyl acetate + hydralazine
p-nitrophenol + N-acetyl-hydralazine
-
-
-
-
?
p-nitrophenyl acetate + isoniazid
p-nitrophenol + N-acetyl-isoniazid
-
-
-
-
?
p-nitrophenyl acetate + p-aminobenzoic acid
p-nitrophenol + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
p-nitrophenyl acetate + p-anisidine
p-nitrophenol + N-acetyl-4-anisidine
-
-
-
-
?
p-nitrophenylacetate + 5-aminosalicylic acid
4-nitrophenol + N-acetyl-5-aminosalicylate
-
-
-
-
?
propionyl-CoA + 5-aminosalicylate
CoA + N-propionyl-5-aminosalicylate
-
-
-
?
succinyl-CoA + 5-aminosalicylate
CoA + N-succinyl-5-aminosalicylate
-
-
-
?
sulphamethazine + acetyl-CoA
N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]acetamide
-
-
-
?
4-nitrophenyl acetate + 2-aminofluorene
4-nitrophenol + N-acetyl-2-aminofluorene
-
-
-
?
4-nitrophenyl acetate + 2-aminofluorene
4-nitrophenol + N-acetyl-2-aminofluorene
-
-
-
-
?
4-nitrophenyl acetate + 2-aminofluorene
4-nitrophenol + N-acetyl-2-aminofluorene
-
-
-
-
?
4-nitrophenyl acetate + 4-amino-3-methylbenzoic acid
4-nitrophenol + N-acetyl-4-amino-3-methylbenzoic acid
-
-
-
?
4-nitrophenyl acetate + 4-amino-3-methylbenzoic acid
4-nitrophenol + N-acetyl-4-amino-3-methylbenzoic acid
substrate of isozyme NAT1
-
-
?
4-nitrophenyl acetate + 4-amino-3-methylbenzoic acid
4-nitrophenol + N-acetyl-4-amino-3-methylbenzoic acid
very low activity with isozyme NAT2
-
-
?
4-nitrophenyl acetate + 4-amino-3-methylbenzoic acid
4-nitrophenol + N-acetyl-4-amino-3-methylbenzoic acid
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
a sunscreen additive
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
substrate of isozyme NAT1
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
very low activity with isozyme NAT2
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
-
-
-
?
4-nitrophenyl acetate + 4-aminobenzoic acid
4-nitrophenol + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
4-nitrophenyl acetate + 4-aminobiphenyl
4-nitrophenol + N-acetyl-4-aminobiphenyl
a tobacco smoke carcinogen
-
-
?
4-nitrophenyl acetate + 4-aminobiphenyl
4-nitrophenol + N-acetyl-4-aminobiphenyl
substrate of isozyme NAT1
-
-
?
4-nitrophenyl acetate + 4-aminobiphenyl
4-nitrophenol + N-acetyl-4-aminobiphenyl
very low activity with isozyme NAT2
-
-
?
4-nitrophenyl acetate + 4-aminobiphenyl
4-nitrophenol + N-acetyl-4-aminobiphenyl
-
-
-
?
4-nitrophenyl acetate + anisidine
4-nitrophenol + N-acetyl-anisidine
-
-
-
-
?
4-nitrophenyl acetate + anisidine
4-nitrophenol + N-acetyl-anisidine
-
-
-
?
4-nitrophenyl acetate + hydralazine
4-nitrophenol + N-acetyl-hydralazine
-
-
-
?
4-nitrophenyl acetate + hydralazine
4-nitrophenol + N-acetyl-hydralazine
-
-
-
-
?
4-nitrophenyl acetate + N-(4-aminobenzoyl)-L-glutamate
4-nitrophenol + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
-
?
4-nitrophenyl acetate + N-(4-aminobenzoyl)-L-glutamate
4-nitrophenol + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
?
acetyl-CoA + (1-methyl-5-piperazin-1-yl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-(5-methyl-pyridin-2-yl)-amine
CoA + ?
-
i.e. UK-469,413. Acetylation by isozyme NAT2 in liver cytosol to N-acetylpiperazine metabolite
-
-
?
acetyl-CoA + (1-methyl-5-piperazin-1-yl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-(5-methyl-pyridin-2-yl)-amine
CoA + ?
-
i.e. UK-469,413. Rapid acetylation in liver cytosol to N-acetylpiperazine metabolite
-
-
?
acetyl-CoA + 2-(4-aminobenzamido)pyridine
CoA + 2-(4-acetylamidobenzamido)pyridine
-
-
-
-
?
acetyl-CoA + 2-(4-aminobenzamido)pyridine
CoA + 2-(4-acetylamidobenzamido)pyridine
-
-
-
-
?
acetyl-CoA + 2-(4-aminobenzamido)pyridine
CoA + 2-(4-acetylamidobenzamido)pyridine
-
-
-
-
?
acetyl-CoA + 2-(4-aminobenzamido)pyridine
CoA + 2-(4-acetylamidobenzamido)pyridine
-
-
-
-
?
acetyl-CoA + 2-aminobenzoic acid
CoA + N-acetyl-2-aminobenzoic acid
-
relative activity: 0%
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
N-acetyltransferase 2
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
interactions and substrate binding structure, overview
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
NAT1, poor substrate
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + 2-acetylaminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
high specific activity
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
mutant Y71F, 128% of wild-type activity, mutant M209T, 62% of wild-type activity
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
Mycobacteroides abscessus CIP 104536T
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
-
-
-
-
?
acetyl-CoA + 2-aminofluorene
CoA + N-acetyl-2-aminofluorene
Vibrio cholerae serotype O1 54.315
-
-
-
-
?
acetyl-CoA + 2-aminophenol
CoA + 2-acetylaminophenol
-
-
-
?
acetyl-CoA + 2-aminophenol
CoA + N-acetyl-2-aminophenol
-
relative activity: 36%
-
-
?
acetyl-CoA + 2-aminophenol
CoA + N-acetyl-2-aminophenol
-
relative activity: 72%
-
-
?
acetyl-CoA + 2-chloroaniline
CoA + N-acetyl-2-chloroaniline
-
relative activity: 12%
-
-
?
acetyl-CoA + 2-chloroaniline
CoA + N-acetyl-2-chloroaniline
-
relative activity: 18%
-
-
?
acetyl-CoA + 2-nitroaniline
CoA + N-acetyl-2-nitroaniline
-
relative activity: 0%
-
-
?
acetyl-CoA + 2-nitroaniline
CoA + N-acetyl-2-nitroaniline
-
relative activity: 3%
-
-
?
acetyl-CoA + 2-toluidine
CoA + N-acetyl-2-toluidine
-
relative activity: 0%
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)acetamide
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-(3,4-dichlorophenyl)acetamide
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-acetyl-3,4-dichloroaniline
-
mutant Y71F, 194% of wild-type activity, mutant M209T, 88% of wild-type activity
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-acetyl-3,4-dichloroaniline
-
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-acetyl-3,4-dichloroaniline
-
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-acetyl-3,4-dichloroaniline
Mycobacteroides abscessus CIP 104536T
-
-
-
-
?
acetyl-CoA + 3,4-dichloroaniline
CoA + N-acetyl-3,4-dichloroaniline
-
-
-
-
?
acetyl-CoA + 3,5-dimethylaniline
CoA + N-acetyl-3,5-dimethylaniline
-
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzaldehyde
CoA + 3-acetylamino-4-hydroxybenzaldehyde
-
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzaldehyde
CoA + 3-acetylamino-4-hydroxybenzaldehyde
an intermediate of grixazone synthesis
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzaldehyde
CoA + 3-acetylamino-4-hydroxybenzaldehyde
-
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzaldehyde
CoA + 3-acetylamino-4-hydroxybenzaldehyde
an intermediate of grixazone synthesis
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzoic acid
CoA + 3-acetylamino-4-hydroxybenzoic acid
best substrate
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzoic acid
CoA + 3-acetylamino-4-hydroxybenzoic acid
an intermediate of grixazone synthesis
-
-
?
acetyl-CoA + 3-amino-4-hydroxybenzoic acid
CoA + 3-acetylamino-4-hydroxybenzoic acid
best substrate
-
-
?
acetyl-CoA + 3-aminobenzoic acid
CoA + N-acetyl-3-aminobenzoic acid
-
relative activity: 105%
-
-
?
acetyl-CoA + 3-aminobenzoic acid
CoA + N-acetyl-3-aminobenzoic acid
-
relative activity: 122%
-
-
?
acetyl-CoA + 3-aminobenzoic acid
CoA + N-acetyl-3-aminobenzoic acid
-
relative activity: 105%
-
-
?
acetyl-CoA + 3-aminobenzoic acid
CoA + N-acetyl-3-aminobenzoic acid
-
relative activity: 122%
-
-
?
acetyl-CoA + 3-aminobenzoic acid
CoA + N-acetyl-3-aminobenzoic acid
-
-
-
?
acetyl-CoA + 3-aminophenol
CoA + N-acetyl-3-aminophenol
-
relative activity: 33%
-
-
?
acetyl-CoA + 3-aminophenol
CoA + N-acetyl-3-aminophenol
-
relative activity: 56%
-
-
?
acetyl-CoA + 3-nitroaniline
CoA + N-acetyl-3-nitroaniline
-
relative activity: 2%
-
-
?
acetyl-CoA + 3-nitroaniline
CoA + N-acetyl-3-nitroaniline
-
relative activity: 6%
-
-
?
acetyl-CoA + 3-toluidine
CoA + N-acetyl-3-toluidine
-
relative activity: 21%
-
-
?
acetyl-CoA + 3-toluidine
CoA + N-acetyl-3-toluidine
-
relative activity: 28%
-
-
?
acetyl-CoA + 4,4'-methylenebis(2-chloroaniline)
CoA + N-acetyl-4,4'-methylenebis(2-chloroaniline)
-
-
-
?
acetyl-CoA + 4,4'-methylenebis(2-chloroaniline)
CoA + N-acetyl-4,4'-methylenebis(2-chloroaniline)
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + 4-acetylaminobenzoate
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + 4-acetylaminobenzoate
-
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + N-acetyl-4-aminobenzoate
-
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + N-acetyl-4-aminobenzoate
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + N-acetyl-4-aminobenzoate
-
-
-
?
acetyl-CoA + 4-aminobenzoate
CoA + N-acetyl-4-aminobenzoate
6% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
N-acetyltransferase 1
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
poor
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
poor
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
the catalytic mechanism depends on the formation of a thiolate-imidazolium ion pair (Cys-S-)-(His-ImH+)
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + 4-acetylaminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoate
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoate
-
best substrate
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
relative activity: 19%
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
relative activity: 26%
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
isozyme NAT1
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
preferred substrate
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
high specific activity
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
?
acetyl-CoA + 4-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + 4-aminobiphenyl
CoA + N-acetyl-4-aminobiphenyl
-
-
-
?
acetyl-CoA + 4-aminobiphenyl
N-acetyl-4-aminobiphenyl + CoA
substrate of isozyme NAT2 in liver cytosol
-
-
?
acetyl-CoA + 4-aminobiphenyl
N-acetyl-4-aminobiphenyl + CoA
substrate of isozyme NAT2
-
-
?
acetyl-CoA + 4-aminophenol
?
-
-
-
-
?
acetyl-CoA + 4-aminophenol
CoA + N-acetyl-4-aminophenol
-
relative activity: 48%
-
-
?
acetyl-CoA + 4-aminophenol
CoA + N-acetyl-4-aminophenol
-
relative activity: 94%
-
-
?
acetyl-CoA + 4-aminopyridine
?
-
very low activity
-
-
?
acetyl-CoA + 4-aminosalicylate
CoA + N-acetyl-4-aminosalicylate
-
substrate for isoform NAT1
-
-
?
acetyl-CoA + 4-aminosalicylate
CoA + N-acetyl-4-aminosalicylate
-
-
-
?
acetyl-CoA + 4-aminosalicylate
CoA + N-acetyl-4-aminosalicylate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylate
CoA + N-acetyl-4-aminosalicylate
-
-
-
?
acetyl-CoA + 4-aminosalicylate
CoA + N-acetyl-4-aminosalicylate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
N-acetyltransferase 1
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + 4-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
relative activity: 100%
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
relative activity: 90%
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
high specific activity
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
mutant Y71F, 17% of wild-type activity, mutant M209T, 128% of wild-type activity
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 4-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
Vibrio cholerae serotype O1 54.315
-
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + 1,2-dimethoxy-4-acetylaminobenzene
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + 1,2-dimethoxy-4-acetylaminobenzene
-
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + 1,2-dimethoxy-4-acetylaminobenzene
-
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + N-acetyl-4-aminoveratrole
57% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + N-acetyl-4-aminoveratrole
-
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + N-acetyl-4-aminoveratrole
-
-
-
?
acetyl-CoA + 4-aminoveratrole
CoA + N-acetyl-4-aminoveratrole
-
-
-
-
?
acetyl-CoA + 4-anisidine
CoA + 4-methoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-anisidine
CoA + N-acetyl-4-anisidine
-
mutant Y71F, 860% of wild-type activity, mutant M209T, 673% of wild-type activity
-
-
?
acetyl-CoA + 4-bromoaniline
CoA + 4-bromoacetanilide
-
-
-
?
acetyl-CoA + 4-bromoaniline
CoA + 4-bromoacetanilide
-
-
-
-
?
acetyl-CoA + 4-bromoaniline
CoA + N-acetyl-4-bromoaniline
72% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-butoxyaniline
CoA + 4-butoxyacetanilide
-
-
-
?
acetyl-CoA + 4-butoxyaniline
CoA + 4-butoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-butoxyaniline
CoA + N-acetyl-4-butoxyaniline
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + 4-chloroacetanilide
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + 4-chloroacetanilide
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-(4-chlorophenyl)acetamide
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-(4-chlorophenyl)acetamide
-
-
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
-
relative activity: 18%
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
-
relative activity: 21%
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
71% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
-
mutant Y71F, 174% of wild-type activity, mutant M209T, 122% of wild-type activity
-
-
?
acetyl-CoA + 4-chloroaniline
CoA + N-acetyl-4-chloroaniline
-
-
-
-
?
acetyl-CoA + 4-chlorobenzoic hydrazide
?
-
-
-
-
?
acetyl-CoA + 4-chlorobenzoic hydrazide
CoA + N-acetyl-4-chlorobenzoic hydrazide
-
-
-
-
?
acetyl-CoA + 4-chlorobenzoic hydrazide
CoA + N-acetyl-4-chlorobenzoic hydrazide
-
-
-
-
?
acetyl-CoA + 4-ethoxyaniline
CoA + 4-ethoxyacetanilide
-
-
-
?
acetyl-CoA + 4-ethoxyaniline
CoA + 4-ethoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + 4-hexyloxyacetanilide
best substrate
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + 4-hexyloxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + N-acetyl-4-hexyloxyaniline
51% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + N-acetyl-4-hexyloxyaniline
-
-
-
-
?
acetyl-CoA + 4-hexyloxyaniline
CoA + N-acetyl-4-hexyloxyaniline
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + 4-iodoacetanilide
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + 4-iodoacetanilide
-
-
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
65% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
-
mutant Y71F, 196% of wild-type activity, mutant M209T, 83% of wild-type activity
-
-
?
acetyl-CoA + 4-iodoaniline
CoA + N-acetyl-4-iodoaniline
Mycobacteroides abscessus CIP 104536T
-
-
-
-
?
acetyl-CoA + 4-methoxyaniline
CoA + N-acetyl-4-methoxyaniline
9% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-methylaniline
CoA + N-acetyl-4-methylaniline
-
-
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
-
relative activity: 0%
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
-
relative activity: 0%
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
-
-
-
-
?
acetyl-CoA + 4-nitroaniline
CoA + N-acetyl-4-nitroaniline
-
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + 4-phenoxyacetanilide
-
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + 4-phenoxyacetanilide
-
-
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + N-acetyl-4-phenoxyaniline
62% activity compared to hydralazine
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + N-acetyl-4-phenoxyaniline
-
-
-
-
?
acetyl-CoA + 4-phenoxyaniline
CoA + N-acetyl-4-phenoxyaniline
-
-
-
-
?
acetyl-CoA + 4-toluidine
CoA + N-acetyl-4-toluidine
-
relative activity: 40%
-
-
?
acetyl-CoA + 4-toluidine
CoA + N-acetyl-4-toluidine
-
relative activity: 80%
-
-
?
acetyl-CoA + 4-trifluoromethylaniline
?
-
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + 5-acetylamino-2-hydroxybenzoate
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + 5-acetylamino-2-hydroxybenzoate
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + 5-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
64% activity compared to hydralazine
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
?
acetyl-CoA + 5-aminosalicylate
CoA + N-acetyl-5-aminosalicylate
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylamino-2-hydroxybenzoate
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylaminosalicylic acid
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylaminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylaminosalicylic acid
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + 5-acetylaminosalicylic acid
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
relative activity: 510%
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
relative activity: 550%
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
high specific activity
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
mutant Y71F, 147% of wild-type activity, mutant M209T, 21% of wild-type activity
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + 5-aminosalicylic acid
CoA + N-acetyl-5-aminosalicylic acid
Vibrio cholerae serotype O1 54.315
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
-
-
-
?
acetyl-CoA + 5-methoxytryptamine
CoA + N-acetyl-5-methoxytryptamine
-
poor substrate
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
constitutive enzyme
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
constitutive enzyme
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
involved in metabolism of drugs and endogenous substances containing an amine or hydrazine group
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
expression of NAT1 in muscle cells may be an important factor in the detoxification/activation process because of the potential involvement of the muscle in the pharmacokinetics of many xenobiotics
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
important role in detoxification and metabolic activation of a variety of aromatic xenobiotics, including numerous carcinogens. Cellular generation of peroxinitrite may contribute to carcinogenesis and tumor progression by weakening key cellular defense enzymes such as NAT1
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
constitutive enzyme
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
constitutive enzyme
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
pineal gland: inducible
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
constitutive enzyme
-
-
?
acetyl-CoA + an arylamine
CoA + a N-acetylarylamine
-
pineal gland: inducible
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
NAT2 is responsible for the biotransformation of numerous arylamine drugs and carcinogens
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
NATs are important enzymes involved in the metabolic activation of aromatic and heterocyclic amines
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
NATs are xenobiotic metabolizing enzymes responsible for the acetylation of many arylamine and heterocyclic amines, they therefore play an important role in the detoxification and activation of numerous drugs and carcinogens, regulation, overview
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
the enzyme is important for the activation and deactivation of exocyclic amine-containing pro-carcinogens, and for the metabolism of some pharmaceutical drugs
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
the enzyme catalyzes the N-acetylation of arylamines and hydrazines and O-acetylation of N-hydroxy-arylamines and heterocyclic amines
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
endogenous role of the enzyme in the protection of bacteria from aromatic and lipophilic toxins
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
catalytic pathway, overview
-
-
?
acetyl-CoA + an arylamine
CoA + an N-acetylarylamine
-
-
-
?
acetyl-CoA + an N-hydroxyarylamine
CoA + an N-acetoxyarylamine
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
poor substrate
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
not chicken pineal gland and brain
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + beta-phenylethylamine
CoA + N-(2-phenylethyl)-acetaminde
-
-
-
-
?
acetyl-CoA + histamine
CoA + N-acetylhistamine
-
-
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetyl-hydralazine
-
low specific activity
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetylhydralazine
-
substrate for isoform NAT2
-
-
?
acetyl-CoA + hydralazine
CoA + N-acetylhydralazine
-
-
-
?
acetyl-CoA + isoniazid
?
inactivation of the anti-tubercular drug isoniazid by acetyltransfer
-
-
?
acetyl-CoA + isoniazid
CoA + acetylniazide
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetyl-isoniazid
-
-
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetylisoniazid
62% activity compared to hydralazine
-
-
?
acetyl-CoA + isoniazid
CoA + N-acetylisoniazid
-
mutant Y71F, 102% of wild-type activity, mutant M209T, 229% of wild-type activity
-
-
?
acetyl-CoA + isoniazide
CoA + acetylniazide
-
-
-
-
?
acetyl-CoA + isoniazide
CoA + acetylniazide
-
i.e. isonicotinyl hydrazide
-
?
acetyl-CoA + isoniazide
CoA + acetylniazide
-
isoniazide binds the enzyme prior to acetyl-CoA
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
3% activity compared to hydralazine
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
substrate for isoform NAT1
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
-
?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
-
-
-
?
acetyl-CoA + N-hydroxy-4-aminobiphenyl
N-hydroxy-O-acetyl-4-aminobiphenyl + CoA
substrate of isozyme NAT2, O-acetylation activity of NAT2
-
-
?
acetyl-CoA + N-hydroxy-4-aminobiphenyl
N-hydroxy-O-acetyl-4-aminobiphenyl + CoA
O-acetylation activity
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
activity assay
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
in vitro N-acetylation assay
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-4-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
poor activity
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
-
-
-
-
?
acetyl-CoA + p-aminobenzoic acid
CoA + N-acetyl-p-aminobenzoic acid
Vibrio cholerae serotype O1 54.315
-
-
-
-
?
acetyl-CoA + p-aminobenzoylglutamate
CoA + N-[(4-acetylamino)]benzoyl-L-glutamate
-
-
-
-
?
acetyl-CoA + p-aminobenzoylglutamate
CoA + N-[(4-acetylamino)]benzoyl-L-glutamate
-
-
-
-
?
acetyl-CoA + p-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + p-aminosalicylic acid
CoA + N-acetyl-4-aminosalicylic acid
-
-
-
-
?
acetyl-CoA + p-phenetidine
CoA + N-(4-ethoxyphenyl)-acetamide
-
-
-
-
?
acetyl-CoA + p-phenetidine
CoA + N-(4-ethoxyphenyl)-acetamide
-
i.e. 4-ethoxybenzenamine, best substrate
-
-
?
acetyl-CoA + p-phenetidine
CoA + N-(4-ethoxyphenyl)-acetamide
-
-
-
-
?
acetyl-CoA + p-tyramine
CoA + N-acetyl-p-tyramine
-
ie. 4-(2-aminoethyl)phenol
-
-
?
acetyl-CoA + procainamide
?
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
lower activity
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetyl-2-procainamide
Vibrio cholerae serotype O1 54.315
-
-
-
-
?
acetyl-CoA + procainamide
CoA + N-acetylprocainamide
-
N-acetyltransferase 2
-
-
?
acetyl-CoA + serotonin
CoA + N-acetylserotonin
-
-
-
-
?
acetyl-CoA + sulfamethazine
?
-
very low activity
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-4-acetylsulfamethazine
-
N-acetyltransferase 2
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-4-acetylsulfamethazine
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-4-acetylsulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
relative activity: 0%
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
relative activity: 46%
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
isozyme NAT2
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
low specific activity
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetyl-sulfamethazine
-
-
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetylsulfamethazine
46% activity compared to hydralazine
-
-
?
acetyl-CoA + sulfamethazine
CoA + N-acetylsulfamethazine
-
-
-
?
acetyl-CoA + sulfamethoxazole
CoA + N-acetyl-sulfamethoxazole
-
-
-
?
acetyl-CoA + tryptamine
CoA + N-acetyltryptamine
-
not chicken pineal gland and brain
-
-
?
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid
CoA + UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronic acid
-
WbpD is a putative 3-N-acetyltransferase that has been implicated in the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid, a precursor for the D-Man(2NAc3NAc)A residues in the B-band O antigen of Pseudomonas aeruginosa, the enzyme is involved in the catalysis of the fourth step by acting as an UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid 3-N-acetyltransferase
-
-
?
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid
CoA + UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronic acid
-
WbpD utilizes a direct-transfer reaction mechanism
-
-
?
malonyl-CoA + 2-aminophenol
CoA + N-malonyl-2-aminophenol
-
-
-
?
malonyl-CoA + 2-aminophenol
CoA + N-malonyl-2-aminophenol
-
-
-
?
malonyl-CoA + 3,4-dichloroaniline
CoA + 3-(3,4-dichloroanilino)-3-oxopropanoic acid
-
-
-
?
malonyl-CoA + 3,4-dichloroaniline
CoA + 3-(3,4-dichloroanilino)-3-oxopropanoic acid
-
-
-
?
malonyl-CoA + 4-aminobenzoate
CoA + N-malonyl-4-aminobenzoate
-
-
-
?
malonyl-CoA + 4-aminobenzoate
CoA + N-malonyl-4-aminobenzoate
-
-
-
?
additional information
?
-
-
no substrate: 2-methyl-4-nitroaniline, 2,4-dinitroaniline, 4-nitrophenylhydrazine, carbopyridine
-
-
?
additional information
?
-
-
the reaction proceeds via a covalent acetyl-enzyme intermediate
-
-
?
additional information
?
-
-
4-nitroacetanilide, 4-nitrophenylacetate can replace acetyl-CoA
-
-
?
additional information
?
-
-
the reaction proceeds via a covalent acetyl-enzyme intermediate
-
-
?
additional information
?
-
-
xenobiotic metabolizing enzyme. Catalyzes the biotransformation of primary aromatic amine or hydrazine drugs and carcinogens. In addition to genetically controlled interindividual variations in NAT1 activity, oxidative stress and cellular redox status may also regulate NAT1 activity
-
-
?
additional information
?
-
isozyme NAT1 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT1 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
-
isozyme NAT1 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT1 is not increased in breast tumors compared to healthy tissue, the grade of malignancy is positively related with NAT1
-
-
?
additional information
?
-
isozyme NAT1 is not increased in breast tumors compared to healthy tissue, the grade of malignancy is positively related with NAT1
-
-
?
additional information
?
-
isozyme NAT2 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT2 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
-
isozyme NAT2 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT2 is increased in breast tumors compared to healthy tissue, the grade of malignancy is negatively associated with NAT2
-
-
?
additional information
?
-
isozyme NAT2 is increased in breast tumors compared to healthy tissue, the grade of malignancy is negatively associated with NAT2
-
-
?
additional information
?
-
NAT plays a key role in the metabolic activation of aromatic amine and nitroaromatic mutagens to electrophilic reactive intermediates
-
-
?
additional information
?
-
-
NAT plays a key role in the metabolic activation of aromatic amine and nitroaromatic mutagens to electrophilic reactive intermediates
-
-
?
additional information
?
-
the enzyme catalyzes the acetylation of arylamines, a key step in the detoxification of many carcinogens
-
-
?
additional information
?
-
the enzyme catalyzes the acetylation of arylamines, a key step in the detoxification of many carcinogens
-
-
?
additional information
?
-
-
the enzyme catalyzes the acetylation of arylamines, a key step in the detoxification of many carcinogens
-
-
?
additional information
?
-
-
the human enzyme NAT1 bioactivates arylamine and heterocyclic amine carcinogens present in red meat and tobacco products, overview
-
-
?
additional information
?
-
the human enzyme NAT1 bioactivates arylamine and heterocyclic amine carcinogens present in red meat and tobacco products, overview
-
-
?
additional information
?
-
-
variable expression of isozyme NAT1 due to genetic polymorphism, gene regulation or environmental influences is associated with individual susceptibility to various cancers, overview
-
-
?
additional information
?
-
poor activity wit 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
poor activity wit 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
-
poor activity wit 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
poor activity with 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
poor activity with 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
-
poor activity with 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
-
isoform NAT1 catalyzes acetyl-CoA hydrolysis in a folate-dependent manner, while isoform NAT2 does not
-
-
?
additional information
?
-
enzyme additionally O-acetylates N-hydroxy-4,4'-methylenebis(2-chloroaniline)
-
-
-
additional information
?
-
-
enzyme additionally O-acetylates N-hydroxy-4,4'-methylenebis(2-chloroaniline)
-
-
-
additional information
?
-
-
no substrate: glucosamine 6-phosphate
-
-
?
additional information
?
-
-
no substrate: glucosamine 6-phosphate
-
-
?
additional information
?
-
-
propionyl-CoA can replace acetyl-CoA
-
-
?
additional information
?
-
-
the reaction proceeds via a covalent acetyl-enzyme intermediate
-
-
?
additional information
?
-
-
no acetylation of sulfamethazine and procainamide
-
-
?
additional information
?
-
isozyme NAT1 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT1 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT2 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
isozyme NAT2 acetylates and detoxifies arylamine carcinogens
-
-
?
additional information
?
-
the enzyme catalyzes an acetyl group transfer from AcCoA to primary arylamines, hydrazines, and hydrazides and play a very important role in the metabolism and bioactivation of drugs, carcinogens, and other xenobiotics
-
-
?
additional information
?
-
the enzyme catalyzes the acetylation of arylamines, a key step in the detoxification of many carcinogens
-
-
?
additional information
?
-
4-aminobenzoic acid is the preferred substrate
-
-
?
additional information
?
-
poor activity wit 2-toluidine and other arylamines linked to bladder cancer
-
-
?
additional information
?
-
-
the reaction proceeds via a covalent acetyl-enzyme intermediate
-
-
?
additional information
?
-
the isozymes catalyze the N-acetylation of aromatic amine and hydrazine drugs and carcinogens, after N-hydroxylation, they also catalyze the metabolic activation of N-hydroxy-arylamines via O-acetylation
-
-
?
additional information
?
-
the isozymes catalyze the N-acetylation of aromatic amine and hydrazine drugs and carcinogens, after N-hydroxylation, they also catalyze the metabolic activation of N-hydroxy-arylamines via O-acetylation
-
-
?
additional information
?
-
-
mouse Nat2 is very similar to human NAT1 in substrate specificity
-
-
?
additional information
?
-
-
the reaction proceeds via a covalent acetyl-enzyme intermediate
-
-
?
additional information
?
-
-
results confirm that substituted anilines are excellent substrates and that TBNAT is ineffective in hydrazide N-acetylation
-
-
?
additional information
?
-
-
the enzyme is required for synthesis of mycolic acids and complex lipids
-
-
?
additional information
?
-
-
no activity with 4-aminobenzoic acid, ambroxol, trimethoprim, sulfamethazine, sulfamethoxazole, sulfadiazine, and sulfapyridine
-
-
?
additional information
?
-
Mycobacteroides abscessus CIP 104536T
-
no activity with 4-aminobenzoic acid, ambroxol, trimethoprim, sulfamethazine, sulfamethoxazole, sulfadiazine, and sulfapyridine
-
-
?
additional information
?
-
-
the enzyme exhibits arylhydroxamic acid N,O-acetyltransferase activity
-
-
?
additional information
?
-
-
the reaction proceeds via a covalent acetyl-enzyme intermediate
-
-
?
additional information
?
-
-
N-diacetyl cysteamine can replace acetyl-CoA with less than 10% efficiency
-
-
?
additional information
?
-
-
N-diacetyl cysteamine can replace acetyl-CoA with less than 10% efficiency
-
-
?
additional information
?
-
-
no substrate: phenylalanine, cyclohexylamine
-
-
?
additional information
?
-
-
acetylthiocholine can replace acetyl-CoA
-
-
?
additional information
?
-
-
the enzyme is an important drug- and carcinogen metabolising enzyme that catalyses the transfer of an acetyl group from a donor, such as acetyl coenzyme A, to an aromatic or heterocyclic amine, hydrazine, hydrazide or N-hydroxylamine acceptor substrate
-
-
?
additional information
?
-
-
NAT acceptor substrate specificity, overview
-
-
?
additional information
?
-
-
enzyme follows a Ping Pong Bi Bi kinetic mechanism
-
-
?
additional information
?
-
substrate specificities of isozymes Nat1-Nat3, overview
-
-
?
additional information
?
-
substrate specificity, product identification by LC-MS, 4-aminobenzoic acid, 3-aminobenzoic acid, and aniline are poor substrates, overview
-
-
?
additional information
?
-
-
substrate specificity, product identification by LC-MS, 4-aminobenzoic acid, 3-aminobenzoic acid, and aniline are poor substrates, overview
-
-
?
additional information
?
-
substrate specificity, product identification by LC-MS, 4-aminobenzoic acid, 3-aminobenzoic acid, and aniline are poor substrates, overview
-
-
?
additional information
?
-
-
no substrate: polyamines, amino acids, sphingosine bases, ethanolamine, C1-C4 primary amines, some secondary and tertiary amines
-
-
?
