2.2.1.6: acetolactate synthase
This is an abbreviated version!
For detailed information about acetolactate synthase, go to the full flat file.
Word Map on EC 2.2.1.6
-
2.2.1.6
-
herbicide
-
weed
-
sulfonylurea
-
als-inhibiting
-
branched-chain
-
imidazolinone
-
biotype
-
cross-resistance
-
herbicide-resistant
-
imazethapyr
-
chlorsulfuron
-
triazolopyrimidine
-
4.1.3.18
-
als-inhibitors
-
glyphosate
-
target-site
-
amaranthus
-
imazamox
-
acetoin
-
sulfometuron
-
2,3-butanediol
-
echinochloa
-
protoporphyrinogen
-
broadleaf
-
2-ketobutyrate
-
non-target-site
-
whole-plant
-
nicosulfuron
-
accase
-
hybridus
-
rigidum
-
waterhemp
-
mesotrione
-
postemergence
-
crus-galli
-
safener
-
5-enolpyruvylshikimate-3-phosphate
-
ilvced
-
alpha-ketobutyrate
-
brewing
-
rudis
-
dicamba
-
synthesis
-
agriculture
-
molecular biology
-
glufosinate
-
thdp-dependent
-
palmeri
-
tuberculatus
-
analysis
-
alopecurus
-
isomeroreductase
-
pharmacology
-
herbicide-binding
-
drug development
-
glyphosate-resistant
-
kochia
-
biotechnology
- 2.2.1.6
-
herbicide
-
weed
- sulfonylurea
-
als-inhibiting
-
branched-chain
- imidazolinone
-
biotype
-
cross-resistance
-
herbicide-resistant
- imazethapyr
- chlorsulfuron
- triazolopyrimidine
-
4.1.3.18
-
als-inhibitors
- glyphosate
-
target-site
- amaranthus
- imazamox
- acetoin
- sulfometuron
- 2,3-butanediol
- echinochloa
- protoporphyrinogen
-
broadleaf
- 2-ketobutyrate
-
non-target-site
-
whole-plant
- nicosulfuron
- accase
- hybridus
- rigidum
-
waterhemp
- mesotrione
-
postemergence
- crus-galli
-
safener
- 5-enolpyruvylshikimate-3-phosphate
-
ilvced
- alpha-ketobutyrate
- brewing
- rudis
- dicamba
- synthesis
- agriculture
- molecular biology
- glufosinate
-
thdp-dependent
- palmeri
- tuberculatus
- analysis
-
alopecurus
-
isomeroreductase
- pharmacology
-
herbicide-binding
- drug development
-
glyphosate-resistant
- kochia
- biotechnology
Reaction
2 pyruvate
=
Synonyms
aceto-hydroxy acid synthase, acetohydroxy acid synthase, acetohydroxy acid synthase I, acetohydroxy acid synthetase, acetohydroxyacid synthase, acetolactate pyruvate-lyase (carboxylating), acetolactate synthase, acetolactate synthetase, acetolactate-synthase, acetolactic synthetase, AHAS, AHAS II, AHAS1, AHAS2, AHAS3, AHASL, AHASS, alpha-acetohydroxy acid synthetase, alpha-acetohydroxyacid synthase, alpha-acetolactate synthase, alpha-acetolactate synthetase, alpha-ALS, ALS, ALS1, ALS1R, ALS2, AlsS, CalS, catabolic acetolactate synthase, EC 4.1.3.18, GST-mALS, GST-wALS, Ilv2, Ilv6, ilvB, ilvB1, ilvB2, ilvG, IlvN, ilvX, Moilv2, Moilv6, More, PF0935, sll1981, synthase, acetolactate, TM_0548, TM_0549, TTHA1213
ECTree
2.2.1.6 acetolactate synthaseAdvanced search results
results (
results (KI Value
KI Value on EC 2.2.1.6 - acetolactate synthase
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Ki VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0421
(2E)-3,3'-dioxo-1,1',3,3'-tetrahydro-2,2'-biindole-5,5'-disulfonate
-
pH 7.0, 37°C
0.00291
2'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.0757 - 0.0929
2-(2,3-dichlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
0.0158 - 0.228
2-(2,3-difluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
0.00212 - 0.00758
2-(2,4-dichlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
0.0147 - 0.0843
2-(2,4-difluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
0.0144 - 0.0553
2-(2,5-dichlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
0.00572 - 0.0263
2-(2,5-difluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
0.00458 - 0.047
2-(2-bromo-4-fluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
3.62
2-(2-bromobenzyl)-8-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylphthalazin-1(2H)-one
-
0.00159 - 0.0037
2-(2-chloro-4-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
2.1
2-(2-chlorobenzyl)-8-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylphthalazin-1(2H)-one
-
0.00694 - 0.145
2-(3-bromo-4-fluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
2.16
2-(3-chlorobenzyl)-8-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylphthalazin-1(2H)-one
-
0.00184 - 0.0434
2-(3-chlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
0.00141 - 0.00334
2-(4-bromo-3-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
0.0157 - 0.0189
2-(4-chloro-2-fluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
0.00325 - 0.00916
2-(4-chloro-2-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
0.00134 - 0.00642
2-(4-chloro-3-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
2.03
2-(4-chlorobenzyl)-8-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylphthalazin-1(2H)-one
-
0.00452
2-(5-chloropyridin-3-yl)-6-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylbenzoic acid
pH and temperature not specified in the publication
0.00000939 - 0.181
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
0.00989
2-(6-chloropyridin-3-yl)-6-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylbenzoic acid
pH and temperature not specified in the publication
0.0000153
2-bromo-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
apparent value, pH and temperature not specified in the publication
4.41
2-butyl-8-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylphthalazin-1(2H)-one
-
0.0001729
2-chloro-N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
apparent value, pH and temperature not specified in the publication
0.0000115
2-fluoro-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
apparent value, pH and temperature not specified in the publication
0.0000229
2-iodo-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
apparent value, pH and temperature not specified in the publication
0.00053 - 0.00335
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluoro-3-methylphenoxy)benzoic acid
0.00607 - 0.0202
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluoro-4-methylphenoxy)benzoic acid
0.00537 - 0.0612
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluoro-5-methylphenoxy)benzoic acid
0.00201 - 0.0605
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(3-fluorophenoxy)benzoic acid
0.00645 - 0.0201
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(3-methylphenoxy)benzoic acid
0.00179 - 0.00317
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(naphthalen-2-yloxy)benzoic acid
0.0498
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(5-methylpyridin-3-yl)benzoic acid
pH and temperature not specified in the publication
0.00025
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(naphthalen-2-yl)benzoic acid
pH and temperature not specified in the publication
0.00531
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(pyridin-3-yl)benzoic acid
pH and temperature not specified in the publication
0.705
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(pyrimidin-5-yl)benzoic acid
pH and temperature not specified in the publication
0.0597
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(2-methoxypyrimidin-5-yl)-4-methylbenzoic acid
pH and temperature not specified in the publication
0.00378
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methylbenzoic acid
pH and temperature not specified in the publication
0.0309
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(6-fluoropyridin-3-yl)-4-methylbenzoic acid
pH and temperature not specified in the publication
0.00066
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(furan-2-yl)-4-methylbenzoic acid
pH and temperature not specified in the publication
0.00051
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(furan-3-yl)-4-methylbenzoic acid
pH and temperature not specified in the publication
0.00271 - 0.00369
2-[([1,1'-biphenyl]-4-yl)oxy]-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
0.00403
3'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.0907
3-(7H-cyclopenta[b]pyridin-5-yl)-N-[(2-nitrophenyl)sulfanyl]alanine
-
pH 7.0, 37°C
0.00207
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-2'-fluoro-5-methylbiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.00728
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3',5'-difluoro-5-methylbiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.00215
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3'-fluoro-5-methylbiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.00018
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4',5-dimethylbiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.00067
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4'-fluoro-5-methylbiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.00154
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4'-methoxy-5-methylbiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.663
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-fluorobiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.0268
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methoxybiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.00273
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methyl-4'-nitrobiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.00009
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.00002
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]biphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.00041
4'-bromo-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.0391
4'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methoxybiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
0.0002
4'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
pH and temperature not specified in the publication
1
5-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]biphenyl-2-carboxylic acid
IC50 above 1.0 mM, pH and temperature not specified in the publication
0.0152
6,6'-disulfanediyldipyridine-3-carboxylic acid
-
pH 7.0, 37°C
0.789
8-(4,6-dimethoxypyrimidin-2-yloxy)-4-methylphthalazin-1(2H)-one
-
-
7.89
8-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylphthalazin-1(2H)-one
-
0.0000524
chlorsulfuron
-
apparent value, pH and temperature not specified in the publication
0.00000045 - 0.79
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
0.0000283
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-fluoro-6-nitrobenzenesulfonamide
-
apparent value, pH and temperature not specified in the publication
0.0001127
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-iodo-6-nitrobenzenesulfonamide
-
apparent value, pH and temperature not specified in the publication
0.0001658
N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-2-nitro-6-(2,2,2-trifluoroethoxy)benzenesulfonamide
-
apparent value, pH and temperature not specified in the publication
0.00000823 - 0.00086
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
0.0757
2-(2,3-dichlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.0929
2-(2,3-dichlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0158
2-(2,3-difluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.228
2-(2,3-difluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00212
2-(2,4-dichlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.00758
2-(2,4-dichlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.0147
2-(2,4-difluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0843
2-(2,4-difluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.0144
2-(2,5-dichlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0553
2-(2,5-dichlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00572
2-(2,5-difluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0263
2-(2,5-difluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00458
2-(2-bromo-4-fluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.047
2-(2-bromo-4-fluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.0257
2-(2-bromophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0657
2-(2-bromophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00159
2-(2-chloro-4-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0037
2-(2-chloro-4-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00827
2-(2-chlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.212
2-(2-chlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00694
2-(3-bromo-4-fluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.145
2-(3-bromo-4-fluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00184
2-(3-chlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0434
2-(3-chlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00141
2-(4-bromo-3-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.00334
2-(4-bromo-3-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.0157
2-(4-chloro-2-fluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0189
2-(4-chloro-2-fluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00325
2-(4-chloro-2-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.00916
2-(4-chloro-2-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00134
2-(4-chloro-3-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.00642
2-(4-chloro-3-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00451
2-(4-chlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.056
2-(4-chlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00000939
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
wild-type, pH 7.5, 37°C
0.0000168
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
mutant C411S, pH 7.5, 37°C
0.0000202
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
mutant C607S, pH 7.5, 37°C
0.0008
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
mutant D375A, pH 7.5, 37°C
0.00109
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
mutant K299Q pH 7.5, 37°C
0.00122
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
wild-type, pH 7.5, 37°C
0.00135
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
wild-type, 37°C, pH 7.5
0.00205
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
mutant H392M, 37°C, pH 7.5
0.0041
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
wild-type, pH 7.5, 37°C
0.0133
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
mutant D374A/D375A, pH 7.5, 37°C
0.0155
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
mutant D374E, pH 7.5, 37°C
0.01735
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
mutantH351F, 37°C, pH 7.5
0.0296
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
mutant D374E/D375E, pH 7.5, 37°C
0.0389
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
mutant D375E, pH 7.5, 37°C
0.181
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
mutant D374A, pH 7.5, 37°C
0.00053
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluoro-3-methylphenoxy)benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.00335
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluoro-3-methylphenoxy)benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00607
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluoro-4-methylphenoxy)benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0202
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluoro-4-methylphenoxy)benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00537
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluoro-5-methylphenoxy)benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0612
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluoro-5-methylphenoxy)benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.0274
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluorophenoxy)benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.108
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluorophenoxy)benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00201
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(3-fluorophenoxy)benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0605
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(3-fluorophenoxy)benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00645
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(3-methylphenoxy)benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0201
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(3-methylphenoxy)benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.0119
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(4-fluorophenoxy)benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0214
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(4-fluorophenoxy)benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.0178
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(4-methylphenoxy)benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0234
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(4-methylphenoxy)benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00179
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(naphthalen-2-yloxy)benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.00317
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(naphthalen-2-yloxy)benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.0042
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-phenoxybenzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.0528
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-phenoxybenzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00271
2-[([1,1'-biphenyl]-4-yl)oxy]-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00369
2-[([1,1'-biphenyl]-4-yl)oxy]-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
wild type enzyme, pH and temperature not specified in the publication
0.000054
bispyribac
-
wild type enzyme, pH and temperature not specified in the publication
0.00054
bispyribac
pH and temperature not specified in the publication
0.00247
bispyribac
-
mutant enzyme P197L, pH and temperature not specified in the publication
0.00038
flumetsulam
pH and temperature not specified in the publication
0.00000045
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
mutantH351F, 37°C, pH 7.5
0.00000311
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
wild-type, 37°C, pH 7.5
0.00000365
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
mutant H392M, 37°C, pH 7.5
0.00000368
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
mutant H351M, 37°C, pH 7.5
0.00000939
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
wild-type, pH 7.5, 37°C
0.0000168
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
mutant C411S, pH 7.5, 37°C
0.0000202
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
mutant C607S, pH 7.5, 37°C
0.00004857
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
mutant H351Q, 37°C, pH 7.5
0.00301
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
mutant K299Q pH 7.5, 37°C
0.00527
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
wild-type, pH 7.5, 37°C
0.0293
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
wild-type, pH 7.5, 37°C
0.036
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
mutant D374E, pH 7.5, 37°C
0.0741
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
mutant D374A, pH 7.5, 37°C
0.198
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
mutant D375A, pH 7.5, 37°C
0.309
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
mutant D374A/D375A, pH 7.5, 37°C
0.79
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
mutant D374E/D375E, pH 7.5, 37°C
0.00000823
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
-
wild-type, pH 7.5, 37°C
0.00000902
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
-
mutant K299Q pH 7.5, 37°C
0.0000093
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
-
mutant H392M, 37°C, pH 7.5
0.0000109
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
-
wild-type, 37°C, pH 7.5
0.000013
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
-
wild-type, pH 7.5, 37°C
0.00002304
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
-
mutantH351F, 37°C, pH 7.5
0.000108
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
-
mutant D374E, pH 7.5, 37°C
0.00086
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
-
mutant D374A, pH 7.5, 37°C
0.012
sulfometuron methyl
holoenzyme, pH 7.9, 55°C
0.00008
tribenuron-methyl
-
wild type enzyme, pH and temperature not specified in the publication
0.212
tribenuron-methyl
-
mutant enzyme P197L, pH and temperature not specified in the publication
additional information
leucine/valine
-
an equimolar mixture of leucine and valine
additional information
additional information
-
inhibition kinetics of sulfonylurea herbicides
-
