2.2.1.6: acetolactate synthase
This is an abbreviated version!
For detailed information about acetolactate synthase, go to the full flat file.
Word Map on EC 2.2.1.6
-
2.2.1.6
-
herbicide
-
weed
-
sulfonylurea
-
als-inhibiting
-
branched-chain
-
imidazolinone
-
biotype
-
cross-resistance
-
herbicide-resistant
-
imazethapyr
-
chlorsulfuron
-
triazolopyrimidine
-
4.1.3.18
-
als-inhibitors
-
glyphosate
-
target-site
-
amaranthus
-
imazamox
-
acetoin
-
sulfometuron
-
2,3-butanediol
-
echinochloa
-
protoporphyrinogen
-
broadleaf
-
2-ketobutyrate
-
non-target-site
-
whole-plant
-
nicosulfuron
-
accase
-
hybridus
-
rigidum
-
waterhemp
-
mesotrione
-
postemergence
-
crus-galli
-
safener
-
5-enolpyruvylshikimate-3-phosphate
-
ilvced
-
alpha-ketobutyrate
-
brewing
-
rudis
-
dicamba
-
synthesis
-
agriculture
-
molecular biology
-
glufosinate
-
thdp-dependent
-
palmeri
-
tuberculatus
-
analysis
-
alopecurus
-
isomeroreductase
-
pharmacology
-
herbicide-binding
-
drug development
-
glyphosate-resistant
-
kochia
-
biotechnology
- 2.2.1.6
-
herbicide
-
weed
- sulfonylurea
-
als-inhibiting
-
branched-chain
- imidazolinone
-
biotype
-
cross-resistance
-
herbicide-resistant
- imazethapyr
- chlorsulfuron
- triazolopyrimidine
-
4.1.3.18
-
als-inhibitors
- glyphosate
-
target-site
- amaranthus
- imazamox
- acetoin
- sulfometuron
- 2,3-butanediol
- echinochloa
- protoporphyrinogen
-
broadleaf
- 2-ketobutyrate
-
non-target-site
-
whole-plant
- nicosulfuron
- accase
- hybridus
- rigidum
-
waterhemp
- mesotrione
-
postemergence
- crus-galli
-
safener
- 5-enolpyruvylshikimate-3-phosphate
-
ilvced
- alpha-ketobutyrate
- brewing
- rudis
- dicamba
- synthesis
- agriculture
- molecular biology
- glufosinate
-
thdp-dependent
- palmeri
- tuberculatus
- analysis
-
alopecurus
-
isomeroreductase
- pharmacology
-
herbicide-binding
- drug development
-
glyphosate-resistant
- kochia
- biotechnology
Reaction
2 pyruvate
=
Synonyms
aceto-hydroxy acid synthase, acetohydroxy acid synthase, acetohydroxy acid synthase I, acetohydroxy acid synthetase, acetohydroxyacid synthase, acetolactate pyruvate-lyase (carboxylating), acetolactate synthase, acetolactate synthetase, acetolactate-synthase, acetolactic synthetase, AHAS, AHAS II, AHAS1, AHAS2, AHAS3, AHASL, AHASS, alpha-acetohydroxy acid synthetase, alpha-acetohydroxyacid synthase, alpha-acetolactate synthase, alpha-acetolactate synthetase, alpha-ALS, ALS, ALS1, ALS1R, ALS2, AlsS, CalS, catabolic acetolactate synthase, EC 4.1.3.18, GST-mALS, GST-wALS, Ilv2, Ilv6, ilvB, ilvB1, ilvB2, ilvG, IlvN, ilvX, Moilv2, Moilv6, More, PF0935, sll1981, synthase, acetolactate, TM_0548, TM_0549, TTHA1213
ECTree
2.2.1.6 acetolactate synthaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 2.2.1.6 - acetolactate synthase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(2E)-3,3'-dioxo-1,1',3,3'-tetrahydro-2,2'-biindole-5,5'-disulfonate
-
inhibition profile and inhibition of root growth, overview
(5-bromo-2-[[([2-[(2-chloroethoxy)methyl]phenyl]sulfonyl)carbamoyl]amino]pyrimidin-4-yl)methyl benzoate
-
-
(5-bromo-2-[[([2-[(2-chloroethoxy)methyl]phenyl]sulfonyl)carbamoyl]amino]pyrimidin-4-yl)methyl phenylacetate
-
-
(5-bromo-2-[[([2-[(2-chloroethoxy)methyl]phenyl]sulfonyl)carbamoyl]amino]pyrimidin-4-yl)methyl prop-2-enoate
-
-
1-(4,6-dimethoxypyrimidin-2-yl)-5-methoxymethyl-N-(2-isopropyl-6-nitrophenyl)-1H-1,2,4-triazole-3-sulfonamide
-
-
1-(4,6-dimethoxypyrimidin-2-yl)-5-methyl-N-(2-isopropyl-6-nitrophenyl)-1H-1,2,4-triazole-3-sulfonamide
-
-
1-(4,6-dimethoxypyrimidin-2-yl)-5-methylthio-N-(2-chloro-6-fluorophenyl)-1H-1,2,4-triazole-3-sulfonamide
-
-
1-(4-chloro-6-methoxypyrimidin-2-yl)-5-methoxy-N-(2-methyl-6-nitrophenyl)-1H-1,2,4-triazole-3-sulfonamide
-
-
1-methoxy-1-oxopropan-2-yl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methyl[1,1'-biphenyl]-2-carboxylate
-
2'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
-
2,3-dichloro-6-[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid
-
2-(1,1-dihydroxyethyl)-6-[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid
-
2-(2,3-dichlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(2,3-difluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(2,4-dichlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(2,4-difluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(2,5-dichlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(2,5-difluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(2-bromo-4-fluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(2-bromobenzyl)-8-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylphthalazin-1(2H)-one
-
2-(2-bromophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(2-chloro-4-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(2-chlorobenzyl)-8-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylphthalazin-1(2H)-one
-
2-(2-chloroethoxy)-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]benzenesulfonamide
-
-
2-(2-chloroethoxy)-N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]benzenesulfonamide
-
-
2-(2-chlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(3-bromo-4-fluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(3-chlorobenzyl)-8-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylphthalazin-1(2H)-one
-
2-(3-chlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-(trifluoromethyl)benzoate
-
30% inhibition at 0.1 mM
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-chlorobenzoate
-
42.5% inhibition at 0.1 mM
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-fluorobenzoate
-
72% inhibition at 0.1 mM
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-methoxybenzoate
-
28% inhibition at 0.1 mM
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl benzoate
-
26% inhibition at 0.1 mM
2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-(trifluoromethyl)benzoate
-
73.2% inhibition at 0.1 mM
2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-chlorobenzoate
-
23.5% inhibition at 0.1 mM
2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-nitrobenzoate
-
94% inhibition at 0.1 mM
2-(4-bromo-3-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(4-chloro-2-fluorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(4-chloro-2-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(4-chloro-3-methylphenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(4-chlorobenzyl)-8-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylphthalazin-1(2H)-one
-
2-(4-chlorophenoxy)-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-(5-chloropyridin-3-yl)-6-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylbenzoic acid
-
2-(6-chloropyridin-3-yl)-6-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylbenzoic acid
-
2-(difluoromethoxy)-6-[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid
-
2-acetyl-6-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]benzoic acid
-
2-bromo-6-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]benzoic acid
-
2-butyl-8-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylphthalazin-1(2H)-one
-
2-chloro-3-oxocyclohex-1-en-1-yl 3-(trifluoromethyl)benzoate
-
2-chloro-3-oxocyclohex-1-en-1-yl-3-(trifluoromethyl)benzoate
-
2-chloro-5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-chlorobenzoate
-
2-chloro-5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-chlorobenzoic acid
no inhibition by bensulfuron methyl. Feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme. Molecular docking of benzoyl ester compounds. AHAS-inhibitors and the probable binding pattern
2-chloro-5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-chlorobenzoic acid ester
-
2-chloro-6-(methoxycarbonyl)-5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-chlorobenzoate
-
2-chloro-6-methoxycarbonyl-5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-chlorobenzoate
-
2-chloro-6-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]benzoic acid
-
2-chloro-N-(4-chloro-3-[[(4-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl]phenyl)acetamide
-
2-chloro-N-(4-chloro-3-[[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl]phenyl)acetamide
-
2-chloro-N-([4-(methylamino)-6-[(1-methylethyl)sulfanyl]-1,3,5-triazin-2-yl]carbamoyl)benzenesulfonamide
-
-
2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]benzenesulfonamide
-
-
2-chloro-N-[[4-(ethylsulfanyl)-6-(methylamino)-1,3,5-triazin-2-yl]carbamoyl]benzenesulfonamide
-
-
2-chloro-N-[[4-(ethylsulfanyl)-6-methoxy-1,3,5-triazin-2-yl]carbamoyl]benzenesulfonamide
-
-
2-chloro-N-[[4-(ethylsulfanyl)-6-methylpyrimidin-2-yl]carbamoyl]benzenesulfonamide
-
-
2-chloro-N-[[4-(methylamino)-6-(methylsulfanyl)-1,3,5-triazin-2-yl]carbamoyl]benzenesulfonamide
-
-
2-chloro-N-[[4-methoxy-6-(methylsulfanyl)pyrimidin-2-yl]carbamoyl]benzenesulfonamide
-
-
2-chloro-N-[[4-methoxy-6-(propylsulfanyl)-1,3,5-triazin-2-yl]carbamoyl]benzenesulfonamide
-
-
2-chloro-N-[[4-methyl-6-(propylsulfanyl)pyrimidin-2-yl]carbamoyl]benzenesulfonamide
-
-
2-ethoxy-2-oxoethyl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methyl[1,1'-biphenyl]-2-carboxylate
-
2-methoxy-2-oxoethyl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methyl[1,1'-biphenyl]-2-carboxylate
-
2-nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate
-
2-phenyl-3-[[3-(trifluoromethyl)benzoyl]oxy]quinazolin-4(3H)-one
-
2-phenyl-3-{[3-(trifluoromethyl)benzoyl]oxy}quinazolin-4-one
-
2-substituted-8-(4,6-dimethoxypyrimidin-2-yloxy)-4-methylphthalazin-1-one derivatives
-
synthesis of diverse derivatives and inhibitory potency, overview
-
2-[(2-chloroethoxy)methyl]-N-[(4-chloropyrimidin-2-yl)carbamoyl]benzenesulfonamide
-
-
2-[(2-chloroethoxy)methyl]-N-[(4-methylpyrimidin-2-yl)carbamoyl]benzenesulfonamide
-
-
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluoro-3-methylphenoxy)benzoic acid
-
-
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluoro-4-methylphenoxy)benzoic acid
-
-
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluoro-5-methylphenoxy)benzoic acid
-
-
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(2-fluorophenoxy)benzoic acid
-
-
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(3-fluorophenoxy)benzoic acid
-
-
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(3-methylphenoxy)benzoic acid
-
-
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(4-fluorophenoxy)benzoic acid
-
-
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(4-methylphenoxy)benzoic acid
-
-
2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(naphthalen-2-yloxy)benzoic acid
-
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(5-methylpyridin-3-yl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(naphthalen-2-yl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(pyridin-3-yl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(pyrimidin-5-yl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-(methylsulfanyl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(1-methylethoxy)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(1H-pyrrol-1-yl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(2-methoxypyrimidin-5-yl)-4-methylbenzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methylbenzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(6-fluoropyridin-3-yl)-4-methylbenzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(ethylsulfanyl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(furan-2-yl)-4-methylbenzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(furan-3-yl)-4-methylbenzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(methylsulfanyl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(methylsulfonyl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(phenylcarbonyl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(propylsulfanyl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(trifluoromethoxy)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-(1-methylethoxy)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-(ethylsulfanyl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-(methylsulfanyl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-(phenylcarbonyl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-(propylsulfanyl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-(trifluoromethyl)benzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-ethoxybenzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-fluorobenzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-iodobenzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-methoxybenzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-methylbenzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-nitrobenzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-phenoxybenzoic acid
-
2-[(4,6-dimethoxypyrimidin-2-yl)sulfanyl]-6-propoxybenzoic acid
-
2-[([1,1'-biphenyl]-4-yl)oxy]-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]benzoic acid
-
-
2-[[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl]-N,N-dimethylbenzamide
-
-
3'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
-
3-(7H-cyclopenta[b]pyridin-5-yl)-N-[(2-nitrophenyl)sulfanyl]alanine
-
inhibition profile and inhibition of root growth, overview
3-[(3-bromobenzoyl)oxy]-2-phenylquinazolin-4(3H)-one
-
3-[(3-bromobenzoyl)oxy]-2-phenylquinazolin-4-one
-
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-2'-fluoro-5-methylbiphenyl-2-carboxylic acid
-
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3',5'-difluoro-5-methylbiphenyl-2-carboxylic acid
-
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3'-fluoro-5-methylbiphenyl-2-carboxylic acid
-
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4',5-dimethylbiphenyl-2-carboxylic acid
-
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4'-fluoro-5-methylbiphenyl-2-carboxylic acid
-
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4'-methoxy-5-methylbiphenyl-2-carboxylic acid
-
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-fluorobiphenyl-2-carboxylic acid
-
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methoxybiphenyl-2-carboxylic acid
-
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methyl-4'-nitrobiphenyl-2-carboxylic acid
-
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
-
3-[(4-nitrobenzoyl)oxy]quinazolin-4-one
-
4'-bromo-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
-
4'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methoxybiphenyl-2-carboxylic acid
-
4'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
-
4-(cyclopropylcarbonyl)-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-1-methyl-1H-pyrazole-5-sulfonamide
-
i.e. K13030
4-acetyl-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-1-methyl-1H-pyrazole-5-sulfonamide
-
i.e. K13010
4-oxo-2-m-tolylquinazolin-3(4H)-yl 3-fluorobenzoate
-
9.5% inhibition at 0.1 mM
4-oxo-2-m-tolylquinazolin-3(4H)-yl 3-methylbenzoate
-
10.5% inhibition at 0.1 mM
4-oxo-2-m-tolylquinazolin-3(4H)-yl 4-chlorobenzoate
-
no inhibition at 0.1 mM
4-oxo-2-m-tolylquinazolin-3(4H)-yl 4-methylbenzoate
-
33% inhibition at 0.1 mM
4-oxo-2-m-tolylquinazolin-3(4H)-yl benzoate
-
40.5% inhibition at 0.1 mM
4-oxo-2-m-tolylquinazolin-3(4H)-yl-3-(trifluoromethyl)benzoate
-
9.5% inhibition at 0.1 mM
4-oxo-2-o-tolylquinazolin-3(4H)-yl 3-fluorobenzoate
-
30% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 2-methylbenzoate
-
16.5% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 3-chlorobenzoate
-
80.5% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 3-fluorobenzoate
-
26% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 3-methoxybenzoate
-
27% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 3-methylbenzoate
-
4% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 3-nitrobenzoate
-
91.5% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 4-chlorobenzoate
-
7.5% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 4-methylbenzoate
-
18% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl benzoate
-
20.5% inhibition at 0.1 mM
5-bromo-2-([[(2-chlorophenyl)sulfonyl]carbamoyl]amino)pyrimidin-4-yl benzoate
-
-
5-chloro-1-(4-chlorophenyl)-3-methyl-N-((4-(trifluoromethoxy)phenyl)sulfonyl)-1H-pyrazole-4-carboxamide
-
5-chloro-1-(4-chlorophenyl)-3-methyl-N-(phenylsulfonyl)-1H-pyrazole-4-carboxamide
-
5-chloro-1-(4-chlorophenyl)-3-methyl-N-tosyl-1H-pyrazole-4-carboxamide
-
5-chloro-1-(4-chlorophenyl)-N-((4-chlorophenyl)sulfonyl)-3-methyl-1H-pyrazole-4-carboxamide
-
5-chloro-1-(4-chlorophenyl)-N-((4-methoxyphenyl)-sulfonyl)-3-methyl-1H-pyrazole-4-carboxamide
73% inhibition at 100 mg/l
5-chloro-1-(4-fluorophenyl)-3-methyl-N-((4-(trifluoromethoxy)phenyl)sulfonyl)-1H-pyrazole-4-carboxamide
-
5-chloro-1-(4-fluorophenyl)-3-methyl-N-(phenylsulfonyl)-1H-pyrazole-4-carboxamide
-
5-chloro-1-(4-fluorophenyl)-3-methyl-N-tosyl-1H-pyrazole-4-carboxamide
-
5-chloro-1-(4-fluorophenyl)-N-((4-methoxyphenyl)-sulfonyl)-3-methyl-1H-pyrazole-4-carboxamide
-
5-chloro-3-methyl-1-(p-tolyl)-N-((4-(trifluoromethoxy)-phenyl)sulfonyl)-1H-pyrazole-4-carboxamide
-
5-chloro-3-methyl-1-(p-tolyl)-N-tosyl-1H-pyrazole-4-carboxamide
-
5-chloro-3-methyl-1-phenyl-N-((4-(trifluoromethoxy)phenyl)-sulfonyl)-1H-pyrazole-4-carboxamide
81% inhibition at 100 mg/l
5-chloro-3-methyl-1-phenyl-N-(phenylsulfonyl)-1H-pyrazole-4-carboxamide
-
5-chloro-3-methyl-N-(phenylsulfonyl)-1-(p-tolyl)-1H-pyrazole-4-carboxamide
-
5-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]biphenyl-2-carboxylic acid
-
5-chloro-N-((4-chlorophenyl)sulfonyl)-1-(4-fluorophenyl)-3-methyl-1H-pyrazole-4-carboxamide
-
5-chloro-N-((4-chlorophenyl)sulfonyl)-3-methyl-1-(p-tolyl)-1H-pyrazole-4-carboxamide
-
5-chloro-N-((4-chlorophenyl)sulfonyl)-3-methyl-1-phenyl-1H-pyrazole-4-carboxamide
65% inhibition at 100 mg/l
5-chloro-N-((4-methoxyphenyl)sulfonyl)-3-methyl-1-(p-tolyl)-1H-pyrazole-4-carboxamide
-
5-chloro-N-((4-methoxyphenyl)sulfonyl)-3-methyl-1-phenyl-1H-pyrazole-4-carboxamide
-
6,6'-disulfanediyldipyridine-3-carboxylic acid
-
inhibition profile and inhibition of root growth, overview
8-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylphthalazin-1(2H)-one
-
bensulfuron-methyl
a sulfonylurea herbicide; mutant W548L/S627I, 22% inhibition at 0.1 nM
branched-chain amino acids
-
feedback inhibition, differential inhibition of isozymes, overview
-
chlorimuronethyl
-
noncompetitive, lowest total interaction energy and highest MolDock score of 140054 kcal/mol and -141.52, respectively, of the compounds analyzed
ethyl 2-([(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl)benzoate
-
compound binds within a pocket of the enzyme formed by amino acid residues Met351, Asp375, Arg377, Gly509, Met570 and Val571
ethyl 2-([(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl)benzoate
-
compound binds within a pocket of the enzyme formed by amino acid residues Met351, Asp375, Arg377, Gly509, Met570 and Val571
ethyl 2-([[5-bromo-4-(bromomethyl)pyrimidin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
ethyl 2-([[5-bromo-4-(ethoxymethyl)pyrimidin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
ethyl 2-([[5-bromo-4-(methoxymethyl)pyrimidin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
ethyl 2-[([4-[(acryloyloxy)methyl]-5-bromopyrimidin-2-yl]carbamoyl)sulfamoyl]benzoate
-
-
ethyl 2-[[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl]benzoate
-
-
ethyl 2-[[(5-bromo-4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl]benzoate
-
-
ethyl 2-[[(5-bromo-4,6-dimethylpyrimidin-2-yl)carbamoyl]sulfamoyl]benzoate
-
-
ethyl 2-[[(5-bromo-4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl]benzoate
-
-
ethyl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methyl[1,1'-biphenyl]-2-carboxylate
-
ethyl 4-chloro-2-[[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl]benzoate
-
Hydroxypyruvate
-
progressive inactivation of enzyme with kinetics of suicide inhibition, mechanism
methyl 2-([(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl)benzoate
-
methyl 2-([[4-(ethylsulfanyl)-6-methoxypyrimidin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
methyl 2-([[4-(methylamino)-6-(propylsulfanyl)-1,3,5-triazin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
methyl 2-([[4-chloro-6-(methylamino)-1,3,5-triazin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
methyl 2-([[4-chloro-6-(methylsulfanyl)pyrimidin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
methyl 2-([[4-ethoxy-6-(methylamino)-1,3,5-triazin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
methyl 2-([[4-methoxy-6-(methylsulfanyl)pyrimidin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
methyl 2-([[4-methoxy-6-(propylsulfanyl)-1,3,5-triazin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
methyl 2-([[5-bromo-4-(bromomethyl)pyrimidin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
methyl 2-([[5-bromo-4-(dibromomethyl)pyrimidin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
methyl 2-([[5-bromo-4-(ethoxymethyl)pyrimidin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
methyl 2-([[5-bromo-4-(methoxymethyl)pyrimidin-2-yl]carbamoyl]sulfamoyl)benzoate
-
-
methyl 2-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]sulfamoyl]benzoate
-
-
methyl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylate
-
methyl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]biphenyl-2-carboxylate
-
methyl-2-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoylsulfamoyl]benzoate
-
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
N-([4-[(benzyloxy)methyl]-5-bromopyrimidin-2-yl]carbamoyl)-2-chlorobenzenesulfonamide
-
-
N-([5-bromo-4-[(prop-2-en-1-yloxy)methyl]pyrimidin-2-yl]carbamoyl)-2-(2-chloroethoxy)benzenesulfonamide
-
-
N-phenyl-3-(phenyldisulfanyl)-1H-1,2,4-triazole-1-carboxamide
strong inhibition
N-phthalyl-L-isoleucine anilide
50% inhibition at 0.1 mM, crude enzyme preparation
N-phthalyl-L-phenylalanine anilide
50% inhibition at 0.047 mM, crude enzyme preparation
N-phthalyl-L-valine anilide
50% inhibition at 0.0023 mM, crude enzyme preparation
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-(ethylsulfanyl)-6-(2-fluoro-1-hydroxyethyl)benzenesulfonamide
-
i.e. K12147
N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-2-nitro-6-(2,2,2-trifluoroethoxy)benzenesulfonamide
N-[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide
-
-
N-[(5-bromo-4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-chlorobenzenesulfonamide
-
-
N-[(5-bromo-4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide
-
-
N-[(5-bromo-4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-[(2-chloroethoxy)methyl]benzenesulfonamide
-
-
N-[(5-bromo-4,6-dimethylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide
-
-
N-[(5-bromo-4,6-dimethylpyrimidin-2-yl)carbamoyl]-2-[(2-chloroethoxy)methyl]benzenesulfonamide
-
-
N-[(5-bromo-4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]-2-chlorobenzenesulfonamide
-
-
N-[(5-bromo-4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]-2-[(2-chloroethoxy)methyl]benzenesulfonamide
-
-
N-[(5-bromo-4-methoxypyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide
-
-
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
N-[[5-bromo-4-(1-methylethoxy)pyrimidin-2-yl]carbamoyl]-2-nitrobenzenesulfonamide
-
-
N-[[5-bromo-4-(bromomethyl)pyrimidin-2-yl]carbamoyl]-2-nitrobenzenesulfonamide
-
-
N-[[5-bromo-4-(bromomethyl)pyrimidin-2-yl]carbamoyl]-2-[(2-chloroethoxy)methyl]benzenesulfonamide
-
-
N-[[5-bromo-4-(dibromomethyl)pyrimidin-2-yl]carbamoyl]-2-nitrobenzenesulfonamide
-
-
N-[[5-bromo-4-(dibromomethyl)pyrimidin-2-yl]carbamoyl]-2-[(2-chloroethoxy)methyl]benzenesulfonamide
-
-
N-[[5-bromo-4-(ethenyloxy)pyrimidin-2-yl]carbamoyl]-2-nitrobenzenesulfonamide
-
-
N-[[5-bromo-4-(ethoxymethyl)pyrimidin-2-yl]carbamoyl]-2-chlorobenzenesulfonamide
-
-
N-[[5-bromo-4-(ethoxymethyl)pyrimidin-2-yl]carbamoyl]-2-[(2-chloroethoxy)methyl]benzenesulfonamide
-
-
N-[[5-bromo-4-(methoxymethyl)pyrimidin-2-yl]carbamoyl]-2-chlorobenzenesulfonamide
-
-
N-[[5-bromo-4-(methoxymethyl)pyrimidin-2-yl]carbamoyl]-2-[(2-chloroethoxy)methyl]benzenesulfonamide
-
-
N-[[5-bromo-4-(tribromomethyl)pyrimidin-2-yl]carbamoyl]-2-nitrobenzenesulfonamide
-
-
primisulfuron methyl
-
IC50: 0.0042 mM, over 80% inhibition at 0.04 mM
propan-2-yl 4-bromo-3-[[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl]benzoate
-
pyriminobac
a pyrimidinylcarboxylate herbicide; mutant W548L/S627I, 13% inhibition at 0.1 nM
pyriminobac-methyl
herbicide-resistant enzyme variant from Pseudomonas sp. Lm10 shows 9.2fold higher resistance than the sensitive variant from Pseudomonas putida KT2440
pyrithiobac sodium
inhibitor of wild-type enzyme, poor inhibition of the P197E mutant enzyme
pyrithiobac-sodium
a pyrimidinylcarboxylate herbicide; mutant W548L/S627I, 32% inhibition at 0.1 nM
SO42-
-
competitive when assayed in phosphate buffer, mixed type, when assayed in acetate buffer
sodium 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylate
-
sodium 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]biphenyl-2-carboxylate
-
triasulfuron
-
21 out of 27 isolated bacteria in pure culture are inhibited by triasulfuron, the addition of isoleucine and/or valine reverses the effect in 19 cases
tribenuron
inhibitor of wild-type enzyme, poor inhibition of the P197E mutant enzyme
[5-bromo-2-[([[2-(1-methoxyethenyl)phenyl]sulfonyl]carbamoyl)amino]pyrimidin-4-yl]methyl prop-2-enoate
-
-
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
wild-type, 50% inhibition at 0.00318 mM, mutant C411S, 50% inhibition at 0.00426 mM, mutant C607S, 50% inhibition at 0.00099 mM
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
i.e. Cadre
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
-
2-(5-ethyl-3-methylpyridin-2-yl)-5-isopropyl-5-methyl-3,5-dihydro-4H-imidazol-4-one
-
i.e. Cadre
2-bromo-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-bromo-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
67.5% inhibition at 10 mg/l
2-bromo-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-bromo-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-bromo-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-bromo-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-bromo-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
68.9% inhibition at 10 mg/l
2-bromo-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-bromo-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-bromo-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-bromo-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-bromo-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
64.8% inhibition at 10 mg/l
2-bromo-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-bromo-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-bromo-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
69.9% inhibition at 10 mg/l
2-chloro-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
68.2% inhibition at 10 mg/l
2-chloro-N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
62.2% inhibition at 10 mg/l
2-chloro-N-[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
64.1% inhibition at 10 mg/l
2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
62.2% inhibition at 10 mg/l
2-chloro-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
67.7% inhibition at 10 mg/l
2-chloro-N-[(4-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-chloro-N-[(4-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-fluoro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-fluoro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
44.5% inhibition at 10 mg/l
2-fluoro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-fluoro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-fluoro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-fluoro-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-fluoro-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
67.9% inhibition at 10 mg/l
2-fluoro-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-fluoro-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-fluoro-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-fluoro-N-[(4-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-fluoro-N-[(4-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
72.6% inhibition at 10 mg/l
2-fluoro-N-[(4-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-fluoro-N-[(4-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-iodo-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-iodo-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
68.9% inhibition at 10 mg/l
2-iodo-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-iodo-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-iodo-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-iodo-N-[(4-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-iodo-N-[(4-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
68.5% inhibition at 10 mg/l
2-iodo-N-[(4-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-iodo-N-[(4-methylpyrimidin-2-yl)carbamoyl]-6-nitrobenzenesulfonamide
-
-
2-oxobutanoate
-
isoenzyme I has lower sensitivity to inhibition than isoenzyme III
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]biphenyl-2-carboxylic acid
-
bispyribac
about 58% enzyme inhibition after 2 h at enzyme:inhibitor ratio of 10:1
bispyribac-sodium
almost no effect on the mutant W548L/S627I even at 100 mM, which is an approximately 10000fold higher concentration than the concentration required for 50% inhibition of the wild-type; a pyrimidinylcarboxylate herbicide
Cadre
-
an imidazole herbicide, no inhibition of mutant R372S/F373P/D374V/D375E/R376Y
chlorimuron ethyl
-
a sulfonylurea herbicide, complex inhibition, binding structure, overview
chlorimuron ethyl
about 90% enzyme inhibition after 2 h at enzyme:inhibitor ratio of 10:1
chlorimuron ethyl
a sulfonylurea herbicide, complex inhibition, overview
chlorimuron ethyl
-
IC50: 0.009 mM, over 80% inhibition at 0.04 mM
chlorsulphuron
-
inhibition of the enzyme from Arabidopsis thaliana and of the enzyme expressed in E. coli
florasulam
inhibitor of wild-type enzyme, poor inhibition of the P197E mutant enzyme
flumetsulam
herbicide-resistant enzyme variant from Pseudomonas sp. Lm10 shows 6.5fold higher resistance than the sensitive variant from Pseudomonas putida KT2440
Ile
-
isoenzyme AHS I is sensitive to feed-back inhibition, isoenzyme AHS II is insensitive
Ile
-
inhibition of isoenzyme I, no inhibition of isoenzyme II
imazapyr
-
i.e. 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid
imazapyr
an imidazolinon herbicide; mutant W548L/S627I, 27% inhibition at 0.1 nM
imazaquin
-
an imidazolinone herbicide, complex inhibition, binding structure, overview
imazaquin
about 20% enzyme inhibition after 2 h at enzyme:inhibitor ratio of 10:1, about 85% enzyme inhibition after 2 days at enzyme:inhibitor ratio of 1000:1
imazethapyr
inhibitor of wild-type enzyme, poor inhibition of the P197E mutant enzyme
imazethapyr
herbicide-resistant enzyme variant from Pseudomonas sp. Lm10 shows 12.6fold higher resistance than the sensitive variant from Pseudomonas putida KT2440
imazosulfuron
-
sulfonylurea-resistant biotype, 50% inhibition above 3000 nM, sulfonylurea-susceptible biotype, 50% inhibition at 15 nM
imazosulfuron
60-80% inhibition at 0.1-100 mM imazosulfuron; no or poor inhibition of resistant mutant enzyme, IC50 values in different plant accessions, overview; no or poor inhibition of resistant mutant enzyme, IC50 values in different plant accessions, overview
imidazolinones
-
the imidazolinones behave as non-competitive or uncompetitive inhibitors
isoleucine
-
feedback inhibition of wild-type enzyme about 50% at 10 mM, M8 and M13 mutants are resistant
isoleucine
feedback inhibition; feedback inhibition; feedback inhibition
isoleucine
-
1 mM, about 90% residual activity in both sulfonylurea-susceptible and sulfonylurea-resistant biotype
KHG20612
-
inhibition kinetics and antimycobacterial activity, overview
L-valine
-
inhibits to a maximal activity of approximately 50% at concentrations higher than 0.5 mM
L-valine
-
not inhibitory for catalytic subunit alone, inhibitory for catalytic subunit plus small subunit
Leu
-
inhibition of the enzyme from Arabidopsis thaliana, no inhibition of the enzyme expressed in E. coli
Leu
-
mixed noncompetitive inhibition of isoenzyme, pH-independent inhibition of isoenzyme III
Leu
-
isoenzyme AHS I is sensitive to feed-back inhibition, isoenzyme AHS II is insensitive
Leu
-
inhibition of isoenzyme I, no inhibition of isoenzyme II
leucine
-
feedback inhibition of wild-type enzyme about 50% at 10 mM, M8 and M13 mutants are resistant
leucine
feedback inhibition; feedback inhibition; feedback inhibition
leucine
-
feedback inhibition
leucine
-
1 mM, about 50% residual activity in both sulfonylurea-susceptible and sulfonylurea-resistant biotype
Londax
-
a sulfonylurea herbicide, no inhibition of mutant R372S/F373P/D374V/D375E/R376Y
metsulfuron methyl
-
a sulfonylurea herbicide, complex inhibition, overview
metsulfuron methyl
a sulfonylurea herbicide, complex inhibition, overview
metsulfuron methyl
-
a sulfonylurea herbicide, complex inhibition, overview
metsulfuron methyl
-
IC50: 0.006 mM, over 80% inhibition at 0.04 mM
metsulfuron methyl
-
a sulfonylurea herbicide, complex inhibition, overview
metsulfuron-methyl
herbicide-resistant enzyme variant from Pseudomonas sp. Lm10 shows 56fold higher resistance than the sensitive variant from Pseudomonas putida KT2440
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
wild-type, 50% inhibition at 0.00262 mM, mutant C411S, 50% inhibition at 0.00668 mM, mutant C607S, 50% inhibition at 0.00887 mM
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
i.e. TP
N-(4,6-dimethylpyrimidin-2-yl)-5-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
-
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-fluoro-6-nitrobenzenesulfonamide
-
-
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-fluoro-6-nitrobenzenesulfonamide
-
68.4% inhibition at 10 mg/l
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-fluoro-6-nitrobenzenesulfonamide
-
-
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-fluoro-6-nitrobenzenesulfonamide
-
-
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-fluoro-6-nitrobenzenesulfonamide
-
-
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-iodo-6-nitrobenzenesulfonamide
-
-
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-iodo-6-nitrobenzenesulfonamide
-
65.1% inhibition at 10 mg/l
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-iodo-6-nitrobenzenesulfonamide
-
-
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-iodo-6-nitrobenzenesulfonamide
-
-
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-iodo-6-nitrobenzenesulfonamide
-
-
N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-2-nitro-6-(2,2,2-trifluoroethoxy)benzenesulfonamide
-
-
N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-2-nitro-6-(2,2,2-trifluoroethoxy)benzenesulfonamide
-
65.1% inhibition at 10 mg/l
N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-2-nitro-6-(2,2,2-trifluoroethoxy)benzenesulfonamide
-
-
N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-2-nitro-6-(2,2,2-trifluoroethoxy)benzenesulfonamide
-
-
N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-2-nitro-6-(2,2,2-trifluoroethoxy)benzenesulfonamide
-
-
N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide
-
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
-
ratio 1:1, i.e. Londax
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
-
ratio 1:1
N-[[(4-methoxy-1,3,5-triazin-2-yl)amino]carbonyl]-1-phenylmethanesulfonamide - methyl hydroperoxide
-
ratio 1:1, i.e. Londax
NC-311
-
sulfonylurea derivative, wild-type, 50% inhibition at 9.39 nM, mutant C411S, 50% inhibition at 16.83 nM, mutant C607S, 50% inhibition at 20.25 nM
propoxycarbazone
about 55% enzyme inhibition after 2 h at enzyme:inhibitor ratio of 10:1
propyl 4-(2-(4,6-dimethoxypyrimidin-2-yloxy)benzylamino)benzoate
-
i.e. ZJ0273. Moderate susceptibility of plants
propyl 4-(2-(4,6-dimethoxypyrimidin-2-yloxy)benzylamino)benzoate
-
i.e. ZJ0273. ALS activity in vivo is hardly affected by ZJ0273 at 100 mg/l
propyl 4-(2-(4,6-dimethoxypyrimidin-2-yloxy)benzylamino)benzoate
-
i.e. ZJ0273. Decline of ALS activity and lower biomass production at a rate of 10 mg/l of ZJ0273
propyl 4-(2-(4,6-dimethoxypyrimidin-2-yloxy)benzylamino)benzoate
Malachium aquaticum
-
i.e. ZJ0273. Moderate susceptibility of plants
pyrazosulfuron ethyl
-
IC50: 87 nM, over 80% inhibition at 0.04 mM
pyrithiobac
about 70% enzyme inhibition after 2 h at enzyme:inhibitor ratio of 10:1
pyroxsulam
inhibitor of wild-type enzyme, poor inhibition of the P197E mutant enzyme
sulfometuron methyl
-
the enzyme inhibitor shows activity against Mycobacterium tuberculosis both in vitro and in vivo
sulfometuron methyl
-
the enzyme inhibitor shows activity against Mycobacterium tuberculosis both in vitro and in vivo
sulfometuron methyl
-
IC50: 0.0048 mM, over 80% inhibition at 0.04 mM
sulfometuron methyl
-
active against Mycobacterium tuberculosis both in vitro and in vivo
sulfometuron methyl
-
the enzyme inhibitor shows activity against Mycobacterium tuberculosis both in vitro and in vivo
sulfonylurea
-
the inhibition by sulfonylurea is non-competitive or nearly competitive with respect to pyruvate
thiencarbazone methyl
about 40% enzyme inhibition after 2 h at enzyme:inhibitor ratio of 10:1
thiencarbazone methyl
94% inhibition after 60 min at 0.002 mM
Val
-
inhibition of the enzyme from Arabidopsis thaliana, no inhibition of the enzyme expressed in E. coli
Val
-
isoenzyme AHS I is sensitive to feed-back inhibition, isoenzyme AHS II is insensitive
Val
-
isoenzymes I and II are inhibited, isoenzyme II is not inhibited
Val
-
two enzyme forms: one is very sensitive to inhibition by Val, the second is not subject to feedback inhibition
valine
-
feedback inhibition of wild-type enzyme about 50% at 10 mM, M8 and M13 mutants are resistant
valine
feedback inhibition; feedback inhibition; feedback inhibition
valine
feedback inhibition, the inhibition by valine is uniquely in fungi reversed by MgATP
valine
-
1 mM, about 70%% residual activity in sulfonylurea-susceptible and 80% in sulfonylurea-resistant biotype
[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
a triazolopyrimidine derivative herbicide, no inhibition of mutant R372S/F373P/D374V/D375E/R376Y
[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
-
a triazolopyrimidine derivative herbicide, wild-type enzyme IC50: 0.0293 mM
additional information
-
ligand binding structures, and inhibition mechanism, overview
-
additional information
-
AHAS from Bacillus anthracis shows strong resistance to three classes of herbicides, the sulfonylurea Londax, the imidazolinone Cadre, and the triazolopyrimidine TP
-
additional information
-
ligand binding structures, and inhibition mechanism, overview
-
additional information
-
computational database screening for non-sulfonylurea inhibitors of AHAS, overview
-
additional information
-
inhibition kinetics or recombinant wild.type and reconstituted isozymes AHAS I
-
additional information
-
inhibitor synthesis, overview. Determination of ligand-receptor interaction and resistance mechanism in AHAS-sulfonylurea herbicide system, molecular modeling, overview
-
additional information
-
bulky substitutions in ortho-position of the sulfamoyl group in N-[(4-chloropyrimidin-2-yl)carbamoyl]benzenesulfonamide may enhance inhibitory activity. Negative charge distributed over a large surface area may enhance this activity. For better activity, the number of electronegative atoms present in the molecule should be high
-
additional information
P00892; P0ADG1
feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme. Certain imidazolinones show significant activity against the bacterial enzyme with Ki values of below 0.11 mM. Molecular docking of benzoyl ester compounds. AHAS-inhibitors and the probable binding pattern; feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme. Certain imidazolinones show significant activity against the bacterial enzyme with Ki values of below 0.11 mM. Molecular docking of benzoyl ester compounds. AHAS-inhibitors and the probable binding pattern; feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme. Certain imidazolinones show significant activity against the bacterial enzyme with Ki values of below 0.11 mM. Molecular docking of benzoyl ester compounds. AHAS-inhibitors and the probable binding pattern
-
additional information
feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme. Certain imidazolinones show significant activity against the bacterial enzyme with Ki values of below 0.11 mM. Molecular docking of benzoyl ester compounds. AHAS-inhibitors and the probable binding pattern; feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme. Certain imidazolinones show significant activity against the bacterial enzyme with Ki values of below 0.11 mM. Molecular docking of benzoyl ester compounds. AHAS-inhibitors and the probable binding pattern; feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme. Certain imidazolinones show significant activity against the bacterial enzyme with Ki values of below 0.11 mM. Molecular docking of benzoyl ester compounds. AHAS-inhibitors and the probable binding pattern
-
additional information
feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme. Certain imidazolinones show significant activity against the bacterial enzyme with Ki values of below 0.11 mM. Molecular docking of benzoyl ester compounds. AHAS-inhibitors and the probable binding pattern; feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme. Certain imidazolinones show significant activity against the bacterial enzyme with Ki values of below 0.11 mM. Molecular docking of benzoyl ester compounds. AHAS-inhibitors and the probable binding pattern; feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme. Certain imidazolinones show significant activity against the bacterial enzyme with Ki values of below 0.11 mM. Molecular docking of benzoyl ester compounds. AHAS-inhibitors and the probable binding pattern
-
additional information
ligand binding structures, and inhibition mechanism, overview
-
additional information
-
ligand binding structures, and inhibition mechanism, overview
-
additional information
-
screening of 100 sulfonylurea analogues for antimycobacterial activity, minimal inhibitory concentrations, overview
-
additional information
-
screening of 100 sulfonylurea analogues for antimycobacterial activity, minimal inhibitory concentrations, overview
-
additional information
-
mechanism and potency of enzyme inhibition by sulfonylurea herbicides, overview
-
additional information
-
screening of chemical libraries for effective inhibitors of the enzyme, overview
-
additional information
-
screening of 100 sulfonylurea analogues for antimycobacterial activity, minimal inhibitory concentrations, overview
-
additional information
not inhibited by bensulfuron methyl
-
additional information
-
single stranded DNA aptamers Apt1 (CGAGTGAGGGCGAGGCGCGCTCCTGCCGGT) and Apt6 (CGGCCAGGGGACGAGCGCGCCCTGATCGTG) demonstrate the greatest inhibitory potential against the enzyme activity with IC50 values in the low nanomolar range (28.94 and 22.35 nM respectively). Aptamers Apt2, Apt3 and Apt4 show moderate to lower inhibition specificities
-
additional information
-
screening of 100 sulfonylurea analogues for antimycobacterial activity, minimal inhibitory concentrations, overview
-
additional information
-
enzyme mutation P197E causes chick weed plant resistance to ALS inhibitors in population WRR04
-
additional information
enzyme mutation P197E causes chick weed plant resistance to ALS inhibitors in population WRR04
-
additional information
-
IC50 values of herbicides with mutant enzymes, overview
-
additional information
-
ligand binding structures, and inhibition mechanism, overview
-
additional information
-
feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme
-
additional information
molecular docking of inhibitor molecules to the enzyme crystal structure, 3D-QSAR modeling, overview
-
additional information
-
feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme
-
additional information
-
feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme
-
additional information
-
the majority of soil bacteria contain only one functional acetohydroxyacid synthase enzyme sensitive to sulfonylurea herbicides
-
