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2.2.1.6: acetolactate synthase

This is an abbreviated version!
For detailed information about acetolactate synthase, go to the full flat file.

Word Map on EC 2.2.1.6

Reaction

2 pyruvate =

2-acetolactate
+
CO2

Synonyms

aceto-hydroxy acid synthase, acetohydroxy acid synthase, acetohydroxy acid synthase I, acetohydroxy acid synthetase, acetohydroxyacid synthase, acetolactate pyruvate-lyase (carboxylating), acetolactate synthase, acetolactate synthetase, acetolactate-synthase, acetolactic synthetase, AHAS, AHAS II, AHAS1, AHAS2, AHAS3, AHASL, AHASS, alpha-acetohydroxy acid synthetase, alpha-acetohydroxyacid synthase, alpha-acetolactate synthase, alpha-acetolactate synthetase, alpha-ALS, ALS, ALS1, ALS1R, ALS2, AlsS, CalS, catabolic acetolactate synthase, EC 4.1.3.18, GST-mALS, GST-wALS, Ilv2, Ilv6, ilvB, ilvB1, ilvB2, ilvG, IlvN, ilvX, Moilv2, Moilv6, More, PF0935, sll1981, synthase, acetolactate, TM_0548, TM_0549, TTHA1213

ECTree

     2 Transferases
         2.2 Transferring aldehyde or ketonic groups
             2.2.1 Transketolases and transaldolases
                2.2.1.6 acetolactate synthase

Renatured

Renatured on EC 2.2.1.6 - acetolactate synthase

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RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
reconstitution of enzyme from small and catalytic subunit each overexpressed in Escherichia coli and purified. Small subunit protein stimulates catalytic subunit up to 7fold and confers upon it sensitivity to inhibition by valine
-
reconstitution of the holoenzyme from recombinant small and large subunits, not highly dependent on MgCl2, but when no extraneous magnesium is added the enzyme does not reach its full potential for activity
-
reconstitution of the holoenzyme from recombinantly expressed, purified subunits encoded by genes ilvB and ilvN
-
reconstitution with purified large subunit from Nicotiana plumbaginifolia or Arabidopsis thaliana results in both increased specific activity and increased stability of enzymic activity
-
the isolated large subunit has about one-third the activity of the holoenzyme, but it can be reconstituted to nearly complete activity by the addition of purified small subunits