2.1.1.20: glycine N-methyltransferase
This is an abbreviated version!
For detailed information about glycine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.20
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2.1.1.20
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s-adenosylmethionine
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s-adenosylhomocysteine
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homocysteine
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folate
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sarcosine
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adenosyltransferase
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cystathionine
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transmethylation
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adomet
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betaine-homocysteine
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remethylation
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beta-synthase
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one-carbon
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transsulfuration
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5-methyltetrahydrofolate
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medicine
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folate-dependent
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n-methylglycine
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s-methyltransferase
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glycine-n-methyltransferase
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guanidinoacetate
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folate-deficient
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pentaglutamate
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pah-binding
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adohcy
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diagnostics
- 2.1.1.20
- s-adenosylmethionine
- s-adenosylhomocysteine
- homocysteine
- folate
- sarcosine
-
adenosyltransferase
- cystathionine
-
transmethylation
- adomet
-
betaine-homocysteine
-
remethylation
- beta-synthase
-
one-carbon
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transsulfuration
- 5-methyltetrahydrofolate
- medicine
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folate-dependent
- n-methylglycine
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s-methyltransferase
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glycine-n-methyltransferase
- guanidinoacetate
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folate-deficient
- pentaglutamate
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pah-binding
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adohcy
- diagnostics
Reaction
Synonyms
4S polycyclic aromatic hydrocarbon binding protein, glycine methyltransferase, glycine N-methyltransferase, glycine-N methyltransferase, GNMT, Gnmt gene product, methyltransferase, glycine, S-adenosyl-L-methionine:glycine methyltransferase
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Substrates Products
Substrates Products on EC 2.1.1.20 - glycine N-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-homocysteine + N-methylglycine
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S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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N-methylglycine = sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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key regulatory enzyme for methyl group metabolism by regulating the S-adenosyl-L-methionine/S-adenosyl-L-homocysteine ratio
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine
N-methylglycine = sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine
N-methylglycine = sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, affects genetic stability by regulating DNA-methylation, key role in the one-carbon metabolism pathway
N-methylglycine = sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
key regulatory enzyme for methyl group metabolism by regulating the S-adenosyl-L-methionine/S-adenosyl-L-homocysteine ratio
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine
N-methylglycine = sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, affects genetic stability by regulating DNA methylation and interacting with environmental carcinogens
N-methylglycine = sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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N-methylglycine = sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
key regulatory enzyme for methyl group metabolism by regulating the S-adenosyl-L-methionine/S-adenosyl-L-homocysteine ratio
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine
N-methylglycine = sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, control of the methylating potential of the cell
N-methylglycine = sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + N-methylglycine
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?
S-adenosyl-L-homocysteine + sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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mechanism: the bound S-adenosyl-L-methionine is firmly connected to protein and a Gly pocket" is created near the bound S-adenosyl-L-methionine. The second substrate Gly binds to Arg175 and is brought into the Gly pocket. Five hydrogen bonds connect the Gly in the proximity of the bound S-adenosyl-L-methionine and orient the lone pair orbital on the amino nitrogen of Gly towards the donor methyl group of S-adenosyl-L-methionine. Thermal motion of the enzyme leads to a collision of the N and C(E) so that a SN2 methyltransfer reaction occurs
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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mechanism: the bound S-adenosyl-L-methionine is firmly connected to protein and a Gly pocket" is created near the bound S-adenosyl-L-methionine. The second substrate Gly binds to Arg175 and is brought into the Gly pocket. Five hydrogen bonds connect the Gly in the proximity of the bound S-adenosyl-L-methionine and orient the lone pair orbital on the amino nitrogen of Gly towards the donor methyl group of S-adenosyl-L-methionine. Thermal motion of the enzyme leads to a collision of the N and C(E) so that a SN2 methyltransfer reaction occurs
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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strict specificity for glycine as methyl acceptor
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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strict specificity for glycine as methyl acceptor
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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regulates the ratio of S-adenosylmethionine to S-adenosylhomocysteine
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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the enzyme regulates the methyl group supply for S-adenosylmethionine-dependent transmethylation reactions. All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats
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?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
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mechanism: the bound S-adenosyl-L-methionine is firmly connected to protein and a Gly pocket" is created near the bound S-adenosyl-L-methionine. The second substrate Gly binds to Arg175 and is brought into the Gly pocket. Five hydrogen bonds connect the Gly in the proximity of the bound S-adenosyl-L-methionine and orient the lone pair orbital on the amino nitrogen of Gly towards the donor methyl group of S-adenosyl-L-methionine. Thermal motion of the enzyme leads to a collision of the N and C(E) so that a SN2 methyltransfer reaction occurs
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-
?
S-adenosyl-L-methionine + glycine
S-adenosyl-L-homocysteine + sarcosine
mechanism: the bound S-adenosyl-L-methionine is firmly connected to protein and a Gly pocket" is created near the bound S-adenosyl-L-methionine. The second substrate Gly binds to Arg175 and is brought into the Gly pocket. Five hydrogen bonds connect the Gly in the proximity of the bound S-adenosyl-L-methionine and orient the lone pair orbital on the amino nitrogen of Gly towards the donor methyl group of S-adenosyl-L-methionine. Thermal motion of the enzyme leads to a collision of the N and C(E) so that a SN2 methyltransfer reaction occurs
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interaction of benzo(a)pyrene with the enzyme may contribute to carcinogenesis
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additional information
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major folate binding protein, interacts with environmental carcinogens such as benzo(a)pyrene
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additional information
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a mammalian target of rapamycin (mTOR) inhibitor (DEP domain containing MTOR-interacting protein [DEPDC6/DEPTOR]) is identified as a GNMT-binding protein by using yeast two-hybrid screening. The C-terminal half of GNMT interacts with the PSD-95/Dlg1/ZO-1 (PDZ) domain of DEPDC6/DEPTOR
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additional information
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major folate binding protein, involved in the regulation of the expression of S-adenosylhomocysteine hydrolase and formiminotransferase cyclodeaminase, binds benzo(a)pyrene and prevents DNA-adduct formation
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additional information
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GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241
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additional information
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GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241
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additional information
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all-trans-retinoic acid and dexamethasone independently induce GNMT in liver, no effect on enzyme from pancreas
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additional information
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kinetic isotope effects at the transferred methyl group implicate a compaction effect that is conferred by the protein structure
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