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Disease on EC 2.1.1.20 - glycine N-methyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Epigenetic Silencing of GNMT Gene in Pancreatic Adenocarcinoma.
adenosine kinase deficiency
Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders.
S-adenosylmethionine induces mitochondrial dysfunction, permeability transition pore opening and redox imbalance in subcellular preparations of rat liver.
adenosylhomocysteinase deficiency
Inherited disorders in the conversion of methionine to homocysteine.
Atherosclerosis
Deficiency of Glycine N-methyltransferase Aggravates Atherosclerosis in Apolipoprotein E-null Mice.
Role of glycine N-methyltransferase in experimental ulcerative colitis.
Brain Neoplasms
Expression of sarcosine metabolism-related proteins according to metastatic site in breast cancer.
Breast Neoplasms
Expression of sarcosine metabolism-related proteins according to metastatic site in breast cancer.
Implications of differences in expression of sarcosine metabolism-related proteins according to the molecular subtype of breast cancer.
MAT2A Localization and Its Independently Prognostic Relevance in Breast Cancer Patients.
Carcinogenesis
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma.
Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis.
Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates.
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.
GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation.
Hepatoma Cells From Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1.
Higher susceptibility to aflatoxin B(1)-related hepatocellular carcinoma in glycine N-methyltransferase knockout mice.
MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma.
The important role of glycine N-methyltransferase in the carcinogenesis and progression of prostate cancer.
The role of stem cells/progenitor cells in liver carcinogenesis in glycine N-methyltransferase deficient mice.
Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma.
Carcinoma, Hepatocellular
A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma.
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage.
Alteration of glycine N-methyltransferase activity in fetal, adult, and tumor tissues.
Alterations of methionine metabolism in hepatocarcinogenesis: the emergent role of glycine N-methyltransferase in liver injury.
Benzo(a)pyrene induced glycine N-methyltransferase messenger RNA expression in Fundulus heteroclitus embryos.
Blocking sphingosine 1-phosphate receptor 2 accelerates hepatocellular carcinoma progression in a mouse model of NASH.
Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility.
Characterization of reduced expression of glycine N-methyltransferase in cancerous hepatic tissues using two newly developed monoclonal antibodies.
Characterization of the 5' regulatory region of the human glycine N-methyltransferase gene.
Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver.
Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.
Functional Characterization of Glycine N-methyltransferase and its Interactive Protein-DEPDC6/DEPTOR in Hepatocellular Carcinoma.
Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene.
Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer.
Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect.
Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates.
Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma.
Glycine N-methyltransferase is a mediator of cytochrome P4501A1 gene expression.
Glycine-N Methyltransferase Expression in HepG2 Cells Is Involved in Methyl Group Homeostasis by Regulating Transmethylation Kinetics and DNA Methylation.
GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation.
Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer.
Hepatoma Cells From Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1.
Higher susceptibility to aflatoxin B(1)-related hepatocellular carcinoma in glycine N-methyltransferase knockout mice.
Identification of 1,2,3,4,6-Penta-O-galloyl-?-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma.
Identification of FKBP11 as a biomarker for hepatocellular carcinoma.
Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma.
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma.
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis.
Rat liver cytosolic 4 S polycyclic aromatic hydrocarbon-binding protein is glycine N-methyltransferase.
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma.
Retinoic acid and glucocorticoid treatment induce hepatic glycine N-methyltransferase and lower plasma homocysteine concentrations in rats and rat hepatoma cells.
Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and HCV co-infection.
Targeted and untargeted metabolomics provide insight into the consequences of glycine-N-methyltransferase deficiency including the novel finding of defective immune function.
The multi-functional roles of GNMT in toxicology and cancer.
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency.
Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma.
Cholangiocarcinoma
Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma.
Cholestasis
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis.
Cleft Lip
Common polymorphism in the glycine N-methyltransferase gene as a novel risk factor for cleft lip with or without cleft palate.
Cleft Palate
Common polymorphism in the glycine N-methyltransferase gene as a novel risk factor for cleft lip with or without cleft palate.
Colitis
Role of glycine N-methyltransferase in experimental ulcerative colitis.
Colitis, Ulcerative
Role of glycine N-methyltransferase in experimental ulcerative colitis.
Diabetes Mellitus
Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver.
Diabetes Mellitus, Type 2
Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver.
Diabetic Nephropathies
Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis.
Dysplastic Nevus Syndrome
Promoter CpG Island Hypermethylation in Dysplastic Nevus and Melanoma: CLDN11 as an Epigenetic Biomarker for Malignancy.
Encephalomyelitis
Role of Glycine N-methyltransferase in The Regulation of T Cell Responses in Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Role of Glycine N-methyltransferase in The Regulation of T Cell Responses in Experimental Autoimmune Encephalomyelitis.
Fatty Liver
Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.
Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide.
Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver.
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease.
The multi-functional roles of GNMT in toxicology and cancer.
Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression.
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency.
glycine n-methyltransferase deficiency
Characterization of reduced expression of glycine N-methyltransferase in cancerous hepatic tissues using two newly developed monoclonal antibodies.
Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver.
Glycine N -methyltransferase deficiency: a new patient with a novel mutation.
Glycine N-methyltransferase Deficiency Affects Niemann-Pick Type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis.
Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver.
Glycine N-Methyltransferase Deficiency: A Member of Dysmethylating Liver Disorders?
Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia.
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.
Inherited disorders in the conversion of methionine to homocysteine.
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.
Methyl balance and transmethylation fluxes in humans.
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis.
Role of Glycine N-methyltransferase in The Regulation of T Cell Responses in Experimental Autoimmune Encephalomyelitis.
The multi-functional roles of GNMT in toxicology and cancer.
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency.
Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma.
guanidinoacetate n-methyltransferase deficiency
Methyl balance and transmethylation fluxes in humans.
Heart Defects, Congenital
Maternal and infant genetic variants, maternal periconceptional use of selective serotonin reuptake inhibitors, and risk of congenital heart defects in offspring: population based study.
Hepatitis
Role of glycine N-methyltransferase in experimental ulcerative colitis.
Hepatitis, Chronic
Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver.
Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect.
Glycine N-methyltransferase Deficiency Affects Niemann-Pick Type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis.
Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver.
Hepatoblastoma
Characterization of reduced expression of glycine N-methyltransferase in cancerous hepatic tissues using two newly developed monoclonal antibodies.
Hepatomegaly
Characterization of reduced expression of glycine N-methyltransferase in cancerous hepatic tissues using two newly developed monoclonal antibodies.
Hyperlipidemias
Deficiency of Glycine N-methyltransferase Aggravates Atherosclerosis in Apolipoprotein E-null Mice.
Infections
Enhanced expression of glycine N-methyltransferase by adenovirus-mediated gene transfer in CNS culture is neuroprotective.
Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection.
Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway.
Insulin Resistance
Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver.
Liver Cirrhosis
AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage.
MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma.
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis.
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma.
Liver Diseases
AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage.
Deficiency of Glycine N-methyltransferase Aggravates Atherosclerosis in Apolipoprotein E-null Mice.
Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide.
Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver.
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.
S-adenosylmethionine induces mitochondrial dysfunction, permeability transition pore opening and redox imbalance in subcellular preparations of rat liver.
Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and HCV co-infection.
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency.
Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma.
Liver Neoplasms
Benzo[a]pyrene and glycine N-methyltransferse interactions: gene expression profiles of the liver detoxification pathway.
Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility.
Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma.
Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis.
Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis.
Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer.
Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver.
Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway.
GNMT negatively regulates MAPK pathway and suppresses the growth and metastasis of hepatocellular cancer cells.
Higher susceptibility to aflatoxin B(1)-related hepatocellular carcinoma in glycine N-methyltransferase knockout mice.
Identification of 1,2,3,4,6-Penta-O-galloyl-?-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma.
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
Malaria
Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India.
Melanoma
Promoter CpG Island Hypermethylation in Dysplastic Nevus and Melanoma: CLDN11 as an Epigenetic Biomarker for Malignancy.
Metabolic Syndrome
Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver.
Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice.
Neoplasm Metastasis
Expression of sarcosine metabolism-related proteins according to metastatic site in breast cancer.
GNMT negatively regulates MAPK pathway and suppresses the growth and metastasis of hepatocellular cancer cells.
Neoplasms
A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma.
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization.
AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage.
Alteration of glycine N-methyltransferase activity in fetal, adult, and tumor tissues.
Alterations of methionine metabolism in hepatocarcinogenesis: the emergent role of glycine N-methyltransferase in liver injury.
Androgen Response Element of the Glycine N-Methyltransferase Gene is Located in the Coding Region of its First Exon.
Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility.
Characterization of the 5' regulatory region of the human glycine N-methyltransferase gene.
Functional Characterization of Glycine N-methyltransferase and its Interactive Protein-DEPDC6/DEPTOR in Hepatocellular Carcinoma.
Genetic polymorphisms of the glycine N-methyltransferase and prostate cancer risk in the health professionals follow-up study.
Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer.
Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect.
Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma.
Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway.
Glycine-N Methyltransferase Expression in HepG2 Cells Is Involved in Methyl Group Homeostasis by Regulating Transmethylation Kinetics and DNA Methylation.
Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer.
Identification of 1,2,3,4,6-Penta-O-galloyl-?-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma.
Identification of FKBP11 as a biomarker for hepatocellular carcinoma.
MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma.
Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).
Role of Glycine N-methyltransferase in The Regulation of T Cell Responses in Experimental Autoimmune Encephalomyelitis.
The multi-functional roles of GNMT in toxicology and cancer.
The role of sarcosine metabolism in prostate cancer progression.
Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma.
Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene.
Non-alcoholic Fatty Liver Disease
Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis.
Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver.
Glycine N-methyltransferase Deficiency Affects Niemann-Pick Type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis.
Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease.
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease.
Proteomic analysis of liver mitochondria of apolipoprotein E knockout mice treated with metformin.
Pancreatic Neoplasms
The Case for GNMT as a Biomarker and a Therapeutic Target in Pancreatic Cancer.
Pellagra
Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide.
Prostatic Hyperplasia
Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer.
Prostatic Neoplasms
Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells.
Characterization of the 5' regulatory region of the human glycine N-methyltransferase gene.
Genetic polymorphisms of the glycine N-methyltransferase and prostate cancer risk in the health professionals follow-up study.
Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer.
Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.
Strong cis-acting expression quantitative trait loci for the genes encoding SNHG5 and PEX6.
The important role of glycine N-methyltransferase in the carcinogenesis and progression of prostate cancer.
Psoriasis
Polymorphisms in GNMT and DNMT3b are associated with methotrexate treatment outcome in plaque psoriasis.
Sarcoma, Avian
Glycine N-methyltransferase is an example of functional diversity. Role as a polycyclic aromatic hydrocarbon-binding receptor.
Squamous Cell Carcinoma of Head and Neck
Identification of novel methylation markers in HPV-associated oropharyngeal cancer: genome-wide discovery, tissue verification and validation testing in ctDNA.