2.1.1.20: glycine N-methyltransferase
This is an abbreviated version!
For detailed information about glycine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.20
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2.1.1.20
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s-adenosylmethionine
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s-adenosylhomocysteine
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homocysteine
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folate
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sarcosine
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adenosyltransferase
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cystathionine
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transmethylation
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adomet
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betaine-homocysteine
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remethylation
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beta-synthase
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one-carbon
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transsulfuration
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5-methyltetrahydrofolate
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medicine
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folate-dependent
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n-methylglycine
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s-methyltransferase
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glycine-n-methyltransferase
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guanidinoacetate
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folate-deficient
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pentaglutamate
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pah-binding
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adohcy
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diagnostics
- 2.1.1.20
- s-adenosylmethionine
- s-adenosylhomocysteine
- homocysteine
- folate
- sarcosine
-
adenosyltransferase
- cystathionine
-
transmethylation
- adomet
-
betaine-homocysteine
-
remethylation
- beta-synthase
-
one-carbon
-
transsulfuration
- 5-methyltetrahydrofolate
- medicine
-
folate-dependent
- n-methylglycine
-
s-methyltransferase
-
glycine-n-methyltransferase
- guanidinoacetate
-
folate-deficient
- pentaglutamate
-
pah-binding
-
adohcy
- diagnostics
Reaction
Synonyms
4S polycyclic aromatic hydrocarbon binding protein, glycine methyltransferase, glycine N-methyltransferase, glycine-N methyltransferase, GNMT, Gnmt gene product, methyltransferase, glycine, S-adenosyl-L-methionine:glycine methyltransferase
ECTree
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Inhibitors
Inhibitors on EC 2.1.1.20 - glycine N-methyltransferase
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5-methyltetrahydrofolate monoglutamate
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native N-acetylated form of the enzyme shows 50% inhibition at 0.05 mM while the recombinant non-acetylated form shows 50% inhibition at 1.89 mM
folate
the native rat liver GNMT contains an acetylated N-terminal valine and is inhibited much more efficiently compared to the recombinant protein
additional information
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folate-containing diets attenuate GNMT activity in diabetic rats but are without effect on abundance
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5-Methyltetrahydrofolate pentaglutamate
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noncompetitive inhibitor with respect to substrates S-adenosyl-L-methionine and glycine
5-Methyltetrahydrofolate pentaglutamate
noncompetitive inhibitor regarding substrates S-adenosyl-L-methionine and glycine
5-Methyltetrahydrofolate pentaglutamate
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noncompetitive inhibitor with respect to substrates S-adenosyl-L-methionine and glycine
5-Methyltetrahydrofolate pentaglutamate
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native N-acetylated form of the enzyme shows 50% inhibition at 0.0013 mM while the recombinant non-acetylated form shows 50% inhibition at 0.59 mM
5-Methyltetrahydrofolate pentaglutamate
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noncompetitive inhibitor with respect to substrates S-adenosyl-L-methionine and glycine
5-Methyltetrahydrofolate pentaglutamate
noncompetitive inhibitor with respect to substrates S-adenosyl-L-methionine and glycine