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2.1.1.20: glycine N-methyltransferase

This is an abbreviated version!
For detailed information about glycine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.20

Reaction

S-adenosyl-L-methionine
+
glycine
=
S-adenosyl-L-homocysteine
+
sarcosine

Synonyms

4S polycyclic aromatic hydrocarbon binding protein, glycine methyltransferase, glycine N-methyltransferase, glycine-N methyltransferase, GNMT, Gnmt gene product, methyltransferase, glycine, S-adenosyl-L-methionine:glycine methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.20 glycine N-methyltransferase

Inhibitors

Inhibitors on EC 2.1.1.20 - glycine N-methyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2'-deoxyadenosine
-
-
3-deazaadenosine
-
-
5'-N-ethylcarboxamidoadenosine
-
-
5'-S-isobutylthio-5'-deoxyadenosine
-
-
5'-[p-(fluorosulfonyl)benzoyl]adenosine
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
-
5-methyl-tetrahydrofolate
5-methyltetrahydrofolate
-
5-Methyltetrahydrofolate hexaglutamate
-
-
5-methyltetrahydrofolate monoglutamate
-
native N-acetylated form of the enzyme shows 50% inhibition at 0.05 mM while the recombinant non-acetylated form shows 50% inhibition at 1.89 mM
5-Methyltetrahydrofolate pentaglutamate
5-Methyltetrahydrofolate triglutamate
-
-
5-methyltetrahydrofolic acid
-
-
5-Methyltetrahydropteroylpentaglutamate
folate
the native rat liver GNMT contains an acetylated N-terminal valine and is inhibited much more efficiently compared to the recombinant protein
folinic acid
-
-
Gly
-
at very high concentrations
iodoacetate
-
-
methotrexate
-
-
p-chloromercuribenzoate
-
-
S-adenosyl-L-homocysteine
sarcosine
-
weak
thioglycolic acid
-
weak
Urea
-
-
additional information
-
folate-containing diets attenuate GNMT activity in diabetic rats but are without effect on abundance
-