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2.1.1.20: glycine N-methyltransferase

This is an abbreviated version!
For detailed information about glycine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.20

Reaction

S-adenosyl-L-methionine
+
glycine
=
S-adenosyl-L-homocysteine
 +
sarcosine

Synonyms

4S polycyclic aromatic hydrocarbon binding protein, glycine methyltransferase, glycine N-methyltransferase, glycine-N methyltransferase, GNMT, Gnmt gene product, methyltransferase, glycine, S-adenosyl-L-methionine:glycine methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.20 glycine N-methyltransferase

Reference

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Reference on EC 2.1.1.20 - glycine N-methyltransferase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Heady, J.E.; Kerr, S.J.
Purification and characterization of glycine N-methyltransferase
J. Biol. Chem.
248
69-72
1973
Oryctolagus cuniculus
Manually annotated by BRENDA team
Wagner, C.; Decha-Umphai, W.; Corbin, J.
Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural folate ligand
J. Biol. Chem.
264
9638-9642
1989
Rattus norvegicus
Manually annotated by BRENDA team
Ogawa, H.; Fujioka, M.
Purification and properties of glycine N-methyltransferase from rat liver
J. Biol. Chem.
257
3447-3452
1982
Rattus norvegicus
Manually annotated by BRENDA team
Fujioka, M.; Ishiguro, Y.
Reaction of rat liver glycine methyltransferase with 5-p-fluorosulfonylbenzoyladenosine
J. Biol. Chem.
261
6346-6351
1986
Rattus norvegicus
Manually annotated by BRENDA team
Yeo, E.J.; Wagner, C.
Purification and properties of pancreatic glycine N-methyltransferase
J. Biol. Chem.
267
24669-24674
1992
Rattus norvegicus
Manually annotated by BRENDA team
Fujioka, M.; Takata, Y.; Konishi, K.; Ogawa, H.
Function and reactivity of sulfhydryl groups of rat liver glycine methyltransferase
Biochemistry
26
5696-5702
1987
Rattus norvegicus
Manually annotated by BRENDA team
Wagner, C.; Briggs, W.T.; Cook, R.J.
Inhibition of glycine N-methyltransferase activity by folate derivatives: implications for regulation of methyl group metabolism
Biochem. Biophys. Res. Commun.
127
746-752
1985
Rattus norvegicus
Manually annotated by BRENDA team
Pattanayek, R.; Newcomer, M.E.; Wagner, C.
Crystal structure of apo-glycine N-methyltransferase (GNMT)
Protein Sci.
7
1326-1331
1998
Rattus norvegicus
Manually annotated by BRENDA team
Fu, Z.; Hu, Y.; Konishi, K.; Takata, Y.; Ogawa, H.; Gomi, T.; Fujioka, M.; Takusagawa, F.
Crystal structure of glycine N-methyltransferase from rat liver
Biochemistry
35
11985-11993
1996
Rattus norvegicus (P13255)
Manually annotated by BRENDA team
Huang, Y.; Komoto, J.; Konishi, K.; Takata, Y.; Ogawa, H.; Gomi, T.; Fujioka, M.; Takusagawa, F.
Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: Crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes
J. Mol. Biol.
298
149-162
2000
Rattus norvegicus (P13255)
Manually annotated by BRENDA team
Bhat, R.; Bresnick, E.
Glycine N-methyltransferase is an example of functional diversity. Role as a polycyclic aromatic hydrocarbon-binding receptor
J. Biol. Chem.
272
21221-21226
1997
Rattus norvegicus
Manually annotated by BRENDA team
Bhat, R.; Wagner, C.; Bresnick, E.
The homodimeric form of glycine N-methyltransferase acts as a polycyclic aromatic hydrocarbon-binding receptor
Biochemistry
36
9906-9910
1997
Rattus norvegicus
Manually annotated by BRENDA team
Ogawa, H.; Gomi, T.; Imamura, T.; Kobayashi, M.; Huh, N.H.
Rat liver 4 S-benzo[a]pyrene-binding protein is distinct from glycine N-methyltransferase
Biochem. Biophys. Res. Commun.
233
300-304
1997
Rattus norvegicus
Manually annotated by BRENDA team
Raha, A.; Wagner, C.; MacDonald, R.G.; Bresnick, E.
Rat liver cytosolic 4 S polycyclic aromatic hydrocarbon-binding protein is glycine N-methyltransferase
J. Biol. Chem.
269
5750-5756
1994
Rattus norvegicus
Manually annotated by BRENDA team
Ogawa, H.; Gomi, T.; Takusagawa, F.; Fujioka, M.
Structure, function and physiological role of glycine N-methyltransferase
Int. J. Biochem. Cell Biol.
30
13-26
1998
Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Luka, Z.; Cerone, R.; Phillips, J.A.; Mudd, S.H.; Wagner, C.
Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism
Hum. Genet.
110
68-74
2002
Homo sapiens
Manually annotated by BRENDA team
Rowling, M.J.; McMullen, M.H.; Schalinske, K.L.
Vitamin A and its derivatives induce hepatic glycine N-methyltransferase and hypomethylation of DNA in rats
J. Nutr.
132
365-369
2002
Rattus norvegicus
Manually annotated by BRENDA team
Rowling, M.J.; McMullen, M.H.; Chipman, D.C.; Schalinske, K.L.
Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats
J. Nutr.
132
2545-2550
2002
Rattus norvegicus
Manually annotated by BRENDA team
Aida, K.; Tawata, M.; Negishi, M.; Onaya, T.
Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone
Horm. Metab. Res.
29
646-649
1997
Mus musculus
Manually annotated by BRENDA team
Yeo, E.J.; Wagner, C.
Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver
Proc. Natl. Acad. Sci. USA
91
210-214
1994
Rattus norvegicus
Manually annotated by BRENDA team
McMullen, M.H.; Rowling, M.J.; Ozias, M.K.; Schalinske, K.L.
Activation and induction of glycine N-methyltransferase by retinoids are tissue- and gender-specific
Arch. Biochem. Biophys.
401
73-80
2002
Rattus norvegicus
Manually annotated by BRENDA team
Luka, Z.; Wagner, C.
Human glycine N-methyltransferase is unfolded by urea through a compact monomer state
Arch. Biochem. Biophys.
420
153-160
2003
Homo sapiens
Manually annotated by BRENDA team
Luka, Z.; Wagner, C.
Effect of naturally occurring mutations in human glycine N-methyltransferase on activity and conformation
Biochem. Biophys. Res. Commun.
312
1067-1072
2003
Homo sapiens
Manually annotated by BRENDA team
Kloor, D.; Karnahl, K.; Kompf, J.
Characterization of glycine N-methyltransferase from rabbit liver
Biochem. Cell Biol.
82
369-374
2004
Oryctolagus cuniculus
Manually annotated by BRENDA team
Takata, Y.; Huang, Y.; Komoto, J.; Yamada, T.; Konishi, K.; Ogawa, H.; Gomi, T.; Fujioka, M.; Takusagawa, F.
Catalytic mechanism of glycine N-methyltransferase
Biochemistry
42
8394-8402
2003
Rattus norvegicus (P13255)
Manually annotated by BRENDA team
Chen, S.Y.; Lin, J.R.; Darbha, R.; Lin, P.; Liu, T.Y.; Chen, Y.M.
Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway
Cancer Res.
64
3617-3623
2004
Homo sapiens
Manually annotated by BRENDA team
Rowling, M.J.; Schalinske, K.L.
Retinoic acid and glucocorticoid treatment induce hepatic glycine N-methyltransferase and lower plasma homocysteine concentrations in rats and rat hepatoma cells
J. Nutr.
133
3392-3398
2003
Rattus norvegicus
Manually annotated by BRENDA team
Ozias, M.K.; Schalinske, K.L.
All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats
J. Nutr.
133
4090-4094
2003
Rattus norvegicus
Manually annotated by BRENDA team
Luka, Z.; Wagner, C.
Expression and purification of glycine N-methyltransferases in Escherichia coli
Protein Expr. Purif.
28
280-286
2003
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Pakhomova, S.; Luka, Z.; Grohmann, S.; Wagner, C.; Newcomer, M.E.
Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes
Proteins
57
331-337
2004
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Nieman, K.M.; Hartz, C.S.; Szegedi, S.S.; Garrow, T.A.; Sparks, J.D.; Schalinske, K.L.
Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats
Am. J. Physiol. Endocrinol. Metab.
291
E1235-E1242
2006
Rattus norvegicus
Manually annotated by BRENDA team
Huang, Y.C.; Lee, C.M.; Chen, M.; Chung, M.Y.; Chang, Y.H.; Huang, W.J.; Ho, D.M.; Pan, C.C.; Wu, T.T.; Yang, S.; Lin, M.W.; Hsieh, J.T.; Chen, Y.M.
Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer
Clin. Cancer Res.
13
1412-1420
2007
Homo sapiens
Manually annotated by BRENDA team
Luka, Z.; Pakhomova, S.; Loukachevitch, L.V.; Egli, M.; Newcomer, M.E.; Wagner, C.
5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase
J. Biol. Chem.
282
4069-4075
2007
Rattus norvegicus (P13255)
Manually annotated by BRENDA team
Beagle, B.; Yang, T.L.; Hung, J.; Cogger, E.A.; Moriarty, D.J.; Caudill, M.A.
The glycine N-methyltransferase (GNMT) 1289 C->T variant influences plasma total homocysteine concentrations in young women after restricting folate intake
J. Nutr.
135
2780-2785
2005
Homo sapiens
Manually annotated by BRENDA team
Luka, Z.; Ham, A.J.; Norris, J.L.; Yeo, E.J.; Yermalitsky, V.; Glenn, B.; Caprioli, R.M.; Liebler, D.C.; Wagner, C.
Identification of phosphorylation sites in glycine N-methyltransferase from rat liver
Protein Sci.
15
785-794
2006
Rattus norvegicus
Manually annotated by BRENDA team
Lee, C.M.; Chen, S.Y.; Lee, Y.C.; Huang, C.Y.; Chen, Y.M.
Benzo[a]pyrene and glycine N-methyltransferse interactions: gene expression profiles of the liver detoxification pathway
Toxicol. Appl. Pharmacol.
214
126-135
2006
Homo sapiens
Manually annotated by BRENDA team
Luka, Z.; Capdevila, A.; Mato, J.M.; Wagner, C.
A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme
Transgenic Res.
15
393-397
2006
Homo sapiens, Mus musculus (Q9QXF8), Mus musculus
Manually annotated by BRENDA team
Luka, Z.; Loukachevitch, L.V.; Wagner, C.
Acetylation of N-terminal valine of glycine N-methyltransferase affects enzyme inhibition by folate
Biochim. Biophys. Acta
1784
1342-1346
2008
Rattus norvegicus
Manually annotated by BRENDA team
Martinez-Chantar, M.L.; Vazquez-Chantada, M.; Ariz, U.; Martinez, N.; Varela, M.; Luka, Z.; Capdevila, A.; Rodriguez, J.; Aransay, A.M.; Matthiesen, R.; Yang, H.; Calvisi, D.F.; Esteller, M.; Fraga, M.; Lu, S.C.; Wagner, C.; Mato, J.M.
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
Hepatology
47
1191-1199
2008
Mus musculus
Manually annotated by BRENDA team
Liu, S.; Li, Y.; Chen, Y.; Chiang, E.; Li, A.F.; Lee, Y.; Tsai, T.; Hsiao, M.; Huang, S.; Chen, Y.A.
Glycine N-methyltransferase -/- mice develop chronic hepatitis and glycogen storage disease in the liver
Hepatology
47
768-769
2008
Mus musculus
-
Manually annotated by BRENDA team
Huang, Y.C.; Chen, M.; Shyr, Y.M.; Su, C.H.; Chen, C.K.; Li, A.F.; Ho, D.M.; Chen, Y.M.
Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma
J. Gastroenterol. Hepatol.
23
1384-1389
2008
Homo sapiens
Manually annotated by BRENDA team
Luka, Z.; Pakhomova, S.; Luka, Y.; Newcomer, M.E.; Wagner, C.
Destabilization of human glycine N-methyltransferase by H176N mutation
Protein Sci.
16
1957-1964
2007
Homo sapiens (Q14749), Homo sapiens
Manually annotated by BRENDA team
Fang, X.; Dong, W.; Thornton, C.; Scheffler, B.; Willett, K.L.
Benzo(a)pyrene induced glycine N-methyltransferase messenger RNA expression in Fundulus heteroclitus embryos
Mar. Environ. Res.
69S1
S74-S76
2010
Fundulus heteroclitus (D3GAN3), Fundulus heteroclitus
Manually annotated by BRENDA team
Lee, C.M.; Shih, Y.P.; Wu, C.H.; Chen, Y.M.
Characterization of the 5 regulatory region of the human glycine N-methyltransferase gene
Gene
443
151-157
2009
Homo sapiens
Manually annotated by BRENDA team
Liao, Y.J.; Liu, S.P.; Lee, C.M.; Yen, C.H.; Chuang, P.C.; Chen, C.Y.; Tsai, T.F.; Huang, S.F.; Lee, Y.H.; Chen, Y.M.
Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility
Int. J. Cancer
124
816-826
2009
Mus musculus
Manually annotated by BRENDA team
Luka, Z.; Mudd, S.H.; Wagner, C.
Glycine N-methyltransferase and regulation of S-adenosylmethionine levels
J. Biol. Chem.
284
22507-22511
2009
Danio rerio, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Sus scrofa, Rattus norvegicus (P13255)
Manually annotated by BRENDA team
Yen, C.H.; Hung, J.H.; Ueng, Y.F.; Liu, S.P.; Chen, S.Y.; Liu, H.H.; Chou, T.Y.; Tsai, T.F.; Darbha, R.; Hsieh, L.L.; Chen, Y.M.
Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect
Toxicol. Appl. Pharmacol.
235
296-304
2009
Homo sapiens
Manually annotated by BRENDA team
Luka, Z.
Methyltetrahydrofolate in folate-binding protein glycine N-methyltransferase
Vitam. Horm.
79
325-345
2008
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus scrofa (Q29555), Mus musculus (Q9QXF8), Mus musculus
Manually annotated by BRENDA team
Wang, Y.C.; Tang, F.Y.; Chen, S.Y.; Chen, Y.M.; Chiang, E.P.
Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation
J. Nutr.
141
777-782
2011
Homo sapiens
Manually annotated by BRENDA team
Song, Y.H.; Shiota, M.; Kuroiwa, K.; Naito, S.; Oda, Y.
The important role of glycine N-methyltransferase in the carcinogenesis and progression of prostate cancer
Mod. Pathol.
24
1272-1280
2011
Homo sapiens
Manually annotated by BRENDA team
Yen, C.H.; Lu, Y.C.; Li, C.H.; Lee, C.M.; Chen, C.Y.; Cheng, M.Y.; Huang, S.F.; Chen, K.F.; Cheng, A.L.; Liao, L.Y.; Lee, Y.H.; Chen, Y.M.
Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma
Mol. Med.
18
286-296
2012
Homo sapiens
Manually annotated by BRENDA team
Luka, Z.; Pakhomova, S.; Loukachevitch, L.; Newcomer, M.; Wagner, C.
Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate
Biochim. Biophys. Acta
1824
286-291
2012
Rattus norvegicus (P13255)
Manually annotated by BRENDA team
Chou, W.Y.; Zhao, J.F.; Chen, Y.M.; Lee, K.I.; Su, K.H.; Shyue, S.K.; Lee, T.S.
Role of glycine N-methyltransferase in experimental ulcerative colitis
J. Gastroenterol. Hepatol.
29
494-501
2014
Mus musculus
Manually annotated by BRENDA team
Ottaviani, S.; Brooke, G.N.; OHanlon-Brown, C.; Waxman, J.; Ali, S.; Buluwela, L.
Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells
J. Mol. Endocrinol.
51
301-312
2013
Homo sapiens
Manually annotated by BRENDA team
Li, C.H.; Lin, M.H.; Chu, S.H.; Tu, P.H.; Fang, C.C.; Yen, C.H.; Liang, P.I.; Huang, J.C.; Su, Y.C.; Sytwu, H.K.; Chen, Y.M.
Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis
Mol. Med.
20
684-696
2014
Mus musculus (Q9QXF8)
Manually annotated by BRENDA team
DebRoy, S.; Kramarenko, I.I.; Ghose, S.; Oleinik, N.V.; Krupenko, S.A.; Krupenko, N.I.
A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization
PLoS ONE
8
e70062
2013
Homo sapiens
Manually annotated by BRENDA team
Tain, L.S.; Jain, C.; Nespital, T.; Froehlich, J.; Hinze, Y.; Groenke, S.; Partridge, L.
Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production
Aging Cell
19
e13043
2019
Mus musculus (Q9QXF8), Drosophila melanogaster (Q9VG42)
Manually annotated by BRENDA team
Zhang, J.; Klinman, J.P.
Convergent mechanistic features between the structurally diverse N- and O-methyltransferases glycine N-methyltransferase and catechol O-methyltransferase
J. Am. Chem. Soc.
138
9158-9165
2016
Rattus norvegicus (P13255)
Manually annotated by BRENDA team
Swiderek, K.; Tunon, I.; Williams,I. H.; Moliner, V.
Insights on the origin of catalysis on glycine N-methyltransferase from computational modeling
J. Am. Chem. Soc.
140
4327-4334
2018
Rattus norvegicus (P13255)
Manually annotated by BRENDA team
Wang, Y.; Wu, M.; Lin, Y.; Tang, F.; Ko, H.; Chiang, E.
Regulation of folate-mediated one-carbon metabolism by glycine N-methyltransferase (GNMT) and methylenetetrahydrofolate reductase (MTHFR)
J. Nutr. Sci. Vitaminol.
61
S148-S150
2015
Mus musculus (Q9QXF8)
Manually annotated by BRENDA team