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2.1.1.20: glycine N-methyltransferase

This is an abbreviated version!
For detailed information about glycine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.20

Reaction

S-adenosyl-L-methionine
+
glycine
=
S-adenosyl-L-homocysteine
 +
sarcosine

Synonyms

4S polycyclic aromatic hydrocarbon binding protein, glycine methyltransferase, glycine N-methyltransferase, glycine-N methyltransferase, GNMT, Gnmt gene product, methyltransferase, glycine, S-adenosyl-L-methionine:glycine methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.20 glycine N-methyltransferase

Source Tissue

Source Tissue on EC 2.1.1.20 - glycine N-methyltransferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
high expression in normal tissue, reduced expression in tumorous tissue, some tumor samples show no enzyme expression
Manually annotated by BRENDA team
-
GNMT is expressed in the epithelium of the colon under normal conditions, and with dextran sulfate sodium treatment, its expression is predominant in infiltrated leukocytes of lesions
Manually annotated by BRENDA team
in unfertilized, 2 days postfertilization, and 3 days postfertilization embryos GNMT is constitutively higher than in 4, 7, 10 or 14 days postfertilization embryos
Manually annotated by BRENDA team
-
GNMT is expressed in the epithelium of the colon under normal conditions, and with dextran sulfate sodium treatment, its expression is predominant in infiltrated leukocytes of lesions
Manually annotated by BRENDA team
-
DNA extracted from peripherial blood cells
Manually annotated by BRENDA team
-
36.4% of tissues show loss of heterozygosity of the GNMT gene, GNMT expression diminished in 82.2% of tissues
Manually annotated by BRENDA team
-
LNCaP cells and PC-3 cells
Manually annotated by BRENDA team
additional information