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1.14.19.9: tryptophan 7-halogenase

This is an abbreviated version!
For detailed information about tryptophan 7-halogenase, go to the full flat file.

Word Map on EC 1.14.19.9

Reaction

tryptophan
+
FADH2
 +
chloride
 +
O2
 +
H+
=
7-chloro-L-tryptophan
 +
FAD
 + 2 H2O

Synonyms

EC 1.14.14.7, FAD-dependent halogenase, flavin-dependent halogenase, flavin-dependent tryptophan halogenase, halogenase, KtzQ, L-tryptophan-7-halogenase, PrnA, RebH, Trp 7-hal, Trp halogenase, Trp-7-Hal, Trp-7-halogenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.9 tryptophan 7-halogenase

Natural Substrates Products

Natural Substrates Products on EC 1.14.19.9 - tryptophan 7-halogenase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
6-chloro-L-tryptophan + FADH2 + chloride + O2 + H+
6,7-dichloro-L-tryptophan + FAD + 2 H2O
show the reaction diagram
-
-
-
?
L-tryptophan + FADH2 + chloride + O2 + H+
7-chloro-L-tryptophan + FAD + 2 H2O
show the reaction diagram
L-tryptophan + FADH2 + Cl- + O2
7-chloro-L-tryptophan + FAD + H2O
show the reaction diagram
-
formation of 7-chlorotryptophan as the initial step in the biosynthesis of antitumor agent rebeccamycin
-
-
?
L-tryptophan + FADH2 + Cl- + O2 + H+
7-chloro-L-tryptophan + FAD + H2O
show the reaction diagram
tryptophan + FADH2 + chloride + O2 + H+
7-chloro-L-tryptophan + FAD + 2 H2O
show the reaction diagram
-
-
-
?
tryptophan + FADH2 + Cl- + O2 + H+
7-chloro-L-tryptophan + FAD + 2 H2O
show the reaction diagram
-
-
-
-
?
tryptophan + FADH2 + Cl- + O2 + H+
7-chloro-L-tryptophan + FAD + H2O
show the reaction diagram
-
-
-
?
tryptophan + FADH2 + Cl- + O2 + H+
7-chloro-tryptophan + FAD + H2O
show the reaction diagram
tryptophan + FADH2 + O2 + Cl- + H+
7-chlorotryptophan + FAD + H2O
show the reaction diagram
-
initial step of rebeccamycin biosynthesis
-
-
?
additional information
?
-