1.14.19.9: tryptophan 7-halogenase

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For detailed information about tryptophan 7-halogenase, go to the full flat file.

Reaction

Synonyms

EC 1.14.14.7, FAD-dependent halogenase, flavin-dependent halogenase, flavin-dependent tryptophan halogenase, halogenase, KtzQ, L-tryptophan-7-halogenase, PrnA, RebH, Trp 7-hal, Trp halogenase, Trp-7-Hal, Trp-7-halogenase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

                1.14.19.9 tryptophan 7-halogenase

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Results	in table
578	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
15	Cofactor
5	Crystallization (Commentary)
3	General Information
1	Inhibitors
9	KM Value [mM]
3	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
23	Organism
5	Pathway
9	PDB ID
4	pH Optimum
10	Protein Variants
8	Purification (Commentary)
8	Reaction
7	Reaction Type
23	Reference
3	Specific Activity [micromol/min/mg]
46	Substrates and Products (Substrate)
2	Subunits
32	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
11	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.19.9 - tryptophan 7-halogenase

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SYSTEMATIC NAME

IUBMB Comments

L-tryptophan:FADH2 oxidoreductase (7-halogenating)

A flavin-dependent halogenase. The enzyme from the bacterium Lechevalieria aerocolonigenes catalyses the initial step in the biosynthesis of rebeccamycin [2]. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. Also acts on bromide ion. cf. EC 1.14.19.58, tryptophan 5-halogenase, and EC 1.14.19.59, tryptophan 6-halogenase.